Deborah A Cory-Slechta

Summary

Affiliation: Rutgers University
Country: USA

Publications

  1. pmc Maternal stress modulates the effects of developmental lead exposure
    Deborah A Cory-Slechta
    Department of Environmental Medicine and National Institute of Environmental Health Environmental Health Sciences Center, University of Rochester Medical School, Rochester, New York, USA
    Environ Health Perspect 112:717-30. 2004
  2. ncbi request reprint Developmental pesticide exposures and the Parkinson's disease phenotype
    Deborah A Cory-Slechta
    Environmental and Occupational Health Sciences Institute, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Birth Defects Res A Clin Mol Teratol 73:136-9. 2005
  3. ncbi request reprint Interactions of chronic lead exposure and intermittent stress: consequences for brain catecholamine systems and associated behaviors and HPA axis function
    Miriam B Virgolini
    Environmental and Occupational Health Sciences Institute, a Joint Institute of the Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, 08854, USA
    Toxicol Sci 87:469-82. 2005
  4. pmc Developmental pesticide models of the Parkinson disease phenotype
    Deborah A Cory-Slechta
    Environmental and Occupational Health Sciences Institute, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 07920, USA
    Environ Health Perspect 113:1263-70. 2005
  5. ncbi request reprint Overexpression of superoxide dismutase or glutathione peroxidase protects against the paraquat + maneb-induced Parkinson disease phenotype
    Mona Thiruchelvam
    Department of Biochemistry, and Environmental and Occupational Health Sciences Institute, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    J Biol Chem 280:22530-9. 2005
  6. ncbi request reprint Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice
    Eric K Richfield
    Department of Pathology and Lab Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Exp Neurol 175:35-48. 2002
  7. ncbi request reprint Behavioral sensitization and long-term neurochemical alterations associated with the fungicide triadimefon
    Ruth Reeves
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Pharmacol Biochem Behav 76:315-26. 2003
  8. ncbi request reprint A fetal risk factor for Parkinson's disease
    Brian K Barlow
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Dev Neurosci 26:11-23. 2004
  9. pmc Fish consumption and prenatal methylmercury exposure: cognitive and behavioral outcomes in the main cohort at 17 years from the Seychelles child development study
    Philip W Davidson
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Neurotoxicology 32:711-7. 2011
  10. pmc Subchronic polychlorinated biphenyl (Aroclor 1254) exposure produces oxidative damage and neuronal death of ventral midbrain dopaminergic systems
    Donna W Lee
    Department of Environmental Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA
    Toxicol Sci 125:496-508. 2012

