Robert Wilson

Summary

Affiliation: Rush University Medical Center
Country: USA

Publications

  1. ncbi request reprint Loneliness and risk of Alzheimer disease
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL 60612, USA
    Arch Gen Psychiatry 64:234-40. 2007
  2. pmc Odor identification and progression of parkinsonian signs in older persons
    Robert S Wilson
    Rush Alzheimer s Disease Center and Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    Exp Aging Res 34:173-87. 2008
  3. pmc Loneliness and the rate of motor decline in old age: the Rush Memory and Aging Project, a community-based cohort study
    Aron S Buchman
    Department of Neurological Sciences, Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S, Paulina, Chicago, Illinois 60612, USA
    BMC Geriatr 10:77. 2010
  4. pmc Cognitive decline after hospitalization in a community population of older persons
    R S Wilson
    Rush Alzheimer s Disease Center, Chicago, IL, USA
    Neurology 78:950-6. 2012
  5. pmc Clinical-pathologic study of depressive symptoms and cognitive decline in old age
    Robert S Wilson
    From the Rush Alzheimer s Disease Center R S W, A W C, P A B, G M H, L P H, R C S, S N, J A S, D A B and Departments of Behavioral Sciences R S W, P A B, Neurological Sciences R S W, A W C, J A S, D A B, Pathology S N, J A S, and Family Medicine R C S, Rush University Medical Center, Chicago, IL and Departments of Psychiatry and Neurology S E A, University of Pennsylvania, Philadelphia
    Neurology 83:702-9. 2014
  6. pmc Cognitive aging and rate of hospitalization in an urban population of older people
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina Street, Suite 1038, Chicago, IL 60612
    J Gerontol A Biol Sci Med Sci 69:447-54. 2014
  7. pmc Life-span cognitive activity, neuropathologic burden, and cognitive aging
    Robert S Wilson
    Rush Alzheimer s Disease Center and Departments of Neurological Sciences, Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA
    Neurology 81:314-21. 2013
  8. pmc The influence of cognitive decline on well-being in old age
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Psychol Aging 28:304-13. 2013
  9. pmc Neural reserve, neuronal density in the locus ceruleus, and cognitive decline
    Robert S Wilson
    Rush Alzheimer s Disease Center and Departments of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
    Neurology 80:1202-8. 2013
  10. pmc Terminal decline in motor function
    Robert S Wilson
    Rush Alzheimer s Disease Center, Chicago, IL 60612, USA
    Psychol Aging 27:998-1007. 2012

Detail Information

Publications115 found, 100 shown here

  1. ncbi request reprint Loneliness and risk of Alzheimer disease
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL 60612, USA
    Arch Gen Psychiatry 64:234-40. 2007
    ..Social isolation in old age has been associated with risk of developing dementia, but the risk associated with perceived isolation, or loneliness, is not well understood...
  2. pmc Odor identification and progression of parkinsonian signs in older persons
    Robert S Wilson
    Rush Alzheimer s Disease Center and Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    Exp Aging Res 34:173-87. 2008
    ..The results suggest that impaired odor identification is associated with more rapid progression of parkinsonism in old age, particularly parkinsonian gait disturbance...
  3. pmc Loneliness and the rate of motor decline in old age: the Rush Memory and Aging Project, a community-based cohort study
    Aron S Buchman
    Department of Neurological Sciences, Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S, Paulina, Chicago, Illinois 60612, USA
    BMC Geriatr 10:77. 2010
    ..We tested the hypothesis that feeling alone is associated with the rate of motor decline in community-dwelling older persons...
  4. pmc Cognitive decline after hospitalization in a community population of older persons
    R S Wilson
    Rush Alzheimer s Disease Center, Chicago, IL, USA
    Neurology 78:950-6. 2012
    ..To test the hypothesis that hospitalization in old age is associated with subsequent cognitive decline...
  5. pmc Clinical-pathologic study of depressive symptoms and cognitive decline in old age
    Robert S Wilson
    From the Rush Alzheimer s Disease Center R S W, A W C, P A B, G M H, L P H, R C S, S N, J A S, D A B and Departments of Behavioral Sciences R S W, P A B, Neurological Sciences R S W, A W C, J A S, D A B, Pathology S N, J A S, and Family Medicine R C S, Rush University Medical Center, Chicago, IL and Departments of Psychiatry and Neurology S E A, University of Pennsylvania, Philadelphia
    Neurology 83:702-9. 2014
    ..To clarify the relationship between depressive symptoms and the clinical and neuropathologic manifestations of dementia...
