Affiliation: Rutgers University
- Pokeweed antiviral protein: its cytotoxicity mechanism and applications in plant disease resistanceRong Di
Department of Plant Biology and Pathology, Rutgers, The State University of New Jersey, 59 Dudley Road, New Brunswick, NJ 08901, USA
Toxins (Basel) 7:755-72. 2015..Transgenic plants expressing PAP and non-toxic PAP mutants have displayed broad-spectrum resistance to both viral and fungal infection. The mechanism of PAP-induced disease resistance in transgenic plants is summarized. ..
- Acetylcholineestarase-inhibiting alkaloids from Lycoris radiata delay paralysis of amyloid beta-expressing transgenic C. elegans CL4176Lijuan Xin
College of Life and Environmental Sciences, Minzu University of China, Beijing, China
PLoS ONE 8:e63874. 2013..Lycoris compounds were shown to significantly inhibit the gene expression of ace-1 and ace-2. Additionally, the Lycoris compounds may modulate inflammatory and stress-related gene expressions to combat the Aβ-toxicity in C. elegans...
- An N-terminal fragment of yeast ribosomal protein L3 inhibits the cytotoxicity of pokeweed antiviral protein in Saccharomyces cerevisiaeRong Di
Department of Plant Biology and Pathology, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ 08901, USA
Toxins (Basel) 6:1349-61. 2014....
- Anti-inflammatory activities of mogrosides from Momordica grosvenori in murine macrophages and a murine ear edema modelRong Di
Department of Plant Biology and Pathology, Rutgers University, New Brunswick, NJ 08901, USA
J Agric Food Chem 59:7474-81. 2011..This study shows that the anticancer and antidiabetic effects of M. grosvenori may result in part from its anti-inflammatory activity...
- Evidence for retro-translocation of pokeweed antiviral protein from endoplasmic reticulum into cytosol and separation of its activity on ribosomes from its activity on capped RNABijal A Parikh
Graduate Program in Microbiology and Molecular Genetics, Rutgers University, New Brunswick, New Jersey 08901 8520, USA
Biochemistry 44:2478-90. 2005..These findings suggest that the altered active site of PAP might accommodate a narrower range of substrates, thus reducing ribotoxicity while maintaining potential therapeutic benefits...
- Expression of a truncated form of ribosomal protein L3 confers resistance to pokeweed antiviral protein and the Fusarium mycotoxin deoxynivalenolRong Di
Biotechnology Center for Agriculture and the Environment, Cook College, Rutgers University, New Brunswick, New Jersey 08901 8520, USA
Mol Plant Microbe Interact 18:762-70. 2005..These results demonstrate that expression of an N-terminal fragment of yeast L3 leads to trans-dominant resistance to PAP and the trichothecene mycotoxin DON, providing evidence that both toxins target L3 by a common mechanism...
- Enhancement of the primary flavor compound methional in potato by increasing the level of soluble methionineRong Di
Biotechnology Center for the Agriculture and the Environment, Department of Plant Biology and Pathology, Rutgers University, Cook College, 59 Dudley Road, New Brunswick, NJ 08901 8520, USA
J Agric Food Chem 51:5695-702. 2003..These results provide the first evidence that the methional level can be enhanced in processed potatoes by increasing the production of its precursor, methionine...
- Identification of amino acids critical for the cytotoxicity of Shiga toxin 1 and 2 in Saccharomyces cerevisiaeRong Di
Department of Plant Biology and Pathology, School of Environmental and Biological Sciences, Rutgers University, 59 Dudley Road, New Brunswick, NJ 08901 8502, USA
Toxicon 57:525-39. 2011..The extent of ribosome depurination and translation inhibition did not correlate with the extent of cell death, indicating that depurination of the SRL and inhibition of translation are not entirely responsible for cell death...
- Evaluating pH-induced gastrointestinal aggregation of Arachis hypogaea 1 fragments as potential components of peanut allergyI John Khan
Center for Advanced Biotechnology and Medicine, Department of Biochemistry and Molecular Biology, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, 679 Hoes Lane, Piscataway, New Jersey 08854, United States
J Agric Food Chem 61:8430-5. 2013..It is proposed that peptide fragments which survive gastric conditions form large aggregates in basic environments such as the small intestine, making epitopes available for triggering an allergic response. ..
- Biodegradable ferulic acid-containing poly(anhydride-ester): degradation products with controlled release and sustained antioxidant activityMichelle A Ouimet
Department of Chemistry and Chemical Biology, Rutgers University, 610 Taylor Road, Piscataway, NJ 08854, USA
Biomacromolecules 14:854-61. 2013..This renders the polymer a potential candidate for use as a controlled release system for skin care formulations...
- Generation of pokeweed antiviral protein mutations in Saccharomyces cerevisiae: evidence that ribosome depurination is not sufficient for cytotoxicityKatalin A Hudak
Biotechnology Center for Agriculture and the Environment and the Department of Plant Biology and Pathology, Cook College, Rutgers University, New Brunswick, NJ 08901 8520, USA
Nucleic Acids Res 32:4244-56. 2004..These results demonstrate that the ability to depurinate ribosomes in trans in a catalytic manner is required for the inhibition of translation, but is not sufficient for cytotoxicity...
- Effect of Pokeweed antiviral protein on hepatitis C virus IRESRong Di; Fiscal Year: 2007..This study will lay the groundwork for designing novel drugs against HCV for the treatment of chronic hepatitis. [unreadable] [unreadable]..