Research Topics
Species | Allan ConneySummaryAffiliation: Rutgers University Country: USA Publications
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Publications
Effect of caffeine on the ATR/Chk1 pathway in the epidermis of UVB-irradiated miceYao Ping Lu
Susan Lehman Cullman Laboratory for Cancer Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
Cancer Res 68:2523-9. 2008....
Stimulatory effect of oral administration of tea, coffee or caffeine on UVB-induced apoptosis in the epidermis of SKH-1 miceAllan H Conney
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
Toxicol Appl Pharmacol 224:209-13. 2007..Further studies are needed to determine mechanisms of these effects of caffeine and to determine the effects of caffeine administration on sunlight-induced actinic keratoses and squamous cell carcinomas in humans...- Enzyme induction and dietary chemicals as approaches to cancer chemoprevention: the Seventh DeWitt S. Goodman LectureAllan H Conney
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, New Jersey 08854 8020, USA
Cancer Res 63:7005-31. 2003.... 
Effect of caffeine on UVB-induced carcinogenesis, apoptosis, and the elimination of UVB-induced patches of p53 mutant epidermal cells in SKH-1 miceAllan H Conney
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA
Photochem Photobiol 84:330-8. 2008..Our studies indicate that caffeine and caffeine sodium benzoate may be useful as novel inhibitors of sunlight-induced skin cancer...- Tailoring cancer chemoprevention regimens to the individualAllan H Conney
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854 8020, USA
J Cell Biochem 91:277-86. 2004..How to tailor cancer chemoprevention regimens to the individual is an important challenge for the future... - Induction of drug-metabolizing enzymes: a path to the discovery of multiple cytochromes P450Allan H Conney
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, New Jersey 08854, USA
Annu Rev Pharmacol Toxicol 43:1-30. 2003.... - Inhibitory effects of tea and caffeine on UV-induced carcinogenesis: relationship to enhanced apoptosis and decreased tissue fatAllan H Conney
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, College of Pharmacy, Rutgers, The State University of New Jersey, NJ 08854, USA
Eur J Cancer Prev 11:S28-36. 2002..Using data from individual mice and linear regression analysis, we found a highly significant positive correlation between the thickness of the dermal fat layer away from tumors and the number of tumors per mouse... - Atorvastatin and celecoxib inhibit prostate PC-3 tumors in immunodeficient miceXi Zheng
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, The State University of New Jersey, Piscataway, New Jersey 08854, USA
Clin Cancer Res 13:5480-7. 2007..To investigate the effects and mechanisms of atorvastatin and celecoxib administered individually or in combination on human prostate cancer PC-3 cells cultured in vitro or grown as xenograft tumors in immunodeficient mice... - Topical applications of caffeine or (-)-epigallocatechin gallate (EGCG) inhibit carcinogenesis and selectively increase apoptosis in UVB-induced skin tumors in miceYao-Ping Lu
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, State University of New Jersey, Piscataway, NJ 08854-8020, USA
Proc Natl Acad Sci U S A 99:12455-60. 2002..The results suggest a need for further studies to determine whether topical applications of caffeine or EGCG can inhibit sunlight-induced skin cancer in humans... - Administration of green tea or caffeine enhances the disappearance of UVB-induced patches of mutant p53 positive epidermal cells in SKH-1 miceYao Ping Lu
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
Carcinogenesis 26:1465-72. 2005..Our studies indicate that the chemopreventive effect of caffeine or green tea may occur by a proapoptotic effect preferentially in early precancerous lesions... - Caffeine and caffeine sodium benzoate have a sunscreen effect, enhance UVB-induced apoptosis, and inhibit UVB-induced skin carcinogenesis in SKH-1 miceYao Ping Lu
William M and Myrle W Garbe Professor of Cancer and Leukemia Research, Ernest Mario School of Pharmacy, Rutgers, NJ, USA
Carcinogenesis 28:199-206. 2007..Our studies suggest that caffeine-SB and caffeine may be good agents for inhibiting the formation of sunlight-induced skin cancer... - Effects of 12-O-tetradecanoylphorbol-13-acetate (TPA) in combination with paclitaxel (Taxol) on prostate Cancer LNCaP cells cultured in vitro or grown as xenograft tumors in immunodeficient miceXi Zheng
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway 08854, USA
