Research Topics
Species | Julie A SchneiderSummaryAffiliation: Rush University Medical Center Country: USA Publications
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Publications
Cognitive impairment, decline and fluctuations in older community-dwelling subjects with Lewy bodiesJ A Schneider
Rush Alzheimer s Disease Centre, Rush University Medical Centre, Chicago, IL 60612, USA
Brain 135:3005-14. 2012..Limbic-type Lewy body pathology is specifically associated with lower and more rapid decline in visuospatial skills. The effect of Lewy body pathology on cognition appears to be independent of Alzheimer's disease pathology...- Increasing incidence of dementia in the oldest old: evidence and implicationsBryan D James
Rush Alzheimer s Disease Center, 600 South Paulina Street, Room 1038, Chicago, IL 60612, USA, Department of Medicine, Rush University Medical Center, Chicago, IL, USA
Alzheimers Res Ther 2:9. 2010..Strategies for prevention and treatment will require more information regarding risk factors and the etiopathogenesis of dementia in the oldest old... 
The apolipoprotein E epsilon4 allele increases the odds of chronic cerebral infarction [corrected] detected at autopsy in older personsJ A Schneider
Rush AD Center and Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, Ill, USA
Stroke 36:954-9. 2005..Little data are available regarding the relation of apoE epsilon4 to cerebral infarctions documented on postmortem examination...- Folic acid and cognition in older personsJulie A Schneider
Rush University Medical Center, Rush Alzheimer s Disease Center and Department of Neurological Sciences, 600 S Paulina St, Suite 1022F, Chicago, IL 60612, USA
Expert Opin Drug Saf 5:511-22. 2006..Whether or not folic acid supplementation exacerbates neurological symptoms of vitamin B12 deficiency is not clear. Further studies are needed to determine the possible risks and benefits of folic acid supplementation in older persons... - The neuropathology of probable Alzheimer disease and mild cognitive impairmentJulie A Schneider
Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL, USA
Ann Neurol 66:200-8. 2009..The objective of this study was to investigate single and mixed common age-related neuropathologies in persons with probable AD and MCI... - Where vascular meets neurodegenerative diseaseJulie A Schneider
Department of Pathology and Neurological Sciences, Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Center, 600 S Paulina St, Suite 1022F, Chicago, IL 60612, USA
Stroke 41:S144-6. 2010..Finally, because dementia in older persons often results from mixed pathology and the clinical phenotypes overlap, some risk factors may increase risk for clinical Alzheimer's disease through an increase in vascular pathology... - Substantia nigra tangles are related to gait impairment in older personsJulie A Schneider
Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina Street, Chicago, IL, USA
Ann Neurol 59:166-73. 2006..Our objective was to test the hypothesis that substantia nigra neurofibrillary tangles (NFTs) are related to parkinsonian signs in older persons with and without dementia... - The neuropathology of older persons with and without dementia from community versus clinic cohortsJulie A Schneider
Department of Pathology Neuropathology and Neurological Sciences, Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Center, 600 South Paulina Street, Suite 1022F, Chicago, IL 60612, USA
J Alzheimers Dis 18:691-701. 2009..Overall, clinic-based persons have more Lewy bodies and atypical pathologies. The spectrum of pathologies underlying cognitive impairment in clinic-based cohorts differs from community-based cohorts... - Subcortical infarcts, Alzheimer's disease pathology, and memory function in older personsJulie A Schneider
Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, Department of Neurological Sciences, Rush University Medical Center, 600 South Paulina Street, Chicago, IL 60612, USA
Ann Neurol 62:59-66. 2007..Examine the effects of subcortical infarcts with Alzheimer's disease (AD) pathology on dementia, episodic memory, and other cognitive abilities in older persons... - Mixed brain pathologies account for most dementia cases in community-dwelling older personsJulie A Schneider
Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Center, 600 S Paulina Street, Suite 1022F, Chicago, IL 60612, USA
Neurology 69:2197-204. 2007..To examine the spectrum of neuropathology in persons from the Rush Memory and Aging Project, a longitudinal community-based clinical-pathologic cohort study... - Cerebral infarctions and the likelihood of dementia from Alzheimer disease pathologyJ A Schneider
Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL 60612, USA
Neurology 62:1148-55. 2004..Alzheimer disease (AD) is the most common cause of dementia. The effect of cerebral infarctions on the likelihood of dementia from AD pathology is not well understood... - Relation of neuropathology to cognition in persons without cognitive impairmentDavid A Bennett
Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL Departments of Neurological Sciences, Rush University Medical Center, Chicago, IL
Ann Neurol 72:599-609. 2012..A study was undertaken to examine the relation of Alzheimer disease (AD) pathology, cerebral infarcts, and Lewy body (LB) pathology to cognition in persons without cognitive impairment... - Olfactory identification and incidence of mild cognitive impairment in older ageRobert S Wilson
Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina, Ste 1038, Chicago, IL 60612, USA
Arch Gen Psychiatry 64:802-8. 2007..Mild cognitive impairment (MCI) is often a precursor to Alzheimer disease, but knowledge about factors that predict its development is limited... - Conscientiousness and the incidence of Alzheimer disease and mild cognitive impairmentRobert S Wilson
Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina, Chicago, IL 60612, USA
Arch Gen Psychiatry 64:1204-12. 2007..The personality trait of conscientiousness has been related to morbidity and mortality in old age, but its association with the development of Alzheimer disease is not known... - Sex differences in the clinical manifestations of Alzheimer disease pathologyLisa L Barnes
Rush Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
Arch Gen Psychiatry 62:685-91. 2005.... - Vulnerability to stress, anxiety, and development of dementia in old ageRobert S Wilson
Rush Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
Am J Geriatr Psychiatry 19:327-34. 2011..To identify the components of the neuroticism trait most responsible for its association with cognitive decline and dementia in old age... - Cerebral amyloid angiopathy pathology and cognitive domains in older personsZoe Arvanitakis
Rush Alzheimer s Disease Center, Chicago, IL, USA
Ann Neurol 69:320-7. 2011..To examine the relation of cerebral amyloid angiopathy (CAA) to cognitive domains in older community-dwelling persons with and without dementia... - The apolipoprotein E epsilon 4 allele and decline in different cognitive systems during a 6-year periodRobert S Wilson
Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, 1645 W Jackson Blvd, Suite 675, Chicago, IL 60612, USA
Arch Neurol 59:1154-60. 2002..The apolipoprotein E (APOE) epsilon 4 allele is known to influence risk of AD but it has been difficult to establish whether it affects episodic memory differently from other cognitive functions... - Overview and findings from the rush Memory and Aging ProjectDavid A Bennett
Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina, Suite 1028, Chicago, IL 60612, USA
Curr Alzheimer Res 9:646-63. 2012..The findings are discussed and contextualized... - Nigral pathology and parkinsonian signs in elders without Parkinson diseaseAron S Buchman
Rush Alzheimer s Disease Center, Chicago, IL, USA
Ann Neurol 71:258-66. 2012..We tested the hypothesis that nigral pathology is related to parkinsonism in older persons without Parkinson disease (PD)... - Loneliness and risk of Alzheimer diseaseRobert S Wilson
Rush Alzheimer s Disease Center, Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL 60612, USA
Arch Gen Psychiatry 64:234-40. 2007..Social isolation in old age has been associated with risk of developing dementia, but the risk associated with perceived isolation, or loneliness, is not well understood... - Dietary folate and vitamins B-12 and B-6 not associated with incident Alzheimer's diseaseMartha Clare Morris
Rush Institute for Healthy Aging, Rush University Medical Center, 1645 W Jackson 675, Chicago, IL 60612, USA
