Research Topics
Species | Deborah A Cory-SlechtaSummaryAffiliation: Rutgers University Country: USA Publications
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Publications
Interactions of chronic lead exposure and intermittent stress: consequences for brain catecholamine systems and associated behaviors and HPA axis functionMiriam B Virgolini
Environmental and Occupational Health Sciences Institute, a Joint Institute of the Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, 08854, USA
Toxicol Sci 87:469-82. 2005....
Maternal stress modulates the effects of developmental lead exposureDeborah A Cory-Slechta
Department of Environmental Medicine and National Institute of Environmental Health Environmental Health Sciences Center, University of Rochester Medical School, Rochester, New York, USA
Environ Health Perspect 112:717-30. 2004....- Developmental pesticide models of the Parkinson disease phenotypeDeborah A Cory-Slechta
Environmental and Occupational Health Sciences Institute, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 07920, USA
Environ Health Perspect 113:1263-70. 2005..As such, this hypothesis presents a biologic strategy for identifying potentially significant neurotoxic mixtures for hazard identification in future studies... - Developmental pesticide exposures and the Parkinson's disease phenotypeDeborah A Cory-Slechta
Environmental and Occupational Health Sciences Institute, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA
Birth Defects Res A Clin Mol Teratol 73:136-9. 2005..In addition, they demonstrate the fact that silent neurotoxicity produced by developmental insults can be unmasked by challenges later during life as well as the potential for cumulative neurotoxicity over the life span... - Overexpression of superoxide dismutase or glutathione peroxidase protects against the paraquat + maneb-induced Parkinson disease phenotypeMona Thiruchelvam
Department of Biochemistry, and Environmental and Occupational Health Sciences Institute, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
J Biol Chem 280:22530-9. 2005.... - Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic miceEric K Richfield
Department of Pathology and Lab Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, New York 14642, USA
Exp Neurol 175:35-48. 2002..Expression of hm2alpha-SYN adversely affects the integrity of dopaminergic terminals and leads to age-related declines in motor coordination and dopaminergic markers... - Behavioral sensitization and long-term neurochemical alterations associated with the fungicide triadimefonRuth Reeves
Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Pharmacol Biochem Behav 76:315-26. 2003..Thus, TDF exposure may serve as an environmental risk factor for DA system dysfunctions... - A fetal risk factor for Parkinson's diseaseBrian K Barlow
Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
Dev Neurosci 26:11-23. 2004..This study implicates a role for developmental neurotoxicant exposure in the induction of neurodegenerative disorders such as PD... - Fish consumption and prenatal methylmercury exposure: cognitive and behavioral outcomes in the main cohort at 17 years from the Seychelles child development studyPhilip W Davidson
Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Neurotoxicology 32:711-7. 2011..For some endpoints we found performance improved with increasing prenatal exposure to MeHg. Follow up studies indicate this association is related to the beneficial nutrients present in fish... - Subchronic polychlorinated biphenyl (Aroclor 1254) exposure produces oxidative damage and neuronal death of ventral midbrain dopaminergic systemsDonna W Lee
Department of Environmental Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA
Toxicol Sci 125:496-508. 2012..In this study, we suggest that both OS and the uncoupling of iron regulation contribute to dopamine neuron degeneration and hyperactivity following PCB exposure... 