Clin Cancer Res 12:3444-51. 2006..Clinical trials with TPA alone or in combination with paclitaxel in patients with prostate cancer may be warranted... - Patches of mutant p53-immunoreactive epidermal cells induced by chronic UVB Irradiation harbor the same p53 mutations as squamous cell carcinomas in the skin of hairless SKH-1 micePavel Kramata
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854 8020, USA
Cancer Res 65:3577-85. 2005.... - Effect of administration of caffeine or green tea on the mutation profile in the p53 gene in early mutant p53-positive patches of epidermal cells induced by chronic UVB-irradiation of hairless SKH-1 micePavel Kramata
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
Carcinogenesis 26:1965-74. 2005.... - Stimulatory effect of topical application of caffeine on UVB-induced apoptosis in the epidermis of p53 and Bax knockout miceYao Ping Lu
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
Cancer Res 64:5020-7. 2004.... - A novel Gemini vitamin D analog represses the expression of a stem cell marker CD44 in breast cancerJae Young So
Department of Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
Mol Pharmacol 79:360-7. 2011..The novel Gemini vitamin D analog, BXL0124, represses CD44 expression in MCF10DCIS.com cells in vitro and in xenograft tumors, suggesting an inhibitory role of a Gemini vitamin D derivative on breast cancer stem cells... - Atorvastatin and celecoxib in combination inhibits the progression of androgen-dependent LNCaP xenograft prostate tumors to androgen independenceXi Zheng
Department of Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, 08854, USA
Cancer Prev Res (Phila) 3:114-24. 2010..Our results indicate that administration of a combination of atorvastatin and celecoxib may be an effective strategy for the prevention of prostate cancer progression from androgen dependence to androgen independence... - Combined inhibitory effects of curcumin and phenethyl isothiocyanate on the growth of human PC-3 prostate xenografts in immunodeficient miceTin Oo Khor
Center for Cancer Prevention Research, Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers-The State University of New Jersey, 160 Freilinghuysen Road, Piscataway, NJ 08854, USA
Cancer Res 66:613-21. 2006..Furthermore, we found that combination of PEITC and curcumin could be effective in the cancer-therapeutic treatment of prostate cancers... - Stimulatory effect of topical application of caffeine on UVB-induced apoptosis in mouse skinYao-Ping Lu
Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854-8020, USA
Oncol Res 13:61-70. 2002..The results of this study indicate a proapoptotic effect of topical application of caffeine on UVB-irradiated mouse skin... - Inhibitory effects of voluntary running wheel exercise on UVB-induced skin carcinogenesis in SKH-1 miceLaura Michna
Joint Graduate Program in Toxicology, The State University of New Jersey, Piscataway, NJ 08854, USA
Carcinogenesis 27:2108-15. 2006..The effects described here indicate that voluntary running wheel exercise inhibits UVB-induced skin tumorigenesis and may also inhibit tumor growth... - Inhibitory effect of topical applications of nondenatured soymilk on the formation and growth of UVB-induced skin tumorsMou-Tuan Huang
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854-8020, USA
Oncol Res 14:387-97. 2004..These data suggest that nondenatured soymilk could be applied to humans to prevent sunlight-induced skin damage and to reduce the risk of skin tumor formation and progression... - Inhibitory effect of voluntary running wheel exercise on the growth of human pancreatic Panc-1 and prostate PC-3 xenograft tumors in immunodeficient miceXi Zheng
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
Oncol Rep 19:1583-8. 2008..The present study demonstrated an inhibitory effect of voluntary exercise on the growth of pancreas and prostate tumors in a SCID mouse xenograft model... - In vitro and in vivo studies on stilbene analogs as potential treatment agents for colon cancerShiby Paul
Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
Eur J Med Chem 45:3702-8. 2010..Overall, identification of the anti-tumorigenic potential of these compounds provides opportunities for their use against colorectal cancer... - Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2Changjiang Xu
Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
Cancer Res 66:8293-6. 2006..Taken together, our results show for the first time that Nrf2(-/-) mice are more susceptible to skin tumorigenesis and that the chemopreventive effects of sulforaphane are mediated, at least in part, through Nrf2... - Inhibition of NF-kappaB by (E)3-[(4-methylphenyl)-sulfonyl]-2-propenenitrile (BAY11-7082; BAY) is associated with enhanced 12-O-tetradecanoylphorbol-13-acetate-induced growth suppression and apoptosis in human prostate cancer PC-3 cellsXi Zheng
