Allan Conney

Summary

Affiliation: Rutgers University
Country: USA

Publications

  1. pmc Effect of caffeine on the ATR/Chk1 pathway in the epidermis of UVB-irradiated mice
    Yao Ping Lu
    Susan Lehman Cullman Laboratory for Cancer Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
    Cancer Res 68:2523-9. 2008
  2. ncbi Stimulatory effect of oral administration of tea, coffee or caffeine on UVB-induced apoptosis in the epidermis of SKH-1 mice
    Allan H Conney
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
    Toxicol Appl Pharmacol 224:209-13. 2007
  3. ncbi Enzyme induction and dietary chemicals as approaches to cancer chemoprevention: the Seventh DeWitt S. Goodman Lecture
    Allan H Conney
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, New Jersey 08854 8020, USA
    Cancer Res 63:7005-31. 2003
  4. doi Effect of caffeine on UVB-induced carcinogenesis, apoptosis, and the elimination of UVB-induced patches of p53 mutant epidermal cells in SKH-1 mice
    Allan H Conney
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA
    Photochem Photobiol 84:330-8. 2008
  5. ncbi Tailoring cancer chemoprevention regimens to the individual
    Allan H Conney
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854 8020, USA
    J Cell Biochem 91:277-86. 2004
  6. ncbi Induction of drug-metabolizing enzymes: a path to the discovery of multiple cytochromes P450
    Allan H Conney
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, New Jersey 08854, USA
    Annu Rev Pharmacol Toxicol 43:1-30. 2003
  7. ncbi Inhibitory effects of tea and caffeine on UV-induced carcinogenesis: relationship to enhanced apoptosis and decreased tissue fat
    Allan H Conney
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, College of Pharmacy, Rutgers, The State University of New Jersey, NJ 08854, USA
    Eur J Cancer Prev 11:S28-36. 2002
  8. ncbi Atorvastatin and celecoxib inhibit prostate PC-3 tumors in immunodeficient mice
    Xi Zheng
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Clin Cancer Res 13:5480-7. 2007
  9. pmc Topical applications of caffeine or (-)-epigallocatechin gallate (EGCG) inhibit carcinogenesis and selectively increase apoptosis in UVB-induced skin tumors in mice
    Yao Ping Lu
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, State University of New Jersey, Piscataway, NJ 08854 8020, USA
    Proc Natl Acad Sci U S A 99:12455-60. 2002
  10. ncbi Administration of green tea or caffeine enhances the disappearance of UVB-induced patches of mutant p53 positive epidermal cells in SKH-1 mice
    Yao Ping Lu
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
    Carcinogenesis 26:1465-72. 2005

Collaborators

Detail Information

Publications44

  1. pmc Effect of caffeine on the ATR/Chk1 pathway in the epidermis of UVB-irradiated mice
    Yao Ping Lu
    Susan Lehman Cullman Laboratory for Cancer Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
    Cancer Res 68:2523-9. 2008
    ....
  2. ncbi Stimulatory effect of oral administration of tea, coffee or caffeine on UVB-induced apoptosis in the epidermis of SKH-1 mice
    Allan H Conney
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
    Toxicol Appl Pharmacol 224:209-13. 2007
    ..Further studies are needed to determine mechanisms of these effects of caffeine and to determine the effects of caffeine administration on sunlight-induced actinic keratoses and squamous cell carcinomas in humans...
  3. ncbi Enzyme induction and dietary chemicals as approaches to cancer chemoprevention: the Seventh DeWitt S. Goodman Lecture
    Allan H Conney
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, New Jersey 08854 8020, USA
    Cancer Res 63:7005-31. 2003
    ....
  4. doi Effect of caffeine on UVB-induced carcinogenesis, apoptosis, and the elimination of UVB-induced patches of p53 mutant epidermal cells in SKH-1 mice
    Allan H Conney
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA
    Photochem Photobiol 84:330-8. 2008
    ..Our studies indicate that caffeine and caffeine sodium benzoate may be useful as novel inhibitors of sunlight-induced skin cancer...
