Wilma J Friedman

Summary

Affiliation: Rutgers University
Country: USA

Publications

  1. ncbi request reprint Divergence of the apoptotic pathways induced by 4-hydroxynonenal and amyloid beta-protein
    Sylvia A Rabacchi
    Department of Pathology, Columbia University College of Physicians and Surgeons, 630 W 168th Street, New York, NY 10032, USA
    Neurobiol Aging 25:1057-66. 2004
  2. ncbi request reprint Interactions of interleukin-1 with neurotrophic factors in the central nervous system: beneficial or detrimental?
    Wilma J Friedman
    Department of Biological Sciences, Rutgers University, Newark, NJ, USA
    Mol Neurobiol 32:133-44. 2005
  3. pmc Proneurotrophins, seizures, and neuronal apoptosis
    Wilma J Friedman
    Department of Biological Sciences, Rutgers University, Newark, NJ 07102, USA
    Neuroscientist 16:244-52. 2010
  4. pmc ProNGF induces PTEN via p75NTR to suppress Trk-mediated survival signaling in brain neurons
    Wenyu Song
    Department of Biological Science, Rutgers University, Newark, New Jersey 07102, USA
    J Neurosci 30:15608-15. 2010
  5. pmc Induction of proneurotrophins and activation of p75NTR-mediated apoptosis via neurotrophin receptor-interacting factor in hippocampal neurons after seizures
    Marta Volosin
    Department of Biological Sciences, Rutgers University, Newark, New Jersey 07102, USA
    J Neurosci 28:9870-9. 2008
  6. pmc Nerve growth factor attenuates proliferation of astrocytes via the p75 neurotrophin receptor
    Andrea B Cragnolini
    Department of Biological Sciences, Rutgers University, Newark, New Jersey 07102, USA
    Glia 57:1386-92. 2009
  7. pmc Nerve growth factor induces cell cycle arrest of astrocytes
    Andrea B Cragnolini
    Department of Biological Sciences, Rutgers University, Newark, NJ 07102, USA
    Dev Neurobiol 72:766-76. 2012
  8. pmc Matrix metalloproteinase-7 regulates cleavage of pro-nerve growth factor and is neuroprotective following kainic acid-induced seizures
    Audrey P Le
    Department of Biological Sciences, Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, New Jersey 07102, USA
    J Neurosci 32:703-12. 2012
  9. pmc Neuron-specific effects of interleukin-1β are mediated by a novel isoform of the IL-1 receptor accessory protein
    Yangyang Huang
    Department of Biological Sciences, Rutgers University, Newark, New Jersey 07102, USA
    J Neurosci 31:18048-59. 2011
  10. ncbi request reprint Interaction of survival and death signaling in basal forebrain neurons: roles of neurotrophins and proneurotrophins
    Marta Volosin
    Department of Biological Sciences, Rutgers University, Newark, New Jersey 07102, USA
    J Neurosci 26:7756-66. 2006

Research Grants

  1. A Genetic Approach to Study the p75 Neurotrophin Receptor
    Wilma J Friedman; Fiscal Year: 2010
  2. Neurotrophins in the Injured Brain
    Wilma J Friedman; Fiscal Year: 2010
  3. A Genetic Approach to Study the p75 Neurotrophin Receptor
    Wilma Friedman; Fiscal Year: 2007
  4. Neurotrophin Actions in the Injured Brain
    Wilma Friedman; Fiscal Year: 2006
  5. Neurotrophins in the Injured Brain
    Wilma J Friedman; Fiscal Year: 2011