J Alzheimers Dis 9:435-43. 2006..It is currently not known whether dietary intakes of folate and vitamins B12 and B6, co-factors in the methylation of homocysteine, protect against Alzheimer's disease... - The Rush Memory and Aging Project: study design and baseline characteristics of the study cohortDavid A Bennett
Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina, Suite 1028, Chicago, IL 60612, USA
Neuroepidemiology 25:163-75. 2005..Their mean age was 81 years, about a third had 12 or fewer years of education, a third were men, and about 10% were members of a racial or ethnic minority group. More than 950 already have completed their baseline clinical evaluation... - Neuropathologic intermediate phenotypes enhance association to Alzheimer susceptibility allelesDavid A Bennett
Rush Alzheimer s Disease Center, 600 S Paulina, Suite 1028, Chicago, IL 60062, USA
Neurology 72:1495-503. 2009.... - The Minority Aging Research Study: ongoing efforts to obtain brain donation in African Americans without dementiaLisa L Barnes
Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina, Suite 1038, Chicago, IL 60612, USA
Curr Alzheimer Res 9:734-45. 2012..The implications of these efforts are discussed... - Characteristics of MR infarcts associated with dementia and cognitive function in the elderlyNeelum T Aggarwal
Rush University Medical Center, Chicago, IL 60612, USA Neelum_T_Aggarwal rush edu
Neuroepidemiology 38:41-7. 2012..Little information exists on the simultaneous effects of magnetic resonance (MR) infarct characteristics, that may increase the likelihood of dementia or lower cognitive function in community populations... - Combinations of motor measures more strongly predict adverse health outcomes in old age: the rush memory and aging project, a community-based cohort studyAron S Buchman
Department of Neurological Sciences, Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA
BMC Med 9:42. 2011..We tested the hypothesis that combinations of motor constructs more strongly predict adverse health outcomes in older people... - Parkinsonian signs and functional disability in old ageDebra A Fleischman
Rush Alzheimer s Disease Center and Departments of Neurological Sciences and Behavioral Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
Exp Aging Res 33:59-76. 2007.... - Overview and findings from the religious orders studyDavid A Bennett
Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina, Suite 1028, Chicago, IL 60612, USA
Curr Alzheimer Res 9:628-45. 2012..We then discuss and contextualize the study findings... - Effect of purpose in life on the relation between Alzheimer disease pathologic changes on cognitive function in advanced agePatricia A Boyle
Rush Alzheimer s Disease Center, 600 S Paulina Ave, Ste 1020B, Chicago, IL 60612, USA
Arch Gen Psychiatry 69:499-505. 2012..Purpose in life is associated with a substantially reduced risk of Alzheimer disease (AD), but the neurobiologic basis of this protective effect remains unknown... - Chronic distress, age-related neuropathology, and late-life dementiaRobert S Wilson
Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina, Suite 1038, Chicago, IL 60612, USA
Psychosom Med 69:47-53. 2007..The objective of this study was to test whether common age-related neuropathology could account for the relation of chronic distress to dementia... - Microinfarct pathology, dementia, and cognitive systemsZoe Arvanitakis
Rush Alzheimer s Disease Center, 600 S Paulina, Suite 1020, Rush University Medical Center, Chicago, IL 60612, USA
Stroke 42:722-7. 2011..Little is known about the role of microinfarcts in dementia and cognition. We examined microinfarcts and dementia, global cognition, and 5 cognitive systems in community-dwelling older persons... - Decision rules guiding the clinical diagnosis of Alzheimer's disease in two community-based cohort studies compared to standard practice in a clinic-based cohort studyDavid A Bennett
Rush Alzheimer s Disease Center, Chicago, Ill, USA
Neuroepidemiology 27:169-76. 2006..This approach holds promise for reducing the operational costs of epidemiologic studies of aging and AD... - The relation of cigarette smoking to incident Alzheimer's disease in a biracial urban community populationNeelum T Aggarwal
Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Center, Chicago, IL 60612, USA
Neuroepidemiology 26:140-6. 2006.... - Parkinsonianlike signs and risk of incident Alzheimer disease in older personsRobert S Wilson
Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging and the Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
Arch Neurol 60:539-44. 2003..Parkinsonianlike signs are common in older persons, but little is known about how their severity or rate of progression is related to the development of Alzheimer disease (AD) or decline in cognition... - Neurofibrillary tangles mediate the association of amyloid load with clinical Alzheimer disease and level of cognitive functionDavid A Bennett
Rush Alzheimer s Disease Center and the Department of Neurological Sciences Rush University Medical Center, Chicago, IL 60612, USA
Arch Neurol 61:378-84. 2004..To test the hypothesis that the association of amyloid load with clinical Alzheimer disease (AD) and cognitive impairment is mediated through neurofibrillary tangles... - Chronic psychological distress and risk of Alzheimer's disease in old ageRobert S Wilson
Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, Ill, USA
Neuroepidemiology 27:143-53. 2006..The results support the hypothesis that distress proneness is associated with increased risk of dementia and suggest that neurobiologic mechanisms other than AD pathology may underlie the association... - Olfactory impairment in presymptomatic Alzheimer's diseaseRobert S Wilson
Department of Neurological Sciences, Rush Alzheimer s Disease Center, Rush University Medical Cetner, Chicago, Illinois 60612, USA
Ann N Y Acad Sci 1170:730-5. 2009.... - Lewy bodies and olfactory dysfunction in old ageRobert S Wilson
Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina Avenue, Chicago, IL 60612, USA
Chem Senses 36:367-73. 2011..The findings indicate that Lewy body disease impairs late life olfactory function even in otherwise asymptomatic individuals... - Emotional neglect in childhood and cerebral infarction in older ageRobert S Wilson
Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL, USA
Neurology 79:1534-9. 2012..The purpose of the study was to test the hypothesis that a higher level of childhood adversity is associated with increased risk of cerebral infarction in old age... - Evidence for angiogenesis in Parkinson's disease, incidental Lewy body disease, and progressive supranuclear palsyBrinda Desai Bradaric
Department of Pharmacology, Rush University, Cohn Research Building, 1735 W Harrison Suite 412, Chicago, IL 60612, USA
J Neural Transm 119:59-71. 2012..Such angiogenic vessels could contribute to neuroinflammation by failing to protect the parenchyma from peripheral immune cells and inflammatory or toxic factors in the peripheral circulation... - Dietary folate and vitamin B12 intake and cognitive decline among community-dwelling older personsMartha Clare Morris
Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Ill 60612, USA
Arch Neurol 62:641-5. 2005..Deficiencies in folate and vitamin B12 have been associated with neurodegenerative disease... - Dietary copper and high saturated and trans fat intakes associated with cognitive declineMartha Clare Morris
Department of Internal Medicine, Rush Institute for Healthy Aging, Rush University Medical Center, 1645 W Jackson Street, Chicago, IL 60612, USA
Arch Neurol 63:1085-8. 2006..Evidence from prospective epidemiologic studies and animal models suggests that intakes of dietary fats and copper may be associated with neurodegenerative diseases... - Participation in cognitively stimulating activities and risk of incident Alzheimer diseaseRobert S Wilson
Rush Alzheimer s Disease Center, 1645 W Jackson Blvd, Suite 675, Chicago, IL 60612, USA
JAMA 287:742-8. 2002..Frequent participation in cognitively stimulating activities has been hypothesized to reduce risk of Alzheimer disease (AD), but prospective data regarding an association are lacking... - Cerebral infarctions and the relationship of depression symptoms to level of cognitive functioning in older personsDavid A Bennett
Rush Alzheimer s Disease Center, Departments of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
Am J Geriatr Psychiatry 12:211-9. 2004.... 
