Research Topics
Species | Robert WilsonSummaryAffiliation: Rush University Medical Center Country: USA Publications
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Publications
Odor identification and progression of parkinsonian signs in older personsRobert S Wilson
Rush Alzheimer s Disease Center and Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
Exp Aging Res 34:173-87. 2008..The results suggest that impaired odor identification is associated with more rapid progression of parkinsonism in old age, particularly parkinsonian gait disturbance...- Loneliness and the rate of motor decline in old age: the Rush Memory and Aging Project, a community-based cohort studyAron S Buchman
Department of Neurological Sciences, Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S, Paulina, Chicago, Illinois 60612, USA
BMC Geriatr 10:77. 2010..We tested the hypothesis that feeling alone is associated with the rate of motor decline in community-dwelling older persons... - Terminal decline in motor functionRobert S Wilson
Rush Alzheimer s Disease Center, Chicago, IL 60612, USA
Psychol Aging 27:998-1007. 2012..The results demonstrate that motor and cognitive functions both undergo a period of accelerated decline in the last few years of life... - The natural history of cognitive decline in Alzheimer's diseaseRobert S Wilson
Rush Alzheimer s Disease Center, Chicago, IL 60612, USA
Psychol Aging 27:1008-17. 2012..The results indicate that cognitive decline in AD begins many years before dementia is diagnosed and accelerates during the course of the disease... - Terminal dedifferentiation of cognitive abilitiesR S Wilson
Rush Alzheimer s Disease Center and Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
Neurology 78:1116-22. 2012..To test the cognitive dedifferentiation hypothesis that cognitive abilities become increasingly correlated in late life... - Influence of late-life cognitive activity on cognitive healthRobert S Wilson
Rush Alzheimer s Disease Center and Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
Neurology 78:1123-9. 2012..To test the hypothesis that late-life participation in mentally stimulating activities affects subsequent cognitive health... - Cognitive decline after hospitalization in a community population of older personsR S Wilson
Rush Alzheimer s Disease Center, Chicago, IL, USA
Neurology 78:950-6. 2012..To test the hypothesis that hospitalization in old age is associated with subsequent cognitive decline... 
Relation of cognitive activity to risk of developing Alzheimer diseaseR S Wilson
Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina, Suite 1038, Chicago, IL 60612, USA
Neurology 69:1911-20. 2007..Frequent cognitive activity in old age has been associated with reduced risk of Alzheimer disease (AD), but the basis of the association is uncertain...- Olfactory identification and incidence of mild cognitive impairment in older ageRobert S Wilson
Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina, Ste 1038, Chicago, IL 60612, USA
Arch Gen Psychiatry 64:802-8. 2007..Mild cognitive impairment (MCI) is often a precursor to Alzheimer disease, but knowledge about factors that predict its development is limited... - Conscientiousness and the incidence of Alzheimer disease and mild cognitive impairmentRobert S Wilson
Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina, Chicago, IL 60612, USA
Arch Gen Psychiatry 64:1204-12. 2007..The personality trait of conscientiousness has been related to morbidity and mortality in old age, but its association with the development of Alzheimer disease is not known... - Nursing home placement, day care use, and cognitive decline in Alzheimer's diseaseRobert S Wilson
Alzheimer s Disease Center, Institute for Health Aging, Department of Neurological Sciences, College of Nursing, Rush University Medical Center, 600 S Paulina St, Suite 1038, Chicago, IL 60612, USA
Am J Psychiatry 164:910-5. 2007..The aim of this study was to examine the associations of day care use and nursing home placement with the rate of cognitive decline in Alzheimer's disease... - Terminal cognitive decline: accelerated loss of cognition in the last years of lifeRobert S Wilson
Rush Alzheimer s Disease Center, Rush University Medical Center, Suite 1038, Chicago, IL 60612, USA
