John C Somberg

Summary

Affiliation: Rush University Medical Center
Country: USA

Publications

  1. doi request reprint QT prolongation and serum sotalol concentration are highly correlated following intravenous and oral sotalol
    John C Somberg
    Division of Clinical Pharmacology, Rush University, Chicago, Ill, USA
    Cardiology 116:219-25. 2010
  2. doi request reprint The pleiotropic effects of ethacrynic acid
    John C Somberg
    Department of Pharmacology and Medicine, Division of Clinical Pharmacology, Rush University, Chicago, IL, USA
    Am J Ther 16:102-4. 2009
  3. doi request reprint The impact of comorbidities on stroke prophylaxis strategies in atrial fibrillation patients
    John C Somberg
    Clinical Pharmacology, Rush University, Chicago, IL 60612 3833, USA
    Am J Ther 18:510-7. 2011
  4. doi request reprint The clinical pharmacology of ethacrynic acid
    Janos Molnar
    American Institute of Therapeutics, Lake Bluff, IL 60044, USA
    Am J Ther 16:86-92. 2009
  5. doi request reprint Gender differences in cardiac repolarization following intravenous sotalol administration
    John C Somberg
    Division of Clinical Pharmacology, Rush University, Chicago, IL, USA
    J Cardiovasc Pharmacol Ther 17:86-92. 2012
  6. doi request reprint Therapeutic approaches to the treatment of edema and ascites: the use of diuretics
    John C Somberg
    Department of Pharmacology and Medicine, Division of Clinical Pharmacology, Rush University, Chicago, IL, USA
    Am J Ther 16:98-101. 2009
  7. doi request reprint The management of acute heart failure and diuretic therapy
    John C Somberg
    Department of Pharmacology and Medicine, Division of Clinical Pharmacology, Rush University, Chicago, IL, USA
    Am J Ther 16:93-7. 2009
  8. doi request reprint Developing a safe intravenous sotalol dosing regimen
    John C Somberg
    Division of Clinical Pharmacology, Rush University, Chicago, IL, USA
    Am J Ther 17:365-72. 2010
  9. ncbi request reprint The effect of magnesium sulfate on action potential duration and cardiac arrhythmias
    John C Somberg
    Division of Clinical Pharmacology, Rush University, Chicago, Illinois, USA
    Am J Ther 12:218-22. 2005
  10. ncbi request reprint Comparative effects of rapid bolus administration of aqueous amiodarone versus 10-minute cordarone I.v. infusion on mean arterial blood pressure in conscious dogs
    John Charin Somberg
    Department of Pharmacology, Rush University, Chicago, IL, USA
    Cardiovasc Drugs Ther 18:345-51. 2004