  5. ncbi Tailoring cancer chemoprevention regimens to the individual
    Allan H Conney
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854 8020, USA
    J Cell Biochem 91:277-86. 2004
    ..How to tailor cancer chemoprevention regimens to the individual is an important challenge for the future...
  6. ncbi Induction of drug-metabolizing enzymes: a path to the discovery of multiple cytochromes P450
    Allan H Conney
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, New Jersey 08854, USA
    Annu Rev Pharmacol Toxicol 43:1-30. 2003
    ....
  7. ncbi Inhibitory effects of tea and caffeine on UV-induced carcinogenesis: relationship to enhanced apoptosis and decreased tissue fat
    Allan H Conney
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, College of Pharmacy, Rutgers, The State University of New Jersey, NJ 08854, USA
    Eur J Cancer Prev 11:S28-36. 2002
    ..Using data from individual mice and linear regression analysis, we found a highly significant positive correlation between the thickness of the dermal fat layer away from tumors and the number of tumors per mouse...
  8. ncbi Atorvastatin and celecoxib inhibit prostate PC-3 tumors in immunodeficient mice
    Xi Zheng
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Clin Cancer Res 13:5480-7. 2007
    ..To investigate the effects and mechanisms of atorvastatin and celecoxib administered individually or in combination on human prostate cancer PC-3 cells cultured in vitro or grown as xenograft tumors in immunodeficient mice...
  9. pmc Topical applications of caffeine or (-)-epigallocatechin gallate (EGCG) inhibit carcinogenesis and selectively increase apoptosis in UVB-induced skin tumors in mice
    Yao Ping Lu
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, State University of New Jersey, Piscataway, NJ 08854 8020, USA
    Proc Natl Acad Sci U S A 99:12455-60. 2002
    ..The results suggest a need for further studies to determine whether topical applications of caffeine or EGCG can inhibit sunlight-induced skin cancer in humans...
  10. ncbi Administration of green tea or caffeine enhances the disappearance of UVB-induced patches of mutant p53 positive epidermal cells in SKH-1 mice
    Yao Ping Lu
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
    Carcinogenesis 26:1465-72. 2005
    ..Our studies indicate that the chemopreventive effect of caffeine or green tea may occur by a proapoptotic effect preferentially in early precancerous lesions...
  11. ncbi Caffeine and caffeine sodium benzoate have a sunscreen effect, enhance UVB-induced apoptosis, and inhibit UVB-induced skin carcinogenesis in SKH-1 mice
    Yao Ping Lu
    William M and Myrle W Garbe Professor of Cancer and Leukemia Research, Ernest Mario School of Pharmacy, Rutgers, NJ, USA
    Carcinogenesis 28:199-206. 2007
    ..Our studies suggest that caffeine-SB and caffeine may be good agents for inhibiting the formation of sunlight-induced skin cancer...
  12. ncbi Effects of 12-O-tetradecanoylphorbol-13-acetate (TPA) in combination with paclitaxel (Taxol) on prostate Cancer LNCaP cells cultured in vitro or grown as xenograft tumors in immunodeficient mice
    Xi Zheng
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway 08854, USA
    Clin Cancer Res 12:3444-51. 2006
    ..To investigate the effects of 12-O-tetradecanoylphorbol-13-acetate (TPA) in combination with paclitaxel (Taxol) on prostate cancer cells cultured in vitro or grown as tumors in immunodeficient mice...
  13. ncbi Patches of mutant p53-immunoreactive epidermal cells induced by chronic UVB Irradiation harbor the same p53 mutations as squamous cell carcinomas in the skin of hairless SKH-1 mice
    Pavel Kramata
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854 8020, USA
    Cancer Res 65:3577-85. 2005
    ....
