Julie A Schneider

Summary

Affiliation: Rush University Medical Center
Country: USA

Publications

  1. pmc Cognitive impairment, decline and fluctuations in older community-dwelling subjects with Lewy bodies
    J A Schneider
    Rush Alzheimer s Disease Centre, Rush University Medical Centre, Chicago, IL 60612, USA
    Brain 135:3005-14. 2012
  2. pmc Increasing incidence of dementia in the oldest old: evidence and implications
    Bryan D James
    Rush Alzheimer s Disease Center, 600 South Paulina Street, Room 1038, Chicago, IL 60612, USA, Department of Medicine, Rush University Medical Center, Chicago, IL, USA
    Alzheimers Res Ther 2:9. 2010
  3. ncbi request reprint Substantia nigra tangles are related to gait impairment in older persons
    Julie A Schneider
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina Street, Chicago, IL, USA
    Ann Neurol 59:166-73. 2006
  4. ncbi request reprint Subcortical infarcts, Alzheimer's disease pathology, and memory function in older persons
    Julie A Schneider
    Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, Department of Neurological Sciences, Rush University Medical Center, 600 South Paulina Street, Chicago, IL 60612, USA
    Ann Neurol 62:59-66. 2007
  5. ncbi request reprint Cerebral infarctions and the likelihood of dementia from Alzheimer disease pathology
    J A Schneider
    Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL 60612, USA
    Neurology 62:1148-55. 2004
  6. ncbi request reprint Folic acid and cognition in older persons
    Julie A Schneider
    Rush University Medical Center, Rush Alzheimer s Disease Center and Department of Neurological Sciences, 600 S Paulina St, Suite 1022F, Chicago, IL 60612, USA
    Expert Opin Drug Saf 5:511-22. 2006
  7. pmc Where vascular meets neurodegenerative disease
    Julie A Schneider
    Department of Pathology and Neurological Sciences, Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Center, 600 S Paulina St, Suite 1022F, Chicago, IL 60612, USA
    Stroke 41:S144-6. 2010
  8. ncbi request reprint The apolipoprotein E epsilon4 allele increases the odds of chronic cerebral infarction [corrected] detected at autopsy in older persons
    J A Schneider
    Rush AD Center and Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, Ill, USA
    Stroke 36:954-9. 2005
  9. ncbi request reprint Mixed brain pathologies account for most dementia cases in community-dwelling older persons
    Julie A Schneider
    Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Center, 600 S Paulina Street, Suite 1022F, Chicago, IL 60612, USA
    Neurology 69:2197-204. 2007
  10. pmc The neuropathology of older persons with and without dementia from community versus clinic cohorts
    Julie A Schneider
    Department of Pathology Neuropathology and Neurological Sciences, Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Center, 600 South Paulina Street, Suite 1022F, Chicago, IL 60612, USA
    J Alzheimers Dis 18:691-701. 2009

Collaborators

Detail Information

Publications107 found, 100 shown here

  1. pmc Cognitive impairment, decline and fluctuations in older community-dwelling subjects with Lewy bodies
    J A Schneider
    Rush Alzheimer s Disease Centre, Rush University Medical Centre, Chicago, IL 60612, USA
    Brain 135:3005-14. 2012
    ..Limbic-type Lewy body pathology is specifically associated with lower and more rapid decline in visuospatial skills. The effect of Lewy body pathology on cognition appears to be independent of Alzheimer's disease pathology...
  2. pmc Increasing incidence of dementia in the oldest old: evidence and implications
    Bryan D James
    Rush Alzheimer s Disease Center, 600 South Paulina Street, Room 1038, Chicago, IL 60612, USA, Department of Medicine, Rush University Medical Center, Chicago, IL, USA
    Alzheimers Res Ther 2:9. 2010
    ..Strategies for prevention and treatment will require more information regarding risk factors and the etiopathogenesis of dementia in the oldest old...
  3. ncbi request reprint Substantia nigra tangles are related to gait impairment in older persons
    Julie A Schneider
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina Street, Chicago, IL, USA
    Ann Neurol 59:166-73. 2006
    ..Our objective was to test the hypothesis that substantia nigra neurofibrillary tangles (NFTs) are related to parkinsonian signs in older persons with and without dementia...
  4. ncbi request reprint Subcortical infarcts, Alzheimer's disease pathology, and memory function in older persons
    Julie A Schneider
    Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, Department of Neurological Sciences, Rush University Medical Center, 600 South Paulina Street, Chicago, IL 60612, USA
    Ann Neurol 62:59-66. 2007
    ..Examine the effects of subcortical infarcts with Alzheimer's disease (AD) pathology on dementia, episodic memory, and other cognitive abilities in older persons...
  5. ncbi request reprint Cerebral infarctions and the likelihood of dementia from Alzheimer disease pathology
    J A Schneider
    Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL 60612, USA
    Neurology 62:1148-55. 2004
    ..Alzheimer disease (AD) is the most common cause of dementia. The effect of cerebral infarctions on the likelihood of dementia from AD pathology is not well understood...
