Research Topics
Species | J A SchneiderSummaryAffiliation: Rush University Medical Center Country: USA Publications
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Publications
Relation of cerebral infarctions to dementia and cognitive function in older personsJ A Schneider
Rush AD Center and Rush Institute for Healthy Aging, Chicago, IL 60612, USA
Neurology 60:1082-8. 2003..Cerebral infarctions are common in older persons but their relationship with dementia and cognitive function remains controversial...
Mild cognitive impairment is related to Alzheimer disease pathology and cerebral infarctionsD A Bennett
Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL, USA
Neurology 64:834-41. 2005..To examine the extent to which persons with mild cognitive impairment have intermediate levels of Alzheimer disease (AD) pathology, cerebral infarcts, and Lewy body disease...
Apolipoprotein E epsilon4 allele, AD pathology, and the clinical expression of Alzheimer's diseaseD A Bennett
Rush Alzheimer s Disease Center, Chicago, Illinois 60612, USA
Neurology 60:246-52. 2003..To test the hypothesis that the APOE epsilon4 allele is associated with the clinical manifestations of AD through an association with the pathologic hallmarks of disease...
Neuropathology of older persons without cognitive impairment from two community-based studiesD A Bennett
Rush Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
Neurology 66:1837-44. 2006..To examine the relation of National Institute on Aging-Reagan (NIA-Reagan) neuropathologic criteria of Alzheimer disease (AD) to level of cognitive function in persons without dementia or mild cognitive impairment (MCI)...
Memory complaints are related to Alzheimer disease pathology in older personsL L Barnes
Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Facility, 600 S Paulina, Suite 1038, Chicago, IL 60612, USA
Neurology 67:1581-5. 2006..To study the relationship between Alzheimer disease (AD) pathology and memory complaints proximate to death...
Neurodegenerative basis of age-related cognitive declineR S Wilson
Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina Ave, Suite 1038, Chicago, IL 60612, USA
Neurology 75:1070-8. 2010..To assess the contribution of dementia-related neuropathologic lesions to age-related and disease-related change in cognitive function...
Relation of NSAIDs to incident AD, change in cognitive function, and AD pathologyZ Arvanitakis
Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
Neurology 70:2219-25. 2008..To examine the relation of nonsteroidal anti-inflammatory drugs (NSAIDs) to incident Alzheimer disease (AD), change in cognition, and AD pathology...
Chronic distress and incidence of mild cognitive impairmentR S Wilson
Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
Neurology 68:2085-92. 2007..Here we test the hypothesis that chronic psychological distress is associated with increased incidence of MCI in old age...
Cerebral infarctions and the likelihood of dementia from Alzheimer disease pathologyJ A Schneider
Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL 60612, USA
Neurology 62:1148-55. 2004..Alzheimer disease (AD) is the most common cause of dementia. The effect of cerebral infarctions on the likelihood of dementia from AD pathology is not well understood...
Depressive symptoms, clinical AD, and cortical plaques and tangles in older personsR S Wilson
Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
Neurology 61:1102-7. 2003..Depressive symptoms in old age have been associated with risk of Alzheimer disease (AD), but it is uncertain whether they are an independent risk factor for disease or an early clinical sign of its underlying pathology...
Education modifies the relation of AD pathology to level of cognitive function in older personsD A Bennett
Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, Chicago, IL 60612, USA
Neurology 60:1909-15. 2003..To test the hypothesis that years of formal education modifies the relation of AD pathology to level of cognitive function...
Statins, incident Alzheimer disease, change in cognitive function, and neuropathologyZ Arvanitakis
Rush Alzheimer s Disease Center, Department of Neurological Sciences, 600 S Paulina, Suite 1020, Rush University Medical Center, Chicago, IL 60612, USA
Neurology 70:1795-802. 2008..To examine the relation of statins to incident Alzheimer disease (AD) and change in cognition and neuropathology...
Education modifies the association of amyloid but not tangles with cognitive functionD A Bennett
Rush Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
Neurology 65:953-5. 2005..02) but not the association of neurofibrillary tangles with level of cognition, suggesting that education is related to factors that reduce the effect of amyloid on cognition...
The apolipoprotein E epsilon4 allele increases the odds of chronic cerebral infarction [corrected] detected at autopsy in older personsJ A Schneider
Rush AD Center and Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, Ill, USA
Stroke 36:954-9. 2005..Little data are available regarding the relation of apoE epsilon4 to cerebral infarctions documented on postmortem examination...
Diabetes is related to cerebral infarction but not to AD pathology in older personsZ Arvanitakis
Rush Alzheimer's Disease Center, 600 S. Paulina, Suite 1020, Rush University Medical Center, Chicago, IL 60612, USA
Neurology 67:1960-5. 2006..CONCLUSION: We found a relation between diabetes and cerebral infarction but not between diabetes and Alzheimer disease pathology in older persons...
