Research Topics
Species | Gyorgy BuzsakiSummaryAffiliation: Rutgers University Country: USA Publications
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Publications
Temporal encoding of place sequences by hippocampal cell assembliesGeorge Dragoi
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, New Jersey 07102, USA
Neuron 50:145-57. 2006..These observations suggest that interleaving CA3 neuronal sequences bind CA1 assemblies representing overlapping past, present, and future locations into single episodes...
Neural syntax: cell assemblies, synapsembles, and readersGyorgy Buzsaki
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, NJ 07102, USA
Neuron 68:362-85. 2010..The existing support for this tripartite framework is reviewed and strategies for experimental testing of its predictions are discussed...- Pattern and inhibition-dependent invasion of pyramidal cell dendrites by fast spikes in the hippocampus in vivoG Buzsaki
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark 07102, USA
Proc Natl Acad Sci U S A 93:9921-5. 1996.... - Neuronal oscillations in cortical networksGyorgy Buzsaki
Center for Molecular and Behavioral Neuroscience, Rutgers, State University of New Jersey, Newark, NJ 07102, USA
Science 304:1926-9. 2004.... - Neuroscience. Similar is different in hippocampal networksGyorgy Buzsaki
Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, USA
Science 309:568-9. 2005 - Large-scale recording of neuronal ensemblesGyorgy Buzsaki
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, New Jersey 07102, USA
Nat Neurosci 7:446-51. 2004.... - Hippocampal network patterns of activity in the mouseG Buzsaki
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, NJ 07102, USA
Neuroscience 116:201-11. 2003..We suggest that the main hippocampal network patterns are mediated by similar pathways and mechanisms in mouse and rat... - Homeostatic maintenance of neuronal excitability by burst discharges in vivoGyorgy Buzsaki
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, NJ 07102, USA
Cereb Cortex 12:893-9. 2002.... - Theta oscillations in the hippocampusGyorgy Buzsaki
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey and Neurological Institute of New Jersey, Newark, NJ 07102, USA
Neuron 33:325-40. 2002..Nevertheless, numerous critical issues regarding both the generation of theta oscillations and their functional significance remain challenges for future research... - Inhibition and brain workGyorgy Buzsaki
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, NJ 07102, USA
Neuron 56:771-83. 2007..Herein we examine issues relevant to an assessment of the work performed by inhibitory interneurons in the service of brain function... - Hippocampal GABAergic interneurons: a physiological perspectiveG Buzsaki
Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, USA
Neurochem Res 26:899-905. 2001..Experiments on hippocampal interneurons are reviewed and possible solutions for some of these complex functions are illustrated... - Intracellular features predicted by extracellular recordings in the hippocampus in vivoD A Henze
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, New Jersey 07102, USA
J Neurophysiol 84:390-400. 2000..This theoretical maximum is in contrast to the approximately six units that are usually detected per tetrode. From this, we conclude that a large percentage of hippocampal CA1 pyramidal cells are silent in any given behavioral condition... - Memory consolidation during sleep: a neurophysiological perspectiveG Buzsaki
Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, USA
J Sleep Res 7:17-23. 1998..These observations suggest that sleep patterns in the limbic system are essential for the preservation of experience-induced synaptic modifications... - Theta and gamma coordination of hippocampal networks during waking and rapid eye movement sleepSean M Montgomery
Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, New Jersey 07102, USA
J Neurosci 28:6731-41. 2008..We hypothesize that tonic REM sleep may support off-line mnemonic processing, whereas phasic bursts of activity during REM may promote memory consolidation... - Internally generated cell assembly sequences in the rat hippocampusEva Pastalkova
Center for Molecular and Behavioral Neuroscience, Rutgers, State University of New Jersey, 197 University Avenue, Newark, NJ 07102, USA
Science 321:1322-7. 2008..Such sequences were not formed in control (nonmemory) tasks. We hypothesize that neuronal representations, evolved for encoding distance in spatial navigation, also support episodic recall and the planning of action sequences... - Theta oscillations provide temporal windows for local circuit computation in the entorhinal-hippocampal loopKenji Mizuseki