  6. pmc Cognitive aging and rate of hospitalization in an urban population of older people
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina Street, Suite 1038, Chicago, IL 60612
    J Gerontol A Biol Sci Med Sci 69:447-54. 2014
    ..The association of age-related cognitive change with hospitalization is not well understood...
  7. pmc Life-span cognitive activity, neuropathologic burden, and cognitive aging
    Robert S Wilson
    Rush Alzheimer s Disease Center and Departments of Neurological Sciences, Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA
    Neurology 81:314-21. 2013
    ..To test the hypothesis that cognitive activity across the life span is related to late-life cognitive decline not linked to common neuropathologic disorders...
  8. pmc The influence of cognitive decline on well-being in old age
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Psychol Aging 28:304-13. 2013
    ..The results support the hypothesis that cognitive aging leads to diminished well-being, particularly aspects such as purpose in life that involve behavioral regulation...
  9. pmc Neural reserve, neuronal density in the locus ceruleus, and cognitive decline
    Robert S Wilson
    Rush Alzheimer s Disease Center and Departments of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
    Neurology 80:1202-8. 2013
    ..To test the hypothesis that higher neuronal density in brainstem aminergic nuclei contributes to neural reserve...
  10. pmc Terminal decline in motor function
    Robert S Wilson
    Rush Alzheimer s Disease Center, Chicago, IL 60612, USA
    Psychol Aging 27:998-1007. 2012
    ..The results demonstrate that motor and cognitive functions both undergo a period of accelerated decline in the last few years of life...
  11. pmc The natural history of cognitive decline in Alzheimer's disease
    Robert S Wilson
    Rush Alzheimer s Disease Center, Chicago, IL 60612, USA
    Psychol Aging 27:1008-17. 2012
    ..The results indicate that cognitive decline in AD begins many years before dementia is diagnosed and accelerates during the course of the disease...
  12. pmc Influence of late-life cognitive activity on cognitive health
    Robert S Wilson
    Rush Alzheimer s Disease Center and Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
    Neurology 78:1123-9. 2012
    ..To test the hypothesis that late-life participation in mentally stimulating activities affects subsequent cognitive health...
  13. pmc Terminal dedifferentiation of cognitive abilities
    R S Wilson
    Rush Alzheimer s Disease Center and Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
    Neurology 78:1116-22. 2012
    ..To test the cognitive dedifferentiation hypothesis that cognitive abilities become increasingly correlated in late life...
  14. ncbi request reprint Cognitive decline and survival in Alzheimer's disease
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Int J Geriatr Psychiatry 21:356-62. 2006
    ..To test the association of rate of cognitive decline, an indicator of the severity of the underlying disease process, with risk of death in Alzheimer's disease (AD)...
  15. ncbi request reprint Olfactory identification and incidence of mild cognitive impairment in older age
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina, Ste 1038, Chicago, IL 60612, USA
    Arch Gen Psychiatry 64:802-8. 2007
    ..Mild cognitive impairment (MCI) is often a precursor to Alzheimer disease, but knowledge about factors that predict its development is limited...
  16. ncbi request reprint Relation of cognitive activity to risk of developing Alzheimer disease
    R S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina, Suite 1038, Chicago, IL 60612, USA
    Neurology 69:1911-20. 2007
    ..Frequent cognitive activity in old age has been associated with reduced risk of Alzheimer disease (AD), but the basis of the association is uncertain...
  17. ncbi request reprint Chronic distress and incidence of mild cognitive impairment
    R S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Neurology 68:2085-92. 2007
    ..Here we test the hypothesis that chronic psychological distress is associated with increased incidence of MCI in old age...
  18. ncbi request reprint Nursing home placement, day care use, and cognitive decline in Alzheimer's disease
    Robert S Wilson
    Alzheimer s Disease Center, Institute for Health Aging, Department of Neurological Sciences, College of Nursing, Rush University Medical Center, 600 S Paulina St, Suite 1038, Chicago, IL 60612, USA
    Am J Psychiatry 164:910-5. 2007
    ..The aim of this study was to examine the associations of day care use and nursing home placement with the rate of cognitive decline in Alzheimer's disease...
  19. ncbi request reprint Terminal cognitive decline: accelerated loss of cognition in the last years of life
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, Suite 1038, Chicago, IL 60612, USA
    Psychosom Med 69:131-7. 2007
    ..To test the hypothesis that rate of cognitive decline accelerates in the last years of life...
  20. ncbi request reprint Chronic distress, age-related neuropathology, and late-life dementia
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina, Suite 1038, Chicago, IL 60612, USA
    Psychosom Med 69:47-53. 2007
    ..The objective of this study was to test whether common age-related neuropathology could account for the relation of chronic distress to dementia...
