Affiliation: Rush University Medical Center
Yu L, Boyle P, Wilson R, Levine S, Schneider J, Bennett D. Purpose in life and cerebral infarcts in community-dwelling older people. Stroke. 2015;46:1071-6 pubmed publisher
..Purpose in life may affect risk for cerebral infarcts, specifically macroscopic lacunar infarcts. ..
Yu L, Boyle P, Leurgans S, Schneider J, Kryscio R, Wilson R, et al
. Effect of common neuropathologies on progression of late life cognitive impairment. Neurobiol Aging. 2015;36:2225-2231 pubmed publisher
..Thus, the presence of AD pathology alone nearly doubles the risk of developing cognitive impairment in late life, and the presence of multiple pathologies further increases this risk over multiple years before death. ..
Yu L, Boyle P, Nag S, Leurgans S, Buchman A, Wilson R, et al
. APOE and cerebral amyloid angiopathy in community-dwelling older persons. Neurobiol Aging. 2015;36:2946-2953 pubmed publisher
..APOE Îµ4, but not Îµ2, is associated with capillary amyloid angiopathy. ..
Yu L, Boyle P, Leurgans S, Schneider J, Bennett D. Disentangling the effects of age and APOE on neuropathology and late life cognitive decline. Neurobiol Aging. 2014;35:819-26 pubmed publisher
..There were no direct effects of age and APOE on decline after accounting for these pathologic pathways. ..
Bihlmeyer N, Brody J, Smith A, Lunetta K, Nalls M, Smith J, et al
. Genetic diversity is a predictor of mortality in humans. BMC Genet. 2014;15:159 pubmed publisher
..57%. This effect was consistent between European and African ancestry cohorts, men and women, and major causes of death (cancer and cardiovascular disease), demonstrating the broad positive impact of genomic diversity on human survival. ..
Yu L, Chibnik L, Yang J, McCabe C, Xu J, Schneider J, et al
. Methylation profiles in peripheral blood CD4+ lymphocytes versus brain: The relation to Alzheimer's disease pathology. Alzheimers Dement. 2016;12:942-951 pubmed publisher
..There is no strong evidence of change in CD4+ lymphocytes methylation among older persons over an average of 7.5Â years. Methylation associations with AD pathology found in neocortex are not directly reflected in CD4+ lymphocytes. ..
Yu L, Lutz M, Wilson R, Burns D, Roses A, Saunders A, et al
. TOMM40'523 variant and cognitive decline in older persons with APOE Îµ3/3 genotype. Neurology. 2017;88:661-668 pubmed publisher
Yu L, Lutz M, Farfel J, Wilson R, Burns D, Saunders A, et al
. Neuropathologic features of TOMM40 '523 variant on late-life cognitive decline. Alzheimers Dement. 2017;13:1380-1388 pubmed publisher
..There are two distinct TOMM40 '523 signals in relation to late-life cognitive decline. One signal primarily acts through AD and other common neuropathologies, whereas the other operates through a different mechanism. ..