Research Grants

  1. NMDA RECEPTOR AND BEHAVIORAL TOXICITY OF LEAD
    Deborah Cory Slechta; Fiscal Year: 2002

Collaborators

Detail Information

Publications40

  1. pmc Maternal stress modulates the effects of developmental lead exposure
    Deborah A Cory-Slechta
    Department of Environmental Medicine and National Institute of Environmental Health Environmental Health Sciences Center, University of Rochester Medical School, Rochester, New York, USA
    Environ Health Perspect 112:717-30. 2004
    ....
  2. ncbi request reprint Developmental pesticide exposures and the Parkinson's disease phenotype
    Deborah A Cory-Slechta
    Environmental and Occupational Health Sciences Institute, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Birth Defects Res A Clin Mol Teratol 73:136-9. 2005
    ..In addition, they demonstrate the fact that silent neurotoxicity produced by developmental insults can be unmasked by challenges later during life as well as the potential for cumulative neurotoxicity over the life span...
  3. ncbi request reprint Interactions of chronic lead exposure and intermittent stress: consequences for brain catecholamine systems and associated behaviors and HPA axis function
    Miriam B Virgolini
    Environmental and Occupational Health Sciences Institute, a Joint Institute of the Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, 08854, USA
    Toxicol Sci 87:469-82. 2005
    ....
  4. pmc Developmental pesticide models of the Parkinson disease phenotype
    Deborah A Cory-Slechta
    Environmental and Occupational Health Sciences Institute, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 07920, USA
    Environ Health Perspect 113:1263-70. 2005
    ..As such, this hypothesis presents a biologic strategy for identifying potentially significant neurotoxic mixtures for hazard identification in future studies...
  5. ncbi request reprint Overexpression of superoxide dismutase or glutathione peroxidase protects against the paraquat + maneb-induced Parkinson disease phenotype
    Mona Thiruchelvam
    Department of Biochemistry, and Environmental and Occupational Health Sciences Institute, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    J Biol Chem 280:22530-9. 2005
    ....
  6. ncbi request reprint Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice
    Eric K Richfield
    Department of Pathology and Lab Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Exp Neurol 175:35-48. 2002
    ..Expression of hm2alpha-SYN adversely affects the integrity of dopaminergic terminals and leads to age-related declines in motor coordination and dopaminergic markers...
  7. ncbi request reprint Behavioral sensitization and long-term neurochemical alterations associated with the fungicide triadimefon
    Ruth Reeves
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Pharmacol Biochem Behav 76:315-26. 2003
    ..Thus, TDF exposure may serve as an environmental risk factor for DA system dysfunctions...
  8. ncbi request reprint A fetal risk factor for Parkinson's disease
    Brian K Barlow
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Dev Neurosci 26:11-23. 2004
    ..This study implicates a role for developmental neurotoxicant exposure in the induction of neurodegenerative disorders such as PD...
  9. pmc Fish consumption and prenatal methylmercury exposure: cognitive and behavioral outcomes in the main cohort at 17 years from the Seychelles child development study
    Philip W Davidson
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Neurotoxicology 32:711-7. 2011
    ..For some endpoints we found performance improved with increasing prenatal exposure to MeHg. Follow up studies indicate this association is related to the beneficial nutrients present in fish...
  10. pmc Subchronic polychlorinated biphenyl (Aroclor 1254) exposure produces oxidative damage and neuronal death of ventral midbrain dopaminergic systems
    Donna W Lee
    Department of Environmental Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA
    Toxicol Sci 125:496-508. 2012
    ..In this study, we suggest that both OS and the uncoupling of iron regulation contribute to dopamine neuron degeneration and hyperactivity following PCB exposure...
  11. doi request reprint Lifetime consequences of combined maternal lead and stress
    Deborah A Cory-Slechta
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Basic Clin Pharmacol Toxicol 102:218-27. 2008
    ..Pb + stress effects observed in the absence of either risk factor alone raise questions about the capacity of current hazard identification approaches to adequately identify human health risks posed by neurotoxicants...
  12. ncbi request reprint The effect of developmental exposure to the fungicide triadimefon on behavioral sensitization to triadimefon during adulthood
    Ruth Reeves
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Toxicol Appl Pharmacol 200:54-63. 2004
    ..These results indicate for the first time that TDF may be considered an environmental risk factor for developmental dopaminergic neurotoxicity...
  13. ncbi request reprint Age-related irreversible progressive nigrostriatal dopaminergic neurotoxicity in the paraquat and maneb model of the Parkinson's disease phenotype
    Mona Thiruchelvam
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Eur J Neurosci 18:589-600. 2003
    ..Collectively, these data demonstrate enhanced sensitivity of the ageing nigrostriatal dopamine pathway to these pesticides, particularly paraquat + maneb, resulting in irreversible and progressive neurotoxicity...
