K Masuda

Summary

Affiliation: Rush University Medical Center
Country: USA

Publications

  1. ncbi request reprint Platelet-rich plasma stimulates porcine articular chondrocyte proliferation and matrix biosynthesis
    K Akeda
    Department of Orthopedic Surgery, Rush Medical College at Rush University Medical Center, Chicago, IL 60612, USA
    Osteoarthritis Cartilage 14:1272-80. 2006
  2. ncbi request reprint A novel rabbit model of mild, reproducible disc degeneration by an anulus needle puncture: correlation between the degree of disc injury and radiological and histological appearances of disc degeneration
    Koichi Masuda
    Department of Orthopedic Surgery, Rush Medical College, Chicago, Illinois 60612, USA
    Spine (Phila Pa 1976) 30:5-14. 2005
  3. pmc Prevention of disc degeneration with growth factors
    Koichi Masuda
    Department of Orthopedic Surgery, Rush Medical College at Rush University Medical Center, Chicago, Illinois, USA
    Eur Spine J 15:S422-32. 2006
  4. ncbi request reprint Recombinant osteogenic protein-1 upregulates extracellular matrix metabolism by rabbit annulus fibrosus and nucleus pulposus cells cultured in alginate beads
    K Masuda
    Departments of Orthopedic Surgery and Biochemistry, Rush Medical College at Rush Presbyterian St Luke s Medical Center, 1653 W Congress Parkway, Chicago, IL 60612, USA
    J Orthop Res 21:922-30. 2003
  5. ncbi request reprint Osteogenic protein-1 promotes the formation of tissue-engineered cartilage using the alginate-recovered-chondrocyte method
    K Masuda
    Department of Orthopedic Surgery, Rush Medical College at Rush University Medical Center, 1653 W Congress Parkway, Chicago, IL 60612, USA
    Osteoarthritis Cartilage 14:384-91. 2006
  6. ncbi request reprint A novel two-step method for the formation of tissue-engineered cartilage by mature bovine chondrocytes: the alginate-recovered-chondrocyte (ARC) method
    Koichi Masuda
    Department of Orthopedic Surgery and Biochemistry, Rush Medical College, 1653 W Congress Parkway, Chicago, IL 60612, USA
    J Orthop Res 21:139-48. 2003
  7. ncbi request reprint Osteogenic protein-1 injection into a degenerated disc induces the restoration of disc height and structural changes in the rabbit anular puncture model
    Koichi Masuda
    Department of Orthopedic Surgery, Rush Medical College at Rush University Medical Center, Chicago, IL, USA
    Spine (Phila Pa 1976) 31:742-54. 2006
  8. ncbi request reprint A new culture system to study the metabolism of the intervertebral disc in vitro
    K Chiba
    Department of Orthopedic Surgery, Rush Medical College at Rush Presbyterian St Luke s Medical Center, Chicago, Ilinois, USA
    Spine (Phila Pa 1976) 23:1821-7; discussion 1828. 1998
  9. ncbi request reprint Metabolism of the extracellular matrix formed by intervertebral disc cells cultured in alginate
    K Chiba
    Department of Orthopedic Surgery, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois, USA
    Spine (Phila Pa 1976) 22:2885-93. 1997
  10. ncbi request reprint Compartmentalization of the matrix formed by nucleus pulposus and annulus fibrosus cells in alginate gel
    E Thonar
    Department of Biochemistry, Rush Medical College at Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Biochem Soc Trans 30:874-8. 2002

Collaborators

Detail Information

Publications60

  1. ncbi request reprint Platelet-rich plasma stimulates porcine articular chondrocyte proliferation and matrix biosynthesis
    K Akeda
    Department of Orthopedic Surgery, Rush Medical College at Rush University Medical Center, Chicago, IL 60612, USA
    Osteoarthritis Cartilage 14:1272-80. 2006
    ....
  2. ncbi request reprint A novel rabbit model of mild, reproducible disc degeneration by an anulus needle puncture: correlation between the degree of disc injury and radiological and histological appearances of disc degeneration
    Koichi Masuda
    Department of Orthopedic Surgery, Rush Medical College, Chicago, Illinois 60612, USA
    Spine (Phila Pa 1976) 30:5-14. 2005
    ..OBJECTIVE.: To establish a reproducible rabbit model of disc degeneration by puncturing the anulus with needles of defined gauges and to compare it to the classic stab model...