  6. ncbi request reprint Folic acid and cognition in older persons
    Julie A Schneider
    Rush University Medical Center, Rush Alzheimer s Disease Center and Department of Neurological Sciences, 600 S Paulina St, Suite 1022F, Chicago, IL 60612, USA
    Expert Opin Drug Saf 5:511-22. 2006
    ..Whether or not folic acid supplementation exacerbates neurological symptoms of vitamin B12 deficiency is not clear. Further studies are needed to determine the possible risks and benefits of folic acid supplementation in older persons...
  7. pmc Where vascular meets neurodegenerative disease
    Julie A Schneider
    Department of Pathology and Neurological Sciences, Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Center, 600 S Paulina St, Suite 1022F, Chicago, IL 60612, USA
    Stroke 41:S144-6. 2010
    ..Finally, because dementia in older persons often results from mixed pathology and the clinical phenotypes overlap, some risk factors may increase risk for clinical Alzheimer's disease through an increase in vascular pathology...
  8. ncbi request reprint The apolipoprotein E epsilon4 allele increases the odds of chronic cerebral infarction [corrected] detected at autopsy in older persons
    J A Schneider
    Rush AD Center and Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, Ill, USA
    Stroke 36:954-9. 2005
    ..Little data are available regarding the relation of apoE epsilon4 to cerebral infarctions documented on postmortem examination...
  9. ncbi request reprint Mixed brain pathologies account for most dementia cases in community-dwelling older persons
    Julie A Schneider
    Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Center, 600 S Paulina Street, Suite 1022F, Chicago, IL 60612, USA
    Neurology 69:2197-204. 2007
    ..To examine the spectrum of neuropathology in persons from the Rush Memory and Aging Project, a longitudinal community-based clinical-pathologic cohort study...
  10. pmc The neuropathology of older persons with and without dementia from community versus clinic cohorts
    Julie A Schneider
    Department of Pathology Neuropathology and Neurological Sciences, Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Center, 600 South Paulina Street, Suite 1022F, Chicago, IL 60612, USA
    J Alzheimers Dis 18:691-701. 2009
    ..Overall, clinic-based persons have more Lewy bodies and atypical pathologies. The spectrum of pathologies underlying cognitive impairment in clinic-based cohorts differs from community-based cohorts...
  11. pmc The neuropathology of probable Alzheimer disease and mild cognitive impairment
    Julie A Schneider
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL, USA
    Ann Neurol 66:200-8. 2009
    ..The objective of this study was to investigate single and mixed common age-related neuropathologies in persons with probable AD and MCI...
  12. pmc Relation of neuropathology to cognition in persons without cognitive impairment
    David A Bennett
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Ann Neurol 72:599-609. 2012
    ..A study was undertaken to examine the relation of Alzheimer disease (AD) pathology, cerebral infarcts, and Lewy body (LB) pathology to cognition in persons without cognitive impairment...
  13. ncbi request reprint Olfactory identification and incidence of mild cognitive impairment in older age
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina, Ste 1038, Chicago, IL 60612, USA
    Arch Gen Psychiatry 64:802-8. 2007
    ..Mild cognitive impairment (MCI) is often a precursor to Alzheimer disease, but knowledge about factors that predict its development is limited...
  14. pmc APOE ε4, Alzheimer's disease pathology, cerebrovascular disease, and cognitive change over the years prior to death
    Lei Yu
    Rush Alzheimer s Disease Center, Rush University Medical Center
    Psychol Aging 28:1015-23. 2013
    ..The APOE ε4 allele is an important determinant of late-life change in cognition, including terminal decline, and works primarily through AD pathology...
  15. pmc Neural reserve, neuronal density in the locus ceruleus, and cognitive decline
    Robert S Wilson
    Rush Alzheimer s Disease Center and Departments of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
    Neurology 80:1202-8. 2013
    ..To test the hypothesis that higher neuronal density in brainstem aminergic nuclei contributes to neural reserve...
  16. ncbi request reprint Conscientiousness and the incidence of Alzheimer disease and mild cognitive impairment
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina, Chicago, IL 60612, USA
    Arch Gen Psychiatry 64:1204-12. 2007
    ..The personality trait of conscientiousness has been related to morbidity and mortality in old age, but its association with the development of Alzheimer disease is not known...
  17. pmc Antiphospholipid antibodies, brain infarcts, and cognitive and motor decline in aging (ABICMA): design of a community-based, longitudinal, clinical-pathological study
    Zoe Arvanitakis
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Neuroepidemiology 40:73-84. 2013
    ....
  18. ncbi request reprint Sex differences in the clinical manifestations of Alzheimer disease pathology
    Lisa L Barnes
    Rush Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    Arch Gen Psychiatry 62:685-91. 2005
    ....