  14. pmc Variations in the nature of behavioral experience can differentially alter the consequences of developmental exposures to lead, prenatal stress, and the combination
    Deborah A Cory-Slechta
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Toxicol Sci 131:194-205. 2013
    ....
  15. pmc Enhanced learning deficits in female rats following lifetime pb exposure combined with prenatal stress
    Deborah A Cory-Slechta
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Toxicol Sci 117:427-38. 2010
    ..These findings also underscore the critical need to evaluate toxicants in the context of other risk factors pertinent to human diseases and disorders...
  16. pmc Sustained exposure to the widely used herbicide atrazine: altered function and loss of neurons in brain monoamine systems
    Veronica M Rodriguez
    Environmental and Occupational Health Sciences Institute, and Department of Environmental and Occupational Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
    Environ Health Perspect 113:708-15. 2005
    ....
  17. ncbi request reprint Increased synaptosomal dopamine content and brain concentration of paraquat produced by selective dithiocarbamates
    Brian K Barlow
    Department of Pathology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Neurochem 85:1075-86. 2003
    ..These results suggest that selective dithiocarbamates may alter the kinetics of different endogenous and exogenous compounds to enhance their neurotoxicity...
  18. ncbi request reprint Modulation of antioxidant defense systems by the environmental pesticide maneb in dopaminergic cells
    Brian K Barlow
    Department of Environmental Medicine, School of Medicine, University of Rochester, Rochester, NY, USA
    Neurotoxicology 26:63-75. 2005
    ....
  19. pmc Brain hemispheric differences in the neurochemical effects of lead, prenatal stress, and the combination and their amelioration by behavioral experience
    Deborah A Cory-Slechta
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Toxicol Sci 132:419-30. 2013
    ..Furthermore, assessment of central nervous system mechanisms in the absence of behavioral experience, shown here for males, may constitute less relevant models of human health effects...
  20. pmc Increased lead biomarker levels are associated with changes in hormonal response to stress in occupationally exposed male participants
    Marie C Fortin
    Environmental and Occupational Health Sciences Institute, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey, USA
    Environ Health Perspect 120:278-83. 2012
    ..Objective: We investigated the effects of lead on responses of the HPA axis to a psychosocial laboratory stressor administered to Pb-exposed workers...
  21. ncbi request reprint Lead-induced impairments in complex cognitive function: offerings from experimental studies
    Deborah A Cory-Slechta
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Child Neuropsychol 9:54-75. 2003
    ..The impact of lead exposure on attention has yet to be clearly delineated in either human or experimental studies, although impulsivity or aversion to delay appears to be a sensitive component of attention that may be targeted...
  22. pmc Developmental exposure to concentrated ambient particles and preference for immediate reward in mice
    Joshua L Allen
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Environ Health Perspect 121:32-8. 2013
    ..Neuroinflammation and oxidative stress are two putative biological mechanisms by which air pollutants may adversely affect the brain...
  23. pmc Multisystem physiological dysfunction is associated with depressive symptoms in a population-based sample of older adults
    Roni W Kobrosly
    Department of Community and Preventive Medicine, University of Rochester Medical Center, Rochester, NY, USA
    Int J Geriatr Psychiatry 28:718-27. 2013
    ..To evaluate the association between multisystem physiological dysfunction and depressive symptom severity in the US older adults...
  24. pmc Lead exposure inhibits fracture healing and is associated with increased chondrogenesis, delay in cartilage mineralization, and a decrease in osteoprogenitor frequency
    Jonathan J Carmouche
    Center for Musculoskeletal Research, University of Rochester Medical Center, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642, USA
    Environ Health Perspect 113:749-55. 2005
    ..We conclude that Pb delays fracture healing at environmentally relevant doses and induces fibrous nonunions at higher doses by inhibiting the progression of endochondral ossification...
  25. ncbi request reprint Studying toxicants as single chemicals: does this strategy adequately identify neurotoxic risk?
    Deborah A Cory-Slechta
    Environmental and Occupational Health Sciences Institute, A joint Institute of Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854, USA
    Neurotoxicology 26:491-510. 2005
    ..e., multiple chemical exposures or chemical exposures combined with other risk factors), homeostatic capabilities may be restricted, thereby leading to sustained or cumulative damage...
  26. pmc Heavy metal lead exposure, osteoporotic-like phenotype in an animal model, and depression of Wnt signaling
    Eric E Beier
    Center for Musculoskeletal Research, University of Rochester, School of Medicine and Dentistry, Rochester, New York, USA
    Environ Health Perspect 121:97-104. 2013
    ..Elucidating the effect of Pb on bone cell function is therefore critical for understanding its risk associated with diseases of low bone mass...
  27. pmc Blood pressure and cognitive function: a prospective analysis among adolescents in Seychelles