  3. pmc Prevention of disc degeneration with growth factors
    Koichi Masuda
    Department of Orthopedic Surgery, Rush Medical College at Rush University Medical Center, Chicago, Illinois, USA
    Eur Spine J 15:S422-32. 2006
    ..Therefore, further studies on the effect of growth factor therapy on pain are essential to shed light on its therapeutic usefulness for degenerative disc disease...
  4. ncbi request reprint Recombinant osteogenic protein-1 upregulates extracellular matrix metabolism by rabbit annulus fibrosus and nucleus pulposus cells cultured in alginate beads
    K Masuda
    Departments of Orthopedic Surgery and Biochemistry, Rush Medical College at Rush Presbyterian St Luke s Medical Center, 1653 W Congress Parkway, Chicago, IL 60612, USA
    J Orthop Res 21:922-30. 2003
    ..The results presented here provide evidence of the ability of rhOP-1 to stimulate the metabolism of both rabbit AF and NP cells cultured in alginate beads...
  5. ncbi request reprint Osteogenic protein-1 promotes the formation of tissue-engineered cartilage using the alginate-recovered-chondrocyte method
    K Masuda
    Department of Orthopedic Surgery, Rush Medical College at Rush University Medical Center, 1653 W Congress Parkway, Chicago, IL 60612, USA
    Osteoarthritis Cartilage 14:384-91. 2006
    ....
  6. ncbi request reprint A novel two-step method for the formation of tissue-engineered cartilage by mature bovine chondrocytes: the alginate-recovered-chondrocyte (ARC) method
    Koichi Masuda
    Department of Orthopedic Surgery and Biochemistry, Rush Medical College, 1653 W Congress Parkway, Chicago, IL 60612, USA
    J Orthop Res 21:139-48. 2003
    ..This scaffold-free system appears ideal to study, in vitro, the development of transplantable cartilaginous tissue...
  7. ncbi request reprint Osteogenic protein-1 injection into a degenerated disc induces the restoration of disc height and structural changes in the rabbit anular puncture model
    Koichi Masuda
    Department of Orthopedic Surgery, Rush Medical College at Rush University Medical Center, Chicago, IL, USA
    Spine (Phila Pa 1976) 31:742-54. 2006
    ..In vivo study of the effect of injection of osteogenic protein-1 (OP-1) on a rabbit anular needle puncture model of intervertebral disc (IVD) degeneration...
  8. ncbi request reprint A new culture system to study the metabolism of the intervertebral disc in vitro
    K Chiba
    Department of Orthopedic Surgery, Rush Medical College at Rush Presbyterian St Luke s Medical Center, Chicago, Ilinois, USA
    Spine (Phila Pa 1976) 23:1821-7; discussion 1828. 1998
    ..CONCLUSIONS: This new alginate tissue culture system should prove useful for studying the metabolism of whole intervertebral discs...
  9. ncbi request reprint Metabolism of the extracellular matrix formed by intervertebral disc cells cultured in alginate
    K Chiba
    Department of Orthopedic Surgery, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois, USA
    Spine (Phila Pa 1976) 22:2885-93. 1997
    ..This may help explain why damage to the NP often is accompanied by progressive degeneration of the disc in vivo...
  10. ncbi request reprint Compartmentalization of the matrix formed by nucleus pulposus and annulus fibrosus cells in alginate gel
    E Thonar
    Department of Biochemistry, Rush Medical College at Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Biochem Soc Trans 30:874-8. 2002
    ....
  11. ncbi request reprint Trabecular angle of the human talus is associated with the level of cartilage degeneration
    A Schiff
    Rush Medical College, Chicago, IL 60612, USA
    J Musculoskelet Neuronal Interact 7:224-30. 2007
    ..75, p<0.01; left talus R=0.79, p<0.01)...
  12. pmc Intervertebral disc degeneration: biological and biomechanical factors
    Howard S An
    Department of Orthopedic Surgery, Rush Medical College at Rush University Medical Center, 1653 W Congress Parkway, Chicago, IL 60612, USA
    J Orthop Sci 11:541-52. 2006
  13. ncbi request reprint Tailoring secretion of proteoglycan 4 (PRG4) in tissue-engineered cartilage
    Travis J Klein
    Department of Bioengineering, University of California San Diego, La Jolla, California 92093 0412, USA
    Tissue Eng 12:1429-39. 2006
    ..Tailoring secretion of PRG4 in cartilage constructs may be useful for enhancing low-friction properties at the articular surface, while maintaining other surfaces free of PRG4 for enhancing integration with surrounding tissues...