Psychosom Med 69:131-7. 2007..To test the hypothesis that rate of cognitive decline accelerates in the last years of life... - Loneliness and risk of Alzheimer diseaseRobert S Wilson
Rush Alzheimer s Disease Center, Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL 60612, USA
Arch Gen Psychiatry 64:234-40. 2007..Social isolation in old age has been associated with risk of developing dementia, but the risk associated with perceived isolation, or loneliness, is not well understood... - Chronic distress, age-related neuropathology, and late-life dementiaRobert S Wilson
Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina, Suite 1038, Chicago, IL 60612, USA
Psychosom Med 69:47-53. 2007..The objective of this study was to test whether common age-related neuropathology could account for the relation of chronic distress to dementia... - Chronic distress and incidence of mild cognitive impairmentR S Wilson
Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
Neurology 68:2085-92. 2007..Here we test the hypothesis that chronic psychological distress is associated with increased incidence of MCI in old age... - Cognitive decline in old age: separating retest effects from the effects of growing olderRobert S Wilson
Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
Psychol Aging 21:774-89. 2006..Individual differences in retest effects were substantial but not consistent across cognitive measures. The results suggest that retest-based improvement in cognitive test performance can be substantial and persistent... - Neuroticism, extraversion, and mortality in a defined population of older personsRobert S Wilson
Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
Psychosom Med 67:841-5. 2005..The objective of this study was to test the association of the personality traits of neuroticism and extraversion with risk of death in old age... - Odor identification and decline in different cognitive domains in old ageRobert S Wilson
Rush Alzheimer s Disease Center, Rush Institute for Healthy Aging, and Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
Neuroepidemiology 26:61-7. 2006..The results indicate that impaired odor identification in old age is associated with impaired global cognition and more rapid decline in perceptual processing speed and episodic memory... - Hallucinations, cognitive decline, and death in Alzheimer's diseaseR S Wilson
Rush Alzheimer s Disease Center, Rush Institute for Healthy Aging, and Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
Neuroepidemiology 26:68-75. 2006..Delusions and misperceptions were not strongly related to cognitive decline or mortality. The results suggest that hallucinations in Alzheimer's disease, particularly visual ones, are associated with more rapid progression... - Cognitive decline and survival in Alzheimer's diseaseRobert S Wilson
Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
Int J Geriatr Psychiatry 21:356-62. 2006..To test the association of rate of cognitive decline, an indicator of the severity of the underlying disease process, with risk of death in Alzheimer's disease (AD)... - Childhood adversity and psychosocial adjustment in old ageRobert S Wilson
Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
Am J Geriatr Psychiatry 14:307-15. 2006..The objective of this study was to test the hypothesis that higher level of childhood adversity is associated with lower level of psychosocial adjustment in old age... - Harm avoidance and disability in old ageRobert S Wilson
Rush Alzheimer s Disease Center and Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
Exp Aging Res 32:243-61. 2006..The results suggest that harm avoidance is associated with disability in old age... - Chronic psychological distress and risk of Alzheimer's disease in old ageRobert S Wilson
Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, Ill, USA
Neuroepidemiology 27:143-53. 2006..The results support the hypothesis that distress proneness is associated with increased risk of dementia and suggest that neurobiologic mechanisms other than AD pathology may underlie the association... - The relationship between cerebral Alzheimer's disease pathology and odour identification in old ageR S Wilson
Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina, Suite 1038, Chicago, IL 60612, USA
J Neurol Neurosurg Psychiatry 78:30-5. 2007..Olfactory dysfunction is common in old age, but its basis is uncertain... 
