Steven G Buyske
Affiliation: Rutgers University
- Transmission disequilibrium test power and sample size in the presence of locus heterogeneityChuanwen Chen
Rutgers University, USA
Stat Appl Genet Mol Biol 8:Article 44. 2009..Finally, as the effect size of the disease locus increases, the sample size necessary to detect association decreases in the presence of locus heterogeneity. We provide freely available software that can perform these calculations...
- Genetic variants associated with fasting glucose and insulin concentrations in an ethnically diverse population: results from the Population Architecture using Genomics and Epidemiology (PAGE) studyMegan D Fesinmeyer
Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis MN, USA
BMC Med Genet 14:98. 2013..In contrast, few studies have been conducted within minority groups, which carry the highest burden of impaired glucose homeostasis and type 2 diabetes in the U.S...
- Investigation of gene-by-sex interactions for lipid traits in diverse populations from the population architecture using genomics and epidemiology studyKira C Taylor
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
BMC Genet 14:33. 2013..Here, we investigated whether GWAS-identified SNPs for lipid traits exhibited heterogeneity by sex in the Population Architecture using Genomics and Epidemiology (PAGE) study...
- Enhanced genetic maps from family-based disease studies: population-specific comparisonsChunsheng He
Department of Genetics, Rutgers University, Piscataway, NJ, USA
BMC Med Genet 12:15. 2011..A large set of genetic studies genotyped by the NHLBI Mammalian Genotyping Service (MGS) provide appropriate data for generating more accurate maps...
- Analysis of case-parent trios at a locus with a deletion allele: association of GSTM1 with autismSteven Buyske
Departments of Statistics and Genetics, 110 Frelinghuysen Rd, Rutgers University, Piscataway, NJ 08854, USA
BMC Genet 7:8. 2006..When subjects have already been ascertained in a case-parent design however, the question arises as to whether the data can still be used to test disease association at such a locus...
- Cognitive traits link to human chromosomal regionsSteven Buyske
Department of Statistics, Rutgers University, Piscataway, NJ, USA
Behav Genet 36:65-76. 2006..Although the validity of these results beyond populations with a susceptibility for alcohol dependence is unclear, these results are among the first linkage results for non-language components of cognition...
- HLA-DR4 as a risk allele for autism acting in mothers of probands possibly during pregnancyWilliam G Johnson
Department of Neurology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
Arch Pediatr Adolesc Med 163:542-6. 2009..To test whether HLA-DR4 acts in the mother, possibly during pregnancy, to contribute to the phenotype of autistic disorder in her fetus...
- Risk of autistic disorder in affected offspring of mothers with a glutathione S-transferase P1 haplotypeTanishia A Williams
Department of Neurology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
Arch Pediatr Adolesc Med 161:356-61. 2007..To test whether polymorphisms of the glutathione S-transferase P1 gene (GSTP1) act in the mother during pregnancy to contribute to the phenotype of autistic disorder (AD) in her fetus...
- Systematic evaluation of map quality: human chromosome 22Tara C Matise
Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA
Am J Hum Genet 70:1398-410. 2002....
- Retrieval independence between parts and wholes in successive recognition tasksArnold L Glass
Rutgers University, New Brunswick, NJ, USA
Q J Exp Psychol (Hove) 59:136-49. 2006..All of these results were predicted by a single three-parameter mathematical model derived from the hypothesis that single-word and double-word targets had independent representations in memory...
- A 3.9-centimorgan-resolution human single-nucleotide polymorphism linkage map and screening setTara C Matise
Department of Genetics, Rutgers University, Piscataway, NJ, 08840, USA
Am J Hum Genet 73:271-84. 2003..Evaluations indicate that this SNP screening set is more informative than the Marshfield Clinic's commonly used microsatellite-based screening set...
- A second-generation combined linkage physical map of the human genomeTara C Matise
Department of Genetics, Rutgers University, Piscataway, New Jersey 08854, USA
Genome Res 17:1783-6. 2007..With nearly twice as many markers as our first-generation map, the Rutgers Map continues to be a unique and comprehensive resource for obtaining genetic map information for large sets of polymorphic markers...
- Identification of a schizophrenia-associated functional noncoding variant in NOS1APNaomi S Wratten
Rutgers University Department of Genetics, 145 Bevier Road, Piscataway, NJ 08854, USA
Am J Psychiatry 166:434-41. 2009..In this study the authors sought to apply novel statistical methods and conduct additional biological experiments to isolate at least one risk allele within NOS1AP...
- Altered microRNA expression profiles in postmortem brain samples from individuals with schizophrenia and bipolar disorderMichael P Moreau
Department of Genetics, Rutgers University, Piscataway, New Jersey 08854 8095, USA
Biol Psychiatry 69:188-93. 2011..MicroRNAs (miRNAs) are potent regulators of gene expression with proposed roles in brain development and function. We hypothesized that miRNA expression profiles are altered in individuals with severe psychiatric disorders...
- When a case is not a case: effects of phenotype misclassification on power and sample size requirements for the transmission disequilibrium test with affected child triosSteven Buyske
Department of Genetics, Rutgers University, Piscataway, N J 08854, USA
Hum Hered 67:287-92. 2009..We have developed freely available software that computes power loss for a fixed sample size or sample size for a fixed power in the presence of phenotype misclassification...
- Increased expression in dorsolateral prefrontal cortex of CAPON in schizophrenia and bipolar disorderBin Xu
Department of Genetics, Rutgers University, Piscataway, New Jersey, United States of America
PLoS Med 2:e263. 2005..Prior sequencing of the ten exons of CAPON failed to reveal a coding mutation associated with illness...
- Common dihydrofolate reductase 19-base pair deletion allele: a novel risk factor for preterm deliveryWilliam G Johnson
Department of Neurology, University of Medicine and Dentistry New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ, USA
Am J Clin Nutr 81:664-8. 2005..Dihydrofolate reductase (DHFR) is required to convert the folic acid used in supplements and for food fortification and the dihydrofolate produced by thymidylate synthase during DNA synthesis to the reduced folate forms used by the cell...
- New 19 bp deletion polymorphism in intron-1 of dihydrofolate reductase (DHFR): a risk factor for spina bifida acting in mothers during pregnancy?William G Johnson
Division of Neurogenetics, Department of Neurology, UMDNJ Robert Wood Johnson Medical School, 671 Hoes Lane, Piscataway, NJ 08854, USA
Am J Med Genet A 124:339-45. 2004..About half of dietary folates and all of folic acid supplements must be reduced by DHFR to be available for mother and fetus. Reduced folates could be preferable for supplements during pregnancy to prevent SB...
- Widespread RNA editing of embedded alu elements in the human transcriptomeDennis D Y Kim
Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA
Genome Res 14:1719-25. 2004..Therefore, Alu-associated RNA editing may be a mechanism for marking nonstandard transcripts, not destined for translation...