  14. ncbi request reprint Osteogenic protein-1 is most effective in stimulating nucleus pulposus and annulus fibrosus cells to repair their matrix after chondroitinase ABC-induced in vitro chemonucleolysis
    Kenji Takegami
    Department of Biochemistry, Rush University Medical Center, 1653 West Congress Parkway, Chicago, IL 60612, USA
    Spine J 5:231-8. 2005
    ..A recent study showed that osteogenic protein-1 (OP-1) is very effective in stimulating the production and formation of the extracellular matrix by rabbit intervertebral disc cells...
  15. ncbi request reprint Intradiscal injections of osteogenic protein-1 restore the viscoelastic properties of degenerated intervertebral discs
    Kei Miyamoto
    Department of Orthopedic Surgery, Rush University Medical Center, 1735 W Harrison Street, Chicago, IL 60612 USA
    Spine J 6:692-703. 2006
    ..However, very little is known about how such a biological therapeutic approach affects the biomechanical properties of the degenerated IVD...
  16. ncbi request reprint Effects of growth differentiation factor-5 on the intervertebral disc--in vitro bovine study and in vivo rabbit disc degeneration model study
    Takehide Chujo
    Orthopedic Surgery, Rush Medical College at Rush University Medical Center, Chicago, IL, USA
    Spine (Phila Pa 1976) 31:2909-17. 2006
    ..In vitro studies on the effects of recombinant human growth and differentiation factor-5 (rhGDF-5) on matrix metabolism of bovine intervertebral disc cells and an in vivo study on the effect of rhGDF-5 in the rabbit anular puncture model...
  17. ncbi request reprint Mechanisms of cartilage growth: modulation of balance between proteoglycan and collagen in vitro using chondroitinase ABC
    Anna Asanbaeva
    University of California, San Diego, La Jolla, CA 92093, USA
    Arthritis Rheum 56:188-98. 2007
    ....
  18. ncbi request reprint The expression of NG2 proteoglycan in the human intervertebral disc
    Koji Akeda
    Department of Orthopedic Surgery, Rush Medical College at Rush University Medical Center, Chicago, IL, USA
    Spine (Phila Pa 1976) 32:306-14. 2007
    ..Immunohistochemical and biochemical analyses of NG2 proteoglycan in the human intervertebral disc...
  19. ncbi request reprint Nerve fiber ingrowth into scar tissue formed following nucleus pulposus extrusion in the rabbit anular-puncture disc degeneration model: effects of depth of puncture
    Yasuchika Aoki
    Departments of Orthopedic Surgery, Rush Medical College at Rush University Medical Center, Chicago, IL 60612, USA
    Spine (Phila Pa 1976) 31:E774-80. 2006
    ..In vivo histologic study of nerve ingrowth in the rabbit anular-puncture disc degeneration model...
  20. ncbi request reprint Proinflammatory cytokines stimulate the expression of nerve growth factor by human intervertebral disc cells
    Yumiko Abe
    Department of Orthopedic Surgery, Rush Medical College at Rush University Medical Center, Chicago IL, USA
    Spine (Phila Pa 1976) 32:635-42. 2007
    ..In vitro studies of the effects of proinflammatory cytokines on the production of nerve growth factor (NGF) by human intervertebral disc (IVD) cells...
  21. pmc Shaped, stratified, scaffold-free grafts for articular cartilage defects
    Eunhee Han
    Department of Bioengineering, University of California San Diego, 9500 Gilman Drive, MC 0412, La Jolla, CA 92093 0412, USA
    Clin Orthop Relat Res 466:1912-20. 2008
    ..This shaping method, combined with biomimetic stratification, has the potential to create anatomically contoured large cartilaginous constructs...
  22. pmc Articular cartilage tensile integrity: modulation by matrix depletion is maturation-dependent
    Anna Asanbaeva
    Department of Bioengineering and Whitaker Institute of Biomedical Engineering, 9500 Gilman Drive, Mail Code 0412, University of California, San Diego, La Jolla, CA 92093 0412, USA
    Arch Biochem Biophys 474:175-82. 2008
    ....
