X Xu

Summary

Affiliation: Rush University Medical Center
Country: USA

Publications

  1. ncbi request reprint In vivo and in vitro degradation of heparan sulfate (HS) proteoglycans by HPR1 in pancreatic adenocarcinomas. Loss of cell surface HS suppresses fibroblast growth factor 2-mediated cell signaling and proliferation
    Xiulong Xu
    Department of General Surgery, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Biol Chem 282:2363-73. 2007
  2. ncbi request reprint Evidence that one subset of anaplastic thyroid carcinomas are derived from papillary carcinomas due to BRAF and p53 mutations
    Roderick M Quiros
    Department of General Surgery, Rush University Medical Center, Chicago, Illinois 60612, USA
    Cancer 103:2261-8. 2005
  3. ncbi request reprint Elevated serum heparanase-1 levels in patients with pancreatic carcinoma are associated with poor survival
    Roderick M Quiros
    Department of General Surgery, Rush University Medical Center, Chicago, Illinois 60612, and Department of Surgery, Mayo Clinic, Rochester, MN, USA
    Cancer 106:532-40. 2006
  4. ncbi request reprint Clinicopathological significance of major histocompatibility complex class I-related chain a and B expression in thyroid cancer
    Xiulong Xu
    Department of General Surgery, Rush University Medical Center, 1653 West Congress Parkway, Chicago, Illinois 60612, USA
    J Clin Endocrinol Metab 91:2704-12. 2006
  5. doi request reprint Activation of the Sonic Hedgehog pathway in thyroid neoplasms and its potential role in tumor cell proliferation
    Xiulong Xu
    Department of General Surgery, Rush University Medical Center, Chicago, Illinois 60612, USA
    Endocr Relat Cancer 19:167-79. 2012
  6. pmc Major histocompatibility complex class I-related chain A/B (MICA/B) expression in tumor tissue and serum of pancreatic cancer: role of uric acid accumulation in gemcitabine-induced MICA/B expression
    Xiulong Xu
    Department of General Surgery, Rush University Medical Center, Chicago, IL 60612, USA
    BMC Cancer 11:194. 2011
  7. ncbi request reprint Immunohistochemical detection of heparanase-1 expression in eutopic and ectopic endometrium from women with endometriosis
    Xiulong Xu
    Department of General Surgery, Rush University Medical Center, Chicago, IL 60612, USA
    Fertil Steril 88:1304-10. 2007
  8. ncbi request reprint Estradiol induces heparanase-1 expression and heparan sulphate proteoglycan degradation in human endometrium
    Xiulong Xu
    Department of General Surgery, Rush University Medical Center, Chicago, IL 60612, USA
    Hum Reprod 22:927-37. 2007
  9. ncbi request reprint IFN-gamma induces cell growth inhibition by Fas-mediated apoptosis: requirement of STAT1 protein for up-regulation of Fas and FasL expression
    X Xu
    Department of General Surgery, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    Cancer Res 58:2832-7. 1998
  10. ncbi request reprint Inverse correlation between heparan sulfate composition and heparanase-1 gene expression in thyroid papillary carcinomas: a potential role in tumor metastasis
    Xiulong Xu
    Department of General Surgery, Rush University Medical Center, Chicago, Illinois 60612, USA
    Clin Cancer Res 9:5968-79. 2003