Antiphospholipid Antibodies, Brain Infarcts, and Cognitive and Motor Decline in Aging (ABICMA): Design of a Community-Based, Longitudinal, Clinical-Pathological StudyZoe Arvanitakis
Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, Ill, USA
Neuroepidemiology 40:73-84. 2013....- The CETP I405V polymorphism is associated with an increased risk of Alzheimer's diseaseLei Yu
Rush Alzheimer s Disease Center, Department of Neurological Science, Rush University Medical Center, Chicago, IL 60612, USA
Aging Cell 11:228-33. 2012..This finding is consistent with data showing that the CETP I405V is associated with increased neuritic plaque density at autopsy... - The effect of social networks on the relation between Alzheimer's disease pathology and level of cognitive function in old people: a longitudinal cohort studyDavid A Bennett
Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
Lancet Neurol 5:406-12. 2006..Few data are available about how social networks reduce the risk of cognitive impairment in old age. We aimed to measure this effect using data from a large, longitudinal, epidemiological clinicopathological study... - Implicit memory and Alzheimer's disease neuropathologyDebra A Fleischman
Rush Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
Brain 128:2006-15. 2005..The results suggest that hallmark indices of Alzheimer's disease neuropathology are associated with performance on priming tests to the extent that conceptual, but not perceptual, processing resources are required... - Individual differences in rates of change in cognitive abilities of older personsRobert S Wilson
Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois, USA
Psychol Aging 17:179-93. 2002..The results suggest that change in cognitive function in old age primarily reflects person-specific factors rather than an inevitable developmental process... - Microvascular brain pathology and late-life motor impairmentAron S Buchman
From the Rush Alzheimer s Disease Center A S B, L Y, P A B, S N, J A S, D A B, Neurological Sciences A S B, L Y, D A B, Behavioral Science P A B, and Pathology S N, J A S, Rush University Medical Center, Chicago, IL and Departments of Neurology Stroke Center and Emergency Medicine S R L, SUNY Downstate Medical Center, Brooklyn, NY
Neurology 80:712-8. 2013..To test the hypothesis that microvascular brain pathology is associated with late-life motor impairment... - Cerebrovascular disease pathology and parkinsonian signs in old ageAron S Buchman
Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Facility, Suite 1022, 600 South Paulina Street, Chicago, IL 60612, USA
Stroke 42:3183-9. 2011..Mild motor symptoms including parkinsonian signs are common in old age, but their underlying neuropathology is unclear. We tested the hypothesis that cerebrovascular pathologies are related to parkinsonian signs... - Estimation of the mediation effect with a binary mediatorYan Li
Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL 60612, USA
Stat Med 26:3398-414. 2007.... - Thoughts on B-vitamins and dementiaMartha Clare Morris
Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL 60612, USA
J Alzheimers Dis 9:429-33. 2006..We also comment on the potential benefits and harms of vitamin supplementation as well as make recommendations for the direction of future studies... - Diabetes mellitus and progression of rigidity and gait disturbance in older personsZ Arvanitakis
Rush Alzheimer's Disease Center, Rush University Medical Center, 600 S. Paulina, Suite 1020E, Chicago, IL 60612, USA
Neurology 63:996-1001. 2004..08). CONCLUSION: Diabetes may be a previously unrecognized risk factor for progression of parkinsonian-like signs in older persons... - Relation of NSAIDs to incident AD, change in cognitive function, and AD pathologyZ Arvanitakis
Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
Neurology 70:2219-25. 2008..To examine the relation of nonsteroidal anti-inflammatory drugs (NSAIDs) to incident Alzheimer disease (AD), change in cognition, and AD pathology... - Locus coeruleus neuron density and parkinsonism in older adults without Parkinson's diseaseAron S Buchman
Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA
Mov Disord 27:1625-31. 2012..In older adults without a clinical diagnosis of PD, neuron density in locus coeruleus nuclei is associated with the severity of parkinsonism and may contribute to late-life motor impairments... - Correlation of amyloid PET ligand florbetapir F 18 binding with Aβ aggregation and neuritic plaque deposition in postmortem brain tissueSeok Rye Choi
Avid Radiopharmaceutical Inc, 3711 Market Street, 7th Floor, Philadelphia, PA 19104, USA
