Alan L Landay

Summary

Affiliation: Rush University Medical Center
Country: USA

Publications

  1. doi request reprint A compositional look at the human gastrointestinal microbiome and immune activation parameters in HIV infected subjects
    Ece A Mutlu
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Rush University Medical Center, Chicago, Illinois, United States of America
    PLoS Pathog 10:e1003829. 2014
  2. ncbi request reprint Evidence of immune reconstitution in antiretroviral drug-experienced patients with advanced HIV disease
    Alan L Landay
    Department of Immunology Microbiology, Rush Medical College, Chicago, Illinois 60612, USA
    AIDS Res Hum Retroviruses 18:95-102. 2002
  3. ncbi request reprint Immune reconstitution is comparable in antiretroviral-naive subjects after 1 year of successful therapy with a nucleoside reverse-transcriptase inhibitor- or protease inhibitor-containing antiretroviral regimen
    Alan L Landay
    Department of Immunology Microbiology and Medicine, Rush Medical College, Chicago, Illinois 60612, USA
    J Infect Dis 188:1444-54. 2003
  4. pmc Correlates of immune activation marker changes in human immunodeficiency virus (HIV)-seropositive and high-risk HIV-seronegative women who use illicit drugs
    Alan Landay
    Department of Immunology Microbiology, Rush Medical College, 1735 W Harrison Street, Rm 616 Cohn, Chicago, IL 60612, USA
    J Infect Dis 188:209-18. 2003
  5. ncbi request reprint Evidence of ongoing immune reconstitution in subjects with sustained viral suppression following 6 years of lopinavir-ritonavir treatment
    Alan Landay
    Dept of Immunology Microbiology, Rush University Medical Center, Chicago, IL 60612, USA
    Clin Infect Dis 44:749-54. 2007
  6. pmc Dendritic cells from HIV-1 infected individuals are less responsive to toll-like receptor (TLR) ligands
    Jeffrey A Martinson
    Department of Immunology and Microbiology, Rush University Medical Center, Cohn Research Building, 1735 West Harrison Street, Chicago, IL 60612, USA
    Cell Immunol 250:75-84. 2007
  7. pmc Impact of class A, B and C CpG-oligodeoxynucleotides on in vitro activation of innate immune cells in human immunodeficiency virus-1 infected individuals
    Jeffrey A Martinson
    Department of Immunology Microbiology, Rush University Medical Center, Chicago, IL 60612, USA
    Immunology 120:526-35. 2007
  8. pmc Inflammatory biomarkers and abacavir use in the Women's Interagency HIV Study and the Multicenter AIDS Cohort Study
    Frank J Palella
    Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    AIDS 24:1657-65. 2010
  9. pmc Characterization of human invariant natural killer T subsets in health and disease using a novel invariant natural killer T cell-clonotypic monoclonal antibody, 6B11
    Carlos J Montoya
    Department of Immunology and Microbiology, Rush University Medical Center, Chicago, IL, USA
    Immunology 122:1-14. 2007
  10. doi request reprint Invariant NKT cells from HIV-1 or Mycobacterium tuberculosis-infected patients express an activated phenotype
    Carlos J Montoya
    Department of Immunology and Microbiology, Rush University Medical Center, Chicago, IL, USA
    Clin Immunol 127:1-6. 2008