Collaborators

Detail Information

Publications26

  1. ncbi request reprint In vivo and in vitro degradation of heparan sulfate (HS) proteoglycans by HPR1 in pancreatic adenocarcinomas. Loss of cell surface HS suppresses fibroblast growth factor 2-mediated cell signaling and proliferation
    Xiulong Xu
    Department of General Surgery, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Biol Chem 282:2363-73. 2007
    ..Our results suggest that HPR1 expressed in pancreatic adenocarcinomas can suppress the proliferation of pancreatic tumor cells in response to the growth factors that require HSPGs as their co-receptors...
  2. ncbi request reprint Evidence that one subset of anaplastic thyroid carcinomas are derived from papillary carcinomas due to BRAF and p53 mutations
    Roderick M Quiros
    Department of General Surgery, Rush University Medical Center, Chicago, Illinois 60612, USA
    Cancer 103:2261-8. 2005
    ..In the current study, genetic alterations in a panel of ATC were profiled to determine the origins of ATC...
  3. ncbi request reprint Elevated serum heparanase-1 levels in patients with pancreatic carcinoma are associated with poor survival
    Roderick M Quiros
    Department of General Surgery, Rush University Medical Center, Chicago, Illinois 60612, and Department of Surgery, Mayo Clinic, Rochester, MN, USA
    Cancer 106:532-40. 2006
    ..The purpose of this study was to test whether serum HPR1 levels in pancreatic carcinoma patients are elevated, and whether higher serum HPR1 levels are associated with a shortened survival...
  4. ncbi request reprint Clinicopathological significance of major histocompatibility complex class I-related chain a and B expression in thyroid cancer
    Xiulong Xu
    Department of General Surgery, Rush University Medical Center, 1653 West Congress Parkway, Chicago, Illinois 60612, USA
    J Clin Endocrinol Metab 91:2704-12. 2006
    ..It is not known whether MICA/B expression is up-regulated in thyroid cancer as a result of oncogene activation...
  5. doi request reprint Activation of the Sonic Hedgehog pathway in thyroid neoplasms and its potential role in tumor cell proliferation
    Xiulong Xu
    Department of General Surgery, Rush University Medical Center, Chicago, Illinois 60612, USA
    Endocr Relat Cancer 19:167-79. 2012
    ..Our results suggest that the SHH pathway is widely activated in thyroid neoplasms and may have potential as an early marker of thyroid cancer or as a potential therapeutic target for thyroid cancer treatment...
  6. pmc Major histocompatibility complex class I-related chain A/B (MICA/B) expression in tumor tissue and serum of pancreatic cancer: role of uric acid accumulation in gemcitabine-induced MICA/B expression
    Xiulong Xu
    Department of General Surgery, Rush University Medical Center, Chicago, IL 60612, USA
    BMC Cancer 11:194. 2011
    ..In this study, we sought to study MICA/B expression in pancreatic cancer and to determine whether and how genotoxic drugs such as gemcitabine can affect MICA/B expression and natural killer cytotoxity...
  7. ncbi request reprint Immunohistochemical detection of heparanase-1 expression in eutopic and ectopic endometrium from women with endometriosis
    Xiulong Xu
    Department of General Surgery, Rush University Medical Center, Chicago, IL 60612, USA
    Fertil Steril 88:1304-10. 2007
    ..To investigate the expression of heparanase-1, an endoglycosidase that degrades heparan sulfate proteoglycans, in eutopic and ectopic endometrial tissues from women with endometriosis...
  8. ncbi request reprint Estradiol induces heparanase-1 expression and heparan sulphate proteoglycan degradation in human endometrium
    Xiulong Xu
    Department of General Surgery, Rush University Medical Center, Chicago, IL 60612, USA
    Hum Reprod 22:927-37. 2007
    ..This study seeks to determine whether estrogen is able to regulate the expression of heparanase-1 (HPR1) in human endometrium...
  9. ncbi request reprint IFN-gamma induces cell growth inhibition by Fas-mediated apoptosis: requirement of STAT1 protein for up-regulation of Fas and FasL expression
    X Xu
    Department of General Surgery, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    Cancer Res 58:2832-7. 1998
    ..IFN-gamma-induced cell death was inhibited by caspase-1 inhibitors. Our results suggest that cell growth inhibition by IFN-gamma is due to apoptosis mediated by Fas and FasL interaction...
  10. ncbi request reprint Inverse correlation between heparan sulfate composition and heparanase-1 gene expression in thyroid papillary carcinomas: a potential role in tumor metastasis
    Xiulong Xu
    Department of General Surgery, Rush University Medical Center, Chicago, Illinois 60612, USA
    Clin Cancer Res 9:5968-79. 2003
    ..The purpose of this study was to evaluate HPR1 expression in thyroid neoplasms and its effect in degrading the HSPG substrates in the ECM and BM and to determine its role in thyroid tumor metastasis...
  11. ncbi request reprint High prevalence of BRAF gene mutation in papillary thyroid carcinomas and thyroid tumor cell lines
    Xiulong Xu
    Department of General Surgery, Rush Presbyterian St Luke s Medical Center, 1653 West Congress Parkway, Chicago, IL 60612, USA
    Cancer Res 63:4561-7. 2003
    ..These observations suggest that mutated BRAF gene may cooperate with RET/PTC to induce the oncogenesis of PTC...
  12. ncbi request reprint In vitro and in vivo antitumor activity of a novel immunomodulatory drug, leflunomide: mechanisms of action
    X Xu
    Department of General Surgery, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Biochem Pharmacol 58:1405-13. 1999
    ..The possibility that leflunomide exerts its antitumor activity by inhibition of tyrosine phosphorylation or by a yet unidentified mode of action is discussed...
  13. ncbi request reprint In vivo activity of leflunomide: pharmacokinetic analyses and mechanism of immunosuppression
    A S Chong
    Department of General Surgery, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    Transplantation 68:100-9. 1999
    ..We report the effect of uridine on the in vivo immunosuppressive activities of leflunomide...
