Xuemei Chen

Summary

Affiliation: Rutgers University
Country: USA

Publications

  1. pmc Floral patterning defects induced by Arabidopsis APETALA2 and microRNA172 expression in Nicotiana benthamiana
    Sizolwenkosi Mlotshwa
    Department of Botany and Plant Sciences, University of California, Riverside, California 92521, USA
    Plant Mol Biol 61:781-93. 2006
  2. ncbi request reprint HEN1 functions pleiotropically in Arabidopsis development and acts in C function in the flower
    Xuemei Chen
    Waksman Institute, Rutgers, The State University of New Jersey, 190 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Development 129:1085-94. 2002
  3. ncbi request reprint A microRNA as a translational repressor of APETALA2 in Arabidopsis flower development
    Xuemei Chen
    Waksman Institute, Rutgers University, Piscataway, NJ 08854, USA
    Science 303:2022-5. 2004
  4. ncbi request reprint Two RNA binding proteins, HEN4 and HUA1, act in the processing of AGAMOUS pre-mRNA in Arabidopsis thaliana
    Yulan Cheng
    Waksman Institute, Rutgers University, 190 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Dev Cell 4:53-66. 2003
  5. pmc PAUSED, a putative exportin-t, acts pleiotropically in Arabidopsis development but is dispensable for viability
    Junjie Li
    Waksman Institute, Rutgers University, Piscataway, New Jersey 08854, USA
    Plant Physiol 132:1913-24. 2003
  6. ncbi request reprint HUA ENHANCER2, a putative DExH-box RNA helicase, maintains homeotic B and C gene expression in Arabidopsis
    Tamara L Western
    Waksman Institute, Rutgers University, 190 Frelinghuysen Rd, Piscataway, NJ 08854, USA
    Development 129:1569-81. 2002
  7. ncbi request reprint HUA ENHANCER3 reveals a role for a cyclin-dependent protein kinase in the specification of floral organ identity in Arabidopsis
    Wenming Wang
    Waksman Institute, Rutgers University, 190 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Development 131:3147-56. 2004
  8. ncbi request reprint Methylation as a crucial step in plant microRNA biogenesis
    Bin Yu
    Waksman Institute, Rutgers University, Piscataway, NJ 08854, USA
    Science 307:932-5. 2005
  9. ncbi request reprint CARPEL FACTORY, a Dicer homolog, and HEN1, a novel protein, act in microRNA metabolism in Arabidopsis thaliana
    Wonkeun Park
    Waksman Institute, Rutgers University, Piscataway, NJ 08854, USA
    Curr Biol 12:1484-95. 2002
  10. pmc siRNAs targeting an intronic transposon in the regulation of natural flowering behavior in Arabidopsis
    Jun Liu
    Waksman Institute, Rutgers University, Piscataway, NJ 08854, USA
    Genes Dev 18:2873-8. 2004