Processing resources reduce the effect of Alzheimer pathology on other cognitive systemsP A Boyle
Rush Alzheimer s Disease Center, Department of Behavioral Sciences, Rush University Medical Center, 600 S Paulina, 1020B, Chicago, IL 60612, USA
Neurology 70:1534-42. 2008..If this is an effective compensatory strategy, then involvement of additional cognitive systems may help maintain function in other cognitive systems despite the accumulation of pathology...
Diabetes mellitus and progression of rigidity and gait disturbance in older personsZ Arvanitakis
Rush Alzheimer's Disease Center, Rush University Medical Center, 600 S. Paulina, Suite 1020E, Chicago, IL 60612, USA
Neurology 63:996-1001. 2004..08). CONCLUSION: Diabetes may be a previously unrecognized risk factor for progression of parkinsonian-like signs in older persons...
Amyloid mediates the association of apolipoprotein E e4 allele to cognitive function in older peopleD A Bennett
Rush Alzheimer s Disease Center, Armour Academic Center, 600 South Paulina, Suite 1028 Chicago, IL 60612, USA
J Neurol Neurosurg Psychiatry 76:1194-9. 2005..The neurobiological changes underlying the association of the apolipoprotein E (APOE) e4 allele with level of cognition are poorly understood...
Cognitive activity and incident AD in a population-based sample of older personsR S Wilson
Department of Neurological Sciences, Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
Neurology 59:1910-4. 2002..Participation in cognitively stimulating activities is hypothesized to be associated with risk of AD, but knowledge about this association is limited...
Proneness to psychological distress is associated with risk of Alzheimer's diseaseR S Wilson
Rush Alzheimer s Disease Center, Rush Institute for Healthy Aging, Chicago, IL 60612, USA
Neurology 61:1479-85. 2003..Chronic stress is associated with hippocampal damage and impaired memory in animals and humans...
Gender, cognitive decline, and risk of AD in older personsL L Barnes
Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging and Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
Neurology 60:1777-81. 2003..The authors investigated gender differences in rate of decline for different cognitive systems and for risk of developing AD...
Relation of cognitive activity to risk of developing Alzheimer diseaseR S Wilson
Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina, Suite 1038, Chicago, IL 60612, USA
Neurology 69:1911-20. 2007..Frequent cognitive activity in old age has been associated with reduced risk of Alzheimer disease (AD), but the basis of the association is uncertain...
The relationship between cerebral Alzheimer's disease pathology and odour identification in old ageR S Wilson
Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina, Suite 1038, Chicago, IL 60612, USA
J Neurol Neurosurg Psychiatry 78:30-5. 2007..Olfactory dysfunction is common in old age, but its basis is uncertain...
Body mass index in older persons is associated with Alzheimer disease pathologyA S Buchman
Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Facility, Suite 1038, 600 S Paulina St, Chicago, IL 60612, USA
Neurology 67:1949-54. 2006....
Natural history of mild cognitive impairment in older personsD A Bennett
Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, Rush Presbyterian St Luke s Medical Center, Chicago, IL, USA
Neurology 59:198-205. 2002..Few large longitudinal studies have compared the natural history of mild cognitive impairment with similar persons without cognitive impairment...
Cognitive impairment, decline and fluctuations in older community-dwelling subjects with Lewy bodiesJ A Schneider
Rush Alzheimer s Disease Centre, Rush University Medical Centre, Chicago, IL 60612, USA
Brain 135:3005-14. 2012..Limbic-type Lewy body pathology is specifically associated with lower and more rapid decline in visuospatial skills. The effect of Lewy body pathology on cognition appears to be independent of Alzheimer's disease pathology...
Progression of gait disorder and rigidity and risk of death in older personsR S Wilson
Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
Neurology 58:1815-9. 2002..Bradykinesia, gait disturbance, rigidity, and tremor are common motor signs in old age. All of these signs are associated with increased morbidity and mortality, but the extent to which they are progressive is unknown...
A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutaseS Melov
Center for Molecular Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Nat Genet 18:159-63. 1998..Consequently, MnTBAP-treated Sod2tm1Cje(-/-) mice may provide an excellent model for examining the relationship between free radicals and neurodegenerative diseases and for screening new drugs to treat these disorders...
HIV infection dynamics in rural Andhra Pradesh south India: a sexual-network analysis exploratory studyJ A Schneider
Center for AIOS Research, Lifespan Tufts Brown, Boston, USA
AIDS Care 19:1171-6. 2007..Public health interventions aimed at reducing HIV transmission in rural AP should consider targeting sub-populations of men who engage in covert MSM or CSW, high-risk tribal caste members and at-risk wives...
Lifespan extension and rescue of spongiform encephalopathy in superoxide dismutase 2 nullizygous mice treated with superoxide dismutase-catalase mimeticsS Melov
Buck Institute for Age Research, Novato, California 94945, USA
J Neurosci 21:8348-53. 2001....
