D T Denhardt

Summary

Affiliation: Rutgers University
Country: USA

Publications

  1. ncbi request reprint Mice lacking osteopontin show normal development and bone structure but display altered osteoclast formation in vitro
    S R Rittling
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey, USA
    J Bone Miner Res 13:1101-11. 1998
  2. pmc Tissue inhibitor of metalloproteinase-1 stimulates proliferation of human cancer cells by inhibiting a metalloproteinase
    J F Porter
    The Graduate Program in Microbiology and Molecular Genetics, Department of Cell Biology and Neuroscience, Rutgers University, Nelson Laboratories, 604 Allison Road, Piscataway, NJ 08854, USA
    Br J Cancer 90:463-70. 2004
  3. pmc Osteopontin expression during early cerebral ischemia-reperfusion in rats: enhanced expression in the right cortex is suppressed by acetaminophen
    Sunanda S Baliga
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey, United States of America
    PLoS ONE 6:e14568. 2011
  4. pmc Acetaminophen attenuates doxorubicin-induced cardiac fibrosis via osteopontin and GATA4 regulation: reduction of oxidant levels
    Kathryn J Schunke
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ, USA
    J Cell Physiol 228:2006-14. 2013
  5. ncbi request reprint Transcriptional regulation of osteopontin and the metastatic phenotype: evidence for a Ras-activated enhancer in the human OPN promoter
    David T Denhardt
    Nelson Laboratories, Rutgers University, Piscataway, New Jersey 88854, USA
    Clin Exp Metastasis 20:77-84. 2003
  6. ncbi request reprint Commentary re: Q-T Le et al, identification of osteopontin as a prognostic marker for head and neck squamous cell carcinomas. clin cancer res, 9: 31-32, 2003
    David T Denhardt
    Cell Biology and Neurosciences, Rutgers, The State University of New Jersey, Nelson Biology Laboratories, Piscataway, New Jersey 08854, USA
    Clin Cancer Res 9:31-2. 2003
  7. ncbi request reprint Osteopontin expression and function: role in bone remodeling
    D T Denhardt
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854, USA
    J Cell Biochem Suppl 30:92-102. 1998
  8. ncbi request reprint Osteopontin-deficient bone cells are defective in their ability to produce NO in response to pulsatile fluid flow
    D T Denhardt
    Department of Cell Biology and Neuroscience, Nelson Biological Laboratories, Rutgers University, 604 Allison Road, Piscataway, NJ 08854, USA
    Biochem Biophys Res Commun 288:448-53. 2001
  9. ncbi request reprint Role of osteopontin in cellular signaling and toxicant injury
    D T Denhardt
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854, USA
    Annu Rev Pharmacol Toxicol 41:723-49. 2001
  10. ncbi request reprint Overcoming obstacles to metastasis--defenses against host defenses: osteopontin (OPN) as a shield against attack by cytotoxic host cells
    D T Denhardt
    Department of Biological Sciences, Rutgers University, Piscataway, New Jersey
    J Cell Biochem 56:48-51. 1994