  21. ncbi request reprint Cognitive decline in old age: separating retest effects from the effects of growing older
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Psychol Aging 21:774-89. 2006
    ..Individual differences in retest effects were substantial but not consistent across cognitive measures. The results suggest that retest-based improvement in cognitive test performance can be substantial and persistent...
  22. pmc Cognitive decline in incident Alzheimer disease in a community population
    R S Wilson
    Rush AD Center, Rush University Medical Center, 600 South Paulina Avenue, Suite 1038, Chicago, IL 60612, USA
    Neurology 74:951-5. 2010
    ..To measure the cognitive consequences of incident Alzheimer disease (AD) in older African American and white subjects...
  23. ncbi request reprint Odor identification and decline in different cognitive domains in old age
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush Institute for Healthy Aging, and Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Neuroepidemiology 26:61-7. 2006
    ..The results indicate that impaired odor identification in old age is associated with impaired global cognition and more rapid decline in perceptual processing speed and episodic memory...
  24. pmc The relationship between cerebral Alzheimer's disease pathology and odour identification in old age
    R S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina, Suite 1038, Chicago, IL 60612, USA
    J Neurol Neurosurg Psychiatry 78:30-5. 2007
    ..Olfactory dysfunction is common in old age, but its basis is uncertain...
  25. ncbi request reprint Chronic psychological distress and risk of Alzheimer's disease in old age
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, Ill, USA
    Neuroepidemiology 27:143-53. 2006
    ..The results support the hypothesis that distress proneness is associated with increased risk of dementia and suggest that neurobiologic mechanisms other than AD pathology may underlie the association...
  26. ncbi request reprint Hallucinations, cognitive decline, and death in Alzheimer's disease
    R S Wilson
    Rush Alzheimer s Disease Center, Rush Institute for Healthy Aging, and Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Neuroepidemiology 26:68-75. 2006
    ..Delusions and misperceptions were not strongly related to cognitive decline or mortality. The results suggest that hallucinations in Alzheimer's disease, particularly visual ones, are associated with more rapid progression...
  27. ncbi request reprint Harm avoidance and disability in old age
    Robert S Wilson
    Rush Alzheimer s Disease Center and Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    Exp Aging Res 32:243-61. 2006
    ..The results suggest that harm avoidance is associated with disability in old age...
  28. pmc Childhood adversity and psychosocial adjustment in old age
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Am J Geriatr Psychiatry 14:307-15. 2006
    ..The objective of this study was to test the hypothesis that higher level of childhood adversity is associated with lower level of psychosocial adjustment in old age...
  29. ncbi request reprint Conscientiousness and the incidence of Alzheimer disease and mild cognitive impairment
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina, Chicago, IL 60612, USA
    Arch Gen Psychiatry 64:1204-12. 2007
    ..The personality trait of conscientiousness has been related to morbidity and mortality in old age, but its association with the development of Alzheimer disease is not known...
  30. doi request reprint Change in depressive symptoms during the prodromal phase of Alzheimer disease
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina, Ste 1038, Chicago, IL 60612, USA
    Arch Gen Psychiatry 65:439-45. 2008
    ..Prospective studies have established an association between depressive symptoms and risk of dementia, but how depressive symptoms change during the evolution of dementia is uncertain...
  31. pmc Vulnerability to stress, anxiety, and development of dementia in old age
    Robert S Wilson
    Rush Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Am J Geriatr Psychiatry 19:327-34. 2011
    ..To identify the components of the neuroticism trait most responsible for its association with cognitive decline and dementia in old age...
  32. pmc Cognitive decline in prodromal Alzheimer disease and mild cognitive impairment
    Robert S Wilson
    Rush Alzheimer s Disease Center, Department of Neurological Science, Rush University Medical Center, 600 S Paulina Ave, Ste 1038, Chicago, IL 60612, USA
    Arch Neurol 68:351-6. 2011
    ..To characterize the course of cognitive decline during the prodromal phase of Alzheimer disease...
  33. pmc Lewy bodies and olfactory dysfunction in old age
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina Avenue, Chicago, IL 60612, USA
    Chem Senses 36:367-73. 2011
    ..The findings indicate that Lewy body disease impairs late life olfactory function even in otherwise asymptomatic individuals...
