GEORGE CARMAN

Summary

Affiliation: Rutgers University
Country: USA

Publications

  1. pmc Regulation of phospholipid synthesis in the yeast Saccharomyces cerevisiae
    George M Carman
    Department of Food Science and Rutgers Center for Lipid Research, Rutgers University, New Brunswick, New Jersey 08901, USA
    Annu Rev Biochem 80:859-83. 2011
  2. pmc Transcription factor Reb1p regulates DGK1-encoded diacylglycerol kinase and lipid metabolism in Saccharomyces cerevisiae
    Yixuan Qiu
    From the Department of Food Science, Rutgers Center for Lipid Research, and New Jersey Institute for Food, Nutrition, and Health, Rutgers University, New Brunswick, New Jersey 08901 and
    J Biol Chem 288:29124-33. 2013
  3. ncbi Phosphorylation and regulation of CTP synthetase from Saccharomyces cerevisiae by protein kinase A
    W L Yang
    Department of Food Science, Cook College, New Jersey Agricultural Experiment Station, Rutgers University, New Brunswick, New Jersey 08903, USA
    J Biol Chem 271:28777-83. 1996
  4. pmc Roles of phosphatidate phosphatase enzymes in lipid metabolism
    George M Carman
    Department of Food Science, Cook College, New Jersey Agricultural Experiment Station, Rutgers University, 65 Dudley Road, New Brunswick, NJ 08901, USA
    Trends Biochem Sci 31:694-9. 2006
  5. ncbi Regulation of phospholipid synthesis in yeast by zinc
    G M Carman
    Department of Food Science, Cook College, New Jersey Agricultural Experiment Station, Rutgers University, New Brunswick, NJ 08901, USA
    Biochem Soc Trans 33:1150-3. 2005
  6. pmc Regulation of phospholipid synthesis in Saccharomyces cerevisiae by zinc depletion
    George M Carman
    Department of Food Science, Rutgers University, 65 Dudley Road, New Brunswick, NJ 08901, USA
    Biochim Biophys Acta 1771:322-30. 2007
  7. pmc Regulation of phospholipid synthesis in yeast
    George M Carman
    Department of Food Science and Rutgers Center for Lipid Research, Rutgers University, New Brunswick, NJ 08901, USA
    J Lipid Res 50:S69-73. 2009
  8. pmc Phosphatidic acid plays a central role in the transcriptional regulation of glycerophospholipid synthesis in Saccharomyces cerevisiae
    George M Carman
    Department of Food Science and the Rutgers Center for Lipid Research, Rutgers University, New Brunswick, NJ 08901, USA
    J Biol Chem 282:37293-7. 2007
  9. ncbi Phospholipid biosynthesis in the yeast Saccharomyces cerevisiae and interrelationship with other metabolic processes
    G M Carman
    Department of Food Science, Cook College, New Jersey Agricultural Experiment Station, Rutgers University, New Brunswick 08901, USA
    Prog Lipid Res 38:361-99. 1999
  10. ncbi Phosphatidate phosphatases and diacylglycerol pyrophosphate phosphatases in Saccharomyces cerevisiae and Escherichia coli
    G M Carman
    Department of Food Science, Cook College, New Jersey Agricultural Experiment Station, Rutgers University, New Brunswick 08903, USA
    Biochim Biophys Acta 1348:45-55. 1997

Research Grants

  1. REGULATION OF PHOSPHOLIPID SYNTHESIS
    George M Carman; Fiscal Year: 2010
  2. REGULATION OF PHOSPHOLIPID SYNTHESIS
    GEORGE CARMAN; Fiscal Year: 2002
  3. REGULATION OF PHOSPHOLIPID SYNTHESIS BY CTP
    GEORGE CARMAN; Fiscal Year: 2000
  4. REGULATION OF PHOSPHOLIPID SYNTHESIS
    GEORGE CARMAN; Fiscal Year: 2001
  5. PHOSPHOLIPID METABOLSIM AND MEMBRANE FUNCTION
    GEORGE CARMAN; Fiscal Year: 2001
  6. PHOSPHOLIPID METABOLISM AND MEMBRANE FUNCTION
    GEORGE CARMAN; Fiscal Year: 2002
  7. PHOSPHOLIPID METABOLISM AND MEMBRANE FUNCTION
    GEORGE CARMAN; Fiscal Year: 2003
  8. REGULATION OF PHOSPHOLIPID SYNTHESIS
    GEORGE CARMAN; Fiscal Year: 2003
  9. REGULATION OF PHOSPHOLIPID SYNTHESIS
    GEORGE CARMAN; Fiscal Year: 2004
  10. PHOSPHOLIPID METABOLISM AND MEMBRANE FUNCTION
    GEORGE CARMAN; Fiscal Year: 2005

Collaborators

  • Symeon Siniossoglou