  14. ncbi Effect of administration of caffeine or green tea on the mutation profile in the p53 gene in early mutant p53-positive patches of epidermal cells induced by chronic UVB-irradiation of hairless SKH-1 mice
    Pavel Kramata
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
    Carcinogenesis 26:1965-74. 2005
    ....
  15. ncbi Stimulatory effect of topical application of caffeine on UVB-induced apoptosis in the epidermis of p53 and Bax knockout mice
    Yao Ping Lu
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
    Cancer Res 64:5020-7. 2004
    ....
  16. pmc A novel Gemini vitamin D analog represses the expression of a stem cell marker CD44 in breast cancer
    Jae Young So
    Department of Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Mol Pharmacol 79:360-7. 2011
    ..The novel Gemini vitamin D analog, BXL0124, represses CD44 expression in MCF10DCIS.com cells in vitro and in xenograft tumors, suggesting an inhibitory role of a Gemini vitamin D derivative on breast cancer stem cells...
  17. pmc Atorvastatin and celecoxib in combination inhibits the progression of androgen-dependent LNCaP xenograft prostate tumors to androgen independence
    Xi Zheng
    Department of Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, 08854, USA
    Cancer Prev Res (Phila) 3:114-24. 2010
    ..Our results indicate that administration of a combination of atorvastatin and celecoxib may be an effective strategy for the prevention of prostate cancer progression from androgen dependence to androgen independence...
  18. ncbi Combined inhibitory effects of curcumin and phenethyl isothiocyanate on the growth of human PC-3 prostate xenografts in immunodeficient mice
    Tin Oo Khor
    Center for Cancer Prevention Research, Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers The State University of New Jersey, 160 Freilinghuysen Road, Piscataway, NJ 08854, USA
    Cancer Res 66:613-21. 2006
    ..Furthermore, we found that combination of PEITC and curcumin could be effective in the cancer-therapeutic treatment of prostate cancers...
  19. ncbi Stimulatory effect of topical application of caffeine on UVB-induced apoptosis in mouse skin
    Yao Ping Lu
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
    Oncol Res 13:61-70. 2002
    ..The results of this study indicate a proapoptotic effect of topical application of caffeine on UVB-irradiated mouse skin...
  20. ncbi Inhibitory effects of voluntary running wheel exercise on UVB-induced skin carcinogenesis in SKH-1 mice
    Laura Michna
    Joint Graduate Program in Toxicology, The State University of New Jersey, Piscataway, NJ 08854, USA
    Carcinogenesis 27:2108-15. 2006
    ..The effects described here indicate that voluntary running wheel exercise inhibits UVB-induced skin tumorigenesis and may also inhibit tumor growth...
  21. ncbi Inhibitory effect of topical applications of nondenatured soymilk on the formation and growth of UVB-induced skin tumors
    Mou Tuan Huang
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
    Oncol Res 14:387-97. 2004
    ..These data suggest that nondenatured soymilk could be applied to humans to prevent sunlight-induced skin damage and to reduce the risk of skin tumor formation and progression...
  22. pmc Inhibitory effect of voluntary running wheel exercise on the growth of human pancreatic Panc-1 and prostate PC-3 xenograft tumors in immunodeficient mice
    Xi Zheng
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Oncol Rep 19:1583-8. 2008
    ..The present study demonstrated an inhibitory effect of voluntary exercise on the growth of pancreas and prostate tumors in a SCID mouse xenograft model...
  23. pmc In vitro and in vivo studies on stilbene analogs as potential treatment agents for colon cancer
    Shiby Paul
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Eur J Med Chem 45:3702-8. 2010
    ..Overall, identification of the anti-tumorigenic potential of these compounds provides opportunities for their use against colorectal cancer...
  24. ncbi Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2
    Changjiang Xu
    Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Cancer Res 66:8293-6. 2006
    ..Taken together, our results show for the first time that Nrf2(-/-) mice are more susceptible to skin tumorigenesis and that the chemopreventive effects of sulforaphane are mediated, at least in part, through Nrf2...