  34. pmc Sources of variability in estimates of the prevalence of Alzheimer's disease in the United States
    Robert S Wilson
    Rush University Medical Center, Chicago, IL, USA
    Alzheimers Dement 7:74-9. 2011
    ..3 million in 2002 by the Aging, Demographics, and Memory Study (ADAMS), which is almost 50% less than the estimate of 4.5 million in 2000 derived from the Chicago Health and Aging Project...
  35. pmc Heritability of different forms of memory in the Late Onset Alzheimer's Disease Family Study
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    J Alzheimers Dis 23:249-55. 2011
    ..This suggests that genetic analyses of memory endophenotypes may help to identify genetic variants associated with AD...
  36. pmc Odor identification and mortality in old age
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina Avenue, Suite 1038, Chicago, IL 60612, USA
    Chem Senses 36:63-7. 2011
    ..The results indicate that difficulty identifying familiar odors in old age is associated with increased risk of death...
  37. pmc Cognitive activity and the cognitive morbidity of Alzheimer disease
    R S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Neurology 75:990-6. 2010
    ..To test the hypothesis that frequent cognitive activity predicts slower cognitive decline before dementia onset in Alzheimer disease (AD) and faster decline thereafter...
  38. pmc Loss of basic lexical knowledge in old age
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina Ave, Suite 1038, Chicago, IL 60612, USA
    J Neurol Neurosurg Psychiatry 82:369-72. 2011
    ..Basic lexical skills are hypothesised to be relatively preserved in mild dementia, but clinical studies have reported inconsistent results...
  39. pmc Telephone assessment of cognitive function in the late-onset Alzheimer's disease family study
    Robert S Wilson
    Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Arch Neurol 67:855-61. 2010
    ..Administration of cognitive test batteries by telephone has been shown to be a valid and cost-effective means of assessing cognition, but it remains relatively uncommon in epidemiological research...
  40. pmc Temporal course of depressive symptoms during the development of Alzheimer disease
    R S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina St, Chicago, IL 60612, USA
    Neurology 75:21-6. 2010
    ..To characterize change in depressive symptoms before and after the onset of dementia in Alzheimer disease (AD)...
  41. pmc Neurodegenerative basis of age-related cognitive decline
    R S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina Ave, Suite 1038, Chicago, IL 60612, USA
    Neurology 75:1070-8. 2010
    ..To assess the contribution of dementia-related neuropathologic lesions to age-related and disease-related change in cognitive function...
  42. pmc Olfactory impairment in presymptomatic Alzheimer's disease
    Robert S Wilson
    Department of Neurological Sciences, Rush Alzheimer s Disease Center, Rush University Medical Cetner, Chicago, Illinois 60612, USA
    Ann N Y Acad Sci 1170:730-5. 2009
    ....
  43. pmc Biracial population study of mortality in mild cognitive impairment and Alzheimer disease
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina Ave, Ste 1038, Chicago, IL 60612, USA
    Arch Neurol 66:767-72. 2009
    ..To assess mortality associated with mild cognitive impairment (MCI) and Alzheimer disease (AD) among older African Americans and whites from an urban community...
  44. pmc Educational attainment and cognitive decline in old age
    R S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Neurology 72:460-5. 2009
    ..Level of education is a well-established risk factor for Alzheimer disease but its relation to cognitive decline, the principal clinical manifestation of the disease, is uncertain...
  45. pmc Harm avoidance and risk of Alzheimer's disease
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina, Suite 1038, Chicago, IL 60612, USA
    Psychosom Med 73:690-6. 2011
    ..To test the hypothesis that harm avoidance, a trait associated with behavioral inhibition, is associated with the risk of developing Alzheimer's disease (AD)...
  46. ncbi request reprint Participation in cognitively stimulating activities and risk of incident Alzheimer disease
    Robert S Wilson
    Rush Alzheimer s Disease Center, 1645 W Jackson Blvd, Suite 675, Chicago, IL 60612, USA
    JAMA 287:742-8. 2002
    ..Frequent participation in cognitively stimulating activities has been hypothesized to reduce risk of Alzheimer disease (AD), but prospective data regarding an association are lacking...
  47. ncbi request reprint Education and the course of cognitive decline in Alzheimer disease
    R S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina, Suite 1038, Chicago, IL 60612, USA
    Neurology 63:1198-202. 2004
    ..To test the hypothesis that higher level of education is related to more rapid cognitive decline in Alzheimer disease (AD)...
  48. ncbi request reprint Distress proneness and cognitive decline in a population of older persons
    Robert S Wilson
    Rush Alzheimer s Disease Center and Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Psychoneuroendocrinology 30:11-7. 2005
    ..059) after controlling for depressive symptoms. The results suggest that the tendency to experience psychological distress is associated with increased cognitive decline in old age...