  • W Dowhan
  • S D Emr
  • Thomas J Montville
  • Ying Yu
  • Gil Soo Han
  • Yu Fang Chang
  • Hyeon Son Choi
  • Mal Gi Choi
  • Michael C Kersting
  • Avula Sreenivas
  • Laura O'Hara
  • Wendy M Iwanyshyn
  • June Oshiro
  • Yixuan Qiu
  • Tae Sik Park
  • Karim Nadra
  • Tara Havriluk
  • ANIBAL SOTO
  • Shelley S Martin
  • Enoch P Baldwin
  • Fanny S Chang
  • Seung Hee Han
  • Jennifer Cleveland McEntire
  • António Daniel Barbosa
  • Stylianos Fakas
  • Sandra Gres
  • Anne Sophie de Preux Charles
  • Roman Chrast
  • Jean Jacques Medard
  • Mark H G Verheijen
  • William T Hendriks
  • Fred Lozy
  • Jean Sébastien Saulnier-Blache
  • Wen I Wu
  • Neil Grimsey
  • Sew Peak-Chew
  • Kendall J Blumer
  • Vladlen Kurnov
  • Celeste N Johnston
  • Daniel J O'Brien
  • Kristi Conover
  • Anjon Audhya
  • Daniel J Markley
  • D A Dillon
  • W L Yang
  • B Riedel
  • J B Wissing
  • W I Wu

Detail Information

Publications46

  1. pmc Regulation of phospholipid synthesis in the yeast Saccharomyces cerevisiae
    George M Carman
    Department of Food Science and Rutgers Center for Lipid Research, Rutgers University, New Brunswick, New Jersey 08901, USA
    Annu Rev Biochem 80:859-83. 2011
    ..In addition to the regulation of gene expression, phosphorylation of key phospholipid synthesis catalytic and regulatory proteins controls the metabolism of phospholipid precursors and products...
  2. pmc Transcription factor Reb1p regulates DGK1-encoded diacylglycerol kinase and lipid metabolism in Saccharomyces cerevisiae
    Yixuan Qiu
    From the Department of Food Science, Rutgers Center for Lipid Research, and New Jersey Institute for Food, Nutrition, and Health, Rutgers University, New Brunswick, New Jersey 08901 and
    J Biol Chem 288:29124-33. 2013
    ..Taken together, these results indicate that the Reb1p-mediated regulation of diacylglycerol kinase plays a major role in its in vivo functions in lipid metabolism. ..
  3. ncbi Phosphorylation and regulation of CTP synthetase from Saccharomyces cerevisiae by protein kinase A
    W L Yang
    Department of Food Science, Cook College, New Jersey Agricultural Experiment Station, Rutgers University, New Brunswick, New Jersey 08903, USA
    J Biol Chem 271:28777-83. 1996
    ..Phosphorylation of CTP synthetase with protein kinases A and C together resulted in an increase in CTP synthetase activity that was slightly greater than that obtained when the enzyme was phosphorylated with either protein kinase alone...
  4. pmc Roles of phosphatidate phosphatase enzymes in lipid metabolism
    George M Carman
    Department of Food Science, Cook College, New Jersey Agricultural Experiment Station, Rutgers University, 65 Dudley Road, New Brunswick, NJ 08901, USA
    Trends Biochem Sci 31:694-9. 2006
    ..With molecular information now available for both types of PAP, the specific roles of these enzymes in lipid metabolism are being clarified...
  5. ncbi Regulation of phospholipid synthesis in yeast by zinc
    G M Carman
    Department of Food Science, Cook College, New Jersey Agricultural Experiment Station, Rutgers University, New Brunswick, NJ 08901, USA
    Biochem Soc Trans 33:1150-3. 2005
    ..This regulation may play an important role in allowing cells to adapt to zinc deficiency given the essential roles that phospholipids play in the structure and function of cellular membranes...
  6. pmc Regulation of phospholipid synthesis in Saccharomyces cerevisiae by zinc depletion
    George M Carman
    Department of Food Science, Rutgers University, 65 Dudley Road, New Brunswick, NJ 08901, USA
    Biochim Biophys Acta 1771:322-30. 2007
    ..Regulation of phospholipid synthesis may provide an important mechanism by which cells cope with the stress of zinc depletion, given the roles that phospholipids play in the structure and function of cellular membranes...