Research Grants

  1. FEMALE GENITAL TRACT IN HIV PATHOGENESIS
    Alan Landay; Fiscal Year: 2006

Detail Information

Publications65

  1. doi request reprint A compositional look at the human gastrointestinal microbiome and immune activation parameters in HIV infected subjects
    Ece A Mutlu
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Rush University Medical Center, Chicago, Illinois, United States of America
    PLoS Pathog 10:e1003829. 2014
    ..This is the first report characterizing the terminal ileal and colonic mucosal microbiome in HIV patients with next generation sequencing. Limitations include use of HIV-infected subjects on HAART therapy. ..
  2. ncbi request reprint Evidence of immune reconstitution in antiretroviral drug-experienced patients with advanced HIV disease
    Alan L Landay
    Department of Immunology Microbiology, Rush Medical College, Chicago, Illinois 60612, USA
    AIDS Res Hum Retroviruses 18:95-102. 2002
    ..The results of the study show that patients with extensive experience with NRTIs respond both virologically and immunologically during the first 48 weeks of therapy with a potent antiretroviral regimen...
  3. ncbi request reprint Immune reconstitution is comparable in antiretroviral-naive subjects after 1 year of successful therapy with a nucleoside reverse-transcriptase inhibitor- or protease inhibitor-containing antiretroviral regimen
    Alan L Landay
    Department of Immunology Microbiology and Medicine, Rush Medical College, Chicago, Illinois 60612, USA
    J Infect Dis 188:1444-54. 2003
    ....
  4. pmc Correlates of immune activation marker changes in human immunodeficiency virus (HIV)-seropositive and high-risk HIV-seronegative women who use illicit drugs
    Alan Landay
    Department of Immunology Microbiology, Rush Medical College, 1735 W Harrison Street, Rm 616 Cohn, Chicago, IL 60612, USA
    J Infect Dis 188:209-18. 2003
    ..In summary, this study demonstrated that immune activation was a significant pathogenic feature in women and that activation was driven by HIV infection and not illicit drug use...
  5. ncbi request reprint Evidence of ongoing immune reconstitution in subjects with sustained viral suppression following 6 years of lopinavir-ritonavir treatment
    Alan Landay
    Dept of Immunology Microbiology, Rush University Medical Center, Chicago, IL 60612, USA
    Clin Infect Dis 44:749-54. 2007
    ..We evaluated the immunologic impact of highly active antiretroviral therapy in subjects who maintained human immunodeficiency virus type 1 (HIV-1) suppression through 6 years of receiving a lopinavir-ritonavir-based regimen...
  6. pmc Dendritic cells from HIV-1 infected individuals are less responsive to toll-like receptor (TLR) ligands
    Jeffrey A Martinson
    Department of Immunology and Microbiology, Rush University Medical Center, Cohn Research Building, 1735 West Harrison Street, Chicago, IL 60612, USA
    Cell Immunol 250:75-84. 2007
    ..Understanding pDC and mDC activation and maturation in HIV-1 infection could lead to more rational development of immunotherapeutic strategies to stimulate the adaptive immune response to HIV-1...
  7. pmc Impact of class A, B and C CpG-oligodeoxynucleotides on in vitro activation of innate immune cells in human immunodeficiency virus-1 infected individuals
    Jeffrey A Martinson
    Department of Immunology Microbiology, Rush University Medical Center, Chicago, IL 60612, USA
    Immunology 120:526-35. 2007
    ....
  8. pmc Inflammatory biomarkers and abacavir use in the Women's Interagency HIV Study and the Multicenter AIDS Cohort Study
    Frank J Palella
    Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    AIDS 24:1657-65. 2010
    ..To assess associations between abacavir (ABC) use and systemic inflammation...
  9. pmc Characterization of human invariant natural killer T subsets in health and disease using a novel invariant natural killer T cell-clonotypic monoclonal antibody, 6B11
    Carlos J Montoya
    Department of Immunology and Microbiology, Rush University Medical Center, Chicago, IL, USA
    Immunology 122:1-14. 2007
    ..These differences in iNKT cell subsets suggest that in humans the relative ratio of iNKT cell subsets may influence susceptibility vs. resistance to immune-mediated diseases...
  10. doi request reprint Invariant NKT cells from HIV-1 or Mycobacterium tuberculosis-infected patients express an activated phenotype
    Carlos J Montoya
    Department of Immunology and Microbiology, Rush University Medical Center, Chicago, IL, USA
    Clin Immunol 127:1-6. 2008