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Divergence of the apoptotic pathways induced by 4-hydroxynonenal and amyloid beta-protein
    Sylvia A Rabacchi
    Department of Pathology, Columbia University College of Physicians and Surgeons, 630 W 168th Street, New York, NY 10032, USA
    Neurobiol Aging 25:1057-66. 2004
    ..We conclude that HNE toxicity is mediated via a caspase-9-dependent pathway but that HNE accumulation need not induce cell death nor is it an obligate mediator of Abeta-induced cell death...
  2. ncbi request reprint Interactions of interleukin-1 with neurotrophic factors in the central nervous system: beneficial or detrimental?
    Wilma J Friedman
    Department of Biological Sciences, Rutgers University, Newark, NJ, USA
    Mol Neurobiol 32:133-44. 2005
    ..This article examines the interaction of IL-1 with different trophic factors in the brain...
  3. pmc Proneurotrophins, seizures, and neuronal apoptosis
    Wilma J Friedman
    Department of Biological Sciences, Rutgers University, Newark, NJ 07102, USA
    Neuroscientist 16:244-52. 2010
    ..This review will discuss the evidence that this ligand-receptor system plays an important role in neuronal loss following seizures...
  4. pmc ProNGF induces PTEN via p75NTR to suppress Trk-mediated survival signaling in brain neurons
    Wenyu Song
    Department of Biological Science, Rutgers University, Newark, New Jersey 07102, USA
    J Neurosci 30:15608-15. 2010
    ....
  5. pmc Induction of proneurotrophins and activation of p75NTR-mediated apoptosis via neurotrophin receptor-interacting factor in hippocampal neurons after seizures
    Marta Volosin
    Department of Biological Sciences, Rutgers University, Newark, New Jersey 07102, USA
    J Neurosci 28:9870-9. 2008
    ..Overall, these studies demonstrate the requirement for NRIF to signal p75(NTR)-mediated apoptosis of hippocampal neurons and that blocking pro-NGF can inhibit neuronal loss after seizures...
  6. pmc Nerve growth factor attenuates proliferation of astrocytes via the p75 neurotrophin receptor
    Andrea B Cragnolini
    Department of Biological Sciences, Rutgers University, Newark, New Jersey 07102, USA
    Glia 57:1386-92. 2009
    ..Instead, activation of p75(NTR) by NGF attenuated proliferation induced by mitogens such as EGF or serum. These studies demonstrate the cell type specificity of neurotrophin functions in the brain...
  7. pmc Nerve growth factor induces cell cycle arrest of astrocytes
    Andrea B Cragnolini
    Department of Biological Sciences, Rutgers University, Newark, NJ 07102, USA
    Dev Neurobiol 72:766-76. 2012
    ....
  8. pmc Matrix metalloproteinase-7 regulates cleavage of pro-nerve growth factor and is neuroprotective following kainic acid-induced seizures
    Audrey P Le
    Department of Biological Sciences, Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, New Jersey 07102, USA
    J Neurosci 32:703-12. 2012
    ..These data demonstrate that increased extracellular proNGF levels following seizures are stabilized by altered MMP-7 enzymatic activity, leading to increased neuronal death via activation of p75(NTR)...
  9. pmc Neuron-specific effects of interleukin-1β are mediated by a novel isoform of the IL-1 receptor accessory protein
    Yangyang Huang
    Department of Biological Sciences, Rutgers University, Newark, New Jersey 07102, USA
    J Neurosci 31:18048-59. 2011
    ..AcPb also played a modulatory role in the activation of p38 MAPK, but had no effect on NF-κB signaling. The restricted expression of AcPb in CNS neurons, therefore, governs specific neuronal signaling and functional responses to IL-1β...
  10. ncbi request reprint Interaction of survival and death signaling in basal forebrain neurons: roles of neurotrophins and proneurotrophins
    Marta Volosin
    Department of Biological Sciences, Rutgers University, Newark, New Jersey 07102, USA
    J Neurosci 26:7756-66. 2006
    ..This study shows that proneurotrophins are produced in the brain under pathological conditions, and can elicit apoptosis of BF neurons even when Trk receptors are activated...
  11. doi request reprint The function of p75NTR in glia
    Andrea B Cragnolini
    Department of Biological Sciences, Rutgers University, Newark, NJ 07102, USA
    Trends Neurosci 31:99-104. 2008
    ..In this review, we will examine the potential roles for p75(NTR) in glial function...
  12. ncbi request reprint Differential regulation of neurotrophin expression in basal forebrain astrocytes by neuronal signals
    Hai Wu
    Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    J Neurosci Res 76:76-85. 2004
    ..Critical neuronal-glial interactions may underlie basal forebrain function...

Research Grants13

  1. A Genetic Approach to Study the p75 Neurotrophin Receptor
    Wilma J Friedman; Fiscal Year: 2010
    ....
  2. Neurotrophins in the Injured Brain
    Wilma J Friedman; Fiscal Year: 2010
    ..Our studies will elucidate the mechanisms by which these key factors regulate neuronal death when the p75 receptor is induced, which occurs after different types of brain injury, as well as in neurodegenerative disease. ..
  3. A Genetic Approach to Study the p75 Neurotrophin Receptor
    Wilma Friedman; Fiscal Year: 2007
    ....
  4. Neurotrophin Actions in the Injured Brain
    Wilma Friedman; Fiscal Year: 2006
    ..Thus, the goal of these studies is to define the role of the p75 neurotrophin receptor in mediating cell death in hippocampal neurons, particularly under conditions of brain injury. ..
  5. Neurotrophins in the Injured Brain
    Wilma J Friedman; Fiscal Year: 2011
    ..Our studies will elucidate the mechanisms by which these key factors regulate neuronal death when the p75 receptor is induced, which occurs after different types of brain injury, as well as in neurodegenerative disease. ..