Research Grants

  1. Third International Conference on Osteopontin
    David Denhardt; Fiscal Year: 2002

Collaborators

Detail Information

Publications56

  1. ncbi request reprint Mice lacking osteopontin show normal development and bone structure but display altered osteoclast formation in vitro
    S R Rittling
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey, USA
    J Bone Miner Res 13:1101-11. 1998
    ..These results suggest that OPN is not essential for normal mouse development and osteogenesis, but can modulate osteoclast differentiation...
  2. pmc Tissue inhibitor of metalloproteinase-1 stimulates proliferation of human cancer cells by inhibiting a metalloproteinase
    J F Porter
    The Graduate Program in Microbiology and Molecular Genetics, Department of Cell Biology and Neuroscience, Rutgers University, Nelson Laboratories, 604 Allison Road, Piscataway, NJ 08854, USA
    Br J Cancer 90:463-70. 2004
    ..Assays for ERK1/2 and p38 showed that both were activated by TIMP-1 and GM6001. Mechanisms by which TIMP-1 might act to stimulate cell proliferation are described...
  3. pmc Osteopontin expression during early cerebral ischemia-reperfusion in rats: enhanced expression in the right cortex is suppressed by acetaminophen
    Sunanda S Baliga
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey, United States of America
    PLoS ONE 6:e14568. 2011
    ....
  4. pmc Acetaminophen attenuates doxorubicin-induced cardiac fibrosis via osteopontin and GATA4 regulation: reduction of oxidant levels
    Kathryn J Schunke
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ, USA
    J Cell Physiol 228:2006-14. 2013
    ..These effects were mediated, in part, by the ability of APAP, acting as an anti-inflammatory agent, to decrease intracellular ROS levels, consequently diminishing the injury-induced increase in OPN levels...
  5. ncbi request reprint Transcriptional regulation of osteopontin and the metastatic phenotype: evidence for a Ras-activated enhancer in the human OPN promoter
    David T Denhardt
    Nelson Laboratories, Rutgers University, Piscataway, New Jersey 88854, USA
    Clin Exp Metastasis 20:77-84. 2003
    ..In this communication we address two issues: (1) How does OPN facilitate the metastatic phenotype? (2) What mechanisms are responsible for the increase in OPN transcription in metastatic cells?..
  6. ncbi request reprint Commentary re: Q-T Le et al, identification of osteopontin as a prognostic marker for head and neck squamous cell carcinomas. clin cancer res, 9: 31-32, 2003
    David T Denhardt
    Cell Biology and Neurosciences, Rutgers, The State University of New Jersey, Nelson Biology Laboratories, Piscataway, New Jersey 08854, USA
    Clin Cancer Res 9:31-2. 2003
  7. ncbi request reprint Osteopontin expression and function: role in bone remodeling
    D T Denhardt
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854, USA
    J Cell Biochem Suppl 30:92-102. 1998
    ..Its apparent ability to enhance cell survival by inhibiting apoptosis may explain why the metastatic proficiency of tumor cells increases with increased OPN expression...
  8. ncbi request reprint Osteopontin-deficient bone cells are defective in their ability to produce NO in response to pulsatile fluid flow
    D T Denhardt
    Department of Cell Biology and Neuroscience, Nelson Biological Laboratories, Rutgers University, 604 Allison Road, Piscataway, NJ 08854, USA
    Biochem Biophys Res Commun 288:448-53. 2001
    ..These results suggest that bone cells require OPN to respond fully to PFF as assessed by increased NO and reduced PGE(2) synthesis...
  9. ncbi request reprint Role of osteopontin in cellular signaling and toxicant injury
    D T Denhardt
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854, USA
    Annu Rev Pharmacol Toxicol 41:723-49. 2001
    ..Recent studies have revealed that OPN plays critical roles in bone remodeling and cell-mediated immunity...
  10. ncbi request reprint Overcoming obstacles to metastasis--defenses against host defenses: osteopontin (OPN) as a shield against attack by cytotoxic host cells
    D T Denhardt
    Department of Biological Sciences, Rutgers University, Piscataway, New Jersey
    J Cell Biochem 56:48-51. 1994
    ..We hypothesize that those cancer cells that produce OPN at elevated levels can suppress the oxidative burst, inhibit NO production, and thus protect themselves from killing by specific host cell types...
  11. ncbi request reprint Osteopontin-induced modifications of cellular functions
    D T Denhardt
    Department of Biological Sciences, Rutgers University, Piscataway, New Jersey 08855, USA
    Ann N Y Acad Sci 760:127-42. 1995
    ..OPN can also reduce cell peroxide levels, promote the survival of cells exposed to hypoxia, and inhibit the killing of tumor cells by activated macrophages...
  12. ncbi request reprint Osteopontin function in pathology: lessons from osteopontin-deficient mice