Research Grants

Collaborators

Detail Information

Publications23

  1. doi request reprint QT prolongation and serum sotalol concentration are highly correlated following intravenous and oral sotalol
    John C Somberg
    Division of Clinical Pharmacology, Rush University, Chicago, Ill, USA
    Cardiology 116:219-25. 2010
    ..The aim of this study was to evaluate the correlation between QT interval (QT) and serum sotalol concentration following a single low dose of oral and intravenous sotalol...
  2. doi request reprint The pleiotropic effects of ethacrynic acid
    John C Somberg
    Department of Pharmacology and Medicine, Division of Clinical Pharmacology, Rush University, Chicago, IL, USA
    Am J Ther 16:102-4. 2009
    ..This work may lead to effective therapies in reducing chemotherapy resistance in cancer chemotherapeutics. In addition, EC or conjurers may be a radiation enhancer, an anti-inflammatory agent, or a treatment for glaucoma...
  3. doi request reprint The impact of comorbidities on stroke prophylaxis strategies in atrial fibrillation patients
    John C Somberg
    Clinical Pharmacology, Rush University, Chicago, IL 60612 3833, USA
    Am J Ther 18:510-7. 2011
    ....
  4. doi request reprint The clinical pharmacology of ethacrynic acid
    Janos Molnar
    American Institute of Therapeutics, Lake Bluff, IL 60044, USA
    Am J Ther 16:86-92. 2009
    ....
  5. doi request reprint Gender differences in cardiac repolarization following intravenous sotalol administration
    John C Somberg
    Division of Clinical Pharmacology, Rush University, Chicago, IL, USA
    J Cardiovasc Pharmacol Ther 17:86-92. 2012
    ..Sotalol prolongs the cardiac action potential that can be observed as QT prolongation and can induce TdP. The aim of this study was to assess gender differences in sotalol-induced QTc prolongation...
  6. doi request reprint Therapeutic approaches to the treatment of edema and ascites: the use of diuretics
    John C Somberg
    Department of Pharmacology and Medicine, Division of Clinical Pharmacology, Rush University, Chicago, IL, USA
    Am J Ther 16:98-101. 2009
    ..This article provides a review of the challenges and therapeutic approaches for the treatment of these conditions and provides a review of new therapies on the horizon that may be promising...
  7. doi request reprint The management of acute heart failure and diuretic therapy
    John C Somberg
    Department of Pharmacology and Medicine, Division of Clinical Pharmacology, Rush University, Chicago, IL, USA
    Am J Ther 16:93-7. 2009
    ..However, ethacrynic acid should be used in sulfa-sensitive patients because ethacrynic acid is the only loop diuretic, which does not contain a sulfa moiety...
  8. doi request reprint Developing a safe intravenous sotalol dosing regimen
    John C Somberg
    Division of Clinical Pharmacology, Rush University, Chicago, IL, USA
    Am J Ther 17:365-72. 2010
    ..The food and drug administration-approved dosing regimen is 75 mg intravenous sotalol to replace 80 mg oral sotalol and 150 mg intravenous sotalol to replace 160 mg oral sotalol, both administered over 5 hours...
  9. ncbi request reprint The effect of magnesium sulfate on action potential duration and cardiac arrhythmias
    John C Somberg
    Division of Clinical Pharmacology, Rush University, Chicago, Illinois, USA
    Am J Ther 12:218-22. 2005
    ..The results of these findings indicate that infusion of MgSO4 can prolong the QRS, QT, and JT intervals in the rat and these changes correlate well with arrhythmia suppression...
  10. ncbi request reprint Comparative effects of rapid bolus administration of aqueous amiodarone versus 10-minute cordarone I.v. infusion on mean arterial blood pressure in conscious dogs
    John Charin Somberg
    Department of Pharmacology, Rush University, Chicago, IL, USA
    Cardiovasc Drugs Ther 18:345-51. 2004
    ..Cordarone IV contains polysorbate 80 and benzyl alcohol, each causes hypotension. A new aqueous formulation of amiodarone (Amio-Aqueous) does not contain these agents and therefore may cause less hypotension...
  11. ncbi request reprint Pharmacology and toxicology of a new aqueous formulation of intravenous amiodarone (Amio-Aqueous) compared with Cordarone IV
    John C Somberg
    Rush University, and the American Institute of Therapeutics, 21 North Skokie Valley Highway, Lake Bluff, IL 60044, USA
    Am J Ther 12:9-16. 2005
    ..Therefore, Amio-Aqueous is a safer alternative than the standard formulation...
