Robert Wilson


Affiliation: Rush University Medical Center
Country: USA


  1. Wilson R, Arnold S, Buchman A, Tang Y, Bennett D. Odor identification and progression of parkinsonian signs in older persons. Exp Aging Res. 2008;34:173-87 pubmed publisher
    ..The results suggest that impaired odor identification is associated with more rapid progression of parkinsonism in old age, particularly parkinsonian gait disturbance...
  2. Buchman A, Boyle P, Wilson R, James B, Leurgans S, Arnold S, et al. Loneliness and the rate of motor decline in old age: the Rush Memory and Aging Project, a community-based cohort study. BMC Geriatr. 2010;10:77 pubmed publisher
    ..Among community-dwelling older persons, both feeling alone and being alone are associated with more rapid motor decline, underscoring the importance of psychosocial factors and motor decline in old age. ..
  3. Wilson R, Hebert L, Scherr P, Dong X, Leurgens S, Evans D. Cognitive decline after hospitalization in a community population of older persons. Neurology. 2012;78:950-6 pubmed publisher
    ..In old age, cognitive functioning tends to decline substantially after hospitalization even after controlling for illness severity and prehospital cognitive decline. ..
  4. Wilson R, Yu L, Schneider J, Bennett D, Boyle P. Risk Aversion and Alzheimer Disease in Old Age. Am J Geriatr Psychiatry. 2019;: pubmed publisher
    ..The results support the hypothesis that high risk aversion in old age is partly an early sign of the pathology of Alzheimer disease. ..
  5. Wilson R, Yu L, Lamar M, Schneider J, Boyle P, Bennett D. Education and cognitive reserve in old age. Neurology. 2019;92:e1041-e1050 pubmed publisher
    ..The results suggest that the contribution of education to cognitive reserve is limited to its association with level of cognitive function before old age. ..
  6. Wilson R, Boyle P, Yu L, Barnes L, Schneider J, Bennett D. Life-span cognitive activity, neuropathologic burden, and cognitive aging. Neurology. 2013;81:314-21 pubmed publisher
    ..014, p = 0.163). More frequent cognitive activity across the life span has an association with slower late-life cognitive decline that is independent of common neuropathologic conditions, consistent with the cognitive reserve hypothesis. ..
  7. Wilson R, Yang J, Yu L, Leurgans S, Capuano A, Schneider J, et al. Postmortem neurodegenerative markers and trajectories of decline in cognitive systems. Neurology. 2019;92:e831-e840 pubmed publisher
    ..The results suggest that episodic memory impairment is an early sign of multiple neurodegenerative conditions, which primarily differ in their associations with other cognitive systems. ..
  8. Wilson R, Rajan K, Barnes L, Hebert L, Mendes de Leon C, Evans D. Cognitive aging and rate of hospitalization in an urban population of older people. J Gerontol A Biol Sci Med Sci. 2014;69:447-54 pubmed publisher
    ..Individual differences in trajectories of cognitive aging are associated with subsequent risk of hospitalization. ..
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    Wilson R, Schneider J, Barnes L, Beckett L, Aggarwal N, Cochran E, et al. The apolipoprotein E epsilon 4 allele and decline in different cognitive systems during a 6-year period. Arch Neurol. 2002;59:1154-60 pubmed
    ..06). The results suggest that the APOE epsilon 4 allele influences risk of AD by a relatively selective effect on episodic memory. ..