  49. ncbi request reprint Personality and mortality in old age
    Robert S Wilson
    Rush Institute for Healthy Aging and Rush Alzheimer s Disease Center, Chicago, Illinois 60612, USA
    J Gerontol B Psychol Sci Soc Sci 59:P110-6. 2004
    ..Findings for extraversion were mixed, and neither agreeableness nor openness was strongly related to mortality. The results suggest that personality is associated with mortality in old age...
  50. ncbi request reprint Proneness to psychological distress is associated with risk of Alzheimer's disease
    R S Wilson
    Rush Alzheimer s Disease Center, Rush Institute for Healthy Aging, Chicago, IL 60612, USA
    Neurology 61:1479-85. 2003
    ..Chronic stress is associated with hippocampal damage and impaired memory in animals and humans...
  51. pmc Premorbid proneness to distress and episodic memory impairment in Alzheimer's disease
    R S Wilson
    Rush Alzheimer s Disease Center and Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Neurol Neurosurg Psychiatry 75:191-5. 2004
    ..Chronic stress has been associated with impaired episodic memory, but the association of premorbidly experienced distress with memory function in Alzheimer's disease is unknown...
  52. pmc Depressive symptoms and cognitive decline in a community population of older persons
    R S Wilson
    Department of Neurological Sciences, Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Neurol Neurosurg Psychiatry 75:126-9. 2004
    ..An association between depressive symptoms and cognitive decline has been observed in selected cohorts of older people, but studies of defined populations have had conflicting results...
  53. ncbi request reprint Negative affect and mortality in older persons
    Robert S Wilson
    Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Am J Epidemiol 158:827-35. 2003
    ..The results suggest that negative affect in older persons, especially internally experienced distress, is associated with an increased mortality risk...
  54. ncbi request reprint Depressive symptoms, clinical AD, and cortical plaques and tangles in older persons
    R S Wilson
    Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Neurology 61:1102-7. 2003
    ..Depressive symptoms in old age have been associated with risk of Alzheimer disease (AD), but it is uncertain whether they are an independent risk factor for disease or an early clinical sign of its underlying pathology...
  55. ncbi request reprint Cognitive activity and cognitive decline in a biracial community population
    R S Wilson
    Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging and Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Neurology 61:812-6. 2003
    ..However, the association of cognitive activity with cognitive decline, the principal manifestation of AD, is not well understood...
  56. ncbi request reprint Assessment of lifetime participation in cognitively stimulating activities
    Robert Wilson
    Rush Alzheimer s Disease Center, Rush Institute for Healthy Aging, Chicago, IL 60612, USA
    J Clin Exp Neuropsychol 25:634-42. 2003
    ..The results suggest that the scale provides a psychometrically sound measure of frequency of cognitive activity across the life span...
  57. ncbi request reprint Terminal decline in cognitive function
    R S Wilson
    Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Neurology 60:1782-7. 2003
    ..Impending death is thought to be associated with age-related cognitive decline, but this association has not been well studied...
  58. ncbi request reprint Parkinsonianlike signs and risk of incident Alzheimer disease in older persons
    Robert S Wilson
    Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging and the Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Arch Neurol 60:539-44. 2003
    ..Parkinsonianlike signs are common in older persons, but little is known about how their severity or rate of progression is related to the development of Alzheimer disease (AD) or decline in cognition...
  59. ncbi request reprint Cognitive activity and incident AD in a population-based sample of older persons
    R S Wilson
    Department of Neurological Sciences, Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Neurology 59:1910-4. 2002
    ..Participation in cognitively stimulating activities is hypothesized to be associated with risk of AD, but knowledge about this association is limited...
  60. pmc The apolipoprotein E epsilon 2 allele and decline in episodic memory
    R S Wilson
    Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, USA
    J Neurol Neurosurg Psychiatry 73:672-7. 2002
    ....
  61. ncbi request reprint Depressive symptoms, cognitive decline, and risk of AD in older persons
    Robert S Wilson
    Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, 1645 West Jackson Boulevard, Suite 675, Chicago, IL 60612, USA
    Neurology 59:364-70. 2002
    ..Cross-sectional and retrospective case-control studies suggest an association of depression symptoms with cognitive impairment and AD, but there have been few prospective studies and their results have been inconsistent...
  62. ncbi request reprint Progression of gait disorder and rigidity and risk of death in older persons
    R S Wilson
    Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Neurology 58:1815-9. 2002
    ..Bradykinesia, gait disturbance, rigidity, and tremor are common motor signs in old age. All of these signs are associated with increased morbidity and mortality, but the extent to which they are progressive is unknown...