    Tanica Lyngdoh
    Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland
    J Hypertens 31:1175-82. 2013
    ..We examined the prospective relation between BP and cognitive function in adolescence...
  28. pmc Socioeconomic position and cognitive function in the Seychelles: a life course analysis
    Roni W Kobrosly
    Department of Community and Preventive Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Neuroepidemiology 36:162-8. 2011
    ..In this study, we sought to confirm the relation between early-life socioeconomic position (SEP) and adult cognitive function, and to examine potential mediation by contemporaneous SEP...
  29. ncbi request reprint Paraquat increases cyanide-insensitive respiration in murine lung epithelial cells by activating an NAD(P)H:paraquat oxidoreductase: identification of the enzyme as thioredoxin reductase
    Joshua P Gray
    Department of Environmental and Occupational Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Biol Chem 282:7939-49. 2007
    ..Reactive oxygen intermediates and subsequent oxidative stress generated from this enzyme are likely to contribute to paraquat-induced lung toxicity...
  30. ncbi request reprint Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat
    Alison L McCormack
    The Parkinson s Institute, Sunnyvale, California 94089, USA
    Neurobiol Dis 10:119-27. 2002
    ....
  31. ncbi request reprint Lead exposure and dorsomedial striatum mediation of fixed interval schedule-controlled behavior
    Deborah A Cory-Slechta
    Samueli Institute for Informational Biology, Program on Neuroprotection, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Neurotoxicology 23:313-27. 2002
    ....
  32. ncbi request reprint Developmental exposure to the pesticides paraquat and maneb and the Parkinson's disease phenotype
    Mona Thiruchelvam
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    Neurotoxicology 23:621-33. 2002
    ....
  33. pmc Functional correction of established central nervous system deficits in an animal model of lysosomal storage disease with feline immunodeficiency virus-based vectors
    Andrew I Brooks
    Department of Internal Medicine, University of Iowa Program in Gene Therapy, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 99:6216-21. 2002
    ..These data suggest that enzyme replacement to the MPS VII central nervous system goes beyond restoration of beta-glucuronidase activity in the lysosome, and imparts improvements in plasticity and spatial learning...
  34. ncbi request reprint Interactive effects of a DRD4 polymorphism, lead, and sex on executive functions in children
    Tanya E Froehlich
    Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Biol Psychiatry 62:243-9. 2007
    ..Prior studies have examined independent effects of a dopamine receptor D4 polymorphism (DRD4-7) and lead exposure on executive functions but not their interaction or the role of sex as a modifier of their effects...
  35. ncbi request reprint The gestational environment and Parkinson's disease: evidence for neurodevelopmental origins of a neurodegenerative disorder
    Brian K Barlow
    MD PhD Program, Graduate Program in Neuroscience, UMDNJ RWJMS and Rutgers, USA
    Reprod Toxicol 23:457-70. 2007
    ..Additionally, challenges in studying the neurodevelopmental basis of neurodegeneration experimentally and epidemiologically are presented...
  36. pmc The conundrum of unmeasured confounding: Comment on: "Can some of the detrimental neurodevelopmental effects attributed to lead be due to pesticides? by Brian Gulson"
    Bruce P Lanphear
    Cincinnati Children s Environmental Health Center, Department of Pediatrics and of Environmental Health, Cincinnati Children s Hospital Medical Center, The University of Cincinnati, Cincinnati, Ohio, USA
    Sci Total Environ 396:196-200. 2008
    ..The alternative, to perpetually permit children to be exposed to lead and other emerging toxicants, is both absurd and unacceptable...
  37. ncbi request reprint Impaired neuropsychological functioning in lead-exposed children
    Richard L Canfield
    Division of Nutritional Sciences, College of Human Ecology, Cornell University, Savage Hall, Ithaca, NY 14853, USA
    Dev Neuropsychol 26:513-40. 2004
    ..These findings indicate that the effects of pediatric lead exposure are not restricted to global indexes of general intellectual functioning, and executive processes may be at particular risk of lead-induced neurotoxicity...
  38. ncbi request reprint Intellectual impairment in children with blood lead concentrations below 10 microg per deciliter
    Richard L Canfield
    Division of Nutritional Sciences, College of Human Ecology, Cornell University, Ithaca, NY 14853, USA
    N Engl J Med 348:1517-26. 2003
    ..483 micromol per liter), little is known about children's neurobehavioral functioning at lead concentrations below this level...
  39. pmc Blood lead concentrations < 10 microg/dL and child intelligence at 6 years of age
    Todd A Jusko
    Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA, USA
    Environ Health Perspect 116:243-8. 2008
    ..Few studies provide data directly relevant to the question of whether blood lead concentrations < 10 microg/dL adversely affect children's cognitive function...
  40. ncbi request reprint Letter regarding: "Paraquat: the red herring of Parkinson's disease research"
    Deborah A Cory-Slechta
    Toxicol Sci 103:215-6; author reply 217-8. 2008

Research Grants1

  1. NMDA RECEPTOR AND BEHAVIORAL TOXICITY OF LEAD
    Deborah Cory Slechta; Fiscal Year: 2002
    ....