Genomes and Genes
Affiliation: Rush University Medical Center
- Podocyte biology and pathogenesis of kidney diseaseJochen Reiser
Department of Medicine, Rush University Medical Center, Chicago, Illinois 60612, USA
Annu Rev Med 64:357-66. 2013..Loss of these actin-driven membrane extensions is tightly connected to the presence of protein in the urine, podocyte loss, development of CKD, and ultimately renal failure...
- Leptin deficiency-induced obesity affects the density of mast cells in abdominal fat depots and lymph nodes in miceMehmet M Altintas
Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA
Lipids Health Dis 11:21. 2012..Furthermore, mast cells containing immunoreactive tumor necrosis factor-α (TNF-α), a proinflammatory cytokine involved in obesity-linked insulin resistance, were identified by immunostaining...
- Circulating urokinase receptor as a cause of focal segmental glomerulosclerosisChangli Wei
Department of Medicine, Miller School of Medicine, University of Miami, Miami, Florida, USA
Nat Med 17:952-60. 2011..Our study identifies serum suPAR as a circulating factor that may cause FSGS...
- CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survivalSuma Yaddanapudi
Nephrology Division, Department of Medicine, Harvard Medical School and Massachusetts General Hospital, Charlestown, Massachusetts, USA
J Clin Invest 121:3965-80. 2011..Our study identifies CD2AP as the gatekeeper of the podocyte TGF-β response through its regulation of CatL expression and defines a molecular mechanism underlying proteinuric kidney disease...
- Prkdc participates in mitochondrial genome maintenance and prevents Adriamycin-induced nephropathy in miceNatalia Papeta
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
J Clin Invest 120:4055-64. 2010..These findings implicate mtDNA damage in the development of ADR toxicity and identify Prkdc as a MDDS modifier gene and a component of the mitochondrial genome maintenance pathway...
- Apoptosis, mastocytosis, and diminished adipocytokine gene expression accompany reduced epididymal fat mass in long-standing diet-induced obese miceMehmet M Altintas
Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA
Lipids Health Dis 10:198. 2011..Moreover, gene and/or protein expression of several adipocytokines (leptin, adiponectin, TNF-α, IL-10, IL-6, MCP-1), F4/80, mMCP6, cleaved caspase-3 were determined...
- Proteinuria: an enzymatic disease of the podocyte?Peter Mundel
Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
Kidney Int 77:571-80. 2010..Finally, we describe signaling pathways controlling the podocyte actin cytoskeleton and motility and how these pathways can be manipulated for therapeutic benefit...
- Specialized roles for cysteine cathepsins in health and diseaseJochen Reiser
Department of Medicine, Leonard Miller School of Medicine, University of Miami, Miami, Florida, USA
J Clin Invest 120:3421-31. 2010..In particular, we highlight the emerging roles of various cathepsin forms in disease, particularly those of the cardiac and renal systems...
- Direct dynamin-actin interactions regulate the actin cytoskeletonChangkyu Gu
Nephrology Division, Department of Medicine, Harvard Medical School and Massachusetts General Hospital, Charlestown, MA 02129, USA
EMBO J 29:3593-606. 2010..Together, our results support a model in which assembled dynamin, generated through interactions with short actin filaments, promotes actin polymerization via displacement of actin-CPs...
- Small molecule-mediated activation of the integrin CD11b/CD18 reduces inflammatory diseaseDony Maiguel
Division of Nephrology and Hypertension, Department of Medicine, University of Miami, Miami, FL 33136, USA
Sci Signal 4:ra57. 2011..Thus, we propose that pharmacological activation of CD11b/CD18 offers an alternative therapeutic approach for inflammatory diseases...
- Soluble urokinase receptor and focal segmental glomerulosclerosisJochen Reiser
Department of Medicine, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
Curr Opin Nephrol Hypertens 21:428-32. 2012..We discuss recent work on the pathogenetic mechanism of focal segmental glomerulosclerosis (FSGS) and its relationship to soluble urokinase receptor (suPAR)...
- Circulating suPAR in two cohorts of primary FSGSChangli Wei
Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA
J Am Soc Nephrol 23:2051-9. 2012..The associations between a change in circulating suPAR with different therapeutic regimens and with remission support the role of suPAR in the pathogenesis of FSGS...
- Sensitizing the Slit Diaphragm with TRPC6 ion channelsClemens C Möller
Department of Medicine, Program in Glomerular Disease and Nephrology Division, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
J Am Soc Nephrol 20:950-3. 2009..This article illustrates how recent findings add to emerging concepts in podocyte biology, particularly mechanosensation and signaling at the slit diaphragm...
- The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine AChristian Faul
Department of Medicine, University of Miami Miller School of Medicine, 1600 Northwest Tenth Avenue, Miami, Florida 33136, USA
Nat Med 14:931-8. 2008..Novel calcineurin substrates such as synaptopodin may provide promising starting points for antiproteinuric drugs that avoid the serious side effects of long-term CsA treatment...
- Expression of fgf23 and αklotho in developing embryonic tissues and adult kidney of the zebrafish, Danio rerioSteve Mangos
Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA
Nephrol Dial Transplant 27:4314-22. 2012..These data indicate conservation of the FGF23-αklotho system across species and suggest a likely role for αklotho in the proximal and distal tubules...
- Podocyte GTPases regulate kidney filter dynamicsAndreas D Kistler
Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
Kidney Int 81:1053-5. 2012..Wang et al. show that both overactivation and underactivation of RhoA lead to podocyte foot process effacement and proteinuria in vivo. These data suggest that podocyte health requires a well-controlled balance between the two extremes...
- Rituximab targets podocytes in recurrent focal segmental glomerulosclerosisAlessia Fornoni
Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
Sci Transl Med 3:85ra46. 2011..Our study suggests that treatment of high-risk patients with rituximab at time of kidney transplant might prevent recurrent FSGS by modulating podocyte function in an SMPDL-3b-dependent manner...
- TRPC channel modulation in podocytes-inching toward novel treatments for glomerular diseaseShafic El Hindi
Department of Medicine, Division of Nephrology and Hypertension, Leonard Miller School of Medicine, University of Miami, Miami, FL, USA
Pediatr Nephrol 26:1057-64. 2011..The question now is how to define targets for novel improved therapies. In this review, we summarize critical points around targeting the TRPC6 channel in podocytes...
- Mast cells, macrophages, and crown-like structures distinguish subcutaneous from visceral fat in miceMehmet M Altintas
Department of Medicine, Leonard Miller School of Medicine, University of Miami, Miami, FL, USA
J Lipid Res 52:480-8. 2011..The increase in mast cells in visceral fat of obese mice suggests their role in the pathogenesis of obesity and insulin resistance...
- Modification of kidney barrier function by the urokinase receptorChangli Wei
Nephrology Division and Program in Glomerular Disease, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
Nat Med 14:55-63. 2008..Blockade of alphavbeta3 integrin reduces podocyte motility in vitro and lowers proteinuria in mice. Our findings show a physiological role for uPAR signaling in the regulation of kidney permeability...
- Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney diseaseSanja Sever
Department of Medicine, Nephrology Division and Program in Glomerular Disease, Massachusetts General Hospital MGH and Harvard Medical School, Boston, Massachusetts 02129, USA
J Clin Invest 117:2095-104. 2007..Our study identifies dynamin as a critical regulator of renal permselectivity that is specifically targeted by proteolysis under pathological conditions...