  63. ncbi request reprint Individual differences in rates of change in cognitive abilities of older persons
    Robert S Wilson
    Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois, USA
    Psychol Aging 17:179-93. 2002
    ..The results suggest that change in cognitive function in old age primarily reflects person-specific factors rather than an inevitable developmental process...
  64. ncbi request reprint Proneness to psychological distress and risk of Alzheimer disease in a biracial community
    R S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Center, 600 S Paulina, Suite 1038, Chicago, IL 60612, USA
    Neurology 64:380-2. 2005
    ..4 times more likely to develop AD than persons not distress prone. This effect was substantially stronger in white persons compared to African Americans...
  65. ncbi request reprint Assessment of cognitive decline in old age with brief tests amenable to telephone administration
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Neuroepidemiology 25:19-25. 2005
    ..The results suggest that briefly assessing cognition with tests amenable to telephone administration may prove useful in longitudinal epidemiologic studies of older persons...
  66. ncbi request reprint The apolipoprotein E epsilon 4 allele and decline in different cognitive systems during a 6-year period
    Robert S Wilson
    Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, 1645 W Jackson Blvd, Suite 675, Chicago, IL 60612, USA
    Arch Neurol 59:1154-60. 2002
    ..The apolipoprotein E (APOE) epsilon 4 allele is known to influence risk of AD but it has been difficult to establish whether it affects episodic memory differently from other cognitive functions...
  67. ncbi request reprint Neuroticism, extraversion, and mortality in a defined population of older persons
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Psychosom Med 67:841-5. 2005
    ..The objective of this study was to test the association of the personality traits of neuroticism and extraversion with risk of death in old age...
  68. ncbi request reprint Early and late life cognitive activity and cognitive systems in old age
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Center, 600 South Paulina, Suite 1038, Chicago, IL 60612, USA
    J Int Neuropsychol Soc 11:400-7. 2005
    ..The results suggest that past cognitive activity contributes to current cognition principally through its association with cognitive activity in old age...
  69. ncbi request reprint Early life socioeconomic status and late life risk of Alzheimer's disease
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Neuroepidemiology 25:8-14. 2005
    ..The results suggest that early life socioeconomic level is related to level of cognition in late life but not to rate of cognitive decline or risk of AD...
  70. ncbi request reprint Socioeconomic characteristics of the community in childhood and cognition in old age
    R S Wilson
    Rush Alzheimer s Disease Center, Rush Institute for Healthy Aging and Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Exp Aging Res 31:393-407. 2005
    ..The results suggest that socioeconomic conditions in early life are associated with level of cognitive function in old age but not with rate of cognitive decline...
  71. ncbi request reprint Hallucinations and mortality in Alzheimer disease
    Robert S Wilson
    Rush Alzheimer s Disease Center, Dept of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Am J Geriatr Psychiatry 13:984-90. 2005
    ..The authors tested the relationship of hallucinations and delusions to mortality in Alzheimer disease (AD)...
  72. ncbi request reprint Motor dysfunction in mild cognitive impairment and the risk of incident Alzheimer disease
    Neelum T Aggarwal
    Rush Alzheimer s Disease Center, Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL 60612, USA
    Arch Neurol 63:1763-9. 2006
    ..Little is known about motor function in mild cognitive impairment (MCI) and its relation to the risk of Alzheimer disease (AD)...
  73. pmc Social engagement and cognitive function in old age
    Kristin R Krueger
    Rush Alzheimer s Disease Center and Department of Behavioral Sciences, Rush University Medical Center, Chicago, Illinois, USA
    Exp Aging Res 35:45-60. 2009
    ..The results confirm that higher level of social engagement in old age is associated with better cognitive function but the association varies across domains of social engagement...
  74. pmc Anti-inflammatory agents and cognitive decline in a bi-racial population
    Francine Grodstein
    Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL, USA
    Neuroepidemiology 30:45-50. 2008
    ..no use: mean difference = 0.12; p trend = 0.03). Overall, we found no relation between regular aspirin use and cognitive decline, but long-term use of ibuprofen may be related to decreased rates of cognitive decline in older persons...
  75. pmc Association of personality traits with elder self-neglect in a community-dwelling population
    XinQi Dong
    Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA
    Am J Geriatr Psychiatry 19:743-51. 2011
    ..The objectives of this study are as follows: 1) to examine the association of personality traits with elder self-neglect and 2) to examine the association of personality traits with elder self-neglect severity...