Alzheimer Dis Assoc Disord 26:8-16. 2012..This study used human autopsy brain tissue to evaluate the correlation between in vitro florbetapir F 18 binding and Aβ density measured by established neuropathologic methods... - Physical frailty in older persons is associated with Alzheimer disease pathologyAron S Buchman
Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Facility, Suite 1038, 600 S Paulina St, Chicago, IL 60612, USA
Neurology 71:499-504. 2008..We examined the extent to which physical frailty in older persons is associated with common age-related brain pathology, including cerebral infarcts, Lewy body pathology, and Alzheimer disease (AD) pathology... - Improved detection of substantia nigra pathology in Alzheimer's diseaseJulie A Schneider
Rush Alzheimer s Disease Center, Rush University and Rush Presbyterian St Luke s Medical Center, Chicago, Illinois, USA
J Histochem Cytochem 50:99-106. 2002..We show that detection of nigra pathology is influenced by histological method. Clinicopathological studies using these methods are needed to determine the role of nigral pathology in AD... - Statins, incident Alzheimer disease, change in cognitive function, and neuropathologyZ Arvanitakis
Rush Alzheimer s Disease Center, Department of Neurological Sciences, 600 S Paulina, Suite 1020, Rush University Medical Center, Chicago, IL 60612, USA
Neurology 70:1795-802. 2008..To examine the relation of statins to incident Alzheimer disease (AD) and change in cognition and neuropathology... - Diabetes is related to cerebral infarction but not to AD pathology in older personsZ Arvanitakis
Rush Alzheimer's Disease Center, 600 S. Paulina, Suite 1020, Rush University Medical Center, Chicago, IL 60612, USA
Neurology 67:1960-5. 2006..CONCLUSION: We found a relation between diabetes and cerebral infarction but not between diabetes and Alzheimer disease pathology in older persons... - Selected findings from the Religious Orders Study and Rush Memory and Aging ProjectDavid A Bennett
Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA David A
J Alzheimers Dis 33:S397-403. 2013..The findings illustrate the range of insights that can be gained into cognitive aging by incorporating neuropathologic indices into well designed, prospective cohort studies... - Levels of estrogen receptors alpha and beta in frontal cortex of patients with Alzheimer's disease: relationship to Mini-Mental State Examination scoresJeremiah F Kelly
Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
Curr Alzheimer Res 5:45-51. 2008.... - The relationship between cerebral Alzheimer's disease pathology and odour identification in old ageR S Wilson
Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina, Suite 1038, Chicago, IL 60612, USA
J Neurol Neurosurg Psychiatry 78:30-5. 2007..Olfactory dysfunction is common in old age, but its basis is uncertain... - Neuropathology of older persons without cognitive impairment from two community-based studiesD A Bennett
Rush Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
Neurology 66:1837-44. 2006..To examine the relation of National Institute on Aging-Reagan (NIA-Reagan) neuropathologic criteria of Alzheimer disease (AD) to level of cognitive function in persons without dementia or mild cognitive impairment (MCI)... - Education modifies the association of amyloid but not tangles with cognitive functionD A Bennett
Rush Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
Neurology 65:953-5. 2005..02) but not the association of neurofibrillary tangles with level of cognition, suggesting that education is related to factors that reduce the effect of amyloid on cognition... - Amyloid mediates the association of apolipoprotein E e4 allele to cognitive function in older peopleD A Bennett
Rush Alzheimer s Disease Center, Armour Academic Center, 600 South Paulina, Suite 1028 Chicago, IL 60612, USA
J Neurol Neurosurg Psychiatry 76:1194-9. 2005..The neurobiological changes underlying the association of the apolipoprotein E (APOE) e4 allele with level of cognition are poorly understood... - Gender, cognitive decline, and risk of AD in older personsL L Barnes
Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging and Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
Neurology 60:1777-81. 2003..The authors investigated gender differences in rate of decline for different cognitive systems and for risk of developing AD... - Mild cognitive impairment is related to Alzheimer disease pathology and cerebral infarctionsD A Bennett
Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL, USA
Neurology 64:834-41. 2005..To examine the extent to which persons with mild cognitive impairment have intermediate levels of Alzheimer disease (AD) pathology, cerebral infarcts, and Lewy body disease... - Proneness to psychological distress is associated with risk of Alzheimer's diseaseR S Wilson