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, NJ 07102, USA
Neuron 64:267-80. 2009..We hypothesize that the temporal windows set by the theta cycles allow for local circuit interactions and thus a considerable degree of computational independence in subdivisions of the EC-hippocampal loop... - Entrainment of neocortical neurons and gamma oscillations by the hippocampal theta rhythmAnton Sirota
Center for Molecular and Behavioral Neuroscience, Rutgers, State University of New Jersey, 197 University Avenue, Newark, NJ 07102, USA
Neuron 60:683-97. 2008.... - Interneuron Diversity series: Circuit complexity and axon wiring economy of cortical interneuronsGyorgy Buzsaki
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, NJ 07102, USA
Trends Neurosci 27:186-93. 2004..The complex wiring of diverse interneuron classes could represent an economic solution for supporting global synchrony and oscillations at multiple timescales with minimum axon length... - Characterization of neocortical principal cells and interneurons by network interactions and extracellular featuresPeter Bartho
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Ave, Newark, NJ 07102, USA
J Neurophysiol 92:600-8. 2004..High-density parallel recordings of neuronal activity, determination of their physical location and their classification into pyramidal and interneuron classes provide the necessary tools for local circuit analysis... - Spike phase precession persists after transient intrahippocampal perturbationMichaël B Zugaro
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, New Jersey 07102, USA
Nat Neurosci 8:67-71. 2005..These findings indicate that phase advancement that emerges within hippocampal circuitry may be updated at the beginning of each theta cycle by extrahippocampal inputs... - Intrinsic circuit organization and theta-gamma oscillation dynamics in the entorhinal cortex of the ratPascale Quilichini
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, New Jersey 07102, USA
J Neurosci 30:11128-42. 2010..The special wiring architecture and unique membrane properties of EC neurons may underlie their behaviorally distinct firing patterns in the waking animal... - Temporal delays among place cells determine the frequency of population theta oscillations in the hippocampusCaroline Geisler
Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, USA
Proc Natl Acad Sci U S A 107:7957-62. 2010.... - Relationships between hippocampal sharp waves, ripples, and fast gamma oscillation: influence of dentate and entorhinal cortical activityDavid Sullivan
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, New Jersey 07102, USA
J Neurosci 31:8605-16. 2011..We hypothesize that each hippocampal subnetwork possesses distinct resonant properties, tuned by the magnitude of the excitatory drive... 
The origin of extracellular fields and currents--EEG, ECoG, LFP and spikesGyorgy Buzsaki
Center for Molecular and Behavioural Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, New Jersey 07102, USA
Nat Rev Neurosci 13:407-20. 2012....- Theta rhythm of navigation: link between path integration and landmark navigation, episodic and semantic memoryGyorgy Buzsaki
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, 07102, USA
Hippocampus 15:827-40. 2005..Theta oscillation can hence be conceived as the navigation rhythm through both physical and mnemonic space, facilitating the formation of maps and episodic/semantic memories... - Diode probes for spatiotemporal optical control of multiple neurons in freely moving animalsEran Stark
Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, USA
J Neurophysiol 108:349-63. 2012..The capacity of the system to generate unique neural activity patterns facilitates multisite manipulation of neural circuits in a closed-loop manner and opens the door to addressing novel questions... - Activity dynamics and behavioral correlates of CA3 and CA1 hippocampal pyramidal neuronsKenji Mizuseki
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, New Jersey, USA
Hippocampus 22:1659-80. 2012..Our findings suggest that these distinct activity dynamics of CA1 and CA3 pyramidal cells support their distinct computational roles... - REM sleep reorganizes hippocampal excitabilityAndres D Grosmark
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, NJ 07102, USA
Neuron 75:1001-7. 2012..These findings assign a prominent role of REM sleep in sleep-related neuronal plasticity... - Hippocampal network dynamics constrain the time lag between pyramidal cells across modified environmentsKamran Diba