  76. ncbi request reprint The relation of cigarette smoking to incident Alzheimer's disease in a biracial urban community population
    Neelum T Aggarwal
    Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Center, Chicago, IL 60612, USA
    Neuroepidemiology 26:140-6. 2006
    ....
  77. pmc Racial differences in the association of education with physical and cognitive function in older blacks and whites
    Lisa L Barnes
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina, Suite 1038, Chicago, IL 60612, USA
    J Gerontol B Psychol Sci Soc Sci 66:354-63. 2011
    ..We examined racial differences in the cross-sectional association of education with physical and cognitive function performance in older adults...
  78. ncbi request reprint Repetition priming and recognition memory in younger and older persons: temporal stability and performance
    Debra A Fleischman
    Rush University Medical Center, Chicago, IL 60612, USA
    Neuropsychology 19:750-9. 2005
    ..Results indicate that dissociations between priming and explicit memory performances cannot be accounted for by differential reliability of the measures...
  79. pmc Musculoskeletal pain and incident disability in community-dwelling older adults
    Aron S Buchman
    Rush University Medical Center, Chicago, Illinois 60612, USA
    Arthritis Care Res (Hoboken) 62:1287-93. 2010
    ..To test the hypothesis that the number of areas of musculoskeletal pain reported is related to incident disability...
  80. ncbi request reprint Association between blood pressure and cognitive function in a biracial community population of older persons
    Martha Clare Morris
    Department of Internal Medicine, Rush University and Rush Presbyterian St Luke s Medical Center, Chicago, Ill 60612, USA
    Neuroepidemiology 21:123-30. 2002
    ..The cross-sectional association between blood pressure and cognitive functions is small and curvilinear and more apparent in persons with cardiovascular conditions...
  81. ncbi request reprint Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease
    Martha Clare Morris
    Rush Institute for Healthy Aging, Department of Internal Medicine, Rush Alzheimer s Disease Center, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Arch Neurol 60:940-6. 2003
    ..Dietary n-3 polyunsaturated fatty acids improve brain functioning in animal studies, but there is limited study of whether this type of fat protects against Alzheimer disease...
  82. ncbi request reprint Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study
    Martha Clare Morris
    Rush Institute for Healthy Aging, Rush Presbyterian St Luke s Medical Center, 1645 W Jackson, Suite 675, Chicago, IL 60612, USA
    JAMA 287:3230-7. 2002
    ..Oxidative processes have been suggested as elements in the development of Alzheimer disease (AD), but whether dietary intake of vitamin E and other antioxidant nutrients prevents its development is unknown...
  83. ncbi request reprint Parkinsonian signs and cognitive function in old age
    Debra A Fleischman
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Int Neuropsychol Soc 11:591-7. 2005
    ..The results suggest that parkinsonian signs have a modest, but statistically reliable, association with level of cognitive function in old age...
  84. ncbi request reprint The effect of social networks on the relation between Alzheimer's disease pathology and level of cognitive function in old people: a longitudinal cohort study
    David A Bennett
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Lancet Neurol 5:406-12. 2006
    ..Few data are available about how social networks reduce the risk of cognitive impairment in old age. We aimed to measure this effect using data from a large, longitudinal, epidemiological clinicopathological study...
  85. ncbi request reprint Is lower cognitive function in one spouse associated with depressive symptoms in the other spouse?
    Kimberly A Skarupski
    Rush Institute for Healthy Aging, Rush University Medical Center, 1645 W Jackson, Suite 675, Chicago, IL 60612 3227, USA
    Aging Ment Health 10:621-30. 2006
    ..Our findings suggest that husbands may be particularly psychologically vulnerable to the negative effects of their wives' cognitive impairment. This vulnerability may have a range of long-term health and caregiving implications...
  86. ncbi request reprint Incidence of Alzheimer disease in a biracial urban community: relation to apolipoprotein E allele status
    Denis A Evans
    Rush Institute on Healthy Aging, Chicago, IL, USA
    Arch Neurol 60:185-9. 2003
    ..Few studies compare Alzheimer disease (AD) incidence among black and white subjects...
  87. ncbi request reprint Vitamin E and cognitive decline in older persons
    Martha Clare Morris
    Department of Preventive Medicine, Rush Institute for Healthy Aging, Rush Presbyterian St Luke s Medical Center, 1645 W Jackson, Suite 675, Chicago, IL 60612, USA
    Arch Neurol 59:1125-32. 2002
    ..Previous studies raise the possibility that antioxidants protect against neurodegenerative diseases...