  25. ncbi Inhibition of NF-kappaB by (E)3-[(4-methylphenyl)-sulfonyl]-2-propenenitrile (BAY11-7082; BAY) is associated with enhanced 12-O-tetradecanoylphorbol-13-acetate-induced growth suppression and apoptosis in human prostate cancer PC-3 cells
    Xi Zheng
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Int J Oncol 32:257-64. 2008
    ..Inhibition of NF-kappaB activity by suitable pharmacological inhibitors may be an effective strategy for improving the therapeutic efficacy of TPA in prostate cancer...
  26. ncbi Stimulatory effect of oral administration of green tea and caffeine on locomotor activity in SKH-1 mice
    Laura Michna
    Joint Graduate Program in Toxicology, Rutgers, The State University of New Jersey and The University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ, USA
    Life Sci 73:1383-92. 2003
    ....
  27. pmc Gemini vitamin D analogues inhibit estrogen receptor-positive and estrogen receptor-negative mammary tumorigenesis without hypercalcemic toxicity
    Hong Jin Lee
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Cancer Prev Res (Phila) 1:476-84. 2008
    ..Our results suggest that Gemini vitamin D analogues may be potent agents for the prevention and treatment of both ER-positive and ER-negative breast cancer without hypercalcemia toxicity...
  28. pmc Stimulatory effect of voluntary exercise or fat removal (partial lipectomy) on apoptosis in the skin of UVB light-irradiated mice
    Yao Ping Lu
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
    Proc Natl Acad Sci U S A 103:16301-6. 2006
    ..Our results help explain why exercise or various dietary regimens that decrease tissue fat inhibit carcinogenesis...
  29. ncbi Inhibition of EGFR signaling in human prostate cancer PC-3 cells by combination treatment with beta-phenylethyl isothiocyanate and curcumin
    Jung Hwan Kim
    Center for Cancer Prevention Research, Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Carcinogenesis 27:475-82. 2006
    ....
  30. pmc Voluntary exercise together with oral caffeine markedly stimulates UVB light-induced apoptosis and decreases tissue fat in SKH-1 mice
    Yao Ping Lu
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Department of Neuroscience, and Department of Psychology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 104:12936-41. 2007
    ..Our studies indicate a greater than additive stimulatory effect of combined voluntary exercise and oral administration of a low dose of caffeine on UVB-induced apoptosis...
  31. pmc Tumorigenic effect of some commonly used moisturizing creams when applied topically to UVB-pretreated high-risk mice
    Yao Ping Lu
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854 8020, USA
    J Invest Dermatol 129:468-75. 2009
    ..Further studies are needed to determine the effects of topical applications of moisturizing creams on sunlight-induced skin cancer in humans...
  32. ncbi Enhancement of TPA-induced growth inhibition and apoptosis in myeloid leukemia cells by BAY 11-7082, an NF-kappaB inhibitor
    Annette Hansson
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Int J Oncol 27:941-8. 2005
    ..TPA in combination with pharmacological inhibitors of NF-kappaB may improve the therapeutic efficacy of TPA and overcome the resistance to TPA in some myeloid leukemia patients...
  33. ncbi Inhibitory effects of 12-O-tetradecanoylphorbol-13-acetate alone or in combination with all-trans retinoic acid on the growth of cultured human pancreas cancer cells and pancreas tumor xenografts in immunodeficient mice
    Gina E Avila
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    J Pharmacol Exp Ther 315:170-87. 2005
    ..The inhibitory effects of TPA on tumor growth occurred at clinically achievable blood levels...
  34. pmc Caffeine decreases phospho-Chk1 (Ser317) and increases mitotic cells with cyclin B1 and caspase 3 in tumors from UVB-treated mice
    Yao Ping Lu
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
    Cancer Prev Res (Phila) 4:1118-25. 2011
    ....