Center for Molecular and Behavioral Neuroscience, Rutgers University Newark, Newark, New Jersey 07102, USA
J Neurosci 28:13448-56. 2008..The freedoms permit the necessary flexibility for the network to distinctly represent unique patterns, whereas the dynamics constrain the speed at which activity propagates between the cell assemblies representing the patterns... - Alteration of theta timescale dynamics of hippocampal place cells by a cannabinoid is associated with memory impairmentDavid Robbe
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, NJ 07102, USA
J Neurosci 29:12597-605. 2009..We hypothesize that precise temporal coordination of hippocampal neurons is necessary for guiding behavior in spatial memory tasks... - Hippocampal CA1 pyramidal cells form functionally distinct sublayersKenji Mizuseki
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, New Jersey, USA
Nat Neurosci 14:1174-81. 2011..Thus, CA1 pyramidal cells in adjacent sublayers can address their targets jointly or differentially, depending on brain states... - Forward and reverse hippocampal place-cell sequences during ripplesKamran Diba
Center for Molecular and Behavioral Neurobiology, Rutgers University, 197 University Ave, Newark, New Jersey 07102, USA
Nat Neurosci 10:1241-2. 2007..This bidirectional re-enactment of temporal sequences may contribute to the establishment of higher-order associations in episodic memory... - Transcranial electric stimulation entrains cortical neuronal populations in ratsSimal Ozen
Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, New Jersey 07102, USA
J Neurosci 30:11476-85. 2010..We suggest that TES in chronic preparations may be used for experimental and therapeutic control of brain activity... - Cross-frequency phase-phase coupling between θ and γ oscillations in the hippocampusMariano A Belluscio
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, New Jersey 07102, USA
J Neurosci 32:423-35. 2012..We suggest that cross-frequency phase coupling can support multiple time-scale control of neuronal spikes within and across structures... - Three-dimensional reconstruction of the axon arbor of a CA3 pyramidal cell recorded and filled in vivoLucia Wittner
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, NJ 07102, USA
Brain Struct Funct 212:75-83. 2007..This arrangement, in combination with the parallel input granule cells and parallel output CA1 pyramidal cells, appears ideal for segregation and integration of information and memories... - Distinct representations and theta dynamics in dorsal and ventral hippocampusSebastien Royer
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, New Jersey 07102, USA
J Neurosci 30:1777-87. 2010..This change is paralleled with a reduction of theta rhythm and an increased representation of nonspatial information... - Place representation within hippocampal networks is modified by long-term potentiationGeorge Dragoi
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, NJ 07102, USA
Neuron 39:843-53. 2003..The findings support the view that learned place representation can be accomplished by LTP-like synaptic plasticity within intrahippocampal networks... - Single granule cells reliably discharge targets in the hippocampal CA3 network in vivoDarrell A Henze
Center for Molecular and Behavioral Neuroscience, Rutgers University, The State University of New Jersey, 197 University Avenue, Newark, New Jersey 07102, USA
Nat Neurosci 5:790-5. 2002..In addition, we suggest that information in single granule cells is converted into a temporal delay code in target CA3 pyramidal cells and interneurons. These data demonstrate how a neural circuit of the CNS may process information... - Mechanisms of gamma oscillations in the hippocampus of the behaving ratJozsef Csicsvari
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, NJ 07102, USA
Neuron 37:311-22. 2003..CA3 pyramidal neurons discharged CA3 and CA1 interneurons at latencies indicative of monosynaptic connections. Intrahippocampal gamma oscillation emerges in the CA3 recurrent system, which entrains the CA1 region via its interneurons... - Hippocampal pyramidal cell-interneuron spike transmission is frequency dependent and responsible for place modulation of interneuron dischargeLisa Marshall
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, New Jersey 07102, USA
J Neurosci 22:RC197. 2002..Thus, single pyramidal neurons can effectively determine the firing patterns of their interneuron targets... - Traveling theta waves along the entire septotemporal axis of the hippocampusJagdish Patel
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, NJ 07102, USA