  7. pmc Regulation of phospholipid synthesis in yeast
    George M Carman
    Department of Food Science and Rutgers Center for Lipid Research, Rutgers University, New Brunswick, NJ 08901, USA
    J Lipid Res 50:S69-73. 2009
    ..Phosphatidic acid, whose levels are controlled by the biochemical regulation of key phospholipid synthesis enzymes, plays a central role in the regulation of phospholipid synthesis gene expression...
  8. pmc Phosphatidic acid plays a central role in the transcriptional regulation of glycerophospholipid synthesis in Saccharomyces cerevisiae
    George M Carman
    Department of Food Science and the Rutgers Center for Lipid Research, Rutgers University, New Brunswick, NJ 08901, USA
    J Biol Chem 282:37293-7. 2007
  9. ncbi Phospholipid biosynthesis in the yeast Saccharomyces cerevisiae and interrelationship with other metabolic processes
    G M Carman
    Department of Food Science, Cook College, New Jersey Agricultural Experiment Station, Rutgers University, New Brunswick 08901, USA
    Prog Lipid Res 38:361-99. 1999
    ....
  10. ncbi Phosphatidate phosphatases and diacylglycerol pyrophosphate phosphatases in Saccharomyces cerevisiae and Escherichia coli
    G M Carman
    Department of Food Science, Cook College, New Jersey Agricultural Experiment Station, Rutgers University, New Brunswick 08903, USA
    Biochim Biophys Acta 1348:45-55. 1997
    ..Rat liver PAP2 displays diacylglycerol pyrophosphate phosphatase activity...
  11. ncbi The Escherichia coli pgpB gene encodes for a diacylglycerol pyrophosphate phosphatase activity
    D A Dillon
    Department of Food Science, Cook College, New Jersey Agricultural Experiment Station, Rutgers University, New Brunswick, New Jersey 08903, USA
    J Biol Chem 271:30548-53. 1996
    ..Pure DGPP phosphatase from Saccharomyces cerevisiae was shown to be similar to the E. coli DGPP phosphatase in its ability to utilize lyso-PA and phosphatidylglycerophosphate as substrates in vitro...
  12. pmc Casein kinase II phosphorylation of the yeast phospholipid synthesis transcription factor Opi1p
    Yu Fang Chang
    Department of Food Science, Cook College, New Jersey Agricultural Experiment Station, Rutgers University, New Brunswick, New Jersey 08901, USA
    J Biol Chem 281:4754-61. 2006
    ..These data supported the conclusion that casein kinase II phosphorylation at Ser10 played a role in stimulating the repression of INO1 when Opi1p was not in its most active state (i.e. in inositol-deprived cells)...
  13. ncbi Regulation of phospholipid synthesis in Saccharomyces cerevisiae by zinc
    Wendy M Iwanyshyn
    Department of Food Science, Rutgers University, New Brunswick, New Jersey 08901, USA
    J Biol Chem 279:21976-83. 2004
    ..These results indicated that a decrease in the cytoplasmic levels of zinc was responsible for the alterations in phospholipid composition...
  14. ncbi Phosphorylation of the yeast phospholipid synthesis regulatory protein Opi1p by protein kinase A
    Avula Sreenivas
    Department of Food Science, Cook College, New Jersey Agricultural Experiment Station, Rutgers University, New Brunswick, New Jersey 08901, USA
    J Biol Chem 278:20673-80. 2003
    ..These data supported the conclusion that phosphorylation of Opi1p at Ser31 and Ser251 mediated the stimulation of the negative regulatory function of Opi1p on the expression of the INO1 gene...
  15. pmc Phosphorylation of yeast phosphatidylserine synthase by protein kinase A: identification of Ser46 and Ser47 as major sites of phosphorylation
    Hyeon Son Choi
    Department of Food Science and Rutgers Center for Lipid Research, Rutgers University, New Brunswick, New Jersey 08901, USA
    J Biol Chem 285:11526-36. 2010
    ..These results indicate that phosphatidylserine synthase is phosphorylated on Ser(46) and Ser(47) by protein kinase A, which results in a higher amount of enzyme for the net effect of stimulating the synthesis of phosphatidylserine...
  16. ncbi Regulation of the yeast DPP1-encoded diacylglycerol pyrophosphate phosphatase by transcription factor Gis1p
    June Oshiro
    Graduate Program in Microbiology and Molecular Genetics and Deparetment of Food Science, Rutgers University, New Brunswick, New Jersey 08901, USA
    J Biol Chem 278:31495-503. 2003
    ....