Change in depressive symptoms during the prodromal phase of Alzheimer diseaseRobert S Wilson
Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina, Ste 1038, Chicago, IL 60612, USA
Arch Gen Psychiatry 65:439-45. 2008..Prospective studies have established an association between depressive symptoms and risk of dementia, but how depressive symptoms change during the evolution of dementia is uncertain...- Vulnerability to stress, anxiety, and development of dementia in old ageRobert S Wilson
Rush Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
Am J Geriatr Psychiatry 19:327-34. 2011..To identify the components of the neuroticism trait most responsible for its association with cognitive decline and dementia in old age... - Cognitive decline in prodromal Alzheimer disease and mild cognitive impairmentRobert S Wilson
Rush Alzheimer s Disease Center, Department of Neurological Science, Rush University Medical Center, 600 S Paulina Ave, Ste 1038, Chicago, IL 60612, USA
Arch Neurol 68:351-6. 2011..To characterize the course of cognitive decline during the prodromal phase of Alzheimer disease... - Lewy bodies and olfactory dysfunction in old ageRobert S Wilson
Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina Avenue, Chicago, IL 60612, USA
Chem Senses 36:367-73. 2011..The findings indicate that Lewy body disease impairs late life olfactory function even in otherwise asymptomatic individuals... - Sources of variability in estimates of the prevalence of Alzheimer's disease in the United StatesRobert S Wilson
Rush University Medical Center, Chicago, IL, USA
Alzheimers Dement 7:74-9. 2011..3 million in 2002 by the Aging, Demographics, and Memory Study (ADAMS), which is almost 50% less than the estimate of 4.5 million in 2000 derived from the Chicago Health and Aging Project... - Terminal decline in cognitive functionR S Wilson
Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
Neurology 60:1782-7. 2003..Impending death is thought to be associated with age-related cognitive decline, but this association has not been well studied... - Heritability of different forms of memory in the Late Onset Alzheimer's Disease Family StudyRobert S Wilson
Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
J Alzheimers Dis 23:249-55. 2011..This suggests that genetic analyses of memory endophenotypes may help to identify genetic variants associated with AD... - Odor identification and mortality in old ageRobert S Wilson
Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina Avenue, Suite 1038, Chicago, IL 60612, USA
Chem Senses 36:63-7. 2011..The results indicate that difficulty identifying familiar odors in old age is associated with increased risk of death... - Neurodegenerative basis of age-related cognitive declineR S Wilson
Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina Ave, Suite 1038, Chicago, IL 60612, USA
Neurology 75:1070-8. 2010..To assess the contribution of dementia-related neuropathologic lesions to age-related and disease-related change in cognitive function... - Cognitive activity and the cognitive morbidity of Alzheimer diseaseR S Wilson
Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
Neurology 75:990-6. 2010..To test the hypothesis that frequent cognitive activity predicts slower cognitive decline before dementia onset in Alzheimer disease (AD) and faster decline thereafter... - Loss of basic lexical knowledge in old ageRobert S Wilson
Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina Ave, Suite 1038, Chicago, IL 60612, USA
J Neurol Neurosurg Psychiatry 82:369-72. 2011..Basic lexical skills are hypothesised to be relatively preserved in mild dementia, but clinical studies have reported inconsistent results... - Telephone assessment of cognitive function in the late-onset Alzheimer's disease family studyRobert S Wilson
Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL 60612, USA
Arch Neurol 67:855-61. 2010..Administration of cognitive test batteries by telephone has been shown to be a valid and cost-effective means of assessing cognition, but it remains relatively uncommon in epidemiological research... - Temporal course of depressive symptoms during the development of Alzheimer diseaseR S Wilson
Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina St, Chicago, IL 60612, USA
Neurology 75:21-6. 2010..To characterize change in depressive symptoms before and after the onset of dementia in Alzheimer disease (AD)... - Cognitive decline in incident Alzheimer disease in a community populationR S Wilson
Rush AD Center, Rush University Medical Center, 600 South Paulina Avenue, Suite 1038, Chicago, IL 60612, USA
Neurology 74:951-5. 2010..To measure the cognitive consequences of incident Alzheimer disease (AD) in older African American and white subjects... - Olfactory impairment in presymptomatic Alzheimer's diseaseRobert S Wilson