  14. ncbi request reprint Heparanase-1 gene expression and regulation by high glucose in renal epithelial cells: a potential role in the pathogenesis of proteinuria in diabetic patients
    Justin B Maxhimer
    Department of General Surgery, Rush University Medical Center, 1653 W Congress Parkway, Chicago, IL 60612, USA
    Diabetes 54:2172-8. 2005
    ..Our studies suggest that loss of heparan sulfate in the GBM with diabetic nephropathy is attributable to accelerated heparan sulfate degradation by increased HPR1 expression...
  15. doi request reprint Abnormal glomerular permeability characteristics in diabetic nephropathy: implications for the therapeutic use of low-molecular weight heparin
    Edmund J Lewis
    Department of Medicine, Section of Nephrology, Collaborative Study Group, Rush University Medical Center, Chicago, Illinois 60607, USA
    Diabetes Care 31:S202-7. 2008
    ..Two clinical trials are currently being carried out to determine whether sulodexide is renoprotective in diabetic nephropathy...
  16. ncbi request reprint Low frequency of BRAF mutations in adult patients with papillary thyroid cancers following childhood radiation exposure
    Barbara J Collins
    Section of Endocrinology and Metabolism, University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    Thyroid 16:61-6. 2006
    ..In 23 cases, only 1 sample was positive. These results are further evidence that BRAF mutations, while common in sporadic adult papillary thyroid cancers, are rare events in cancers seen in subjects exposed to radiation as children...
  17. doi request reprint Tea catechin EGCg suppresses the mgl gene associated with halitosis
    X Xu
    Department of Pediatric Dentistry, College of Dentistry, University of Illinois at Chicago, MC850, 801 S Paulina Street, Room 469J, Chicago, IL 60612 7212, USA
    J Dent Res 89:1304-8. 2010
    ..05). We conclude that EGCg may represent a natural and alternative agent to the antimicrobial chemicals currently available for halitosis control...
  18. ncbi request reprint The relationship between opsin overexpression and photoreceptor degeneration
    E Tan
    Department of Ophthalmology and Visual Sciences, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA
    Invest Ophthalmol Vis Sci 42:589-600. 2001
    ..To characterize the process by which overexpression of normal opsin leads to photoreceptor degeneration...
  19. doi request reprint Reactive oxygen species mediate high glucose-induced heparanase-1 production and heparan sulphate proteoglycan degradation in human and rat endothelial cells: a potential role in the pathogenesis of atherosclerosis
    G Rao
    Department of General Surgery, Rush University Medical Center, 1653 W Congress Parkway, Chicago, IL 60612, USA
    Diabetologia 54:1527-38. 2011
    ....
  20. ncbi request reprint Human heparanase-1 gene expression in pancreatic adenocarcinoma
    Anthony W Kim
    Department of General Surgery, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    J Gastrointest Surg 6:167-72. 2002
    ..This suggests that HPR1 may contribute to the highly invasive and early metastatic behavior of pancreatic cancer...
  21. ncbi request reprint Differential heparanase-1 expression in malignant and benign pheochromocytomas
    Roderick M Quiros
    Department of General Surgery, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612 3833, USA
    J Surg Res 108:44-50. 2002
    ..Currently, there is no technique that can reliably predict the malignant behavior of some pheochromocytomas. This study tests whether HPR is differentially expressed in malignant and benign pheochromocytomas...
  22. ncbi request reprint Ductal carcinoma in situ of the breast and heparanase-1 expression: a molecular explanation for more aggressive subtypes
    Justin B Maxhimer
    Department of General Surgery, Rush University Medical Center, Chicago, IL 60612, USA
    J Am Coll Surg 200:328-35. 2005
    ..This study tested whether heparanase-1 (HPR1), an endoglycosidase that specifically degrades the heparan sulfate (HS) proteoglycans in the breast extracellular matrix, was associated with the most aggressive DCIS subtypes...
  23. doi request reprint Expression of the sonic hedgehog pathway molecules in synchronous follicular adenoma and papillary carcinoma of the thyroid gland in predicting malignancy
    Kirbylee K Nelson
    Rush Medical College, Chicago, IL, USA
    Surgery 148:654-60; discussion 660. 2010
    ..This study determines whether 3 molecules, Patched, Smoothened, and Sonic Hedgehog, involved in the Sonic Hedgehog pathway are overexpressed equally in synchronous follicular thyroid adenoma and papillary thyroid carcinoma...
  24. ncbi request reprint Cloning and characterization of the human heparanase-1 (HPR1) gene promoter: role of GA-binding protein and Sp1 in regulating HPR1 basal promoter activity
    Ping Jiang
    Department of General Surgery and the Division of Cardiovascular Diseases and Critical Care, Department of Medicine, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    J Biol Chem 277:8989-98. 2002
    ..Coexpression of GABPalpha/beta and Sp1 or Sp3 further increased luciferase reporter gene expression. Our results collectively suggest that Sp1 cooperates with GABP to regulate HPR1 promoter activity...
  25. ncbi request reprint Heparanase-1 expression is associated with the metastatic potential of breast cancer
    Justin B Maxhimer
    Department of General Surgery and Pathology, Rush Presbyterian St Luke s Medical Center, Chicago, Ill 60612, USA
    Surgery 132:326-33. 2002
    ..Heparanase-1 (HPR1) is an endoglycosidase that specifically degrades the heparan sulfate (HS) moiety of proteoglycans, a component of the extracellular matrix and basement membrane...
  26. ncbi request reprint Human serum from patients with septic shock activates transcription factors STAT1, IRF1, and NF-kappaB and induces apoptosis in human cardiac myocytes
    Aseem Kumar
    Department of Chemistry and Biochemistry and the Biomolecular Sciences Programme, Laurentian University, Sudbury, Ontario P3E 2C6, Canada
    J Biol Chem 280:42619-26. 2005
    ..These data suggest that transcription factor activation and early myocyte apoptosis play a mechanistic role in septic myocardial depression and sepsis-induced organ dysfunction...