Ronaldo P Ferraris
Affiliation: Rutgers University
Kishida K, Martinez G, Iida T, Yamada T, Ferraris R, Toyoda Y. d-Allulose is a substrate of glucose transporter type 5 (GLUT5) in the small intestine. Food Chem. 2019;277:604-608 pubmed publisher
..GLUT5 clearly mediates, likely at lower affinity relative to d-fructose, intestinal d-allulose transport. ..
Ferraris R, Choe J, Patel C. Intestinal Absorption of Fructose. Annu Rev Nutr. 2018;38:41-67 pubmed publisher
..Finally, it discusses the potential contributions of dietary fructose to gastrointestinal diseases and to the gut microbiome. ..
Patel C, Douard V, Yu S, Gao N, Ferraris R. Transport, metabolism, and endosomal trafficking-dependent regulation of intestinal fructose absorption. FASEB J. 2015;29:4046-58 pubmed publisher
..GLUT5 is the primary transporter responsible for facilitative absorption of fructose, and its regulation specifically requires fructose uptake and metabolism and normal GLUT5 trafficking to the apical membrane. ..
Patel C, Douard V, Yu S, Tharabenjasin P, Gao N, Ferraris R. Fructose-induced increases in expression of intestinal fructolytic and gluconeogenic genes are regulated by GLUT5 and KHK. Am J Physiol Regul Integr Comp Physiol. 2015;309:R499-509 pubmed publisher
..The feedforward upregulation of fructolytic and gluconeogenic enzymes specifically requires GLUT5 and KHK and may proactively enhance the intestine's ability to process anticipated increases in dietary fructose concentrations. ..
Patel C, Sugimoto K, Douard V, Shah A, Inui H, Yamanouchi T, et al
. Effect of dietary fructose on portal and systemic serum fructose levels in rats and in KHK-/- and GLUT5-/- mice. Am J Physiol Gastrointest Liver Physiol. 2015;309:G779-90 pubmed publisher
..These findings explain the hyperfructosemia of human hereditary fructosuria as well as the hyperglycemia of fructose-induced metabolic syndrome. ..
Pearce S, Al Jawadi A, Kishida K, Yu S, Hu M, Fritzky L, et al
. Marked differences in tight junction composition and macromolecular permeability among different intestinal cell types. BMC Biol. 2018;16:19 pubmed publisher
..This work advances our understanding of how cell differentiation affects the paracellular pathway of epithelia. ..