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
Int J Oncol 32:257-64. 2008..Inhibition of NF-kappaB activity by suitable pharmacological inhibitors may be an effective strategy for improving the therapeutic efficacy of TPA in prostate cancer... - Stimulatory effect of oral administration of green tea and caffeine on locomotor activity in SKH-1 miceLaura Michna
Joint Graduate Program in Toxicology, Rutgers, The State University of New Jersey and The University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, NJ, USA
Life Sci 73:1383-92. 2003.... - Gemini vitamin D analogues inhibit estrogen receptor-positive and estrogen receptor-negative mammary tumorigenesis without hypercalcemic toxicityHong Jin Lee
Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
Cancer Prev Res (Phila) 1:476-84. 2008..Our results suggest that Gemini vitamin D analogues may be potent agents for the prevention and treatment of both ER-positive and ER-negative breast cancer without hypercalcemia toxicity... - Stimulatory effect of voluntary exercise or fat removal (partial lipectomy) on apoptosis in the skin of UVB light-irradiated miceYao-Ping Lu
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers-The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854-8020, USA
Proc Natl Acad Sci U S A 103:16301-6. 2006..Our results help explain why exercise or various dietary regimens that decrease tissue fat inhibit carcinogenesis... - Inhibition of EGFR signaling in human prostate cancer PC-3 cells by combination treatment with beta-phenylethyl isothiocyanate and curcuminJung-Hwan Kim
Center for Cancer Prevention Research, Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
Carcinogenesis 27:475-82. 2006.... - Voluntary exercise together with oral caffeine markedly stimulates UVB light-induced apoptosis and decreases tissue fat in SKH-1 miceYao Ping Lu
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Department of Neuroscience, and Department of Psychology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
Proc Natl Acad Sci U S A 104:12936-41. 2007..Our studies indicate a greater than additive stimulatory effect of combined voluntary exercise and oral administration of a low dose of caffeine on UVB-induced apoptosis... - Tumorigenic effect of some commonly used moisturizing creams when applied topically to UVB-pretreated high-risk miceYao Ping Lu
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854 8020, USA
J Invest Dermatol 129:468-75. 2009..Further studies are needed to determine the effects of topical applications of moisturizing creams on sunlight-induced skin cancer in humans... - Enhancement of TPA-induced growth inhibition and apoptosis in myeloid leukemia cells by BAY 11-7082, an NF-kappaB inhibitorAnnette Hansson
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
Int J Oncol 27:941-8. 2005..TPA in combination with pharmacological inhibitors of NF-kappaB may improve the therapeutic efficacy of TPA and overcome the resistance to TPA in some myeloid leukemia patients... - Inhibitory effects of 12-O-tetradecanoylphorbol-13-acetate alone or in combination with all-trans retinoic acid on the growth of cultured human pancreas cancer cells and pancreas tumor xenografts in immunodeficient miceGina E Avila
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
J Pharmacol Exp Ther 315:170-87. 2005..The inhibitory effects of TPA on tumor growth occurred at clinically achievable blood levels... - Caffeine decreases phospho-Chk1 (Ser317) and increases mitotic cells with cyclin B1 and caspase 3 in tumors from UVB-treated miceYao Ping Lu
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
Cancer Prev Res (Phila) 4:1118-25. 2011.... - Effects of green tea and high-fat diet on arachidonic acid metabolism and aberrant crypt foci formation in an azoxymethane-induced colon carcinogenesis mouse modelJihyeung Ju
Graduate Program of Food Science, Rutgers, The State University of New Jersey, New Brunswick, NJ 08854, USA
Nutr Cancer 46:172-8. 2003..Green tea inhibits ACF formation in mice on a high corn oil diet, suggesting its possible inhibitory effect on colon carcinogenesis in populations such as those in Western countries that consume high amounts of fat... - Inhibitory effect of 12-O-tetradecanoylphorbol-13-acetate alone or in combination with all-trans-retinoic acid on the growth of LNCaP prostate tumors in immunodeficient miceXi Zheng
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
Cancer Res 64:1811-20. 2004..Because the dose of TPA used in this study was effective and resulted in clinically achievable blood levels, clinical trials with TPA alone or in combination with ATRA in patients with prostate cancer may be warranted... - Dietary clofibrate inhibits induction of hepatic antioxidant enzymes by chronic estradiol in female ACI ratsSonia Mesia-Vela