  23. ncbi request reprint Aggrecanases and aggrecanase-generated fragments in the human intervertebral disc at early and advanced stages of disc degeneration
    Kalpa P Patel
    Departmentsof Orthopedic Surgery, Rush Medical College at Rush University Medical Center, Chicago, IL 60612, USA
    Spine (Phila Pa 1976) 32:2596-603. 2007
    ..A comparative study of aggrecanases and aggrecan fragmentation profile in the human intervertebral disc at early and advanced stages of disc degeneration...
  24. pmc Regulation of immature cartilage growth by IGF-I, TGF-beta1, BMP-7, and PDGF-AB: role of metabolic balance between fixed charge and collagen network
    Anna Asanbaeva
    Department of Bioengineering and Whitaker Institute of Biomedical Engineering, University of California San Diego, 9500 Gilman Dr, Mail Code 0412, La Jolla, CA 92093 0412, USA
    Biomech Model Mechanobiol 7:263-76. 2008
    ..These results demonstrate that the phenotype of cartilage growth, and the associated balance between proteoglycan content and integrity of the collagen network, is regulated differentially by certain growth factors...
  25. ncbi request reprint Effect of osteogenic protein-1 on the matrix metabolism of bovine tendon cells
    Michiaki Yamada
    Department of Orthopedic Surgery, Rush University Medical Center, 1735 W Harrison Street, Cohn 720, Chicago, Illinois 60612, USA
    J Orthop Res 26:42-8. 2008
    ..These biological properties may be used in the tissue-engineering of tendon tissues...
  26. pmc Are animal models useful for studying human disc disorders/degeneration?
    Mauro Alini
    AO Research Institute, Clavadelerstrasse, 7270, Davos, Switzerland
    Eur Spine J 17:2-19. 2008
    ....
  27. pmc Articular cartilage mechanical and biochemical property relations before and after in vitro growth
    Timothy Ficklin
    Department of Mechanical Engineering, California Polytechnic State University, San Luis Obispo, CA 93407, USA
    J Biomech 40:3607-14. 2007
    ..COL network weakening during in vitro growth due to reduced COL and PYR was accompanied by reduced CC/UCC moduli and increased UCC Poisson's ratios...
  28. ncbi request reprint Short-term retention of labeled chondrocyte subpopulations in stratified tissue-engineered cartilaginous constructs implanted in vivo in mini-pigs
    Kanika Chawla
    Department of Bioengineering, University of California, San Diego, La Jolla, California 92093 0412, USA
    Tissue Eng 13:1525-37. 2007
    ..Distribution of labeled cells indicated interactions between implanted and host cells. Longer-term in vivo studies will be useful in determining whether implanted cells are sufficient to have a positive effect in repair...
  29. ncbi request reprint Matrix replenishment by intervertebral disc cells after chemonucleolysis in vitro with chondroitinase ABC and chymopapain
    Kazuhiro Chiba
    Department of Orthopedic Surgery, Rush Medical College at Rush University Medical Center, Chicago, IL 60612, USA
    Spine J 7:694-700. 2007
    ..It has been suggested that the enzymes used for chemonucleolysis differentially affect the potential of the disc cells to promote repair...
  30. ncbi request reprint Recombinant human osteogenic protein-1 upregulates proteoglycan metabolism of human anulus fibrosus and nucleus pulposus cells
    Yoshiyuki Imai
    Department of Orthopedic Surgery, Rush Medical College at Rush University Medical Center, Chicago, IL 60612, USA
    Spine (Phila Pa 1976) 32:1303-9; discussion 1310. 2007
    ..In vitro assessment of the effects of recombinant human osteogenic protein-1 (rhOP-1) on the proteoglycan metabolism of human intervertebral disc cells...
  31. ncbi request reprint Restoration of disc height loss by recombinant human osteogenic protein-1 injection into intervertebral discs undergoing degeneration induced by an intradiscal injection of chondroitinase ABC
    Yoshiyuki Imai
    Department of Orthopedic Surgery, Rush Medical College at Rush University Medical Center, Chicago, IL 60612, USA
    Spine (Phila Pa 1976) 32:1197-205. 2007
    ..In vivo study of the effect of an injection of recombinant human osteogenic protein-1 into degenerated discs induced by chondroitinase ABC...