  17. ncbi Regulation of phospholipid synthesis in the yeast cki1Delta eki1Delta mutant defective in the Kennedy pathway. The Cho1-encoded phosphatidylserine synthase is regulated by mRNA stability
    Hyeon Son Choi
    Department of Food Science, Rutgers University, 65 Dudley Road, New Brunswick, NJ 08901, USA
    J Biol Chem 279:12081-7. 2004
    ..These results revealed a novel mechanism that controls phospholipid synthesis in yeast...
  18. ncbi Phospholipid synthesis in yeast: regulation by phosphorylation
    George M Carman
    Department of Food Science, Rutgers University, New Brunswick, NJ 08901, USA
    Biochem Cell Biol 82:62-70. 2004
    ..CTP synthetase and Opi1p are also phosphorylated by protein kinase C. The phosphorylation of these proteins plays a role in regulating their activities and (or) function in phospholipid synthesis...
  19. pmc Regulation of the Saccharomyces cerevisiae CKI1-encoded choline kinase by zinc depletion
    ANIBAL SOTO
    Department of Food Science and Rutgers Center for Lipid Research, Rutgers University, New Brunswick, NJ 08901, USA
    J Biol Chem 283:10079-88. 2008
    ..The induction of CKI1 expression in zinc-depleted cells translated into increased choline kinase activity in vitro and in vivo, and an increase in phosphatidylcholine synthesis via the Kennedy pathway...
  20. ncbi Vacuole membrane topography of the DPP1-encoded diacylglycerol pyrophosphate phosphatase catalytic site from Saccharomyces cerevisiae
    Gil Soo Han
    Department of Food Science, Rutgers University, New Brunswick, New Jersey 08901, USA
    J Biol Chem 279:5338-45. 2004
    ..This work suggested that diacylglycerol pyrophosphate phosphatase functions to regulate the levels of diacylglycerol pyrophosphate and phosphatidate on the cytosolic face of the vacuole membrane...
  21. pmc CTP synthetase and its role in phospholipid synthesis in the yeast Saccharomyces cerevisiae
    Yu Fang Chang
    Department of Food Science, Rutgers Center for Lipid Research, Rutgers University, New Brunswick, NJ 08901, United States
    Prog Lipid Res 47:333-9. 2008
    ..The expression in yeast has revealed that the human CTPS1-encoded enzyme is also phosphorylated and regulated by protein kinases A and C...
  22. pmc Phosphorylation of human CTP synthetase 1 by protein kinase C: identification of Ser(462) and Thr(455) as major sites of phosphorylation
    Yu Fang Chang
    Department of Food Science, Rutgers University, New Brunswick, New Jersey 08901, USA
    J Biol Chem 282:17613-22. 2007
    ..G., and Carman, G.M. (2006) J. Biol. Chem. 282, 5367-5377). These data indicated that protein kinase C phosphorylation at Ser(462) stimulates human CTP synthetase 1 activity, whereas phosphorylation at Thr(455) inhibits activity...
  23. pmc Respiratory deficiency mediates the regulation of CHO1-encoded phosphatidylserine synthase by mRNA stability in Saccharomyces cerevisiae
    Hyeon Son Choi
    Department of Food Science and Rutgers Center for Lipid Research, Rutgers University, New Brunswick, New Jersey 08901, USA
    J Biol Chem 282:31217-27. 2007
    ..This work advances our understanding of phosphatidylserine synthase regulation and underscores the importance of mitochondrial respiration to the regulation of phospholipid synthesis in S. cerevisiae...
  24. ncbi Phosphorylation of CTP synthetase on Ser36, Ser330, Ser354, and Ser454 regulates the levels of CTP and phosphatidylcholine synthesis in Saccharomyces cerevisiae
    Tae Sik Park
    Department of Food Science, Cook College, New Jersey Agricultural Experiment Station, Rutgers University, New Brunswick, New Jersey 08901, USA
    J Biol Chem 278:20785-94. 2003
    ..The alterations in CTP levels correlated with the regulatory effects CTP has on the pathways responsible for the synthesis of the membrane phospholipid phosphatidylcholine...
  25. pmc Lipid phosphate phosphatases from Saccharomyces cerevisiae
    George M Carman
    Department of Food Science, Rutgers University, New Brunswick, New Jersey, USA
    Methods Enzymol 434:305-15. 2007
    ..The properties of the DPP1-encoded and LPP1-encoded lipid phosphate phosphatase enzymes are summarized...