Laboratory for Cellular and Biochemical Toxicology, 41 Gordon Road, Piscataway, NJ 08854, USA
Toxicology 200:103-11. 2004..Both of these actions have the potential to markedly influence the profile of E2 metabolites exported from the liver to E2 sensitive extrahepatic tissues and influence the initiation and progression of hormone-dependent tumors... - Synergistic stimulatory effect of 12-O-tetradecanoylphorbol-13-acetate and capsaicin on macrophage differentiation in HL-60 and HL-525 human myeloid leukemia cellsXi Zheng
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
Int J Oncol 26:441-8. 2005..Results from the present study suggest that a combination of TPA and capsaicin may improve the therapeutic efficacy of TPA and overcome resistance to TPA in some myeloid leukemia patients... - Phenobarbital treatment inhibits the formation of estradiol-dependent mammary tumors in the August-Copenhagen Irish ratSonia Mesia-Vela
Laboratory for Cellular and Biochemical Toxicology, Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers, New Jersey, USA
J Pharmacol Exp Ther 317:590-7. 2006.... - Strong inhibitory effects of common tea catechins and bioflavonoids on the O-methylation of catechol estrogens catalyzed by human liver cytosolic catechol-O-methyltransferaseMime Nagai
Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of South Carolina, Room 617 of Coker Life Sciences Building, 700 Sumter Street, Columbia, SC 29208
Drug Metab Dispos 32:497-504. 2004..More studies are warranted to determine the extent of such inhibition in human subjects and the potential biological consequences... - Environmental and chemical carcinogenesisGerald N Wogan
Biological Engineering Division, Massachusetts Institute of Technology, Room 26 009, Cambridge, MA 02139, USA
Semin Cancer Biol 14:473-86. 2004..These mutations presumably arise via DNA damage by environmental or endogenous agents, but it remains to be determined whether the acquisition of a mutator phenotype is a necessary event during tumor progression... - Inhibitory effects of caffeine analogues on neoplastic transformation: structure-activity relationshipEvgeny A Rogozin
Hormel Institute, University of Minnesota, Austin, MN 55912, USA
Carcinogenesis 29:1228-34. 2008..2 or 62.0%, respectively. Collectively, these results indicated that the number of carbons at R1 and R3 is important for the antitumor-promoting activity of the trialkylxanthines and xanthine 70 might be a promising anticancer agent... - NADPH-dependent metabolism of estrone by human liver microsomesAnthony J Lee
Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of South Carolina, Columbia, South Carolina 29208, USA
J Pharmacol Exp Ther 300:838-49. 2002..It will be of interest to determine the potential biological functions associated with any of the E1 metabolites identified in our present study... - Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoformsAnthony J Lee
Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of South Carolina, Columbia, South Carolina 29208, USA
Endocrinology 144:3382-98. 2003..In conclusion, many human CYP isoforms are involved in the oxidative metabolism of 17beta-estradiol and estrone, with a varying degree of catalytic activity and distinct regioselectivity...
Research Grants
- Inhibition of skin cancer by caffeine: Effects on late stages of carcinogenesisAllan H Conney; Fiscal Year: 2010..Our studies on the effects of caffeine may also have importance for individuals ingesting caffeine-containing beverages and chocolate. ..
- Effect of caffeine on UVB-induced skin cancerAllan Conney; Fiscal Year: 2007..The proposal also includes the first human studies on a path that may lead to a novel way of preventing sunlight-induced skin cancer in humans. ..
- Effects of TPA on Leukemia and Solid TumorsAllan Conney; Fiscal Year: 2006..Blood levels of TPA that are associated with inhibition of tumor growth will be determined. The effect of inhibitors of tumor growth on proliferation and apoptosis in the tumors will be determined. ..
- MODULATION BY TEA OF EARLY EFFECTS OF UV ON SKINAllan Conney; Fiscal Year: 2003..abstract_text> ..
- MECHANISMS OF HOTSPOT MUTAGENESIS BY (+)-BPDEAllan Conney; Fiscal Year: 2001..We will subsequently examine how the adduct position and chirality affect the outcome of the mutation formation. ..
- Effect of caffeine on UVB-induced skin cancerAllan H Conney; Fiscal Year: 2010..The proposal also includes the first human studies on a path that may lead to a novel way of preventing sunlight-induced skin cancer in humans. ..