Rush Alzheimer s Disease Center, Rush Institute for Healthy Aging, Chicago, IL 60612, USA
Neurology 61:1479-85. 2003..Chronic stress is associated with hippocampal damage and impaired memory in animals and humans... - Relation of cerebral infarctions to dementia and cognitive function in older personsJ A Schneider
Rush AD Center and Rush Institute for Healthy Aging, Chicago, IL 60612, USA
Neurology 60:1082-8. 2003..Cerebral infarctions are common in older persons but their relationship with dementia and cognitive function remains controversial... - Depressive symptoms, clinical AD, and cortical plaques and tangles in older personsR S Wilson
Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
Neurology 61:1102-7. 2003..Depressive symptoms in old age have been associated with risk of Alzheimer disease (AD), but it is uncertain whether they are an independent risk factor for disease or an early clinical sign of its underlying pathology... - Memory complaints are related to Alzheimer disease pathology in older personsL L Barnes
Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Facility, 600 S Paulina, Suite 1038, Chicago, IL 60612, USA
Neurology 67:1581-5. 2006..To study the relationship between Alzheimer disease (AD) pathology and memory complaints proximate to death... - Body mass index in older persons is associated with Alzheimer disease pathologyA S Buchman
Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Facility, Suite 1038, 600 S Paulina St, Chicago, IL 60612, USA
Neurology 67:1949-54. 2006.... - Progression of gait disorder and rigidity and risk of death in older personsR S Wilson
Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
Neurology 58:1815-9. 2002..Bradykinesia, gait disturbance, rigidity, and tremor are common motor signs in old age. All of these signs are associated with increased morbidity and mortality, but the extent to which they are progressive is unknown... - Processing resources reduce the effect of Alzheimer pathology on other cognitive systemsP A Boyle
Rush Alzheimer s Disease Center, Department of Behavioral Sciences, Rush University Medical Center, 600 S Paulina, 1020B, Chicago, IL 60612, USA
Neurology 70:1534-42. 2008..If this is an effective compensatory strategy, then involvement of additional cognitive systems may help maintain function in other cognitive systems despite the accumulation of pathology... - Relation of cognitive activity to risk of developing Alzheimer diseaseR S Wilson
Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina, Suite 1038, Chicago, IL 60612, USA
Neurology 69:1911-20. 2007..Frequent cognitive activity in old age has been associated with reduced risk of Alzheimer disease (AD), but the basis of the association is uncertain... - Natural history of mild cognitive impairment in older personsD A Bennett
Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, Rush Presbyterian St Luke s Medical Center, Chicago, IL, USA
Neurology 59:198-205. 2002..Few large longitudinal studies have compared the natural history of mild cognitive impairment with similar persons without cognitive impairment... - Education modifies the relation of AD pathology to level of cognitive function in older personsD A Bennett
Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, Chicago, IL 60612, USA
Neurology 60:1909-15. 2003..To test the hypothesis that years of formal education modifies the relation of AD pathology to level of cognitive function... - Cognitive activity and incident AD in a population-based sample of older personsR S Wilson
Department of Neurological Sciences, Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
Neurology 59:1910-4. 2002..Participation in cognitively stimulating activities is hypothesized to be associated with risk of AD, but knowledge about this association is limited... - Chronic distress and incidence of mild cognitive impairmentR S Wilson
Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
Neurology 68:2085-92. 2007..Here we test the hypothesis that chronic psychological distress is associated with increased incidence of MCI in old age... - Apolipoprotein E epsilon4 allele, AD pathology, and the clinical expression of Alzheimer's diseaseD A Bennett
Rush Alzheimer s Disease Center, Chicago, Illinois 60612, USA
Neurology 60:246-52. 2003..To test the hypothesis that the APOE epsilon4 allele is associated with the clinical manifestations of AD through an association with the pathologic hallmarks of disease... - Neurodegenerative basis of age-related cognitive declineR S Wilson
Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina Ave, Suite 1038, Chicago, IL 60612, USA
Neurology 75:1070-8. 2010..To assess the contribution of dementia-related neuropathologic lesions to age-related and disease-related change in cognitive function... - Association of lower hemoglobin level and neuropathology in community-dwelling older personsRaj C Shah