  26. pmc An unconventional diacylglycerol kinase that regulates phospholipid synthesis and nuclear membrane growth
    Gil Soo Han
    Department of Food Science and the Rutgers Center for Lipid Research, Rutgers University, New Brunswick, NJ 08901, USA
    J Biol Chem 283:20433-42. 2008
    ..Mutations that decrease phosphatidate levels decrease nuclear membrane growth in pah1Delta cells. We propose that phosphatidate metabolism is a critical factor determining nuclear structure by regulating nuclear membrane biogenesis...
  27. ncbi Phosphorylation of Saccharomyces cerevisiae CTP synthetase at Ser424 by protein kinases A and C regulates phosphatidylcholine synthesis by the CDP-choline pathway
    Mal Gi Choi
    Department of Food Science, Cook College, New Jersey Agricultural Experiment Station, Rutgers University, New Brunswick, New Jersey 08901, USA
    J Biol Chem 278:23610-6. 2003
    ....
  28. pmc Regulation of the Saccharomyces cerevisiae EKI1-encoded ethanolamine kinase by zinc depletion
    Michael C Kersting
    Department of Food Science, Cook College, New Jersey Agricultural Experiment Station, Rutgers University, New Brunswick, New Jersey 08901, USA
    J Biol Chem 281:13110-6. 2006
    ..Taken together, this work demonstrated that the zinc-mediated regulation of ethanolamine kinase and the synthesis of phospholipids via the CDP-ethanolamine branch of the Kennedy pathway were controlled in part by Zap1p...
  29. pmc The Saccharomyces cerevisiae Lipin homolog is a Mg2+-dependent phosphatidate phosphatase enzyme
    Gil Soo Han
    Department of Food Science, Cook College, New Jersey Agricultural Experiment Station, Rutgers University, New Brunswick, New Jersey 08901, USA
    J Biol Chem 281:9210-8. 2006
    ..Heterologous expression of human LPIN1 in E. coli showed that lipin 1 is also a Mg(2+)-dependent PA phosphatase enzyme...
  30. pmc Expression of Human CTP synthetase in Saccharomyces cerevisiae reveals phosphorylation by protein kinase A
    Gil Soo Han
    Department of Food Science, Cook College, New Jersey Agricultural Experiment Station, Rutgers University, New Brunswick, New Jersey 08901, USA
    J Biol Chem 280:38328-36. 2005
    ..These studies showed that S. cerevisiae was useful for the analysis of human CTP synthetase phosphorylation...
  31. pmc Regulation of the PIS1-encoded phosphatidylinositol synthase in Saccharomyces cerevisiae by zinc
    Seung Hee Han
    Department of Food Science, Cook College, New Jersey Agricultural Experiment Station, Rutgers University, New Brunswick, NJ 08901, USA
    J Biol Chem 280:29017-24. 2005
    ..This work advances understanding of phospholipid synthesis regulation by zinc and the transcription control of the PIS1 gene...
  32. ncbi Diacylglycerol pyrophosphate phosphatase in Saccharomyces cerevisiae
    June Oshiro
    Graduate Program in Microbiology and Molecular Genetics, Rutgers University, New Brunswick, NJ 08901, USA
    Biochim Biophys Acta 1635:1-9. 2003
    ..Regulation of DPP1 correlates with the expression of DGPP phosphatase activity and the cellular levels of DGPP and PA...
  33. ncbi Regulation of the yeast EKI1-encoded ethanolamine kinase by inositol and choline
    Michael C Kersting
    Department of Food Science, Rutgers University, New Brunswick, New Jersey 08901, USA
    J Biol Chem 279:35353-9. 2004
    ..The repression of ethanolamine kinase by inositol supplementation correlated with a decrease in the incorporation of ethanolamine into CDP-ethanolamine pathway intermediates and into phosphatidylethanolamine and phosphatidylcholine...
  34. ncbi The cellular functions of the yeast lipin homolog PAH1p are dependent on its phosphatidate phosphatase activity
    Gil Soo Han
    Department of Food Science and the Rutgers Center for Lipid Research, Rutgers University, New Brunswick, New Jersey 08901, USA
    J Biol Chem 282:37026-35. 2007
    ..These results demonstrated that the PAP1 activity of the PAH1 gene product is essential for its roles in lipid metabolism and cell physiology...
