Julie A Schneider
Affiliation: Rush University Medical Center
Schneider J, Bienias J, Wilson R, Berry Kravis E, Evans D, Bennett D. The apolipoprotein E epsilon4 allele increases the odds of chronic cerebral infarction [corrected] detected at autopsy in older persons. Stroke. 2005;36:954-9 pubmed
..3 to 7.7) and subcortical infarctions 2.3-fold (95% CI, 1.2 to 4.5). The effect was unchanged after accounting for amyloid angiopathy. apoE epsilon4 increases the odds of chronic cerebral infarction detected at autopsy in older persons. ..
Schneider J, Arvanitakis Z, Yu L, Boyle P, Leurgans S, Bennett D. Cognitive impairment, decline and fluctuations in older community-dwelling subjects with Lewy bodies. Brain. 2012;135:3005-14 pubmed publisher
..Limbic-type Lewy body pathology is specifically associated with lower and more rapid decline in visuospatial skills. The effect of Lewy body pathology on cognition appears to be independent of Alzheimer's disease pathology. ..
Schneider J, Aggarwal N, Barnes L, Boyle P, Bennett D. The neuropathology of older persons with and without dementia from community versus clinic cohorts. J Alzheimers Dis. 2009;18:691-701 pubmed publisher
..Overall, clinic-based persons have more Lewy bodies and atypical pathologies. The spectrum of pathologies underlying cognitive impairment in clinic-based cohorts differs from community-based cohorts. ..
Kapasi A, DeCarli C, Schneider J. Impact of multiple pathologies on the threshold for clinically overt dementia. Acta Neuropathol. 2017;134:171-186 pubmed publisher
..In this review, we provide a clinical-pathological perspective on the role of multiple brain pathologies in dementia followed by a review of the available clinical and biomarker data on some of the mixed pathologies. ..
Schneider J, Arvanitakis Z, Leurgans S, Bennett D. The neuropathology of probable Alzheimer disease and mild cognitive impairment. Ann Neurol. 2009;66:200-8 pubmed publisher
..Clinically diagnosed probable AD and MCI, even amnestic MCI, are pathologically heterogeneous disorders, with many persons exhibiting mixed pathologies. ..
Schneider J, Bennett D. Where vascular meets neurodegenerative disease. Stroke. 2010;41:S144-6 pubmed publisher
..Finally, because dementia in older persons often results from mixed pathology and the clinical phenotypes overlap, some risk factors may increase risk for clinical Alzheimer's disease through an increase in vascular pathology. ..
Kapasi A, Schneider J. Vascular contributions to cognitive impairment, clinical Alzheimer's disease, and dementia in older persons. Biochim Biophys Acta. 2016;1862:878-86 pubmed publisher
..This article is part of a Special Issue entitled: Vascular Contributions to Cognitive Impairment and Dementia edited by M. Paul Murphy, Roderick A. Corriveau and Donna M. Wilcock. ..
Barone F, Gustafson D, Crystal H, Moreno H, Adamski M, Arai K, et al
. First translational 'Think Tank' on cerebrovascular disease, cognitive impairment and dementia. J Transl Med. 2016;14:50 pubmed publisher
..Below summarizes the new data-presentations, concepts, novel directions and specific discussion topics addressed by this international translational team at our "First Leo and Anne Albert Charitable Trust 'Think Tank' VCI workshop". ..
Yu L, De Jager P, Yang J, Trojanowski J, Bennett D, Schneider J. The TMEM106B locus and TDP-43 pathology in older persons without FTLD. Neurology. 2015;84:927-34 pubmed publisher
..The role of GRN expression and epigenetic mechanisms associating TMEM106B in the accumulation of TDP-43 in older persons require further study. ..