  35. ncbi Effects of green tea and high-fat diet on arachidonic acid metabolism and aberrant crypt foci formation in an azoxymethane-induced colon carcinogenesis mouse model
    Jihyeung Ju
    Graduate Program of Food Science, Rutgers, The State University of New Jersey, New Brunswick, NJ 08854, USA
    Nutr Cancer 46:172-8. 2003
    ..Green tea inhibits ACF formation in mice on a high corn oil diet, suggesting its possible inhibitory effect on colon carcinogenesis in populations such as those in Western countries that consume high amounts of fat...
  36. ncbi Inhibitory effect of 12-O-tetradecanoylphorbol-13-acetate alone or in combination with all-trans-retinoic acid on the growth of LNCaP prostate tumors in immunodeficient mice
    Xi Zheng
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Cancer Res 64:1811-20. 2004
    ..Because the dose of TPA used in this study was effective and resulted in clinically achievable blood levels, clinical trials with TPA alone or in combination with ATRA in patients with prostate cancer may be warranted...
  37. ncbi Dietary clofibrate inhibits induction of hepatic antioxidant enzymes by chronic estradiol in female ACI rats
    Sonia Mesia-Vela
    Laboratory for Cellular and Biochemical Toxicology, 41 Gordon Road, Piscataway, NJ 08854, USA
    Toxicology 200:103-11. 2004
    ..Both of these actions have the potential to markedly influence the profile of E2 metabolites exported from the liver to E2 sensitive extrahepatic tissues and influence the initiation and progression of hormone-dependent tumors...
  38. ncbi Synergistic stimulatory effect of 12-O-tetradecanoylphorbol-13-acetate and capsaicin on macrophage differentiation in HL-60 and HL-525 human myeloid leukemia cells
    Xi Zheng
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Int J Oncol 26:441-8. 2005
    ..Results from the present study suggest that a combination of TPA and capsaicin may improve the therapeutic efficacy of TPA and overcome resistance to TPA in some myeloid leukemia patients...
  39. ncbi Phenobarbital treatment inhibits the formation of estradiol-dependent mammary tumors in the August-Copenhagen Irish rat
    Sonia Mesia-Vela
    Laboratory for Cellular and Biochemical Toxicology, Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers, New Jersey, USA
    J Pharmacol Exp Ther 317:590-7. 2006
    ....
  40. ncbi Strong inhibitory effects of common tea catechins and bioflavonoids on the O-methylation of catechol estrogens catalyzed by human liver cytosolic catechol-O-methyltransferase
    Mime Nagai
    Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of South Carolina, Room 617 of Coker Life Sciences Building, 700 Sumter Street, Columbia, SC 29208
    Drug Metab Dispos 32:497-504. 2004
    ..More studies are warranted to determine the extent of such inhibition in human subjects and the potential biological consequences...
  41. ncbi Environmental and chemical carcinogenesis
    Gerald N Wogan
    Biological Engineering Division, Massachusetts Institute of Technology, Room 26 009, Cambridge, MA 02139, USA
    Semin Cancer Biol 14:473-86. 2004
    ..These mutations presumably arise via DNA damage by environmental or endogenous agents, but it remains to be determined whether the acquisition of a mutator phenotype is a necessary event during tumor progression...
  42. pmc Inhibitory effects of caffeine analogues on neoplastic transformation: structure-activity relationship
    Evgeny A Rogozin
    Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Carcinogenesis 29:1228-34. 2008
    ..2 or 62.0%, respectively. Collectively, these results indicated that the number of carbons at R1 and R3 is important for the antitumor-promoting activity of the trialkylxanthines and xanthine 70 might be a promising anticancer agent...
  43. ncbi NADPH-dependent metabolism of estrone by human liver microsomes
    Anthony J Lee
    Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of South Carolina, Columbia, South Carolina 29208, USA
    J Pharmacol Exp Ther 300:838-49. 2002
    ..It will be of interest to determine the potential biological functions associated with any of the E1 metabolites identified in our present study...