  35. pmc Characterization of the yeast DGK1-encoded CTP-dependent diacylglycerol kinase
    Gil Soo Han
    Department of Food Science and the Rutgers Center for Lipid Research, Rutgers University, New Brunswick, NJ 08901, USA
    J Biol Chem 283:20443-53. 2008
    ..4 mm) and competitive inhibitor (apparent K(i) = 0.4 mm) of the enzyme. Diacylglycerol kinase activity was stimulated by major membrane phospholipids and was inhibited by CDP-diacylglycerol and sphingoid bases...
  36. pmc Colorimetric determination of pure Mg(2+)-dependent phosphatidate phosphatase activity
    Tara Havriluk
    Department of Food Science and Rutgers Center for Lipid Research, Rutgers University, New Brunswick, NJ 08901, U S A
    Anal Biochem 373:392-4. 2008
    ..Pure enzyme and a water-soluble phosphatidate substrate were required for the assay, which should be applicable to a well-defined large-scale screen of Mg2(+)-dependent phosphatidate phosphatise inhibitors (or activators)...
  37. pmc Phosphorylation of human CTP synthetase 1 by protein kinase A: identification of Thr455 as a major site of phosphorylation
    Mal Gi Choi
    Department of Food Science, Rutgers University, New Brunswick, New Jersey 08901, USA
    J Biol Chem 282:5367-77. 2007
    ..cerevisiae cells, and this was accompanied by a 2.5-fold increase in the cellular concentration of CTP and a 1.5-fold increase in the choline-dependent synthesis of phosphatidylcholine...
  38. pmc Phosphorylation of the yeast choline kinase by protein kinase C. Identification of Ser25 and Ser30 as major sites of phosphorylation
    Mal Gi Choi
    Department of Food Science, Cook College, New Jersey Agricultural Experiment Station, Rutgers University, New Brunswick, New Jersey 08901, USA
    J Biol Chem 280:26105-12. 2005
    ..Comparison of phosphopeptide maps of the wild type and S30A mutant choline kinase enzymes phosphorylated by protein kinase C confirmed that Ser30 was also a target site for protein kinase C...
  39. ncbi Assaying lipid phosphate phosphatase activities
    Gil Soo Han
    Department of Food Science, Rutgers University, New Brunswick, NJ, USA
    Methods Mol Biol 284:209-16. 2004
    ..These activities are measured by following the release of water-soluble radioactive inorganic phosphate from chloroform-soluble radioactive lipid phosphate substrate following a simple chloroform/methanol/ water phase partition...
  40. ncbi The Saccharomyces cerevisiae LSB6 gene encodes phosphatidylinositol 4-kinase activity
    Gil Soo Han
    Department of Food Science, Cook College, New Jersey Agricultural Experiment Station, Rutgers University, New Brunswick, New Jersey 08901, USA
    J Biol Chem 277:47709-18. 2002
    ..cerevisiae...
  41. ncbi Phosphorylation of Saccharomyces cerevisiae choline kinase on Ser30 and Ser85 by protein kinase A regulates phosphatidylcholine synthesis by the CDP-choline pathway
    Ying Yu
    Department of Food Science, Cook College, New Jersey Agricultural Experiment Station, Rutgers University, New Brunswick, New Jersey 08901, USA
    J Biol Chem 277:34978-86. 2002
    ..These data supported the conclusion that phosphorylation of choline kinase on Ser(30) and Ser(85) by protein kinase A regulates PC synthesis by the CDP-choline pathway...
  42. pmc Characterization of the human LPIN1-encoded phosphatidate phosphatase isoforms
    Gil Soo Han
    Department of Food Science and Rutgers Center for Lipid Research, Rutgers University, New Brunswick, New Jersey 08901, USA
    J Biol Chem 285:14628-38. 2010
    ..2, 15.5, and 18.5 kcal/mol, respectively. The isoform activities were dependent on PA as a substrate and required at least one unsaturated fatty acyl moiety for maximum activity...
  43. pmc Control of phospholipid synthesis by phosphorylation of the yeast lipin Pah1p/Smp2p Mg2+-dependent phosphatidate phosphatase
    Laura O'Hara
    Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust MRC Building, Hills Road, CB2 2XY Cambridge, United Kingdom
    J Biol Chem 281:34537-48. 2006
    ..We also provide evidence that derepression of phospholipid biosynthetic genes is not sufficient to induce the nuclear membrane expansion shown in the pah1delta cells...