    S R Rittling
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, N J, USA
    Exp Nephrol 7:103-13. 1999
    ..These data will be important to the definition of how OPN contributes to mammalian physiology and pathophysiology...
  13. pmc Differential effects of osteopontin on the cytotoxic activity of macrophages from young and old mice
    E E Rollo
    Nelson Biological Laboratories, Rutgers University, Piscataway, NJ 08855, USA
    Immunology 88:642-7. 1996
    ..This may be due to the observed higher level of OPN expression in macrophages from old animals...
  14. pmc Osteopontin is required for full expression of the transformed phenotype by the ras oncogene
    Y Wu
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ, USA
    Br J Cancer 83:156-63. 2000
    ..Taken together, these results indicate that maximal transformation by ras requires OPN expression, and implicate increased OPN expression as an important effector of the transforming activity of the ras oncogene...
  15. ncbi request reprint Osteopontin facilitates bone resorption, decreasing bone mineral crystallinity and content during calcium deficiency
    S A Shapses
    Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ, USA
    Calcif Tissue Int 73:86-92. 2003
    ..These data suggest that osteopontin has both a physicochemical effect (inhibiting crystal growth and crystal proliferation) and a role in osteoclast recruitment, and in its absence, extraskeletal organs maintain calcium homeostasis...
  16. ncbi request reprint Heterogeneity of osteopontin expression among nephrons in mouse kidneys and enhanced expression in sclerotic glomeruli
    C A Lopez
    Department of Biological Sciences, Nelson Biological Laboratories, Rutgers University, Piscataway, New Jersey
    Lab Invest 69:355-63. 1993
    ..OPN mRNA is found at high levels in the kidney, and the protein is found in the urine. Because published reports of where the protein is produced conflict, we undertook a comprehensive study to localize OPN expression...
  17. ncbi request reprint Soluble osteopontin inhibits apoptosis of adherent endothelial cells deprived of growth factors
    S A Khan
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854, USA
    J Cell Biochem 85:728-36. 2002
    ..These data suggest that a function of OPN in homeostatic processes is to facilitate the survival of stressed endothelial cells, possibly by occupying unligated integrins and suppressing integrin-mediated death...
  18. ncbi request reprint Aprt/Opn double knockout mice: osteopontin is a modifier of kidney stone disease severity
    Hilary J Vernon
    Department of Genetics, Rutgers University, Piscataway, New Jersey 08854 8082, USA
    Kidney Int 68:938-47. 2005
    ..We examined the role of OPN in adenine phosphoribosyltransferase (Aprt) knockout mice, in which inflammation and formation of 2,8-dihydroxyadenine (DHA) kidney stones are prominent features, by generating Aprt/Opn double knockout mice...
  19. ncbi request reprint Enhanced cell surface CD44 variant (v6, v9) expression by osteopontin in breast cancer epithelial cells facilitates tumor cell migration: novel post-transcriptional, post-translational regulation
    Subarna A Khan
    Department of Cell Biology and Neuroscience, Nelson Laboratories, Rutgers University, 604 Allison Road, Piscataway, NJ 08854, USA
    Clin Exp Metastasis 22:663-73. 2005
    ..Our data provide evidence that in 21NT cells OPN enhances CD44s mRNA expression, increases cell surface expression of CD44 variant forms without a change in mRNA levels, and stimulates cell migration...
  20. pmc Osteopontin regulates hindlimb-unloading-induced lymphoid organ atrophy and weight loss by modulating corticosteroid production
    Kathryn X Wang
    Graduate Program in Cell and Developmental Biology, The State University of New Jersey, Nelson Biological Laboratories, 604 Allison Road, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 104:14777-82. 2007
    ..These results reveal that OPN is required for enhanced corticosterone production, immune organ atrophy, and weight loss in mice subjected to HU...
  21. doi request reprint Plasma osteopontin modulates chronic restraint stress-induced thymus atrophy by regulating stress hormones: inhibition by an anti-osteopontin monoclonal antibody
    Kathryn X Wang
    Graduate Program in Cell and Developmental Biology, The State University of New Jersey, Nelson Biological Laboratories, Piscataway, NJ 08854, USA
    J Immunol 182:2485-91. 2009
    ..These studies reveal that circulating OPN plays a significant role in the regulation of the hypothalamus-pituitary-adrenal axis hormones and that it augments CRS-induced organ atrophy...
  22. ncbi request reprint Osteopontin expression in osteoblasts and osteocytes during bone formation under mechanical stress in the calvarial suture in vivo
    Mikihiko Morinobu
    Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    J Bone Miner Res 18:1706-15. 2003
    ..Our results indicated that OPN expression was enhanced during the bone formation and that OPN would be one of the positive factors for the bone formation under mechanical stress...
  23. ncbi request reprint Exacerbated tissue destruction in DSS-induced acute colitis of OPN-null mice is associated with downregulation of TNF-alpha expression and non-programmed cell death
    Andre Paes Batista Da Silva
    CIHR Group in Matrix Dynamics, University of Toronto, Toronto, Ontario, Canada
    J Cell Physiol 208:629-39. 2006
    ..Collectively, these studies demonstrate that OPN is required for mucosal protection in acute inflammatory colitis...
  24. ncbi request reprint Increased thalamic neurodegeneration following ischaemic cortical stroke in osteopontin-deficient mice
    Michael Schroeter
    Department of Neurology, Heinrich Heine University Dusseldorf, Germany
    Brain 129:1426-37. 2006
    ..Neuroprotective and anti-inflammatory effects of OPN may be relevant for a variety of neurological disease conditions...
  25. pmc Osteopontin participates in Th1-mediated host resistance against nonlethal malaria parasite Plasmodium chabaudi chabaudi infection in mice
    Yoshimasa Maeno
    Department of Virology and Parasitology, Fujita Health University School of Medicine, 1 98 Kutsukake, Toyoake, Aichi 470 1192, Japan
    Infect Immun 74:2423-7. 2006
    ..OPN-KO mice produced significantly smaller amounts of interleukin-12 and gamma interferon than WT mice produced. These results suggested that OPN is involved in Th1-mediated immunity against malaria infection...
  26. ncbi request reprint Cell type-specific post-translational modifications of mouse osteopontin are associated with different adhesive properties
    Brian Christensen
    Protein Chemistry Laboratory, Department of Molecular Biology, University of Aarhus, DK 8000 Aarhus C, Denmark
    J Biol Chem 282:19463-72. 2007
    ..These results strongly support the hypothesis that the degree of phosphorylation of OPN produced by different cell types can regulate its function...
  27. ncbi request reprint Osteopontin aggravates experimental autoimmune uveoretinitis in mice
    Mizuki Kitamura
    Division of Immunobiology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    J Immunol 178:6567-72. 2007
    ..Our present results demonstrate that OPN may represent a novel therapeutic target to control uveoretinitis...
  28. ncbi request reprint Hypoxia upregulates osteopontin expression in NIH-3T3 cells via a Ras-activated enhancer
    Yonghua Zhu
    Department of Radiation Oncology, 875 Blake Wilbur Dr, R CC G228, Stanford University, Stanford, CA 94305, USA
    Oncogene 24:6555-63. 2005
    ..Taken together, these results have identified a new hypoxia responsive transcriptional enhancer that is regulated by Akt signaling...
  29. ncbi request reprint Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells
    Susan K Nilsson
    Stem Cell Laboratory, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett St, Melbourne, Victoria, Australia, 3000
    Blood 106:1232-9. 2005
    ..These data therefore provide strong evidence that Opn is an important component of the HSC niche which participates in HSC location and as a physiologic-negative regulator of HSC proliferation...
  30. ncbi request reprint Osteopontin deficiency induces parathyroid hormone enhancement of cortical bone formation
    Keiichiro Kitahara
    Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 101 0062, Japan
    Endocrinology 144:2132-40. 2003
    ..These observations indicated that OPN deficiency specifically induces PTH activation of periosteal bone formation in the cortical bone envelope...
  31. pmc The cytokine osteopontin modulates the severity of rotavirus diarrhea
    Ellen E Rollo
    Research Service 151, Northport V A Medical Center, Northport, NY 11768, USA
    J Virol 79:3509-16. 2005
    ..Rotavirus infection of intestinal epithelial cells and murine intestine caused marked increases in OPN mRNA levels and secreted OPN protein. OPN-deficient mice suffered prolonged disease...
  32. ncbi request reprint Osteopontin-deficiency suppresses growth of B16 melanoma cells implanted in bone and osteoclastogenesis in co-cultures
    Yoshio Ohyama
    Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    J Bone Miner Res 19:1706-11. 2004
    ..Osteopontin deficiency decreased tumor invasion in bone based on knockout mouse study. In bone, osteopontin is a positive factor to increase tumor invasion...
  33. ncbi request reprint Rho-dependent Rho kinase activation increases CD44 surface expression and bone resorption in osteoclasts
    Meenakshi A Chellaiah
    Department of Oral Craniofacial Biological Sciences, University of Maryland, Baltimore, Maryland 21201, USA
    J Biol Chem 278:29086-97. 2003