  32. pmc A cartilage growth mixture model with collagen remodeling: validation protocols
    Stephen M Klisch
    Department of Mechanical Engineering, California Polytechnic State University, San Luis Obispo, CA 93407, USA
    J Biomech Eng 130:031006. 2008
    ..The results suggest that the CGM model may help us to guide in vitro growth protocols for AC tissue via the a priori prediction of geometric and biomechanical properties...
  33. ncbi request reprint Comparison of cellular response in bovine intervertebral disc cells and articular chondrocytes: effects .of lipopolysaccharide on proteoglycan metabolism
    Yoichi Aota
    Department of Orthopedic Surgery, Rush Medical College at Rush University Medical Center, Chicago, IL, USA
    Cell Tissue Res 326:787-93. 2006
    ..The dissimilar effects of LPS on the various cell types suggest metabolic differences between these cells and may further indicate a divergence in pathways of LPS signaling and a differential sensitivity to exogenous stimuli such as LPS...
  34. ncbi request reprint Tracking chondrocytes and assessing their proliferation with PKH26: effects on secretion of proteoglycan 4 (PRG4)
    Kanika Chawla
    Department of Bioengineering, University of California San Diego, 9500 Gilman Dr, MC 0412, La Jolla, California 92093 0412, USA
    J Orthop Res 24:1499-508. 2006
    ....
  35. pmc Targeted disruption of TGF-beta/Smad3 signaling modulates skin fibrosis in a mouse model of scleroderma
    Gabriella Lakos
    Section of Rheumatology, College of Medicine, University of Illinois at Chicago, 900 S Ashland Avenue, Chicago, IL 60607, USA
    Am J Pathol 165:203-17. 2004
    ..Reduced fibrosis is due to deregulated fibroblast function, as the inflammatory response induced by bleomycin was similar in wild-type and Smad3(-/-) mice...
  36. ncbi request reprint Growth factors and treatment of intervertebral disc degeneration
    Koichi Masuda
    Department of Orthopedic Surgery, Rush Medical College at Rush University Medical Center, Chicago, IL 60612, USA
    Spine (Phila Pa 1976) 29:2757-69. 2004
    ..Literature review...
  37. ncbi request reprint Age-related differences in the accumulation and size of hyaluronan in alginate culture
    Hiroshi Kamada
    Department of Biochemistry, Rush Medical College at Rush Presbyterian St Luke s Medical Center, 1653 W Congress Parkway, Chicago, IL 60612, USA
    Arch Biochem Biophys 408:192-9. 2002
    ..It does not appear to simply be the result of age-related changes occurring slowly with time after synthesis, as was previously suggested to be the case for human articular cartilage...
  38. ncbi request reprint Growth factor osteogenic protein-1: differing effects on cells from three distinct zones in the bovine intervertebral disc
    Yejia Zhang
    Department of Physical Medicine and Rehabilitation, Rush University Medical Center, Chicago, Illinois, USA
    Am J Phys Med Rehabil 83:515-21. 2004
    ..The new knowledge gained will help determine if treatment of degenerative disc disease with purified growth factors is effective and will provide guidance in terms of the injection technique and frequency of treatments required...
  39. ncbi request reprint Tissue-engineered human nasal septal cartilage using the alginate-recovered-chondrocyte method
    Stanley H Chia
    Division of Head and Neck Surgery, University of California, San Diego, USA
    Laryngoscope 114:38-45. 2004
    ..The objective of this study was to determine whether cartilage tissue could be generated using the alginate-recovered-chondrocyte (ARC) method, in which chondrocytes are cultured in alginate as an intermediate step in tissue fabrication...
  40. ncbi request reprint Growth of immature articular cartilage in vitro: correlated variation in tensile biomechanical and collagen network properties
    Amanda K Williamson
    Department of Bioengineering and Whitaker Institute of Biomedical Engineering, University of California, San Diego, La Jolla, California 92093 0412, USA
    Tissue Eng 9:625-34. 2003
    ..Thus, the tested culture conditions supported growth and maintenance cartilage in an immature state, but did not induce biomechanical or collagen network maturation...
  41. ncbi request reprint Tensile mechanical properties of bovine articular cartilage: variations with growth and relationships to collagen network components
    Amanda K Williamson
    Department of Bioengineering and Whitaker Institute of Biomedical Engineering, University of California, San Diego, 9500 Gilman Dr, Mail Code 0412, La Jolla, CA 92093, USA
    J Orthop Res 21:872-80. 2003
    ....