  44. pmc Increased ATPase activity is responsible for acid sensitivity of nisin-resistant Listeria monocytogenes ATCC 700302
    Jennifer Cleveland McEntire
    Department of Food Science, New Jersey Agricultural Experiment Station, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901, USA
    Appl Environ Microbiol 70:2717-21. 2004
    ..These data support a model in which the increased activity of the mutant ATPase upon acid addition depletes the cells' supply of ATP, resulting in cell death...
  45. pmc A WASp-binding type II phosphatidylinositol 4-kinase required for actin polymerization-driven endosome motility
    Fanny S Chang
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Cell Biol 171:133-42. 2005
    ..Lsb6 therefore is a novel regulator of Las17 that mediates endosome motility independent of phosphatidylinositol 4-phosphate synthesis. Mammalian type II phosphatidylinositol 4-kinases may regulate WASp proteins and endosome motility...
  46. pmc Phosphatidic acid mediates demyelination in Lpin1 mutant mice
    Karim Nadra
    Department of Medical Genetics, University of Lausanne, 1005 Lausanne, Switzerland
    Genes Dev 22:1647-61. 2008
    ..Our results therefore reveal a surprising role for PA in Schwann cell fate determination and provide evidence of a direct link between diseases affecting lipid metabolism and abnormal Schwann cell function...

Research Grants45

  1. REGULATION OF PHOSPHOLIPID SYNTHESIS
    George M Carman; Fiscal Year: 2010
    ..Moreover, unregulated lipid synthesis, as mediated by the PAP1 enzyme, may cause metabolic disorders such as insulin resistance, diabetes, and heart disease. ..
  2. REGULATION OF PHOSPHOLIPID SYNTHESIS
    GEORGE CARMAN; Fiscal Year: 2002
    ..The regulation of phospho lipid synthesis by phosphorylation will be examined in a CTP synthetase mutant defective in CTP product inhibition and in mutants defective in the RASIcAMP pathway. ..
  3. REGULATION OF PHOSPHOLIPID SYNTHESIS BY CTP
    GEORGE CARMAN; Fiscal Year: 2000
    ..This work should also be relevant to other aspects of macromolecular synthesis that are dependent on CTP as a precursor. ..
  4. REGULATION OF PHOSPHOLIPID SYNTHESIS
    GEORGE CARMAN; Fiscal Year: 2001
    ..The regulation of phospho lipid synthesis by phosphorylation will be examined in a CTP synthetase mutant defective in CTP product inhibition and in mutants defective in the RASIcAMP pathway. ..
  5. PHOSPHOLIPID METABOLSIM AND MEMBRANE FUNCTION
    GEORGE CARMAN; Fiscal Year: 2001
    ..cerevisiae. The results of these studies should be relevant to higher eukaryotic organisms. ..
  6. PHOSPHOLIPID METABOLISM AND MEMBRANE FUNCTION
    GEORGE CARMAN; Fiscal Year: 2002
    ..The regulation of PA kinase expression and activity will also be examined. PA kinase will be purified and characterized, and the regulation of activity by phospholipids and water-soluble metabolites will be investigated. ..
  7. PHOSPHOLIPID METABOLISM AND MEMBRANE FUNCTION
    GEORGE CARMAN; Fiscal Year: 2003
    ..The regulation of PA kinase expression and activity will also be examined. PA kinase will be purified and characterized, and the regulation of activity by phospholipids and water-soluble metabolites will be investigated. ..
  8. REGULATION OF PHOSPHOLIPID SYNTHESIS
    GEORGE CARMAN; Fiscal Year: 2003
    ..The regulation of phospho lipid synthesis by phosphorylation will be examined in a CTP synthetase mutant defective in CTP product inhibition and in mutants defective in the RASIcAMP pathway. ..
  9. REGULATION OF PHOSPHOLIPID SYNTHESIS
    GEORGE CARMAN; Fiscal Year: 2004
    ..The regulation of phospho lipid synthesis by phosphorylation will be examined in a CTP synthetase mutant defective in CTP product inhibition and in mutants defective in the RASIcAMP pathway. ..
  10. PHOSPHOLIPID METABOLISM AND MEMBRANE FUNCTION
    GEORGE CARMAN; Fiscal Year: 2005
    ..The regulation of PA kinase expression and activity will also be examined. PA kinase will be purified and characterized, and the regulation of activity by phospholipids and water-soluble metabolites will be investigated. ..
  11. PHOSPHOLIPID METABOLISM AND MEMBRANE FUNCTION
    GEORGE CARMAN; Fiscal Year: 2004
    ..The regulation of PA kinase expression and activity will also be examined. PA kinase will be purified and characterized, and the regulation of activity by phospholipids and water-soluble metabolites will be investigated. ..