  88. ncbi request reprint The relation of lifetime cognitive activity and lifetime access to resources to late-life cognitive function in older African Americans
    Lisa L Barnes
    Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA
    Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 13:516-28. 2006
    ..The results suggest that both measures are psychometrically sound in a minority population and that lifetime cognitive activity may contribute to current cognitive function in African Americans...
  89. ncbi request reprint Change in cognitive function in Alzheimer's disease in African-American and white persons
    Lisa L Barnes
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Neuroepidemiology 26:16-22. 2006
    ..06), perceptual speed (p = 0.07) and naming (p = 0.08). The results suggest that the rate of cognitive decline in AD is slower in African-Americans compared with whites, particularly for episodic memory...
  90. ncbi request reprint Predictors of depressive symptoms in persons with Alzheimer's disease
    David W Gilley
    Rush Institute for Healthy Aging and Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Gerontol B Psychol Sci Soc Sci 59:P75-83. 2004
    ..Depressive symptoms in Alzheimer's disease appear to follow a more predictable pattern of expression than previously described...
  91. ncbi request reprint A longitudinal study of implicit and explicit memory in old persons
    Debra A Fleischman
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Psychol Aging 19:617-25. 2004
    ..Findings indicate that explicit memory and priming are dissociable on the basis of age-related change and that mildly reduced priming is not an inevitable consequence of growing older...
  92. ncbi request reprint Physical activity and leg strength predict decline in mobility performance in older persons
    Aron S Buchman
    Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Am Geriatr Soc 55:1618-23. 2007
    ..To assess the extent to which physical activity and leg strength are associated with change in mobility in older persons...
  93. ncbi request reprint Black-white differences in depressive symptoms among older adults over time
    Kimberly A Skarupski
    Rush Institute for Healthy Aging, 1645 W Jackson, Suite 675, Chicago, IL 60612 3227, USA
    J Gerontol B Psychol Sci Soc Sci 60:P136-42. 2005
    ..225, p < .001) but remained robust. The racial differences increased slightly over time. Our findings support heightened awareness of depression in older Black populations...
  94. ncbi request reprint The apolipoprotein E epsilon4 allele and incident Alzheimer's disease in persons with mild cognitive impairment
    Neelum T Aggarwal
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, Illinois 60612 3872, USA
    Neurocase 11:3-7. 2005
    ..02, 2.63). There was a marginally significant reduction in the effect of epsilon4 in older compared to younger participants (p=.053). The results suggest that possession of an epsilon4 allele does increase risk of AD in persons with MCI...
  95. ncbi request reprint Frailty is associated with incident Alzheimer's disease and cognitive decline in the elderly
    Aron S Buchman
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Psychosom Med 69:483-9. 2007
    ..To assess the association between frailty and incident Alzheimer's disease (AD) and cognitive decline. Frailty is common in older persons and associated with adverse health outcomes...
  96. ncbi request reprint Sex differences in the clinical manifestations of Alzheimer disease pathology
    Lisa L Barnes
    Rush Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    Arch Gen Psychiatry 62:685-91. 2005
    ....
  97. pmc Association between late-life social activity and motor decline in older adults
    Aron S Buchman
    Departments of Neurological Sciences, Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Facility, Chicago, IL 60612, USA
    Arch Intern Med 169:1139-46. 2009
    ..Our objective was to test the hypothesis that late-life social activity is related to the rate of change in motor function in old age...
  98. ncbi request reprint Cerebral infarctions and the relationship of depression symptoms to level of cognitive functioning in older persons
    David A Bennett
    Rush Alzheimer s Disease Center, Departments of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Am J Geriatr Psychiatry 12:211-9. 2004
    ....
  99. pmc Musculoskeletal pain is associated with incident mobility disability in community-dwelling elders
    Raj C Shah
    Rush Alzheimer s Disease Center, 600 South Paulina, Suite 1038, Chicago, IL 60612, USA
    J Gerontol A Biol Sci Med Sci 66:82-8. 2011
    ..We tested the hypothesis that musculoskeletal pain is associated with first occurrence of severe mobility disability...
  100. pmc Physical frailty is associated with incident mild cognitive impairment in community-based older persons
    Patricia A Boyle
    Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Facility, Suite 1020B, 600 South Paulina Street, Chicago, IL 60612, USA
    J Am Geriatr Soc 58:248-55. 2010
    ..To test the hypothesis that physical frailty is associated with risk of mild cognitive impairment (MCI)...
  101. ncbi request reprint Change in motor function and risk of mortality in older persons
    Aron S Buchman
    Rush Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    J Am Geriatr Soc 55:11-9. 2007
    ..To assess the association between change in motor function and mortality...

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