Lifetime consequences of combined maternal lead and stressDeborah A Cory-Slechta
Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Basic Clin Pharmacol Toxicol 102:218-27. 2008..Pb + stress effects observed in the absence of either risk factor alone raise questions about the capacity of current hazard identification approaches to adequately identify human health risks posed by neurotoxicants...- The effect of developmental exposure to the fungicide triadimefon on behavioral sensitization to triadimefon during adulthoodRuth Reeves
Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Toxicol Appl Pharmacol 200:54-63. 2004..These results indicate for the first time that TDF may be considered an environmental risk factor for developmental dopaminergic neurotoxicity... - Age-related irreversible progressive nigrostriatal dopaminergic neurotoxicity in the paraquat and maneb model of the Parkinson's disease phenotypeMona Thiruchelvam
Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Eur J Neurosci 18:589-600. 2003..Collectively, these data demonstrate enhanced sensitivity of the ageing nigrostriatal dopamine pathway to these pesticides, particularly paraquat + maneb, resulting in irreversible and progressive neurotoxicity... - Enhanced learning deficits in female rats following lifetime pb exposure combined with prenatal stressDeborah A Cory-Slechta
Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
Toxicol Sci 117:427-38. 2010..These findings also underscore the critical need to evaluate toxicants in the context of other risk factors pertinent to human diseases and disorders... - Sustained exposure to the widely used herbicide atrazine: altered function and loss of neurons in brain monoamine systemsVeronica M Rodriguez
Environmental and Occupational Health Sciences Institute, and Department of Environmental and Occupational Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
Environ Health Perspect 113:708-15. 2005.... - Increased synaptosomal dopamine content and brain concentration of paraquat produced by selective dithiocarbamatesBrian K Barlow
Department of Pathology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
J Neurochem 85:1075-86. 2003..These results suggest that selective dithiocarbamates may alter the kinetics of different endogenous and exogenous compounds to enhance their neurotoxicity... - Modulation of antioxidant defense systems by the environmental pesticide maneb in dopaminergic cellsBrian K Barlow
Department of Environmental Medicine, School of Medicine, University of Rochester, Rochester, NY, USA
Neurotoxicology 26:63-75. 2005.... - Increased lead biomarker levels are associated with changes in hormonal response to stress in occupationally exposed male participantsMarie C Fortin
Environmental and Occupational Health Sciences Institute, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey, USA
Environ Health Perspect 120:278-83. 2012..Objective: We investigated the effects of lead on responses of the HPA axis to a psychosocial laboratory stressor administered to Pb-exposed workers... - Lead-induced impairments in complex cognitive function: offerings from experimental studiesDeborah A Cory-Slechta
Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Child Neuropsychol 9:54-75. 2003..The impact of lead exposure on attention has yet to be clearly delineated in either human or experimental studies, although impulsivity or aversion to delay appears to be a sensitive component of attention that may be targeted... - Lead exposure inhibits fracture healing and is associated with increased chondrogenesis, delay in cartilage mineralization, and a decrease in osteoprogenitor frequencyJonathan J Carmouche
Center for Musculoskeletal Research, University of Rochester Medical Center, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642, USA
Environ Health Perspect 113:749-55. 2005..We conclude that Pb delays fracture healing at environmentally relevant doses and induces fibrous nonunions at higher doses by inhibiting the progression of endochondral ossification... - Studying toxicants as single chemicals: does this strategy adequately identify neurotoxic risk?Deborah A Cory-Slechta
Environmental and Occupational Health Sciences Institute, A joint Institute of Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854, USA
Neurotoxicology 26:491-510. 2005..e., multiple chemical exposures or chemical exposures combined with other risk factors), homeostatic capabilities may be restricted, thereby leading to sustained or cumulative damage... - Socioeconomic position and cognitive function in the Seychelles: a life course analysisRoni W Kobrosly