  12. REGULATION OF PHOSPHOLIPID SYNTHESIS
    GEORGE CARMAN; Fiscal Year: 2006
    ..The mechanism for CHO1 mRNA (a CDP-diacylgylcerol pathway transcript) degradation will be examined. ..
  13. REGULATION OF PHOSPHOLIPID SYNTHESIS
    GEORGE CARMAN; Fiscal Year: 2007
    ..The mechanism for CHO1 mRNA (a CDP-diacylgylcerol pathway transcript) degradation will be examined. ..
  14. PHOSPHOLIPID METABOLISM AND MEMBRANE FUNCTION
    GEORGE CARMAN; Fiscal Year: 2007
    ..Zinc transport function will be addressed with mutants defective in phospholipid synthesis, and with Zrt1p reconstituted into unilamellar vesicles with varying phospholipid composition. ..
  15. PHOSPHOLIPID METABOLISM AND MEMBRANE FUNCTION
    GEORGE CARMAN; Fiscal Year: 2009
    ..Zinc transport function will be addressed with mutants defective in phospholipid synthesis, and with Zrtlp reconstituted into unilamellar vesicles with varying phospholipid composition. ..
  16. PHOSPHOLIPID METABOLISM AND MEMBRANE FUNCTION
    GEORGE CARMAN; Fiscal Year: 2009
    ..Zinc transport function will be addressed with mutants defective in phospholipid synthesis, and with Zrt1p reconstituted into unilamellar vesicles with varying phospholipid composition. ..
  17. REGULATION OF PHOSPHOLIPID SYNTHESIS
    GEORGE CARMAN; Fiscal Year: 2009
    ..Moreover, unregulated lipid synthesis, as mediated by the PAP1 enzyme, may cause metabolic disorders such as insulin resistance, diabetes, and heart disease. ..
  18. PHOSPHOLIPID METABOLISM AND MEMBRANE FUNCTION
    GEORGE CARMAN; Fiscal Year: 1993
    ..The essential nature of PA phosphatase will also be addressed. The results of the proposed studies with S. cerevisiae should be relevant to higher eukaryotic organisms...
  19. PHOSPHOLIPID METABOLISM AND MEMBRANE FUNCTION
    GEORGE CARMAN; Fiscal Year: 1990
    ..Enzyme regulation will also be studied in clones containing the structural genes encoding for these enzymes. The results found with S. cerevisiae should be relevant to higher eucaryotic organisms...
  20. PHOSPHOLIPID METABOLISM AND MEMBRANE FUNCTION
    GEORGE CARMAN; Fiscal Year: 2006
    ..Zinc transport function will be addressed with mutants defective in phospholipid synthesis, and with Zrt1p reconstituted into unilamellar vesicles with varying phospholipid composition. ..
  21. REGULATION OF PHOSPHOLIPID SYNTHESIS
    GEORGE CARMAN; Fiscal Year: 2005
    ..The mechanism for CHO1 mRNA (a CDP-diacylgylcerol pathway transcript) degradation will be examined. ..
  22. PHOSPHOLIPID METABOLSIM AND MEMBRANE FUNCTION
    GEORGE CARMAN; Fiscal Year: 1999
    ..cerevisiae. The results of these studies should be relevant to higher eukaryotic organisms. ..
  23. REGULATION OF PHOSPHOLIPID SYNTHESIS BY CTP
    GEORGE CARMAN; Fiscal Year: 1999
    ..This work should also be relevant to other aspects of macromolecular synthesis that are dependent on CTP as a precursor. ..
  24. PHOSPHOLIPID METABOLISM AND MEMBRANE FUNCTION
    GEORGE CARMAN; Fiscal Year: 2004
    ..The regulation of PA kinase expression and activity will also be examined. PA kinase will be purified and characterized, and the regulation of activity by phospholipids and water-soluble metabolites will be investigated. ..
  25. PHOSPHOLIPID METABOLSIM AND MEMBRANE FUNCTION
    GEORGE CARMAN; Fiscal Year: 2000
    ..cerevisiae. The results of these studies should be relevant to higher eukaryotic organisms. ..
  26. PHOSPHOLIPID METABOLISM AND MEMBRANE FUNCTION
    GEORGE CARMAN; Fiscal Year: 1991
    ..Enzyme regulation will also be studied in clones containing the structural genes encoding for these enzymes. The results found with S. cerevisiae should be relevant to higher eucaryotic organisms...