  44. ncbi Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms
    Anthony J Lee
    Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of South Carolina, Columbia, South Carolina 29208, USA
    Endocrinology 144:3382-98. 2003
    ..In conclusion, many human CYP isoforms are involved in the oxidative metabolism of 17beta-estradiol and estrone, with a varying degree of catalytic activity and distinct regioselectivity...

Research Grants17

  1. Inhibition of skin cancer by caffeine: Effects on late stages of carcinogenesis
    Allan H Conney; Fiscal Year: 2010
    ..Our studies on the effects of caffeine may also have importance for individuals ingesting caffeine-containing beverages and chocolate. ..
  2. MODULATION BY TEA OF EARLY EFFECTS OF UV ON SKIN
    Allan Conney; Fiscal Year: 2000
    ..abstract_text> ..
  3. Inhibition of skin cancer by caffeine: Effects on late stages of carcinogenesis
    Allan Conney; Fiscal Year: 2009
    ..Our studies on the effects of caffeine may also have importance for individuals ingesting caffeine-containing beverages and chocolate. ..
  4. Effect of caffeine on UVB-induced skin cancer
    Allan Conney; Fiscal Year: 2009
    ..The proposal also includes the first human studies on a path that may lead to a novel way of preventing sunlight-induced skin cancer in humans. ..
  5. Effect of caffeine on UVB-induced skin cancer
    Allan Conney; Fiscal Year: 2007
    ..The proposal also includes the first human studies on a path that may lead to a novel way of preventing sunlight-induced skin cancer in humans. ..
  6. Effect of caffeine on UVB-induced skin cancer
    Allan Conney; Fiscal Year: 2006
    ..The proposal also includes the first human studies on a path that may lead to a novel way of preventing sunlight-induced skin cancer in humans. ..
  7. Effects of TPA on Leukemia and Solid Tumors
    Allan Conney; Fiscal Year: 2006
    ..Blood levels of TPA that are associated with inhibition of tumor growth will be determined. The effect of inhibitors of tumor growth on proliferation and apoptosis in the tumors will be determined. ..
  8. Effects of TPA on Leukemia and Solid Tumors
    Allan Conney; Fiscal Year: 2005
    ..Blood levels of TPA that are associated with inhibition of tumor growth will be determined. The effect of inhibitors of tumor growth on proliferation and apoptosis in the tumors will be determined. ..
  9. Effects of TPA on Leukemia and Solid Tumors
    Allan Conney; Fiscal Year: 2004
    ..Blood levels of TPA that are associated with inhibition of tumor growth will be determined. The effect of inhibitors of tumor growth on proliferation and apoptosis in the tumors will be determined. ..
  10. Effects of TPA on Leukemia and Solid Tumors
    Allan Conney; Fiscal Year: 2003
    ..Blood levels of TPA that are associated with inhibition of tumor growth will be determined. The effect of inhibitors of tumor growth on proliferation and apoptosis in the tumors will be determined. ..
  11. MODULATION BY TEA OF EARLY EFFECTS OF UV ON SKIN
    Allan Conney; Fiscal Year: 2003
    ..abstract_text> ..
  12. MODULATION BY TEA OF EARLY EFFECTS OF UV ON SKIN
    Allan Conney; Fiscal Year: 2002
    ..abstract_text> ..
  13. MODULATION BY TEA OF EARLY EFFECTS OF UV ON SKIN
    Allan Conney; Fiscal Year: 2001
    ..abstract_text> ..
  14. MECHANISMS OF HOTSPOT MUTAGENESIS BY (+)-BPDE
    Allan Conney; Fiscal Year: 2001
    ..We will subsequently examine how the adduct position and chirality affect the outcome of the mutation formation. ..
  15. Effect of caffeine on UVB-induced skin cancer
    Allan H Conney; Fiscal Year: 2010
    ..The proposal also includes the first human studies on a path that may lead to a novel way of preventing sunlight-induced skin cancer in humans. ..