  19. ncbi request reprint The apolipoprotein E epsilon 4 allele and decline in different cognitive systems during a 6-year period
    Robert S Wilson
    Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, 1645 W Jackson Blvd, Suite 675, Chicago, IL 60612, USA
    Arch Neurol 59:1154-60. 2002
    ..The apolipoprotein E (APOE) epsilon 4 allele is known to influence risk of AD but it has been difficult to establish whether it affects episodic memory differently from other cognitive functions...
  20. pmc Vulnerability to stress, anxiety, and development of dementia in old age
    Robert S Wilson
    Rush Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Am J Geriatr Psychiatry 19:327-34. 2011
    ..To identify the components of the neuroticism trait most responsible for its association with cognitive decline and dementia in old age...
  21. pmc Cerebral amyloid angiopathy pathology and cognitive domains in older persons
    Zoe Arvanitakis
    Rush Alzheimer s Disease Center, Chicago, IL, USA
    Ann Neurol 69:320-7. 2011
    ..To examine the relation of cerebral amyloid angiopathy (CAA) to cognitive domains in older community-dwelling persons with and without dementia...
  22. pmc Locus coeruleus neuron density and parkinsonism in older adults without Parkinson's disease
    Aron S Buchman
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA
    Mov Disord 27:1625-31. 2012
    ..In older adults without a clinical diagnosis of PD, neuron density in locus coeruleus nuclei is associated with the severity of parkinsonism and may contribute to late-life motor impairments...
  23. pmc Overview and findings from the rush Memory and Aging Project
    David A Bennett
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina, Suite 1028, Chicago, IL 60612, USA
    Curr Alzheimer Res 9:646-63. 2012
    ..The findings are discussed and contextualized...
  24. pmc Nigral pathology and parkinsonian signs in elders without Parkinson disease
    Aron S Buchman
    Rush Alzheimer s Disease Center, Chicago, IL, USA
    Ann Neurol 71:258-66. 2012
    ..We tested the hypothesis that nigral pathology is related to parkinsonism in older persons without Parkinson disease (PD)...
  25. ncbi request reprint Loneliness and risk of Alzheimer disease
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL 60612, USA
    Arch Gen Psychiatry 64:234-40. 2007
    ..Social isolation in old age has been associated with risk of developing dementia, but the risk associated with perceived isolation, or loneliness, is not well understood...
  26. pmc Life-span cognitive activity, neuropathologic burden, and cognitive aging
    Robert S Wilson
    Rush Alzheimer s Disease Center and Departments of Neurological Sciences, Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA
    Neurology 81:314-21. 2013
    ..To test the hypothesis that cognitive activity across the life span is related to late-life cognitive decline not linked to common neuropathologic disorders...
  27. pmc Dietary folate and vitamins B-12 and B-6 not associated with incident Alzheimer's disease
    Martha Clare Morris
    Rush Institute for Healthy Aging, Rush University Medical Center, 1645 W Jackson 675, Chicago, IL 60612, USA
    J Alzheimers Dis 9:435-43. 2006
    ..It is currently not known whether dietary intakes of folate and vitamins B12 and B6, co-factors in the methylation of homocysteine, protect against Alzheimer's disease...
  28. pmc Neuropathologic intermediate phenotypes enhance association to Alzheimer susceptibility alleles
    David A Bennett
    Rush Alzheimer s Disease Center, 600 S Paulina, Suite 1028, Chicago, IL 60062, USA
    Neurology 72:1495-503. 2009
    ....
  29. ncbi request reprint The Rush Memory and Aging Project: study design and baseline characteristics of the study cohort
    David A Bennett
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina, Suite 1028, Chicago, IL 60612, USA
    Neuroepidemiology 25:163-75. 2005
    ..Their mean age was 81 years, about a third had 12 or fewer years of education, a third were men, and about 10% were members of a racial or ethnic minority group. More than 950 already have completed their baseline clinical evaluation...
  30. pmc The Minority Aging Research Study: ongoing efforts to obtain brain donation in African Americans without dementia
    Lisa L Barnes
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina, Suite 1038, Chicago, IL 60612, USA
    Curr Alzheimer Res 9:734-45. 2012
    ..The implications of these efforts are discussed...
  31. pmc Characteristics of MR infarcts associated with dementia and cognitive function in the elderly
    Neelum T Aggarwal
    Rush University Medical Center, Chicago, IL 60612, USA Neelum_T_Aggarwal rush edu
    Neuroepidemiology 38:41-7. 2012
    ..Little information exists on the simultaneous effects of magnetic resonance (MR) infarct characteristics, that may increase the likelihood of dementia or lower cognitive function in community populations...
  32. pmc Combinations of motor measures more strongly predict adverse health outcomes in old age: the rush memory and aging project, a community-based cohort study
    Aron S Buchman
    Department of Neurological Sciences, Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA
    BMC Med 9:42. 2011
    ..We tested the hypothesis that combinations of motor constructs more strongly predict adverse health outcomes in older people...