More Information


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    Wilson R, Mendes de Leon C, Bienias J, Evans D, Bennett D. Personality and mortality in old age. J Gerontol B Psychol Sci Soc Sci. 2004;59:P110-6 pubmed
    ..Findings for extraversion were mixed, and neither agreeableness nor openness was strongly related to mortality. The results suggest that personality is associated with mortality in old age. ..
  2. Wilson R, Hebert L, Scherr P, Barnes L, Mendes De Leon C, Evans D. Educational attainment and cognitive decline in old age. Neurology. 2009;72:460-5 pubmed publisher
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    Wilson R, Barnes L, Bennett D, Li Y, Bienias J, Mendes De Leon C, et al. Proneness to psychological distress and risk of Alzheimer disease in a biracial community. Neurology. 2005;64:380-2 pubmed
    ..4 times more likely to develop AD than persons not distress prone. This effect was substantially stronger in white persons compared to African Americans. ..
  4. Wilson R, Boyle P, Segawa E, Yu L, Begeny C, Anagnos S, et al. The influence of cognitive decline on well-being in old age. Psychol Aging. 2013;28:304-13 pubmed publisher
    ..The results support the hypothesis that cognitive aging leads to diminished well-being, particularly aspects such as purpose in life that involve behavioral regulation. ..
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    Wilson R, Beck T, Bienias J, Bennett D. Terminal cognitive decline: accelerated loss of cognition in the last years of life. Psychosom Med. 2007;69:131-7 pubmed
    ..In old age, cognitive decline markedly accelerates during the last 3 to 4 years of life, consistent with the terminal decline hypothesis. ..
  6. Buchman A, Wilson R, Leurgans S, Bennett D, Barnes L. Change in motor function and adverse health outcomes in older African-Americans. Exp Gerontol. 2015;70:71-7 pubmed publisher
    ..5-fold higher rate of death and a 3-fold higher rate of developing Katz disability. The rate of declining motor function accelerates with increasing age and its rate of decline predicts adverse health outcomes in older African-Americans. ..
  7. Wilson R, Leurgans S, Boyle P, Schneider J, Bennett D. Neurodegenerative basis of age-related cognitive decline. Neurology. 2010;75:1070-8 pubmed publisher
    ..Mild age-related decline in cognitive function is mainly due to the neuropathologic lesions traditionally associated with dementia. ..
  8. Wilson R, Boyle P, Yu L, Barnes L, Sytsma J, Buchman A, et al. Temporal course and pathologic basis of unawareness of memory loss in dementia. Neurology. 2015;85:984-91 pubmed publisher
    ..Awareness of memory impairment typically begins to decline about 2-3 years before dementia onset and is associated with postmortem evidence of TDP-43 pathology, tangles, and gross cerebral infarcts. ..
  9. Wilson R, Capuano A, Yu L, Yang J, Kim N, Leurgans S, et al. Neurodegenerative disease and cognitive retest learning. Neurobiol Aging. 2018;66:122-130 pubmed publisher
    ..The findings suggest that neurodegeneration does not impact cognitive retest learning. ..
  10. Wilson R, Arnold S, Schneider J, Boyle P, Buchman A, Bennett D. Olfactory impairment in presymptomatic Alzheimer's disease. Ann N Y Acad Sci. 2009;1170:730-5 pubmed publisher
  11. Wilson R, Arnold S, Beck T, Bienias J, Bennett D. Change in depressive symptoms during the prodromal phase of Alzheimer disease. Arch Gen Psychiatry. 2008;65:439-45 pubmed publisher
    ..We found no evidence of an increase in depressive symptoms during the prodromal phase of AD. ..
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    Wilson R, Barnes L, Krueger K, Hoganson G, Bienias J, Bennett D. Early and late life cognitive activity and cognitive systems in old age. J Int Neuropsychol Soc. 2005;11:400-7 pubmed
    ..The results suggest that past cognitive activity contributes to current cognition principally through its association with cognitive activity in old age. ..
  13. Wilson R, Yu L, Bennett D. Odor identification and mortality in old age. Chem Senses. 2011;36:63-7 pubmed publisher
    ..The results indicate that difficulty identifying familiar odors in old age is associated with increased risk of death. ..
  14. Wilson R, Sytsma J, Barnes L, Boyle P. Anosognosia in Dementia. Curr Neurol Neurosci Rep. 2016;16:77 pubmed publisher
    ..Its occurrence is robustly associated with common dementia-related pathologies and damage to memory and self-referential brain networks and their interconnections. ..
  15. Wilson R, Bennett D. How Does Psychosocial Behavior Contribute to Cognitive Health in Old Age?. Brain Sci. 2017;7: pubmed publisher
    ..A better understanding of these mechanisms may lead to novel strategies for preserving cognitive health in old age. ..
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    Wilson R, Krueger K, Kamenetsky J, Tang Y, Gilley D, Bennett D, et al. Hallucinations and mortality in Alzheimer disease. Am J Geriatr Psychiatry. 2005;13:984-90 pubmed
    ..The authors tested the relationship of hallucinations and delusions to mortality in Alzheimer disease (AD)...
  17. Wilson R, Capuano A, James B, Amofa P, Arvanitakis Z, Shah R, et al. Purpose in Life and Hospitalization for Ambulatory Care-Sensitive Conditions in Old Age. Am J Geriatr Psychiatry. 2018;26:364-374 pubmed publisher
    ..In old age, higher level of purpose in life is associated with lower odds of subsequent hospitalizations for ambulatory care-sensitive conditions. ..
  18. Wilson R, Krueger K, Arnold S, Barnes L, Mendes de Leon C, Bienias J, et al. Childhood adversity and psychosocial adjustment in old age. Am J Geriatr Psychiatry. 2006;14:307-15 pubmed
    ..The objective of this study was to test the hypothesis that higher level of childhood adversity is associated with lower level of psychosocial adjustment in old age...
  19. Wilson R, Arnold S, Schneider J, Tang Y, Bennett D. The relationship between cerebral Alzheimer's disease pathology and odour identification in old age. J Neurol Neurosurg Psychiatry. 2007;78:30-5 pubmed
    ..Olfactory dysfunction is common in old age, but its basis is uncertain...
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    Wilson R, Arnold S, Tang Y, Bennett D. Odor identification and decline in different cognitive domains in old age. Neuroepidemiology. 2006;26:61-7 pubmed
    ..The results indicate that impaired odor identification in old age is associated with impaired global cognition and more rapid decline in perceptual processing speed and episodic memory...
  21. Wilson R, Yu L, Schneider J, Arnold S, Buchman A, Bennett D. Lewy bodies and olfactory dysfunction in old age. Chem Senses. 2011;36:367-73 pubmed publisher
    ..The findings indicate that Lewy body disease impairs late life olfactory function even in otherwise asymptomatic individuals...
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    Wilson R, Schneider J, Arnold S, Tang Y, Boyle P, Bennett D. Olfactory identification and incidence of mild cognitive impairment in older age. Arch Gen Psychiatry. 2007;64:802-8 pubmed
    ..Mild cognitive impairment (MCI) is often a precursor to Alzheimer disease, but knowledge about factors that predict its development is limited...