Research Topics
| John C SombergSummaryAffiliation: Rush University Medical Center Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
QT prolongation and serum sotalol concentration are highly correlated following intravenous and oral sotalolJohn C Somberg
Division of Clinical Pharmacology, Rush University, Chicago, Ill, USA
Cardiology 116:219-25. 2010..The aim of this study was to evaluate the correlation between QT interval (QT) and serum sotalol concentration following a single low dose of oral and intravenous sotalol...- The impact of comorbidities on stroke prophylaxis strategies in atrial fibrillation patientsJohn C Somberg
Clinical Pharmacology, Rush University, Chicago, IL 60612 3833, USA
Am J Ther 18:510-7. 2011.... - The clinical pharmacology of ethacrynic acidJanos Molnar
American Institute of Therapeutics, Lake Bluff, IL 60044, USA
Am J Ther 16:86-92. 2009.... - The pleiotropic effects of ethacrynic acidJohn C Somberg
Department of Pharmacology and Medicine, Division of Clinical Pharmacology, Rush University, Chicago, IL, USA
Am J Ther 16:102-4. 2009..This work may lead to effective therapies in reducing chemotherapy resistance in cancer chemotherapeutics. In addition, EC or conjurers may be a radiation enhancer, an anti-inflammatory agent, or a treatment for glaucoma... - Gender differences in cardiac repolarization following intravenous sotalol administrationJohn C Somberg
Division of Clinical Pharmacology, Rush University, Chicago, IL, USA
J Cardiovasc Pharmacol Ther 17:86-92. 2012..Sotalol prolongs the cardiac action potential that can be observed as QT prolongation and can induce TdP. The aim of this study was to assess gender differences in sotalol-induced QTc prolongation... - The management of acute heart failure and diuretic therapyJohn C Somberg
Department of Pharmacology and Medicine, Division of Clinical Pharmacology, Rush University, Chicago, IL, USA
Am J Ther 16:93-7. 2009..However, ethacrynic acid should be used in sulfa-sensitive patients because ethacrynic acid is the only loop diuretic, which does not contain a sulfa moiety... - Therapeutic approaches to the treatment of edema and ascites: the use of diureticsJohn C Somberg
Department of Pharmacology and Medicine, Division of Clinical Pharmacology, Rush University, Chicago, IL, USA
Am J Ther 16:98-101. 2009..This article provides a review of the challenges and therapeutic approaches for the treatment of these conditions and provides a review of new therapies on the horizon that may be promising... 
The quest for an aqueous amiodaroneJohn C Somberg
Academic Pharmaceuticals, Lake Bluff, Illinois 60044, USA
Am J Ther 10:458-61. 2003- Intravenous lidocaine versus intravenous amiodarone (in a new aqueous formulation) for incessant ventricular tachycardiaJohn C Somberg
Rush University, Chicago, Illinois, USA
Am J Cardiol 90:853-9. 2002..01). Drug-related hypotension with aqueous amiodarone was less frequent than with lidocaine. This study found that amiodarone is more effective than lidocaine in the treatment of shock-resistant VT... - Developing a safe intravenous sotalol dosing regimenJohn C Somberg
Division of Clinical Pharmacology, Rush University, Chicago, IL, USA
Am J Ther 17:365-72. 2010..The food and drug administration-approved dosing regimen is 75 mg intravenous sotalol to replace 80 mg oral sotalol and 150 mg intravenous sotalol to replace 160 mg oral sotalol, both administered over 5 hours... - The effect of magnesium sulfate on action potential duration and cardiac arrhythmiasJohn C Somberg
Division of Clinical Pharmacology, Rush University, Chicago, Illinois, USA
Am J Ther 12:218-22. 2005..The results of these findings indicate that infusion of MgSO4 can prolong the QRS, QT, and JT intervals in the rat and these changes correlate well with arrhythmia suppression... - Comparative effects of rapid bolus administration of aqueous amiodarone versus 10-minute cordarone I.v. infusion on mean arterial blood pressure in conscious dogsJohn Charin Somberg