  33. ncbi request reprint Parkinsonian signs and functional disability in old age
    Debra A Fleischman
    Rush Alzheimer s Disease Center and Departments of Neurological Sciences and Behavioral Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    Exp Aging Res 33:59-76. 2007
    ....
  34. pmc Age at surgical menopause influences cognitive decline and Alzheimer pathology in older women
    Riley Bove
    From the Program in Translational NeuroPsychiatric Genomics R B, E S, L B C, P L D, Institute for the Neurosciences, Department of Neurology, Brigham and Women s Hospital Harvard Medical School R B, L B C, P L D, Boston, MA and the Departments of Neurological Sciences L L B and Neuropathology J A S, D A B, Rush University Medical Center, Chicago, IL
    Neurology 82:222-9. 2014
    ..To determine the association between age at surgical menopause and both cognitive decline and Alzheimer disease (AD) pathology in 2 longitudinal cohorts...
  35. pmc TDP-43 pathology, cognitive decline, and dementia in old age
    Robert S Wilson
    Department of Neurological Sciences, Behavioral Sciences, and Pathology, Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, Illinois
    JAMA Neurol 70:1418-24. 2013
    ..Cognitive decline is a leading cause of disability and death in old age but its neurobiological bases are not well understood...
  36. pmc Association of brain pathology with the progression of frailty in older adults
    Aron S Buchman
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL, USA
    Neurology 80:2055-61. 2013
    ..We tested the hypothesis that brain pathology is associated with the rate of progression of physical frailty in older adults...
  37. pmc Selected findings from the Religious Orders Study and Rush Memory and Aging Project
    David A Bennett
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA David A
    J Alzheimers Dis 33:S397-403. 2013
    ..The findings illustrate the range of insights that can be gained into cognitive aging by incorporating neuropathologic indices into well designed, prospective cohort studies...
  38. pmc Overview and findings from the religious orders study
    David A Bennett
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina, Suite 1028, Chicago, IL 60612, USA
    Curr Alzheimer Res 9:628-45. 2012
    ..We then discuss and contextualize the study findings...
  39. pmc Effect of purpose in life on the relation between Alzheimer disease pathologic changes on cognitive function in advanced age
    Patricia A Boyle
    Rush Alzheimer s Disease Center, 600 S Paulina Ave, Ste 1020B, Chicago, IL 60612, USA
    Arch Gen Psychiatry 69:499-505. 2012
    ..Purpose in life is associated with a substantially reduced risk of Alzheimer disease (AD), but the neurobiologic basis of this protective effect remains unknown...
  40. ncbi request reprint Neurofibrillary tangles mediate the association of amyloid load with clinical Alzheimer disease and level of cognitive function
    David A Bennett
    Rush Alzheimer s Disease Center and the Department of Neurological Sciences Rush University Medical Center, Chicago, IL 60612, USA
    Arch Neurol 61:378-84. 2004
    ..To test the hypothesis that the association of amyloid load with clinical Alzheimer disease (AD) and cognitive impairment is mediated through neurofibrillary tangles...
  41. pmc Microinfarct pathology, dementia, and cognitive systems
    Zoe Arvanitakis
    Rush Alzheimer s Disease Center, 600 S Paulina, Suite 1020, Rush University Medical Center, Chicago, IL 60612, USA
    Stroke 42:722-7. 2011
    ..Little is known about the role of microinfarcts in dementia and cognition. We examined microinfarcts and dementia, global cognition, and 5 cognitive systems in community-dwelling older persons...
  42. ncbi request reprint Decision rules guiding the clinical diagnosis of Alzheimer's disease in two community-based cohort studies compared to standard practice in a clinic-based cohort study
    David A Bennett
    Rush Alzheimer s Disease Center, Chicago, Ill, USA
    Neuroepidemiology 27:169-76. 2006
    ..This approach holds promise for reducing the operational costs of epidemiologic studies of aging and AD...
  43. ncbi request reprint Chronic distress, age-related neuropathology, and late-life dementia
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina, Suite 1038, Chicago, IL 60612, USA
    Psychosom Med 69:47-53. 2007
    ..The objective of this study was to test whether common age-related neuropathology could account for the relation of chronic distress to dementia...
  44. ncbi request reprint Parkinsonianlike signs and risk of incident Alzheimer disease in older persons
    Robert S Wilson
    Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging and the Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Arch Neurol 60:539-44. 2003
    ..Parkinsonianlike signs are common in older persons, but little is known about how their severity or rate of progression is related to the development of Alzheimer disease (AD) or decline in cognition...
  45. ncbi request reprint The relation of cigarette smoking to incident Alzheimer's disease in a biracial urban community population
    Neelum T Aggarwal
    Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Center, Chicago, IL 60612, USA
    Neuroepidemiology 26:140-6. 2006
    ....