Collaborators

Detail Information

Publications28

  1. pmc Floral patterning defects induced by Arabidopsis APETALA2 and microRNA172 expression in Nicotiana benthamiana
    Sizolwenkosi Mlotshwa
    Department of Botany and Plant Sciences, University of California, Riverside, California 92521, USA
    Plant Mol Biol 61:781-93. 2006
    ..benthamiana normal floral homeotic gene function in perianth organs. Our studies uncover the potential utility of the Arabidopsis AP2/miR172 system as a tool for manipulation of floral architecture and flowering time in non-model plants...
  2. ncbi request reprint HEN1 functions pleiotropically in Arabidopsis development and acts in C function in the flower
    Xuemei Chen
    Waksman Institute, Rutgers, The State University of New Jersey, 190 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Development 129:1085-94. 2002
    ..Therefore, HEN1, like the A function gene AP2, plays multiple roles in plant development as well as acting in organ identity specification in the flower. HEN1 codes for a novel protein and is expressed throughout the plant...
  3. ncbi request reprint A microRNA as a translational repressor of APETALA2 in Arabidopsis flower development
    Xuemei Chen
    Waksman Institute, Rutgers University, Piscataway, NJ 08854, USA
    Science 303:2022-5. 2004
    ..Therefore, miRNA172 likely acts in cell-fate specification as a translational repressor of APETALA2 in Arabidopsis flower development...
  4. ncbi request reprint Two RNA binding proteins, HEN4 and HUA1, act in the processing of AGAMOUS pre-mRNA in Arabidopsis thaliana
    Yulan Cheng
    Waksman Institute, Rutgers University, 190 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Dev Cell 4:53-66. 2003
    ..Our studies underscore the importance of RNA processing in modulating plant development...
  5. pmc PAUSED, a putative exportin-t, acts pleiotropically in Arabidopsis development but is dispensable for viability
    Junjie Li
    Waksman Institute, Rutgers University, Piscataway, New Jersey 08854, USA
    Plant Physiol 132:1913-24. 2003
    ..In addition, a paused null allele, paused-6, is still viable, suggesting the presence of redundant tRNA export pathway(s) in Arabidopsis...
  6. ncbi request reprint HUA ENHANCER2, a putative DExH-box RNA helicase, maintains homeotic B and C gene expression in Arabidopsis
    Tamara L Western
    Waksman Institute, Rutgers University, 190 Frelinghuysen Rd, Piscataway, NJ 08854, USA
    Development 129:1569-81. 2002
    ....
  7. ncbi request reprint HUA ENHANCER3 reveals a role for a cyclin-dependent protein kinase in the specification of floral organ identity in Arabidopsis
    Wenming Wang
    Waksman Institute, Rutgers University, 190 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Development 131:3147-56. 2004
    ..Therefore, CDK8 plays a role in cell differentiation in a multicellular organism...
  8. ncbi request reprint Methylation as a crucial step in plant microRNA biogenesis
    Bin Yu
    Waksman Institute, Rutgers University, Piscataway, NJ 08854, USA
    Science 307:932-5. 2005
    ..Our studies uncover a new and crucial step in plant miRNA biogenesis and have profound implications in the function of miRNAs...
  9. ncbi request reprint CARPEL FACTORY, a Dicer homolog, and HEN1, a novel protein, act in microRNA metabolism in Arabidopsis thaliana
    Wonkeun Park
    Waksman Institute, Rutgers University, Piscataway, NJ 08854, USA
    Curr Biol 12:1484-95. 2002
    ....
  10. pmc siRNAs targeting an intronic transposon in the regulation of natural flowering behavior in Arabidopsis
    Jun Liu
    Waksman Institute, Rutgers University, Piscataway, NJ 08854, USA
    Genes Dev 18:2873-8. 2004
    ..Our studies have general implications for the role of transposable elements in eukaryotic gene expression and evolution...
  11. pmc Biochemical activities of Arabidopsis RNA-dependent RNA polymerase 6
    Julien Curaba
    Department of Botany and Plant Sciences, University of California, Riverside, California 92521, USA
    J Biol Chem 283:3059-66. 2008
    ..Our findings have important implications on the processes involving RDR6 in vivo and provide new biochemical insights into the mechanisms of RNA silencing in Arabidopsis...
  12. pmc MicroRNA metabolism in plants
    Xuemei Chen
    Department of Botany and Plant Sciences, University of California, Riverside, Riverside, CA 92521, USA
    Curr Top Microbiol Immunol 320:117-36. 2008
    ..This chapter summarizes the current knowledge as well as gaps in our understanding of plant miRNA biogenesis and function...
  13. pmc miR172 regulates stem cell fate and defines the inner boundary of APETALA3 and PISTILLATA expression domain in Arabidopsis floral meristems
    Li Zhao
    Department of Botany and Plant Sciences, Center for Plant Cell Biology, Institute of Integrative Genome Biology, University of California Riverside, Riverside, CA 92521, USA
    Plant J 51:840-9. 2007
    ..Given the antiquity of miR172 in land plants, our findings have implications for the recruitment of a microRNA in the building of a flower in evolution...
  14. pmc DICER-LIKE2 plays a primary role in transitive silencing of transgenes in Arabidopsis
    Sizolwenkosi Mlotshwa
    Department of Biological Sciences, University of South Carolina, Columbia, South Carolina, United States of America
    PLoS ONE 3:e1755. 2008
    ..We conclude that DCL2 plays an essential, as opposed to redundant, role in transitive silencing of transgenes and may play a more important role in silencing of viruses than currently thought...