Neuron 75:410-7. 2012..Thus, theta oscillations can temporally combine or segregate neocortical representations along the septotemporal axis of the hippocampus... - Theta-mediated dynamics of spatial information in hippocampusVladimir Itskov
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, New Jersey 07102, USA
J Neurosci 28:5959-64. 2008.... - Behavior-dependent coordination of multiple theta dipoles in the hippocampusSean M Montgomery
Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, New Jersey 07102, USA
J Neurosci 29:1381-94. 2009..Moreover, our data suggest that these different theta generators flexibly coordinate hippocampal regions and layers to support behavioral task performance... - A 4 Hz oscillation adaptively synchronizes prefrontal, VTA, and hippocampal activitiesShigeyoshi Fujisawa
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, NJ 07102, USA
Neuron 72:153-65. 2011..Thus, multiplexed timing mechanisms in the PFC-VTA-hippocampus axis may support processing of information, including working memory... - GABAergic circuits mediate the reinforcement-related signals of striatal cholinergic interneuronsDaniel F English
Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, New Jersey, USA
Nat Neurosci 15:123-30. 2012..These results reveal a previously unknown circuit mechanism that transmits reinforcement-related information of ChAT interneurons in the mouse neostriatal network... - Behavior-dependent short-term assembly dynamics in the medial prefrontal cortexShigeyoshi Fujisawa
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, New Jersey 07102, USA
Nat Neurosci 11:823-33. 2008..Seeking potential mechanisms for such effects, we found evidence for both firing pattern-dependent facilitation and depression, as well as for a supralinear effect of presynaptic coincidence on the firing of postsynaptic targets... - Hippocampal place cell assemblies are speed-controlled oscillatorsCaroline Geisler
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, NJ 07102, USA
Proc Natl Acad Sci U S A 104:8149-54. 2007..We hypothesize that the speed-correlated acceleration of place cell assembly oscillation is responsible for the phase-distance invariance of hippocampal place cells... - Calcium dynamics of cortical astrocytic networks in vivoHajime Hirase
Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, New Jersey, USA
PLoS Biol 2:E96. 2004..These findings indicate potential neuron-glia communication in the intact brain... - Mechanisms of gamma oscillationsGyorgy Buzsaki
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, New Jersey 07102, USA
Annu Rev Neurosci 35:203-25. 2012..Because of their ubiquitous nature and strong correlation with the "operational modes" of local circuits, gamma oscillations continue to provide important clues about neuronal population dynamics in health and disease... - Selective impairment of hippocampal gamma oscillations in connexin-36 knock-out mouse in vivoDerek L Buhl
Center for Molecular and Behavioral Neuroscience, Rutgers University, The State University of New Jersey, Newark, New Jersey 07102, USA
J Neurosci 23:1013-8. 2003..This suggests that Cx36 interneuronal gap junctions selectively contribute to gamma oscillations... - Gamma oscillations dynamically couple hippocampal CA3 and CA1 regions during memory task performanceSean M Montgomery
Center for Molecular and Behavioral Neuroscience, Rutgers University, 197 University Avenue, Newark, NJ 07102, USA
Proc Natl Acad Sci U S A 104:14495-500. 2007..Based on these findings, we propose that gamma oscillations may serve as a physiological mechanism by which CA3 output can coordinate CA1 activity to support retrieval of hippocampus-dependent memories... - Integration and segregation of activity in entorhinal-hippocampal subregions by neocortical slow oscillationsYoshikazu Isomura
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, New Jersey 07102, USA
Neuron 52:871-82. 2006..Thus, neo/paleocortical and hippocampal networks periodically reset, self-organize, and temporally coordinate their cell assemblies via the slow oscillation... - Hippocampal CA3 pyramidal cells selectively innervate aspiny interneuronsLucia Wittner
Center for Molecular and Behavioural Neuroscience, Rutgers, The State University of New Jersey, 197 University Ave, Newark, 07102, USA
Eur J Neurosci 24:1286-98. 2006..These findings indicate a strong target selection of CA3 pyramidal cells favouring the activation of aspiny classes of interneurons... - Sequential structure of neocortical spontaneous activity in vivoArtur Luczak
Center for Molecular and Behavioral Science, Rutgers University, Newark, NJ 07102, USA