  46. pmc Much of late life cognitive decline is not due to common neurodegenerative pathologies
    Patricia A Boyle
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL
    Ann Neurol 74:478-89. 2013
    ..We tested the hypothesis that these pathologic indices account for the majority of late life cognitive decline...
  47. pmc Microvascular brain pathology and late-life motor impairment
    Aron S Buchman
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL, USA
    Neurology 80:712-8. 2013
    ..To test the hypothesis that microvascular brain pathology is associated with late-life motor impairment...
  48. pmc Olfactory impairment in presymptomatic Alzheimer's disease
    Robert S Wilson
    Department of Neurological Sciences, Rush Alzheimer s Disease Center, Rush University Medical Cetner, Chicago, Illinois 60612, USA
    Ann N Y Acad Sci 1170:730-5. 2009
    ....
  49. pmc Lewy bodies and olfactory dysfunction in old age
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina Avenue, Chicago, IL 60612, USA
    Chem Senses 36:367-73. 2011
    ..The findings indicate that Lewy body disease impairs late life olfactory function even in otherwise asymptomatic individuals...
  50. ncbi request reprint Chronic psychological distress and risk of Alzheimer's disease in old age
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, Ill, USA
    Neuroepidemiology 27:143-53. 2006
    ..The results support the hypothesis that distress proneness is associated with increased risk of dementia and suggest that neurobiologic mechanisms other than AD pathology may underlie the association...
  51. pmc Association of lower hemoglobin level and neuropathology in community-dwelling older persons
    Raj C Shah
    Department of Family Medicine, Rush University Medical Center, Chicago, IL 60612, USA Raj C
    J Alzheimers Dis 32:579-86. 2012
    ..In conclusion, lower hemoglobin levels appear to be associated with chronic macroscopic infarctions but not other common age-related neuropathologies...
  52. pmc Emotional neglect in childhood and cerebral infarction in older age
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL, USA
    Neurology 79:1534-9. 2012
    ..The purpose of the study was to test the hypothesis that a higher level of childhood adversity is associated with increased risk of cerebral infarction in old age...
  53. pmc Evidence for angiogenesis in Parkinson's disease, incidental Lewy body disease, and progressive supranuclear palsy
    Brinda Desai Bradaric
    Department of Pharmacology, Rush University, Cohn Research Building, 1735 W Harrison Suite 412, Chicago, IL 60612, USA
    J Neural Transm 119:59-71. 2012
    ..Such angiogenic vessels could contribute to neuroinflammation by failing to protect the parenchyma from peripheral immune cells and inflammatory or toxic factors in the peripheral circulation...
  54. ncbi request reprint Cerebral infarctions and the relationship of depression symptoms to level of cognitive functioning in older persons
    David A Bennett
    Rush Alzheimer s Disease Center, Departments of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Am J Geriatr Psychiatry 12:211-9. 2004
    ....
  55. ncbi request reprint Dietary folate and vitamin B12 intake and cognitive decline among community-dwelling older persons
    Martha Clare Morris
    Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Ill 60612, USA
    Arch Neurol 62:641-5. 2005
    ..Deficiencies in folate and vitamin B12 have been associated with neurodegenerative disease...
  56. ncbi request reprint Dietary copper and high saturated and trans fat intakes associated with cognitive decline
    Martha Clare Morris
    Department of Internal Medicine, Rush Institute for Healthy Aging, Rush University Medical Center, 1645 W Jackson Street, Chicago, IL 60612, USA
    Arch Neurol 63:1085-8. 2006
    ..Evidence from prospective epidemiologic studies and animal models suggests that intakes of dietary fats and copper may be associated with neurodegenerative diseases...
  57. ncbi request reprint Participation in cognitively stimulating activities and risk of incident Alzheimer disease
    Robert S Wilson
    Rush Alzheimer s Disease Center, 1645 W Jackson Blvd, Suite 675, Chicago, IL 60612, USA
    JAMA 287:742-8. 2002
    ..Frequent participation in cognitively stimulating activities has been hypothesized to reduce risk of Alzheimer disease (AD), but prospective data regarding an association are lacking...
  58. pmc The CETP I405V polymorphism is associated with an increased risk of Alzheimer's disease
    Lei Yu
    Rush Alzheimer s Disease Center, Department of Neurological Science, Rush University Medical Center, Chicago, IL 60612, USA
    Aging Cell 11:228-33. 2012
    ..This finding is consistent with data showing that the CETP I405V is associated with increased neuritic plaque density at autopsy...
  59. ncbi request reprint The effect of social networks on the relation between Alzheimer's disease pathology and level of cognitive function in old people: a longitudinal cohort study
    David A Bennett
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Lancet Neurol 5:406-12. 2006
    ..Few data are available about how social networks reduce the risk of cognitive impairment in old age. We aimed to measure this effect using data from a large, longitudinal, epidemiological clinicopathological study...