Department of Family Medicine, Rush University Medical Center, Chicago, IL 60612, USA Raj C
J Alzheimers Dis 32:579-86. 2012..In conclusion, lower hemoglobin levels appear to be associated with chronic macroscopic infarctions but not other common age-related neuropathologies... - Evidence of angiogenic vessels in Alzheimer's diseaseBrinda S Desai
Department of Pharmacology, Rush University Medical Center, Cohn Research Building, Chicago, IL 60612, USA
J Neural Transm 116:587-97. 2009..These data indicate that ongoing angiogenesis is present in brain regions affected by AD pathology and may be related to tissue injury... - Postmortem MRI of human brain hemispheres: T2 relaxation times during formaldehyde fixationRobert J Dawe
Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, Illinois 60616, USA
Magn Reson Med 61:810-8. 2009..This final increase may be due to the effects of prolonged tissue decomposition, a hypothesis that is supported by numerical simulations of the fixation process... - Soluble α-synuclein is a novel modulator of Alzheimer's disease pathophysiologyMegan E Larson
Department of Neuroscience, N Bud Grossman Center for Memory Research and Care, and Institute for Translational Neuroscience, University of Minnesota, Minneapolis, Minnesota 55414, USA
J Neurosci 32:10253-66. 2012..Altogether, our data reveal an unexpected role for soluble, intraneuronal αSyn in AD pathophysiology... - The significance of Pin1 in the development of Alzheimer's diseaseSuqing Wang
Department of Pathology and Laboratory Medicine, and Waisman Center for Developmental Disabilities, University of Wisconsin School of Medicine, Madison, WI 53705, USA
J Alzheimers Dis 11:13-23. 2007.... - Cognitive performance correlates with cortical isopeptide immunoreactivity as well as Alzheimer type pathologyDeng Shun Wang
Departments of Neuroscience and Pathology, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, FL 32224, USA
J Alzheimers Dis 13:53-66. 2008..Protein cross-linking and aggregation are important molecular processes in Alzheimer's disease (AD), and tissue transglutaminase (tTG) catalyzes protein cross-linking... - Parahippocampal tau pathology in healthy aging, mild cognitive impairment, and early Alzheimer's diseaseThomas W Mitchell
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Ann Neurol 51:182-9. 2002.... - Glial heme oxygenase-1 expression in Alzheimer disease and mild cognitive impairmentHyman M Schipper
Centre for Neurotranslational Research and Bloomfield Centre for Research in Aging, Lady Davis Institute, Sir Mortimer B Davis Jewish General Hospital, 3755 Cote St Catherine Road, Montreal, Que, Canada H3T 1E2
Neurobiol Aging 27:252-61. 2006..Cortical and hippocampal oxidative stress is a very early event in the pathogenesis of sporadic AD and correlates with the development of specific cognitive deficits in this condition... - Early involvement of small inhibitory cortical interneurons in Alzheimer's diseaseVassilis E Koliatsos
Department of Pathology, Division of Neuropathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
Acta Neuropathol 112:147-62. 2006.... - DNA variability of human genesJulie A Schneider
Genaissance Pharmaceuticals, Five Science Park, New Haven, CT 06511, USA
Mech Ageing Dev 124:17-25. 2003..A deeper understanding of these aspects of human genetic variation will be of vital importance when trying to identify the genetic contribution to complex phenotypes such as aging... - Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar DegenerationNigel J Cairns
Department of Neurology, Washington University School of Medicine, Campus Box 8118, 660 South Euclid Avenue, St Louis, MO, 63110, USA
Acta Neuropathol 114:5-22. 2007..These criteria will be of value to the practicing neuropathologist and provide a foundation for clinical, clinico-pathologic, mechanistic studies and in vivo models of pathogenesis of FTLD... - TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusionsNigel J Cairns
MRCPath, Department of Pathology and Immunology, Washington University School of Medicine, Campus Box 8118, St Louis, MO 63110, USA
Am J Pathol 171:227-40. 2007.... - Application of coalescent methods to reveal fine-scale rate variation and recombination hotspotsPaul Fearnhead
Department of Mathematics and Statistics, Lancaster University, Lancaster LA1 4YF, United Kingdom
Genetics 167:2067-81. 2004..Our study suggests that new computational tools for sophisticated analysis of population diversity data are valuable for hotspot detection and fine-scale mapping of local recombination rates... - Brain microbleeds and cognitive functionJulie A Schneider
Stroke 38:1730-1. 2007