    ..Finally, we find that cooperativity exists between alphavbeta3 and CD44 for osteoclast motility and bone resorption...
  34. ncbi request reprint Osteopontin modulates CD44-dependent chemotaxis of peritoneal macrophages through G-protein-coupled receptors: evidence of a role for an intracellular form of osteopontin
    Baoqian Zhu
    CIHR Group in Matrix Dynamics, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada
    J Cell Physiol 198:155-67. 2004
    ....
  35. ncbi request reprint An osteopontin-NADPH oxidase signaling cascade promotes pro-matrix metalloproteinase 9 activation in aortic mesenchymal cells
    Chung Fang Lai
    Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
    Circ Res 98:1479-89. 2006
    ..Thus, OPN provides a paracrine signal that augments vascular pro-MMP9 activity, mediated in part via superoxide generation and oxylipid formation...
  36. ncbi request reprint Osteopontin is required for mechanical stress-dependent signals to bone marrow cells
    Muneaki Ishijima
    Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3 10, Kanda Surugadai 2 Chome, Tokyo, Japan
    J Endocrinol 193:235-43. 2007
    ....
  37. ncbi request reprint Osteopontin deficiency enhances anabolic action of EP4 agonist at a sub-optimal dose in bone
    Norihiko Kato
    Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3 10 Kanda Surugadai 2 Chome, Tokyo, Japan
    J Endocrinol 193:171-82. 2007
    ..Finally, OPN deficiency enhanced anabolic action of EP4A in the mice subjected to ovariectomy. These data indicate that OPN deficiency enhances the actions of EP4A at sub-optimal dose...
  38. ncbi request reprint Resistance to unloading-induced three-dimensional bone loss in osteopontin-deficient mice
    Muneaki Ishijima
    Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Japan
    J Bone Miner Res 17:661-7. 2002
    ..Sp) in wild-type mice. In contrast, these 3D parameters were not altered after tail suspension in OPN-/- mice. These data provided evidence that OPN is required for unloading-induced 3D bone loss...
  39. ncbi request reprint OPN deficiency suppresses appearance of odontoclastic cells and resorption of the tooth root induced by experimental force application
    Chooryung J Chung
    Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    J Cell Physiol 214:614-20. 2008
    ..These observations indicate that OPN deficiency suppresses specifically tooth root resorption in case of experimental force application...
  40. doi request reprint Corneal wound healing in an osteopontin-deficient mouse
    Ken ichi Miyazaki
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Invest Ophthalmol Vis Sci 49:1367-75. 2008
    ..To investigate the effects of loss of osteopontin (OPN) in the healing of the injured cornea in mice. Cell culture study was also conducted to clarify the effects of OPN in fibroblast behaviors...
  41. pmc Osteopontin negatively regulates parathyroid hormone receptor signaling in osteoblasts
    Noriaki Ono
    Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 1 5 45 Yushima, 113 8510, Tokyo, Japan
    J Biol Chem 283:19400-9. 2008
    ..Thus, in addition to the well known calcemic feedback system for PTH, local feedback regulation by the bone matrix protein OPN also plays a significant role in the regulation of PTH actions...
  42. pmc Role of osteopontin in murine Lyme arthritis and host defense against Borrelia burgdorferi
    Melissa R Potter
    Department of Pathology, Division of Cell Biology and Immunology, University of Utah School of Medicine, Salt Lake City, Utah 84132 2501, USA
    Infect Immun 70:1372-81. 2002
    ..Interestingly, there was no alteration in the B. burgdorferi-specific antibody isotypes in OPN-deficient mice, indicating that its effect on helper T-cell responses is not relevant to the host response to B. burgdorferi...
  43. ncbi request reprint Osteopontin-deficient mice exhibit less inflammation, greater tissue damage, and impaired locomotor recovery from spinal cord injury compared with wild-type controls
    Masayuki Hashimoto
    Togane Prefectural Hospital, Togane, Chiba 2838588, Japan
    J Neurosci 27:3603-11. 2007
    ..This result supports a potential neuroprotective role for OPN in the inflammatory response to spinal cord injury...
  44. ncbi request reprint Osteopontin deficiency and aging on nanomechanics of mouse bone
    N Beril Kavukcuoglu
    Department of Materials Science and Engineering, Rutgers University, New Jersey 08854, USA
    J Biomed Mater Res A 83:136-44. 2007
    ..In addition, OPN(+/+) bones show a decrease in mechanical properties between young and older age groups. By contrast, OPN(-/-) bones showed no significant change in mechanical properties with aging...
  45. ncbi request reprint Increased expression of the remodeling- and tumorigenic-associated factor osteopontin in pyramidal neurons of the Alzheimer's disease brain
    John K Wung