  60. ncbi request reprint Individual differences in rates of change in cognitive abilities of older persons
    Robert S Wilson
    Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois, USA
    Psychol Aging 17:179-93. 2002
    ..The results suggest that change in cognitive function in old age primarily reflects person-specific factors rather than an inevitable developmental process...
  61. ncbi request reprint Implicit memory and Alzheimer's disease neuropathology
    Debra A Fleischman
    Rush Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
    Brain 128:2006-15. 2005
    ..The results suggest that hallmark indices of Alzheimer's disease neuropathology are associated with performance on priming tests to the extent that conceptual, but not perceptual, processing resources are required...
  62. pmc Estimating cerebral microinfarct burden from autopsy samples
    M Brandon Westover
    Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital, and Harvard Medical School, Boston, USA
    Neurology 80:1365-9. 2013
    ..To estimate whole-brain microinfarct burden from microinfarct counts in routine postmortem examination...
  63. pmc Cerebrovascular disease pathology and parkinsonian signs in old age
    Aron S Buchman
    Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Facility, Suite 1022, 600 South Paulina Street, Chicago, IL 60612, USA
    Stroke 42:3183-9. 2011
    ..Mild motor symptoms including parkinsonian signs are common in old age, but their underlying neuropathology is unclear. We tested the hypothesis that cerebrovascular pathologies are related to parkinsonian signs...
  64. ncbi request reprint Estimation of the mediation effect with a binary mediator
    Yan Li
    Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL 60612, USA
    Stat Med 26:3398-414. 2007
    ....
  65. pmc Thoughts on B-vitamins and dementia
    Martha Clare Morris
    Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL 60612, USA
    J Alzheimers Dis 9:429-33. 2006
    ..We also comment on the potential benefits and harms of vitamin supplementation as well as make recommendations for the direction of future studies...
  66. ncbi request reprint Diabetes mellitus and progression of rigidity and gait disturbance in older persons
    Z Arvanitakis
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina, Suite 1020E, Chicago, IL 60612, USA
    Neurology 63:996-1001. 2004
    ..Few risk factors for these signs have been identified. Diabetes mellitus, also a common chronic condition in old age and known to be associated with physical and neurologic disability, may be associated with parkinsonian-like signs...
  67. doi request reprint Relation of NSAIDs to incident AD, change in cognitive function, and AD pathology
    Z Arvanitakis
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Neurology 70:2219-25. 2008
    ..To examine the relation of nonsteroidal anti-inflammatory drugs (NSAIDs) to incident Alzheimer disease (AD), change in cognition, and AD pathology...
  68. pmc Ex vivo MR volumetry of human brain hemispheres
    Aikaterini Kotrotsou
    Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, Illinois, USA
    Magn Reson Med 71:364-74. 2014
    ....
  69. pmc Correlation of amyloid PET ligand florbetapir F 18 binding with Aβ aggregation and neuritic plaque deposition in postmortem brain tissue
    Seok Rye Choi
    Avid Radiopharmaceutical Inc, 3711 Market Street, 7th Floor, Philadelphia, PA 19104, USA
    Alzheimer Dis Assoc Disord 26:8-16. 2012
    ..This study used human autopsy brain tissue to evaluate the correlation between in vitro florbetapir F 18 binding and Aβ density measured by established neuropathologic methods...
  70. pmc Physical frailty in older persons is associated with Alzheimer disease pathology
    Aron S Buchman
    Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Facility, Suite 1038, 600 S Paulina St, Chicago, IL 60612, USA
    Neurology 71:499-504. 2008
    ..We examined the extent to which physical frailty in older persons is associated with common age-related brain pathology, including cerebral infarcts, Lewy body pathology, and Alzheimer disease (AD) pathology...
  71. ncbi request reprint Improved detection of substantia nigra pathology in Alzheimer's disease
    Julie A Schneider
    Rush Alzheimer s Disease Center, Rush University and Rush Presbyterian St Luke s Medical Center, Chicago, Illinois, USA
    J Histochem Cytochem 50:99-106. 2002
    ..We show that detection of nigra pathology is influenced by histological method. Clinicopathological studies using these methods are needed to determine the role of nigral pathology in AD...
  72. ncbi request reprint Diabetes is related to cerebral infarction but not to AD pathology in older persons
    Z Arvanitakis
    Rush Alzheimer s Disease Center, 600 S Paulina, Suite 1020, Rush University Medical Center, Chicago, IL 60612, USA
    Neurology 67:1960-5. 2006
    ..To examine the potential relation of diabetes to common neuropathologic causes of dementia, cerebral infarction and Alzheimer disease (AD) neuropathology...
  73. doi request reprint Statins, incident Alzheimer disease, change in cognitive function, and neuropathology
    Z Arvanitakis
    Rush Alzheimer s Disease Center, Department of Neurological Sciences, 600 S Paulina, Suite 1020, Rush University Medical Center, Chicago, IL 60612, USA
    Neurology 70:1795-802. 2008
    ..To examine the relation of statins to incident Alzheimer disease (AD) and change in cognition and neuropathology...