  15. pmc Small RNA-directed epigenetic natural variation in Arabidopsis thaliana
    Jixian Zhai
    State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
    PLoS Genet 4:e1000056. 2008
    ..Methylation analysis revealed that 88% of the examined loci (37 out of 42) were specifically methylated in Ler but not Col, suggesting that small RNA can direct epigenetic differences between two closely related Arabidopsis ecotypes...
  16. pmc A silencing safeguard: links between RNA silencing and mRNA processing in Arabidopsis
    Xuemei Chen
    Department of Botany and Plant Sciences, University of California, Riverside, Riverside, CA 92521, USA
    Dev Cell 14:811-2. 2008
    ....
  17. pmc The FHA domain proteins DAWDLE in Arabidopsis and SNIP1 in humans act in small RNA biogenesis
    Bin Yu
    Department of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, CA 92521, USA
    Proc Natl Acad Sci U S A 105:10073-8. 2008
    ..Therefore, we uncovered an evolutionarily conserved factor in miRNA biogenesis. We propose that DDL participates in miRNA biogenesis by facilitating DCL1 to access or recognize pri-miRNAs...
  18. ncbi request reprint Transgenically expressed viral RNA silencing suppressors interfere with microRNA methylation in Arabidopsis
    Bin Yu
    Department of Botany and Plant Sciences and Institute of Integrative Genome Biology, University of California, Riverside, CA 92521, USA
    FEBS Lett 580:3117-20. 2006
    ..These findings suggest miRNA/miRNA* as the in vivo substrates for the HEN1 miRNA methyltransferase and raise intriguing possibilities regarding the cellular location of miRNA methylation...
  19. ncbi request reprint Arabidopsis HEN1: a genetic link between endogenous miRNA controlling development and siRNA controlling transgene silencing and virus resistance
    Stéphanie Boutet
    Laboratoire de Biologie Cellulaire, INRA, 78026 Versailles Cedex, France
    Curr Biol 13:843-8. 2003
    ....
  20. ncbi request reprint Posttranscriptional control of plant development
    Yulan Cheng
    Developmental Genetics Program and Howard Hughes Medical Institute, Skirball Institute of Biomolecular Medicine, New York, New York 10016, USA
    Curr Opin Plant Biol 7:20-5. 2004
    ..Despite the limited knowledge of the underlying molecular mechanisms, posttranscriptional regulation is known to play a key role in the control of plant development...
  21. ncbi request reprint Methylation protects miRNAs and siRNAs from a 3'-end uridylation activity in Arabidopsis
    Junjie Li
    Department of Botany and Plant Sciences, Institute of Integrative Genome Research, University of California, Riverside, Riverside, California 92508, USA
    Curr Biol 15:1501-7. 2005
    ..We conclude that 3'-end methylation is a common step in miRNA and siRNA metabolism and likely protects the 3' ends of the small RNAs from the uridylation activity...
  22. ncbi request reprint MicroRNA biogenesis and function in plants
    Xuemei Chen
    Department of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, CA 92521, USA
    FEBS Lett 579:5923-31. 2005
    ..A large category of miRNA targets consists of genes encoding transcription factors that play important roles in patterning the plant form...
  23. pmc Degradation of microRNAs by a family of exoribonucleases in Arabidopsis
    Vanitharani Ramachandran
    Department of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California Riverside, Riverside, CA 92521, USA
    Science 321:1490-2. 2008
    ..Therefore, we have uncovered the enzymes that degrade miRNAs and demonstrated that miRNA turnover is crucial for plant development...
  24. pmc Approaches for studying microRNA and small interfering RNA methylation in vitro and in vivo
    Zhiyong Yang
    Department of Botany and Plant Sciences and Institute of Integrative Genome Biology, University of California Riverside, Riverside, California, USA
    Methods Enzymol 427:139-54. 2007
    ..Here we describe methods to characterize the biochemical activities of the HEN1 protein both in vitro and in vivo, and methods to analyze the methylation status of small RNAs in vivo...
  25. ncbi request reprint Overexpression of mtlD gene in transgenic Populus tomentosa improves salt tolerance through accumulation of mannitol
    Lei Hu
    The Tree and Ornamental Plant Breeding and Biotechnology Laboratory of State Forestry Administration, Beijing 100083, P R China
    Tree Physiol 25:1273-81. 2005
    ..The stunted growth of the transgenic plants may in part explain their improved salt tolerance...
  26. pmc HEN1 recognizes 21-24 nt small RNA duplexes and deposits a methyl group onto the 2' OH of the 3' terminal nucleotide
    Zhiyong Yang
    Department of Botany and Plant Sciences, University of California Riverside, Riverside, CA 92521, USA
    Nucleic Acids Res 34:667-75. 2006
    ..These findings indicate that HEN1 specifically methylates miRNAs and siRNAs and implicate the importance of the 2'-O-methyl group in the biology of RNA silencing...
  27. ncbi request reprint The regulation of genes and genomes by small RNAs
    Victor Ambros
    Dartmouth Medical School, Hanover, NH 03755, USA
    Development 134:1635-41. 2007
    ....
  28. pmc A uniform system for microRNA annotation
    Victor Ambros
    Dartmouth Medical School Department of Genetics, Hanover, New Hampshire 03755, USA
    RNA 9:277-9. 2003
    ..Finally, an online clearinghouse for miRNA gene name assignments is provided by the Rfam database of RNA families...