    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Curr Alzheimer Res 4:67-72. 2007
    ....
  46. ncbi request reprint Osteopontin traffic in hypoxic renal epithelial cells
    Dierk J Hampel
    Department of Medicine, Division of Nephrology and Hypertension, State University of New York at Stony Brook, Stony Brook, NY, USA
    Nephron Exp Nephrol 94:e66-76. 2003
    ..These findings demonstrate that stress inhibits OPN secretion by the process dependent on the functional Golgi apparatus and actin cytoskeleton; recovery restores OPN secretion, although its polarity may become perturbed...
  47. ncbi request reprint Prenatal detection of embryo resorption in osteopontin-deficient mice using serial noninvasive magnetic resonance microscopy
    Andrea S Weintraub
    The Mount Sinai School of Medicine, Box 1508, One Gustave L Levy Place, New York, NY 10029, USA
    Pediatr Res 55:419-24. 2004
    ..However, targeted disruption of one or more OPN alleles had no effect on embryo number at any gestational age. Thus, MRM may be a powerful noninvasive method for in vivo prenatal developmental study of genetically engineered mice...
  48. ncbi request reprint Osteopontin affects the persistence of beta-glucan-induced hepatic granuloma formation and tissue injury through two distinct mechanisms
    Junko Morimoto
    Divison of Molecular Immunology, Institute for Genetic Medicine, Hokkaido University, Sapporo 060 0815, Japan
    Int Immunol 16:477-88. 2004
    ....
  49. ncbi request reprint Regulation of collagenase-3 and osteocalcin gene expression by collagen and osteopontin in differentiating MC3T3-E1 cells
    Richard C D'Alonzo
    Department of Physiology and Biophysics, Robert Wood Johnson Medical School and the Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854, USA
    J Biol Chem 277:24788-98. 2002
    ....
  50. ncbi request reprint Osteopontin deficiency suppresses high phosphate load-induced bone loss via specific modulation of osteoclasts
    Yuki Koyama
    Department of Molecular Pharmacology, Tokyo Medical and Dental University, Tokyo 101 0062, Japan
    Endocrinology 147:3040-9. 2006
    ..These data indicated that OPN is needed for osteoclastic activity to resorb bone on high phosphate loading...
  51. ncbi request reprint Osteoclasts resorb protein-free mineral (Osteologic discs) efficiently in the absence of osteopontin
    Tanupriya Contractor
    Program in Biotechnology, Kean University, 1000 Morris Avenue, Union, NJ 07083, USA
    In Vivo 19:335-41. 2005
    ....
  52. ncbi request reprint Osteopontin is associated with nuclear factor kappaB gene expression during tail-suspension-induced bone loss
    Muneaki Ishijima
    Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3 10, Kanda Surugadai 2 Chome, Chiyoda ku, Tokyo 101 0062, Japan
    Exp Cell Res 312:3075-83. 2006
    ..These data indicate that OPN acts to mediate mechanical stress signaling upstream to the genes encoding apoptosis-related molecules, and its action is associated with alteration of the genes...
  53. ncbi request reprint The role of osteopontin in tendon tissue remodeling after denervation-induced mechanical stress deprivation
    Noriaki Mori
    Department of Orthopaedic Surgery, Hokkaido University School of Medicine, Sapporo, Japan
    Matrix Biol 26:42-53. 2007
    ....
  54. ncbi request reprint Loss of osteopontin perturbs the epithelial-mesenchymal transition in an injured mouse lens epithelium
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Lab Invest 87:130-8. 2007
    ..An in vitro experiment shows OPN facilitates cell adhesion of lens epithelial cell line. OPN is required for activation of Smad2/3 signal in an injured lens epithelium and lens cell EMT...
  55. pmc Osteopontin deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice
    Kenji Yumoto
    Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 101 0062, Japan
    Proc Natl Acad Sci U S A 99:4556-61. 2002
    ..These results indicated that OPN plays a critical role in the destruction of joint cartilage in the rheumatoid arthritis model in mice via promotion of angiogenesis and induction of chondrocyte apoptosis...
  56. pmc Osteopontin expression and function within the dorsal root ganglion
    Barnaby C L Marsh
    Department of Pharmacology at South Bristol, University of Bristol, Bristol, UK
    Neuroreport 18:153-7. 2007
    ..Lastly, exogenous recombinant osteopontin has no effect on neurite outgrowth from adult wild-type sensory neurons, nor were differences in neurite outgrowth observed in osteopontin knock-out animals compared with wild-type controls...

Research Grants1

  1. Third International Conference on Osteopontin
    David Denhardt; Fiscal Year: 2002
    ..Publication of many of the contributions in the Journal of Cellular Biochemistry will assure that all the important new information presented at the conference will be widely disseminated. ..