Department of Neurological Sciences, Rush Alzheimer s Disease Center, Rush University Medical Cetner, Chicago, Illinois 60612, USA
Ann N Y Acad Sci 1170:730-5. 2009.... - Biracial population study of mortality in mild cognitive impairment and Alzheimer diseaseRobert S Wilson
Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina Ave, Ste 1038, Chicago, IL 60612, USA
Arch Neurol 66:767-72. 2009..To assess mortality associated with mild cognitive impairment (MCI) and Alzheimer disease (AD) among older African Americans and whites from an urban community... - Educational attainment and cognitive decline in old ageR S Wilson
Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
Neurology 72:460-5. 2009..Level of education is a well-established risk factor for Alzheimer disease but its relation to cognitive decline, the principal clinical manifestation of the disease, is uncertain... - Harm avoidance and risk of Alzheimer's diseaseRobert S Wilson
Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina, Suite 1038, Chicago, IL 60612, USA
Psychosom Med 73:690-6. 2011..To test the hypothesis that harm avoidance, a trait associated with behavioral inhibition, is associated with the risk of developing Alzheimer's disease (AD)... - Hallucinations and mortality in Alzheimer diseaseRobert S Wilson
Rush Alzheimer s Disease Center, Dept of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
Am J Geriatr Psychiatry 13:984-90. 2005..The authors tested the relationship of hallucinations and delusions to mortality in Alzheimer disease (AD)... - Early life socioeconomic status and late life risk of Alzheimer's diseaseRobert S Wilson
Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
Neuroepidemiology 25:8-14. 2005..The results suggest that early life socioeconomic level is related to level of cognition in late life but not to rate of cognitive decline or risk of AD... - Depressive symptoms and cognitive decline in a community population of older personsR S Wilson
Department of Neurological Sciences, Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA
J Neurol Neurosurg Psychiatry 75:126-9. 2004..An association between depressive symptoms and cognitive decline has been observed in selected cohorts of older people, but studies of defined populations have had conflicting results... - Proneness to psychological distress and risk of Alzheimer disease in a biracial communityR S Wilson
Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Center, 600 S Paulina, Suite 1038, Chicago, IL 60612, USA
Neurology 64:380-2. 2005..4 times more likely to develop AD than persons not distress prone. This effect was substantially stronger in white persons compared to African Americans... - Parkinsonianlike signs and risk of incident Alzheimer disease in older personsRobert S Wilson
Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging and the Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
Arch Neurol 60:539-44. 2003..Parkinsonianlike signs are common in older persons, but little is known about how their severity or rate of progression is related to the development of Alzheimer disease (AD) or decline in cognition... - Assessment of lifetime participation in cognitively stimulating activitiesRobert Wilson
Rush Alzheimer s Disease Center, Rush Institute for Healthy Aging, Chicago, IL 60612, USA
J Clin Exp Neuropsychol 25:634-42. 2003..The results suggest that the scale provides a psychometrically sound measure of frequency of cognitive activity across the life span... - Education and the course of cognitive decline in Alzheimer diseaseR S Wilson
Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina, Suite 1038, Chicago, IL 60612, USA
Neurology 63:1198-202. 2004..To test the hypothesis that higher level of education is related to more rapid cognitive decline in Alzheimer disease (AD)... - Distress proneness and cognitive decline in a population of older personsRobert S Wilson
Rush Alzheimer s Disease Center and Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
Psychoneuroendocrinology 30:11-7. 2005..059) after controlling for depressive symptoms. The results suggest that the tendency to experience psychological distress is associated with increased cognitive decline in old age... - Personality and mortality in old ageRobert S Wilson
Rush Institute for Healthy Aging and Rush Alzheimer s Disease Center, Chicago, Illinois 60612, USA
J Gerontol B Psychol Sci Soc Sci 59:P110-6. 2004..Findings for extraversion were mixed, and neither agreeableness nor openness was strongly related to mortality. The results suggest that personality is associated with mortality in old age... - Cognitive activity and cognitive decline in a biracial community populationR S Wilson
Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging and Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
Neurology 61:812-6. 2003..However, the association of cognitive activity with cognitive decline, the principal manifestation of AD, is not well understood... - Depressive symptoms, clinical AD, and cortical plaques and tangles in older personsR S Wilson
Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
Neurology 61:1102-7. 2003..Depressive symptoms in old age have been associated with risk of Alzheimer disease (AD), but it is uncertain whether they are an independent risk factor for disease or an early clinical sign of its underlying pathology... - Negative affect and mortality in older personsRobert S Wilson
Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
Am J Epidemiol 158:827-35. 2003..The results suggest that negative affect in older persons, especially internally experienced distress, is associated with an increased mortality risk... - Proneness to psychological distress is associated with risk of Alzheimer's diseaseR S Wilson
Rush Alzheimer s Disease Center, Rush Institute for Healthy Aging, Chicago, IL 60612, USA
Neurology 61:1479-85. 2003..Chronic stress is associated with hippocampal damage and impaired memory in animals and humans... - Premorbid proneness to distress and episodic memory impairment in Alzheimer's diseaseR S Wilson
Rush Alzheimer s Disease Center and Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
J Neurol Neurosurg Psychiatry 75:191-5. 2004..Chronic stress has been associated with impaired episodic memory, but the association of premorbidly experienced distress with memory function in Alzheimer's disease is unknown... - Cognitive activity and incident AD in a population-based sample of older personsR S Wilson
Department of Neurological Sciences, Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
Neurology 59:1910-4. 2002..Participation in cognitively stimulating activities is hypothesized to be associated with risk of AD, but knowledge about this association is limited... - The apolipoprotein E epsilon 2 allele and decline in episodic memoryR S Wilson
Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, USA
J Neurol Neurosurg Psychiatry 73:672-7. 2002.... - Early and late life cognitive activity and cognitive systems in old ageRobert S Wilson
Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Center, 600 South Paulina, Suite 1038, Chicago, IL 60612, USA
J Int Neuropsychol Soc 11:400-7. 2005..The results suggest that past cognitive activity contributes to current cognition principally through its association with cognitive activity in old age... - Socioeconomic characteristics of the community in childhood and cognition in old ageR S Wilson
Rush Alzheimer s Disease Center, Rush Institute for Healthy Aging and Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
Exp Aging Res 31:393-407. 2005..The results suggest that socioeconomic conditions in early life are associated with level of cognitive function in old age but not with rate of cognitive decline... - Depressive symptoms, cognitive decline, and risk of AD in older personsRobert S Wilson
Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, 1645 West Jackson Boulevard, Suite 675, Chicago, IL 60612, USA
Neurology 59:364-70. 2002..Cross-sectional and retrospective case-control studies suggest an association of depression symptoms with cognitive impairment and AD, but there have been few prospective studies and their results have been inconsistent... - Assessment of cognitive decline in old age with brief tests amenable to telephone administrationRobert S Wilson
Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
Neuroepidemiology 25:19-25. 2005..The results suggest that briefly assessing cognition with tests amenable to telephone administration may prove useful in longitudinal epidemiologic studies of older persons... - Participation in cognitively stimulating activities and risk of incident Alzheimer diseaseRobert S Wilson
Rush Alzheimer s Disease Center, 1645 W Jackson Blvd, Suite 675, Chicago, IL 60612, USA
JAMA 287:742-8. 2002..Frequent participation in cognitively stimulating activities has been hypothesized to reduce risk of Alzheimer disease (AD), but prospective data regarding an association are lacking... - The apolipoprotein E epsilon 4 allele and decline in different cognitive systems during a 6-year periodRobert S Wilson
Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, 1645 W Jackson Blvd, Suite 675, Chicago, IL 60612, USA
Arch Neurol 59:1154-60. 2002..The apolipoprotein E (APOE) epsilon 4 allele is known to influence risk of AD but it has been difficult to establish whether it affects episodic memory differently from other cognitive functions... - Individual differences in rates of change in cognitive abilities of older personsRobert S Wilson
Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois, USA
Psychol Aging 17:179-93. 2002..The results suggest that change in cognitive function in old age primarily reflects person-specific factors rather than an inevitable developmental process... - Progression of gait disorder and rigidity and risk of death in older personsR S Wilson
Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
Neurology 58:1815-9. 2002..Bradykinesia, gait disturbance, rigidity, and tremor are common motor signs in old age. All of these signs are associated with increased morbidity and mortality, but the extent to which they are progressive is unknown... - Motor dysfunction in mild cognitive impairment and the risk of incident Alzheimer diseaseNeelum T Aggarwal
Rush Alzheimer s Disease Center, Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL 60612, USA
Arch Neurol 63:1763-9. 2006..Little is known about motor function in mild cognitive impairment (MCI) and its relation to the risk of Alzheimer disease (AD)... - Social engagement and cognitive function in old ageKristin R Krueger
Rush Alzheimer s Disease Center and Department of Behavioral Sciences, Rush University Medical Center, Chicago, Illinois, USA
Exp Aging Res 35:45-60. 2009..The results confirm that higher level of social engagement in old age is associated with better cognitive function but the association varies across domains of social engagement... - Anti-inflammatory agents and cognitive decline in a bi-racial populationFrancine Grodstein
Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL, USA
Neuroepidemiology 30:45-50. 2008..no use: mean difference = 0.12; p trend = 0.03). Overall, we found no relation between regular aspirin use and cognitive decline, but long-term use of ibuprofen may be related to decreased rates of cognitive decline in older persons... - Association of personality traits with elder self-neglect in a community-dwelling populationXinQi Dong
Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA
Am J Geriatr Psychiatry 19:743-51. 2011..The objectives of this study are as follows: 1) to examine the association of personality traits with elder self-neglect and 2) to examine the association of personality traits with elder self-neglect severity... - The relation of cigarette smoking to incident Alzheimer's disease in a biracial urban community populationNeelum T Aggarwal
Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Center, Chicago, IL 60612, USA
Neuroepidemiology 26:140-6. 2006.... - Physical frailty is associated with incident mild cognitive impairment in community-based older personsPatricia A Boyle
Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Facility, Suite 1020B, 600 South Paulina Street, Chicago, IL 60612, USA
J Am Geriatr Soc 58:248-55. 2010..To test the hypothesis that physical frailty is associated with risk of mild cognitive impairment (MCI)... - Association between blood pressure and cognitive function in a biracial community population of older personsMartha Clare Morris
Department of Internal Medicine, Rush University and Rush Presbyterian St Luke s Medical Center, Chicago, Ill 60612, USA
Neuroepidemiology 21:123-30. 2002..The cross-sectional association between blood pressure and cognitive functions is small and curvilinear and more apparent in persons with cardiovascular conditions... - Association between late-life social activity and motor decline in older adultsAron S Buchman
Departments of Neurological Sciences, Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Facility, Chicago, IL 60612, USA
Arch Intern Med 169:1139-46. 2009..Our objective was to test the hypothesis that late-life social activity is related to the rate of change in motor function in old age... - Consumption of fish and n-3 fatty acids and risk of incident Alzheimer diseaseMartha Clare Morris
Rush Institute for Healthy Aging, Department of Internal Medicine, Rush Alzheimer s Disease Center, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
Arch Neurol 60:940-6. 2003..Dietary n-3 polyunsaturated fatty acids improve brain functioning in animal studies, but there is limited study of whether this type of fat protects against Alzheimer disease... - Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community studyMartha Clare Morris
Rush Institute for Healthy Aging, Rush Presbyterian St Luke s Medical Center, 1645 W Jackson, Suite 675, Chicago, IL 60612, USA
JAMA 287:3230-7. 2002..Oxidative processes have been suggested as elements in the development of Alzheimer disease (AD), but whether dietary intake of vitamin E and other antioxidant nutrients prevents its development is unknown... - Racial differences in the association of education with physical and cognitive function in older blacks and whitesLisa L Barnes
Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina, Suite 1038, Chicago, IL 60612, USA
J Gerontol B Psychol Sci Soc Sci 66:354-63. 2011..We examined racial differences in the cross-sectional association of education with physical and cognitive function performance in older adults... - Musculoskeletal pain and incident disability in community-dwelling older adultsAron S Buchman
Rush University Medical Center, Chicago, Illinois 60612, USA
Arthritis Care Res (Hoboken) 62:1287-93. 2010..To test the hypothesis that the number of areas of musculoskeletal pain reported is related to incident disability... - Musculoskeletal pain is associated with incident mobility disability in community-dwelling eldersRaj C Shah
Rush Alzheimer s Disease Center, 600 South Paulina, Suite 1038, Chicago, IL 60612, USA
J Gerontol A Biol Sci Med Sci 66:82-8. 2011..We tested the hypothesis that musculoskeletal pain is associated with first occurrence of severe mobility disability... - Incidence of Alzheimer disease in a biracial urban community: relation to apolipoprotein E allele statusDenis A Evans
Rush Institute on Healthy Aging, Chicago, IL, USA
Arch Neurol 60:185-9. 2003..Few studies compare Alzheimer disease (AD) incidence among black and white subjects... - Repetition priming and recognition memory in younger and older persons: temporal stability and performanceDebra A Fleischman
Rush University Medical Center, Chicago, IL 60612, USA
Neuropsychology 19:750-9. 2005..Results indicate that dissociations between priming and explicit memory performances cannot be accounted for by differential reliability of the measures... - Change in cognitive function in Alzheimer's disease in African-American and white personsLisa L Barnes
Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
Neuroepidemiology 26:16-22. 2006..06), perceptual speed (p = 0.07) and naming (p = 0.08). The results suggest that the rate of cognitive decline in AD is slower in African-Americans compared with whites, particularly for episodic memory... - The apolipoprotein E epsilon4 allele and incident Alzheimer's disease in persons with mild cognitive impairmentNeelum T Aggarwal
Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, Illinois 60612 3872, USA
Neurocase 11:3-7. 2005..02, 2.63). There was a marginally significant reduction in the effect of epsilon4 in older compared to younger participants (p=.053). The results suggest that possession of an epsilon4 allele does increase risk of AD in persons with MCI... - Is lower cognitive function in one spouse associated with depressive symptoms in the other spouse?Kimberly A Skarupski
Rush Institute for Healthy Aging, Rush University Medical Center, 1645 W Jackson, Suite 675, Chicago, IL 60612 3227, USA
Aging Ment Health 10:621-30. 2006..Our findings suggest that husbands may be particularly psychologically vulnerable to the negative effects of their wives' cognitive impairment. This vulnerability may have a range of long-term health and caregiving implications... - Black-white differences in depressive symptoms among older adults over timeKimberly A Skarupski
Rush Institute for Healthy Aging, 1645 W Jackson, Suite 675, Chicago, IL 60612 3227, USA
J Gerontol B Psychol Sci Soc Sci 60:P136-42. 2005..225, p < .001) but remained robust. The racial differences increased slightly over time. Our findings support heightened awareness of depression in older Black populations... - The relation of lifetime cognitive activity and lifetime access to resources to late-life cognitive function in older African AmericansLisa L Barnes
Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 13:516-28. 2006..The results suggest that both measures are psychometrically sound in a minority population and that lifetime cognitive activity may contribute to current cognitive function in African Americans... - Sex differences in the clinical manifestations of Alzheimer disease pathologyLisa L Barnes
Rush Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
Arch Gen Psychiatry 62:685-91. 2005.... - The effect of social networks on the relation between Alzheimer's disease pathology and level of cognitive function in old people: a longitudinal cohort studyDavid A Bennett
Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
Lancet Neurol 5:406-12. 2006..Few data are available about how social networks reduce the risk of cognitive impairment in old age. We aimed to measure this effect using data from a large, longitudinal, epidemiological clinicopathological study... - Parkinsonian signs and cognitive function in old ageDebra A Fleischman
Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA
J Int Neuropsychol Soc 11:591-7. 2005..The results suggest that parkinsonian signs have a modest, but statistically reliable, association with level of cognitive function in old age... - A longitudinal study of implicit and explicit memory in old personsDebra A Fleischman
Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
Psychol Aging 19:617-25. 2004..Findings indicate that explicit memory and priming are dissociable on the basis of age-related change and that mildly reduced priming is not an inevitable consequence of growing older... - Frailty is associated with incident Alzheimer's disease and cognitive decline in the elderlyAron S Buchman
Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
Psychosom Med 69:483-9. 2007..To assess the association between frailty and incident Alzheimer's disease (AD) and cognitive decline. Frailty is common in older persons and associated with adverse health outcomes... - Physical activity and leg strength predict decline in mobility performance in older personsAron S Buchman
Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
J Am Geriatr Soc 55:1618-23. 2007..To assess the extent to which physical activity and leg strength are associated with change in mobility in older persons... - Predictors of depressive symptoms in persons with Alzheimer's diseaseDavid W Gilley
Rush Institute for Healthy Aging and Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA
J Gerontol B Psychol Sci Soc Sci 59:P75-83. 2004..Depressive symptoms in Alzheimer's disease appear to follow a more predictable pattern of expression than previously described... - Vitamin E and cognitive decline in older personsMartha Clare Morris
Department of Preventive Medicine, Rush Institute for Healthy Aging, Rush Presbyterian St Luke s Medical Center, 1645 W Jackson, Suite 675, Chicago, IL 60612, USA
Arch Neurol 59:1125-32. 2002..Previous studies raise the possibility that antioxidants protect against neurodegenerative diseases... - Cerebral infarctions and the relationship of depression symptoms to level of cognitive functioning in older personsDavid A Bennett
Rush Alzheimer s Disease Center, Departments of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
Am J Geriatr Psychiatry 12:211-9. 2004.... - Apolipoprotein E e4 allele is associated with more rapid motor decline in older personsAron S Buchman
Rush Alzheimer s Disease Center, Armour Academic Facility, Rush University Medical Center, Chicago, IL 60612, USA
Alzheimer Dis Assoc Disord 23:63-9. 2009..These results suggest that the presence of epsilon4 allele is a risk factor for more rapid motor decline in the elderly... - Do depressive symptoms predict declines in physical performance in an elderly, biracial population?Susan A Everson-Rose
Rush Institute for Healthy Aging, Rush University Medical Center, Department of Preventive Medicine, Chicago, Illinois 60612, USA
Psychosom Med 67:609-15. 2005..We investigated whether depressive symptoms, assessed by the 10-item Center for Epidemiological Studies Depression Scale (CES-D), predicted change in physical function in elderly adults... - Validity and reproducibility of a food frequency questionnaire by cognition in an older biracial sampleMartha Clare Morris
Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL 60612, USA
Am J Epidemiol 158:1213-7. 2003..The modified Harvard SFFQ is a reasonable method of dietary assessment even in a population of older persons, some of whom are at advanced age, have chronic health conditions, and have cognitive impairment... - Racial differences in perceived discrimination in a community population of older blacks and whitesLisa L Barnes
Rush Alzheimer s Disease Center and Institute for Healthy Aging
J Aging Health 16:315-37. 2004..To examine the prevalence of perceived discrimination in an older biracial population and to examine its correlation with depressive symptoms... - Self-neglect and cognitive function among community-dwelling older personsXinQi Dong
Rush University Medical Center, Chicago, Illinois, USA
Int J Geriatr Psychiatry 25:798-806. 2010..Elder self-neglect is a common public health issue, but it is unclear to what degree it is associated with cognitive function. This study aimed to examine the cross-sectional association between self-neglect and cognitive function... - Relation of hemoglobin to level of cognitive function in older personsRaj C Shah
Rush Alzheimer s Disease Center, Chicago, Ill 60612, USA
Neuroepidemiology 32:40-6. 2009..While decreased hemoglobin concentration is common in the elderly, the relationship of the entire range of hemoglobin concentrations with cognitive function is not well understood...
Research Grants
- Neurobiologic Study of Psychological Distress & DementiaRobert Wilson; Fiscal Year: 2007....
- Neurobiologic Study of Psychological Distress & DementiaRobert S Wilson; Fiscal Year: 2010....