  12. ncbi request reprint The pharmacologic treatment of heart failure
    John C Somberg
    The Division of Clinical Pharmacology, Rush University, Chicago, Illinois 60044, USA
    Am J Ther 11:480-8. 2004
    ..ICD's are recommended in class II, III CHF with EF < 30 and amiodarone may be the therapy of choice in selected class IV patients and in patients with EF > 30%...
  13. ncbi request reprint Lack of a hypotensive effect with rapid administration of a new aqueous formulation of intravenous amiodarone
    John C Somberg
    Rush University, Chicago, Illinois, USA
    Am J Cardiol 93:576-81. 2004
    ..This is a significant advantage over the standard amiodarone formulation, because Cordarone cannot be administered by rapid bolus owing to excipient-related hypotension...
  14. ncbi request reprint The quest for an aqueous amiodarone
    John C Somberg
    Academic Pharmaceuticals, Lake Bluff, Illinois 60044, USA
    Am J Ther 10:458-61. 2003
  15. ncbi request reprint Intravenous lidocaine versus intravenous amiodarone (in a new aqueous formulation) for incessant ventricular tachycardia
    John C Somberg
    Rush University, Chicago, Illinois, USA
    Am J Cardiol 90:853-9. 2002
    ..01). Drug-related hypotension with aqueous amiodarone was less frequent than with lidocaine. This study found that amiodarone is more effective than lidocaine in the treatment of shock-resistant VT...
  16. ncbi request reprint Enhancement of myocardial vulnerability by atrial fibrillation
    John C Somberg
    Department of Medicine and Pharmacology, Rush University and American Institute of Therapeutics, 21 N Skokie Valley Highway, Suite G 3, Lake Bluff, IL 60044, USA
    Am J Ther 11:33-43. 2004
    ..The association of AF with a higher incidence of sudden death may be due to an enhanced electrical instability...
  17. ncbi request reprint Chiral cardiovascular drugs: an overview
    Vasant V Ranade
    American Institute of Therapeutics, Lake Bluff, Illinois, USA
    Am J Ther 12:439-59. 2005
    ..Chirality has been visualized as an important factor in cardiovascular research. It is also becoming evident in other areas of therapeutics...
  18. ncbi request reprint Evaluation of a 12-lead digital Holter system for 24-hour QT interval assessment
    Janos Molnar
    RFUMS, The Chicago Medical School, Chicago, Ill, USA
    Cardiology 106:224-32. 2006
    ..Evaluation of the QT prolonging effect of new pharmaceutical agents in a 'thorough QT/QTc study' is being mandated by FDA. The purpose of this study was to evaluate an automated 12-lead digital Holter system for a thorough QT/QTc study...
  19. ncbi request reprint Rapid determination of partition coefficients between n-octanol/water for cardiovascular therapies
    Vasant Ranade
    Department of Clinical Pharmacology, Rush University, Chicago, IL, USA
    Am J Ther 9:19-24. 2002
    ..Additionally, lipophilic agents may enter target tissue with greater ease than nonlipophilic compounds and thus possess local intracellular effects in addition to a macro systemic action...
  20. ncbi request reprint Assessment of cardiovascular and noncardiovascular medical device recalls
    John C Somberg
    Department of Medicine and Clinical Pharmacology, Rush University, Chicago, Illinois Electronic address
    Am J Cardiol 113:1899-903. 2014
    ..Modifying the 510(k) process with more rigorous performance testing, a conditional 2-year approval and a mandatory registry may be an approach to reduce recalls...
  21. ncbi request reprint Arrhythmia therapy
    John C Somberg
    Rush Presbyterian St Luke s Medical Center, Rush University, Chicago, Illinois, USA
    Am J Ther 9:537-42. 2002
  22. ncbi request reprint A case of herceptin cardiotoxicity
    Melody Cobleigh
    Comprehensive Breast Center, Rush University, Rush Presbyterian St Luke s Medical Center, 1653 W Congress Parkway, 1589 Jelke, Chicago, IL 60612 3833, USA
    Am J Ther 11:74-6. 2004
  23. ncbi request reprint The cholesterol hypothesis: questioned?
    John C Somberg
    Division of Clinical Pharmacology, Rush University, Chicago, IL, USA
    Am J Ther 15:292-5. 2008

Research Grants1

  1. Digoxin Chiral Isolates as Improved Pharmaceuticals
    John Somberg; Fiscal Year: 2005
    ..The advantage would be a treatment for AF that did not cause cardiac augmentation and vasoconstriction or a treatment for CHF that does not cause heart rate slowing or conduction disturbances. ..