  42. ncbi request reprint Biological repair of intervertebral disc
    Howard S An
    Department of Orthopedic Surgery, Rush Medical College at Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    Spine (Phila Pa 1976) 28:S86-92. 2003
  43. ncbi request reprint The origin of chondrocytes in the nucleus pulposus and histologic findings associated with the transition of a notochordal nucleus pulposus to a fibrocartilaginous nucleus pulposus in intact rabbit intervertebral discs
    Ki Won Kim
    Department of Orthopedic Surgery, St Mary s Hospital, The Catholic University of Korea, Seoul, Korea
    Spine (Phila Pa 1976) 28:982-90. 2003
    ..Intact rabbit lumbar intervertebral discs were examined histologically...
  44. ncbi request reprint [Tissue engineered cartilage for biological repair of cartilage defects]
    Koichi Masuda
    Departments of Orthopedic Surgery and Biochemistry, Rush Medical College
    Clin Calcium 14:79-84. 2004
    ..Using the ARC method, the enhancement of matrix formation by OP-1 will produce a larger volume of tissue-engineered cartilage to cover large defects...
  45. ncbi request reprint Intradiscal administration of osteogenic protein-1 increases intervertebral disc height and proteoglycan content in the nucleus pulposus in normal adolescent rabbits
    Howard S An
    Department of Orthopedic Surgery, Rush Medical College at Rush University Medical Center, Chicago, Illinois, USA
    Spine (Phila Pa 1976) 30:25-31; discussion 31-2. 2005
    ..A study of the disc height and biochemical changes in the rabbit intervertebral disc after injection of osteogenic protein-1 into the nucleus pulposus...
  46. ncbi request reprint Platelet-rich plasma (PRP) stimulates the extracellular matrix metabolism of porcine nucleus pulposus and anulus fibrosus cells cultured in alginate beads
    Koji Akeda
    Department of Orthopedic Surgery, Rush Medical College at Rush University Medical Center, Chicago, IL, USA
    Spine (Phila Pa 1976) 31:959-66. 2006
    ..In vitro assessment of the effects of platelet-rich plasma on the extracellular matrix metabolism of porcine intervertebral disc cells...
  47. ncbi request reprint Relevance of in vitro and in vivo models for intervertebral disc degeneration
    Howard S An
    Department of Orthopaedic Surgery, Rush Medical College, 1725 West Harrison Street, Suite 1063, Chicago, IL 60612, USA
    J Bone Joint Surg Am 88:88-94. 2006
    ..Although all of these studies are helpful in answering specific questions, their relevance in assessing disc degeneration in patients with symptoms of discogenic pain must be carefully considered...
  48. ncbi request reprint Osteogenic protein-1 enhances matrix replenishment by intervertebral disc cells previously exposed to interleukin-1
    Kenji Takegami
    Department of Biochemistry, Orthopedic Surgery, Internal Medicine, Rush Medical College at Rush Presbyterian St Luke s Medical Center, Chicago, Illinois, USA
    Spine (Phila Pa 1976) 27:1318-25. 2002
    ..A study of the mechanisms involved in matrix repair by intervertebral disc cells cultured in alginate gel was performed...
  49. ncbi request reprint Animal models for human disc degeneration
    Kern Singh
    Department of Orthopedic Surgery, Rush University Medical Center, 1725 West Harrison Street, Chicago, IL 60612, USA
    Spine J 5:267S-279S. 2005
    ..With the recent progress in biomechanics, cell biology and molecular biology, an easily reproducible and valid animal model may help unlock the complex cascade of events surrounding human disc degeneration...
  50. ncbi request reprint Exposure to pulsed low intensity ultrasound stimulates extracellular matrix metabolism of bovine intervertebral disc cells cultured in alginate beads
    Kei Miyamoto
    Department of Orthopedic Surgery, Medical College, Rush University Medical Center, Chicago, IL, USA
    Spine (Phila Pa 1976) 30:2398-405. 2005
    ..In vitro study on the effects of pulsed low intensity ultrasound on the cellular metabolism of bovine intervertebral disc cells...