Proc Natl Acad Sci U S A 104:347-52. 2007..We suggest that these stereotyped patterns arise from the interplay of intrinsic cellular conductances and local circuit properties... - Spike train dynamics predicts theta-related phase precession in hippocampal pyramidal cellsKenneth D Harris
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, New Jersey 07102, USA
Nature 417:738-41. 2002.... - Closed-loop control of epilepsy by transcranial electrical stimulationAntal Berenyi
Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, USA
Science 337:735-7. 2012..Closed-loop TES can be an effective clinical tool to reduce pathological brain patterns in drug-resistant patients... - The structure of consciousnessGyorgy Buzsaki
Center for Molecular and Behavioral Neuroscience, Rutgers University, 197 University Avenue, Newark, New Jersey 07102, USA
Nature 446:267. 2007 - Predominant enhancement of glucose uptake in astrocytes versus neurons during activation of the somatosensory cortexJulien Chuquet
Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, New Jersey 07102, USA
J Neurosci 30:15298-303. 2010.... - Two-photon imaging of brain pericytes in vivo using dextran-conjugated dyesHajime Hirase
Center for Molecular and Behavioral Neuroscience, Rutgers, State University of New Jersey, Newark, New Jersey 07102, USA
Glia 46:95-100. 2004..Selective in vivo labeling of pericytes with functional markers may help reveal their physiological function in neuronal activity-associated regulation of local cerebral blood flow... - Organization of cell assemblies in the hippocampusKenneth D Harris
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, New Jersey 07102, USA
Nature 424:552-6. 2003.... - Massively parallel recording of unit and local field potentials with silicon-based electrodesJozsef Csicsvari
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, New Jersey 07102, USA
J Neurophysiol 90:1314-23. 2003..Silicon technology is a promising approach for high-density, high-resolution sampling of neuronal activity in both basic research and prosthetic devices... - Communication between neocortex and hippocampus during sleep in rodentsAnton Sirota
Center for Molecular and Behavioral Neuroscience, Rutgers, State University of New Jersey, 197 University Avenue, Newark, NJ 07102, USA
Proc Natl Acad Sci U S A 100:2065-9. 2003..We hypothesize that oscillation-mediated temporal links coordinate specific information transfer between neocortical and hippocampal cell assemblies. Such a neocortical-hippocampal interplay may be important for memory consolidation... - Klusters, NeuroScope, NDManager: a free software suite for neurophysiological data processing and visualizationLynn Hazan
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, NJ 07102, USA
J Neurosci Methods 155:207-16. 2006..Also included are extensive user manuals and sample data, as well as source code and documentation...
Research Grants
- Imaging Local Network Activity in VivoGyorgy Buzsaki; Fiscal Year: 2006..The electric field-unit imaging methods developed and tested in the hippocampus can be applied for other cortical and subcortical structures. ..
- NETWORK COOPERATION IN THE HIPPOCAMPUS IN VIVOGyorgy Buzsaki; Fiscal Year: 2007..The dysfunction of these hypothesized, cooperative mechanisms may contribute to human diseases, such as Alzheimer's, schizophrenia and epilepsy. ..
- Hippocampal interneuronal network (MH 54671)Gyorgy Buzsaki; Fiscal Year: 2007....
- NETWORK COOPERATION IN THE HIPPOCAMPUS IN VIVOGyorgy Buzsaki; Fiscal Year: 2009..Dysfunction of self-organized cellular-synaptic mechanisms may underline Alzheimer's disease, schizophrenia and other cognitive diseases. ..
- NETWORK COOPERATION IN THE HIPPOCAMPUS IN VIVOGyorgy Buzsaki; Fiscal Year: 2010..Dysfunction of self-organized cellular-synaptic mechanisms may underline Alzheimer's disease, schizophrenia and other cognitive diseases. ..
- Hippocampal interneuronal network (MH 54671)Gyorgy Buzsaki; Fiscal Year: 2010....
- NETWORK COOPERATION IN THE HIPPOCAMPUS IN VIVOGyorgy Buzsaki; Fiscal Year: 2003..The results will be used to moderate conclusions based on EC data if reliability is low. Misses and FA's will be considered. ..
- HIPPOCAMPAL INTERNEURONAL NETWORKGyorgy Buzsaki; Fiscal Year: 1999..Such knowledge is essential for understanding the consequences of interneuronal damage in disease. ..
- CRCNS: Dynamics of the auditory cortical columnGyorgy Buzsaki; Fiscal Year: 2010..Involvement of underrepresented groups is also a priority, and our location at Rutgers Newark allows us a unique opportunity promote diverse participation in this program. ..