  74. pmc Levels of estrogen receptors alpha and beta in frontal cortex of patients with Alzheimer's disease: relationship to Mini-Mental State Examination scores
    Jeremiah F Kelly
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Curr Alzheimer Res 5:45-51. 2008
    ....
  75. ncbi request reprint Body mass index in older persons is associated with Alzheimer disease pathology
    A S Buchman
    Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Facility, Suite 1038, 600 S Paulina St, Chicago, IL 60612, USA
    Neurology 67:1949-54. 2006
    ....
  76. pmc Memory complaints are related to Alzheimer disease pathology in older persons
    L L Barnes
    Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Facility, 600 S Paulina, Suite 1038, Chicago, IL 60612, USA
    Neurology 67:1581-5. 2006
    ..To study the relationship between Alzheimer disease (AD) pathology and memory complaints proximate to death...
  77. ncbi request reprint Neuropathology of older persons without cognitive impairment from two community-based studies
    D A Bennett
    Rush Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Neurology 66:1837-44. 2006
    ..To examine the relation of National Institute on Aging-Reagan (NIA-Reagan) neuropathologic criteria of Alzheimer disease (AD) to level of cognitive function in persons without dementia or mild cognitive impairment (MCI)...
  78. ncbi request reprint Gender, cognitive decline, and risk of AD in older persons
    L L Barnes
    Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging and Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Neurology 60:1777-81. 2003
    ..The authors investigated gender differences in rate of decline for different cognitive systems and for risk of developing AD...
  79. ncbi request reprint Depressive symptoms, clinical AD, and cortical plaques and tangles in older persons
    R S Wilson
    Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Neurology 61:1102-7. 2003
    ..Depressive symptoms in old age have been associated with risk of Alzheimer disease (AD), but it is uncertain whether they are an independent risk factor for disease or an early clinical sign of its underlying pathology...
  80. ncbi request reprint Education modifies the association of amyloid but not tangles with cognitive function
    D A Bennett
    Rush Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
    Neurology 65:953-5. 2005
    ..02) but not the association of neurofibrillary tangles with level of cognition, suggesting that education is related to factors that reduce the effect of amyloid on cognition...
  81. pmc Amyloid mediates the association of apolipoprotein E e4 allele to cognitive function in older people
    D A Bennett
    Rush Alzheimer s Disease Center, Armour Academic Center, 600 South Paulina, Suite 1028 Chicago, IL 60612, USA
    J Neurol Neurosurg Psychiatry 76:1194-9. 2005
    ..The neurobiological changes underlying the association of the apolipoprotein E (APOE) e4 allele with level of cognition are poorly understood...
  82. pmc The relationship between cerebral Alzheimer's disease pathology and odour identification in old age
    R S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina, Suite 1038, Chicago, IL 60612, USA
    J Neurol Neurosurg Psychiatry 78:30-5. 2007
    ..Olfactory dysfunction is common in old age, but its basis is uncertain...
  83. ncbi request reprint Education modifies the relation of AD pathology to level of cognitive function in older persons
    D A Bennett
    Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, Chicago, IL 60612, USA
    Neurology 60:1909-15. 2003
    ..To test the hypothesis that years of formal education modifies the relation of AD pathology to level of cognitive function...
  84. ncbi request reprint Mild cognitive impairment is related to Alzheimer disease pathology and cerebral infarctions
    D A Bennett
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL, USA
    Neurology 64:834-41. 2005
    ..To examine the extent to which persons with mild cognitive impairment have intermediate levels of Alzheimer disease (AD) pathology, cerebral infarcts, and Lewy body disease...
  85. ncbi request reprint Proneness to psychological distress is associated with risk of Alzheimer's disease
    R S Wilson
    Rush Alzheimer s Disease Center, Rush Institute for Healthy Aging, Chicago, IL 60612, USA
    Neurology 61:1479-85. 2003
    ..Chronic stress is associated with hippocampal damage and impaired memory in animals and humans...
  86. ncbi request reprint Relation of cerebral infarctions to dementia and cognitive function in older persons
    J A Schneider
    Rush AD Center and Rush Institute for Healthy Aging, Chicago, IL 60612, USA
    Neurology 60:1082-8. 2003
    ..Cerebral infarctions are common in older persons but their relationship with dementia and cognitive function remains controversial...
  87. pmc Neurodegenerative basis of age-related cognitive decline
    R S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina Ave, Suite 1038, Chicago, IL 60612, USA
    Neurology 75:1070-8. 2010
    ..To assess the contribution of dementia-related neuropathologic lesions to age-related and disease-related change in cognitive function...
  88. doi request reprint Processing resources reduce the effect of Alzheimer pathology on other cognitive systems
    P A Boyle
    Rush Alzheimer s Disease Center, Department of Behavioral Sciences, Rush University Medical Center, 600 S Paulina, 1020B, Chicago, IL 60612, USA
    Neurology 70:1534-42. 2008
    ..If this is an effective compensatory strategy, then involvement of additional cognitive systems may help maintain function in other cognitive systems despite the accumulation of pathology...