  51. ncbi request reprint Changes in mRNA and protein levels of proteoglycans of the anulus fibrosus and nucleus pulposus during intervertebral disc degeneration
    Gabriella Cs-Szabo
    Department of Biochemistry, Rush Medical College at Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    Spine (Phila Pa 1976) 27:2212-9. 2002
    ..This study correlates the mRNA and protein levels of large and small proteoglycans with the morphologic grade of degeneration...
  52. ncbi request reprint Characterization of human nasal septal chondrocytes cultured in alginate
    Stanley H Chia
    Division of Head and Neck Surgery, University of California, San Diego, and San Diego Veterans Affairs Healthcare System, San Diego, CA, USA
    J Am Coll Surg 200:691-704. 2005
    ..After serial passages in monolayer, chondrocytes dedifferentiate into a fibroblast-like phenotype. Our objective was to determine if culture in alginate affects the phenotype of dedifferentiated human nasal septal chondrocytes...
  53. ncbi request reprint Differential effects of fibronectin fragment on proteoglycan metabolism by intervertebral disc cells: a comparison with articular chondrocytes
    Yoichi Aota
    Department of Orthopedic Surgery, Rush Medical College at Rush University Medical Center, Chicago, IL, USA
    Spine (Phila Pa 1976) 30:722-8. 2005
    ....
  54. ncbi request reprint Human septal chondrocyte redifferentiation in alginate, polyglycolic acid scaffold, and monolayer culture
    Mark R Homicz
    Division of Head and Neck Surgery, University of California, San Diego, USA
    Laryngoscope 113:25-32. 2003
    ..The objective of the study was to determine whether different culture systems could induce monolayer-expanded human septal chondrocytes to redifferentiate and form extracellular matrix...
  55. ncbi request reprint Development and characterization of a fusion protein between thermally responsive elastin-like polypeptide and interleukin-1 receptor antagonist: sustained release of a local antiinflammatory therapeutic
    Mohammed F Shamji
    Duke University, Durham, North Carolina 27708, USA
    Arthritis Rheum 56:3650-61. 2007
    ..The purpose of this study was to develop an injectable drug depot composed of IL-1Ra and ELP domains and to evaluate the properties and bioactivity of the recombinant ELP-IL-1Ra fusion protein...
  56. ncbi request reprint Characterization of lesions of the talus and description of tram-track lesions
    Juan Li
    Rush University Medical Center, Chicago, IL 60612, USA
    Foot Ankle Int 27:344-55. 2006
    ..Unlike the knee joint, a thorough investigation of talar cartilage lesions has not been previously reported...
  57. ncbi request reprint Growth factors and the intervertebral disc
    Koichi Masuda
    Department of Orthopedic Surgery and Biochemistry, Rush Medical College at Rush University Medical Center, 1725 West Harrison Street, Chicago, IL 60612, USA
    Spine J 4:330S-340S. 2004
    ..Currently, the effects of recombinant growth factors on IVD cells are less well known than those on articular cartilage chondrocytes...
  58. ncbi request reprint Joint biomarkers in idiopathic femoral head osteonecrosis: comparison with hip osteoarthritis
    Shinichi Kato
    Department of Orthopaedic Surgery, Fujita Health University, Second Hospital, Nagoya, Japan
    J Rheumatol 32:1518-23. 2005
    ..To compare concentrations of joint biomarkers in synovial fluid (SF) between idiopathic osteonecrosis of the femoral head (ION) and osteoarthritis (OA) of the hip joint...
  59. ncbi request reprint Anti-adhesion properties of a thrombin-based hemostatic gelatin in a canine laminectomy model: a biomechanical, biochemical, and histologic study
    Kei Miyamoto
    Department of Orthopedic Surgery, Rush Medical College at Rush University Medical Center, Chicago, IL 60612, USA
    Spine (Phila Pa 1976) 31:E91-7. 2006
    ..An in vivo study on the effects of an agent for scar prevention in a dog laminectomy model...
  60. ncbi request reprint Axonal growth potential of lumbar dorsal root ganglion neurons in an organ culture system: response of nerve growth factor-sensitive neurons to neuronal injury and an inflammatory cytokine
    Yasuchika Aoki
    Department of Orthopedic Surgery, Rush Medical College at Rush University Medical Center, Chicago, IL 60612, USA
    Spine (Phila Pa 1976) 32:857-63. 2007
    ..The axonal growth potential of dorsal root ganglion (DRG) neurons in an organ culture system was investigated...