Department of Community and Preventive Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Neuroepidemiology 36:162-8. 2011..In this study, we sought to confirm the relation between early-life socioeconomic position (SEP) and adult cognitive function, and to examine potential mediation by contemporaneous SEP... - Paraquat increases cyanide-insensitive respiration in murine lung epithelial cells by activating an NAD(P)H:paraquat oxidoreductase: identification of the enzyme as thioredoxin reductaseJoshua P Gray
Department of Environmental and Occupational Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
J Biol Chem 282:7939-49. 2007..Reactive oxygen intermediates and subsequent oxidative stress generated from this enzyme are likely to contribute to paraquat-induced lung toxicity... - Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquatAlison L McCormack
The Parkinson's Institute, Sunnyvale, California 94089, USA
Neurobiol Dis 10:119-27. 2002.... - Lead exposure and dorsomedial striatum mediation of fixed interval schedule-controlled behaviorDeborah A Cory-Slechta
Samueli Institute for Informational Biology, Program on Neuroprotection, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
Neurotoxicology 23:313-27. 2002.... - Developmental exposure to the pesticides paraquat and maneb and the Parkinson's disease phenotypeMona Thiruchelvam
Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, NY 14642, USA
Neurotoxicology 23:621-33. 2002.... - The conundrum of unmeasured confounding: Comment on: "Can some of the detrimental neurodevelopmental effects attributed to lead be due to pesticides? by Brian Gulson"Bruce P Lanphear
Cincinnati Children s Environmental Health Center, Department of Pediatrics and of Environmental Health, Cincinnati Children s Hospital Medical Center, The University of Cincinnati, Cincinnati, Ohio, USA
Sci Total Environ 396:196-200. 2008..The alternative, to perpetually permit children to be exposed to lead and other emerging toxicants, is both absurd and unacceptable... - Functional correction of established central nervous system deficits in an animal model of lysosomal storage disease with feline immunodeficiency virus-based vectorsAndrew I Brooks
Department of Internal Medicine, University of Iowa Program in Gene Therapy, University of Iowa College of Medicine, Iowa City, IA 52242, USA
Proc Natl Acad Sci U S A 99:6216-21. 2002..These data suggest that enzyme replacement to the MPS VII central nervous system goes beyond restoration of beta-glucuronidase activity in the lysosome, and imparts improvements in plasticity and spatial learning... - The gestational environment and Parkinson's disease: evidence for neurodevelopmental origins of a neurodegenerative disorderBrian K Barlow
MD PhD Program, Graduate Program in Neuroscience, UMDNJ RWJMS and Rutgers, USA
Reprod Toxicol 23:457-70. 2007..Additionally, challenges in studying the neurodevelopmental basis of neurodegeneration experimentally and epidemiologically are presented... - Interactive effects of a DRD4 polymorphism, lead, and sex on executive functions in childrenTanya E Froehlich
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
Biol Psychiatry 62:243-9. 2007..Prior studies have examined independent effects of a dopamine receptor D4 polymorphism (DRD4-7) and lead exposure on executive functions but not their interaction or the role of sex as a modifier of their effects... - Blood lead concentrations < 10 microg/dL and child intelligence at 6 years of ageTodd A Jusko
Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA, USA
Environ Health Perspect 116:243-8. 2008..Few studies provide data directly relevant to the question of whether blood lead concentrations < 10 microg/dL adversely affect children's cognitive function... - Letter regarding: "Paraquat: the red herring of Parkinson's disease research"Deborah A Cory-Slechta
Toxicol Sci 103:215-6; author reply 217-8. 2008 - Impaired neuropsychological functioning in lead-exposed childrenRichard L Canfield
Division of Nutritional Sciences, College of Human Ecology, Cornell University, Savage Hall, Ithaca, NY 14853, USA
Dev Neuropsychol 26:513-40. 2004..These findings indicate that the effects of pediatric lead exposure are not restricted to global indexes of general intellectual functioning, and executive processes may be at particular risk of lead-induced neurotoxicity... - Intellectual impairment in children with blood lead concentrations below 10 microg per deciliterRichard L Canfield
Division of Nutritional Sciences, College of Human Ecology, Cornell University, Ithaca, NY 14853, USA
N Engl J Med 348:1517-26. 2003..483 micromol per liter), little is known about children's neurobehavioral functioning at lead concentrations below this level...
Research Grants
- NMDA RECEPTOR AND BEHAVIORAL TOXICITY OF LEADDeborah Cory Slechta; Fiscal Year: 2002....