  89. ncbi request reprint Progression of gait disorder and rigidity and risk of death in older persons
    R S Wilson
    Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Neurology 58:1815-9. 2002
    ..Bradykinesia, gait disturbance, rigidity, and tremor are common motor signs in old age. All of these signs are associated with increased morbidity and mortality, but the extent to which they are progressive is unknown...
  90. ncbi request reprint Relation of cognitive activity to risk of developing Alzheimer disease
    R S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina, Suite 1038, Chicago, IL 60612, USA
    Neurology 69:1911-20. 2007
    ..Frequent cognitive activity in old age has been associated with reduced risk of Alzheimer disease (AD), but the basis of the association is uncertain...
  91. ncbi request reprint Natural history of mild cognitive impairment in older persons
    D A Bennett
    Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, Rush Presbyterian St Luke s Medical Center, Chicago, IL, USA
    Neurology 59:198-205. 2002
    ..Few large longitudinal studies have compared the natural history of mild cognitive impairment with similar persons without cognitive impairment...
  92. ncbi request reprint Cognitive activity and incident AD in a population-based sample of older persons
    R S Wilson
    Department of Neurological Sciences, Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Neurology 59:1910-4. 2002
    ..Participation in cognitively stimulating activities is hypothesized to be associated with risk of AD, but knowledge about this association is limited...
  93. ncbi request reprint Chronic distress and incidence of mild cognitive impairment
    R S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Neurology 68:2085-92. 2007
    ..Here we test the hypothesis that chronic psychological distress is associated with increased incidence of MCI in old age...
  94. ncbi request reprint Apolipoprotein E epsilon4 allele, AD pathology, and the clinical expression of Alzheimer's disease
    D A Bennett
    Rush Alzheimer s Disease Center, Chicago, Illinois 60612, USA
    Neurology 60:246-52. 2003
    ..To test the hypothesis that the APOE epsilon4 allele is associated with the clinical manifestations of AD through an association with the pathologic hallmarks of disease...
  95. pmc Evidence of angiogenic vessels in Alzheimer's disease
    Brinda S Desai
    Department of Pharmacology, Rush University Medical Center, Cohn Research Building, Chicago, IL 60612, USA
    J Neural Transm 116:587-97. 2009
    ..These data indicate that ongoing angiogenesis is present in brain regions affected by AD pathology and may be related to tissue injury...
  96. pmc Postmortem MRI of human brain hemispheres: T2 relaxation times during formaldehyde fixation
    Robert J Dawe
    Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, Illinois 60616, USA
    Magn Reson Med 61:810-8. 2009
    ..This final increase may be due to the effects of prolonged tissue decomposition, a hypothesis that is supported by numerical simulations of the fixation process...
  97. pmc Soluble α-synuclein is a novel modulator of Alzheimer's disease pathophysiology
    Megan E Larson
    Department of Neuroscience, N Bud Grossman Center for Memory Research and Care, and Institute for Translational Neuroscience, University of Minnesota, Minneapolis, Minnesota 55414, USA
    J Neurosci 32:10253-66. 2012
    ..Altogether, our data reveal an unexpected role for soluble, intraneuronal αSyn in AD pathophysiology...
  98. ncbi request reprint Glial heme oxygenase-1 expression in Alzheimer disease and mild cognitive impairment
    Hyman M Schipper
    Centre for Neurotranslational Research and Bloomfield Centre for Research in Aging, Lady Davis Institute, Sir Mortimer B Davis Jewish General Hospital, 3755 Cote St Catherine Road, Montreal, Que, Canada H3T 1E2
    Neurobiol Aging 27:252-61. 2006
    ..Cortical and hippocampal oxidative stress is a very early event in the pathogenesis of sporadic AD and correlates with the development of specific cognitive deficits in this condition...
  99. ncbi request reprint Parahippocampal tau pathology in healthy aging, mild cognitive impairment, and early Alzheimer's disease
    Thomas W Mitchell
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Ann Neurol 51:182-9. 2002
    ....
  100. ncbi request reprint The significance of Pin1 in the development of Alzheimer's disease
    Suqing Wang
    Department of Pathology and Laboratory Medicine, and Waisman Center for Developmental Disabilities, University of Wisconsin School of Medicine, Madison, WI 53705, USA
    J Alzheimers Dis 11:13-23. 2007
    ....
  101. ncbi request reprint Cognitive performance correlates with cortical isopeptide immunoreactivity as well as Alzheimer type pathology
    Deng Shun Wang
    Departments of Neuroscience and Pathology, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    J Alzheimers Dis 13:53-66. 2008
    ..Protein cross-linking and aggregation are important molecular processes in Alzheimer's disease (AD), and tissue transglutaminase (tTG) catalyzes protein cross-linking...