Department of Pharmacology, Rush University, Chicago, IL, USA
Cardiovasc Drugs Ther 18:345-51. 2004..Cordarone IV contains polysorbate 80 and benzyl alcohol, each causes hypotension. A new aqueous formulation of amiodarone (Amio-Aqueous) does not contain these agents and therefore may cause less hypotension... - The pharmacologic treatment of heart failureJohn C Somberg
The Division of Clinical Pharmacology, Rush University, Chicago, Illinois 60044, USA
Am J Ther 11:480-8. 2004..ICD's are recommended in class II, III CHF with EF < 30 and amiodarone may be the therapy of choice in selected class IV patients and in patients with EF > 30%... - Lack of a hypotensive effect with rapid administration of a new aqueous formulation of intravenous amiodaroneJohn C Somberg
Rush University, Chicago, Illinois, USA
Am J Cardiol 93:576-81. 2004..This is a significant advantage over the standard amiodarone formulation, because Cordarone cannot be administered by rapid bolus owing to excipient-related hypotension... - Pharmacology and toxicology of a new aqueous formulation of intravenous amiodarone (Amio-Aqueous) compared with Cordarone IVJohn C Somberg
Rush University, and the American Institute of Therapeutics, 21 North Skokie Valley Highway, Lake Bluff, IL 60044, USA
Am J Ther 12:9-16. 2005..Therefore, Amio-Aqueous is a safer alternative than the standard formulation... - Enhancement of myocardial vulnerability by atrial fibrillationJohn C Somberg
Department of Medicine and Pharmacology, Rush University and American Institute of Therapeutics, 21 N. Skokie Valley Highway, Suite G-3, Lake Bluff, IL 60044, USA
Am J Ther 11:33-43. 2004..The association of AF with a higher incidence of sudden death may be due to an enhanced electrical instability... - Chiral cardiovascular drugs: an overviewVasant V Ranade
American Institute of Therapeutics, Lake Bluff, Illinois, USA
Am J Ther 12:439-59. 2005..Chirality has been visualized as an important factor in cardiovascular research. It is also becoming evident in other areas of therapeutics... - Evaluation of a 12-lead digital Holter system for 24-hour QT interval assessmentJanos Molnar
RFUMS, The Chicago Medical School, Chicago, Ill, USA
Cardiology 106:224-32. 2006..001). CONCLUSIONS: The AQA is not an acceptable method, while the automatic analysis with complete MOR is a highly sensitive and reproducible method. Data sampling by analyzing 5-min segments per hour is sensitive and reproducible... - Rapid determination of partition coefficients between n-octanol/water for cardiovascular therapiesVasant Ranade
Department of Clinical Pharmacology, Rush University, Chicago, IL, USA
Am J Ther 9:19-24. 2002..Additionally, lipophilic agents may enter target tissue with greater ease than nonlipophilic compounds and thus possess local intracellular effects in addition to a macro systemic action... - Arrhythmia therapyJohn C Somberg
Rush-Presbyterian-St. Luke's Medical Center, Rush University, Chicago, Illinois, USA
Am J Ther 9:537-42. 2002 - A case of herceptin cardiotoxicityMelody Cobleigh
Comprehensive Breast Center, Rush University, Rush-Presbyterian St. Luke's Medical Center, 1653 W. Congress Parkway, 1589 Jelke, Chicago, IL 60612-3833, USA
Am J Ther 11:74-6. 2004 - The cholesterol hypothesis: questioned?John C Somberg
Division of Clinical Pharmacology, Rush University, Chicago, IL, USA
Am J Ther 15:292-5. 2008
Research Grants
- Digoxin Chiral Isolates as Improved PharmaceuticalsJohn Somberg; Fiscal Year: 2005..The advantage would be a treatment for AF that did not cause cardiac augmentation and vasoconstriction or a treatment for CHF that does not cause heart rate slowing or conduction disturbances. ..