    ..These findings indicate that peripheral blood iNKT cells in these two chronic infections show an up-regulated expression of activation markers, suggesting their role in the immune response to infection...
  11. pmc Chloroquine modulates HIV-1-induced plasmacytoid dendritic cell alpha interferon: implication for T-cell activation
    Jeffrey A Martinson
    Department of Immunology and Microbiology, Rush University Medical Center, 1735 West Harrison St Cohn Research Building, Lab 641, Chicago, IL 60612, USA
    Antimicrob Agents Chemother 54:871-81. 2010
    ..Our results suggests that a safe, well-tolerated drug such as chloroquine can be proposed as an adjuvant therapeutic candidate along with highly active antiretroviral therapy to control immune activation in HIV-1 infection...
  12. pmc Effect of mucosal fluid from women with bacterial vaginosis on HIV trans-infection mediated by dendritic cells
    Elizabeth P St John
    Department of Immunology Microbiology, Rush University Medical Center, Chicago, IL 60612, USA
    Virology 385:22-7. 2009
    ..However, indirect effects of DC maturation on HIV transmission cannot be ruled out...
  13. pmc The effect of aging on T-regulatory cell frequency in HIV infection
    Allan R Tenorio
    Section of Infectious Diseases, Department of Medicine, Rush Medical College, 600 S Paulina Street, Suite 143 AAC, Chicago, Illinois 60612, USA
    Clin Immunol 130:298-303. 2009
    ..T-reg percentages are increased in the older HIV(+) population and may play a role in the accelerated disease progression seen in older HIV-infected persons...
  14. pmc Identification of rhesus macaque genital microbiota by 16S pyrosequencing shows similarities to human bacterial vaginosis: implications for use as an animal model for HIV vaginal infection
    Gregory T Spear
    Department of Immunology Microbiology, Rush University Medical Center, Chicago, IL 60612, USA
    AIDS Res Hum Retroviruses 26:193-200. 2010
    ..These results also suggest macaques could be used as an animal model to study some aspects of bacterial vaginosis...
  15. pmc Pyrosequencing of the genital microbiotas of HIV-seropositive and -seronegative women reveals Lactobacillus iners as the predominant Lactobacillus Species
    Gregory T Spear
    Department of Immunology Microbiology, Rush University Medical Center, Chicago, IL 60612, USA
    Appl Environ Microbiol 77:378-81. 2011
    ..Lactobacillus iners sequences were the predominant lactobacillus sequences in 66% of HIV(+) women and 90% of HIV(-) women. This has implications for resistance of HIV(+) and HIV(-) women to genital colonization by pathogenic organisms...
  16. ncbi request reprint Relationship of HIV RNA and cytokines in saliva from HIV-infected individuals
    Gregory T Spear
    Department of Immunology Microbiology, Rush University Medical Center, 1653 W Congress Parkway, Chicago, IL 60612, USA
    FEMS Immunol Med Microbiol 45:129-36. 2005
    ..This study shows no association between inflammatory cytokine levels and HIV levels in saliva and suggests that saliva HIV levels are more influenced by blood HIV RNA levels than oral inflammation...
  17. pmc Delaying a treatment switch in antiretroviral-treated HIV type 1-infected patients with detectable drug-resistant viremia does not have a profound effect on immune parameters: AIDS Clinical Trials Group Study A5115
    Allan R Tenorio
    Department of Medicine, Rush Medical College, Rush University Medical Center, 600 S Paulina Street, Chicago, IL 60612, USA
    AIDS Res Hum Retroviruses 25:135-9. 2009
    ..Delaying a treatment switch in patients with partial virologic suppression and stable CD4+ T cells does not have profound effects on immune parameters...
  18. pmc CD1d-restricted natural killer T cells are potent targets for human immunodeficiency virus infection
    Richardson Fleuridor
    Department of Immunology Microbiology and Division of Infectious Diseases, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Immunology 108:3-9. 2003
    ..Collectively, this data demonstrates that NKT cells can be a target for productive HIV infection but with a lag in the time to peak p24 production...
  19. doi request reprint Characterization of CD4⁺ T-cell immune activation and interleukin 10 levels among HIV, hepatitis C virus, and HIV/HCV-coinfected patients
    Aimee C Hodowanec
    Ruth M Rothstein CORE Center, John H Stroger Jr Hospital of Cook County, Chicago, IL Section of Infectious Diseases, Rush University Medical Center, Chicago, IL Department of Immunology and Microbiology, Rush University Medical Center, Chicago, IL and Center for Clinical and Translational Sciences, University of Illinois at Chicago, Chicago, IL
    J Acquir Immune Defic Syndr 64:232-40. 2013
    ..In HIV-positive patients with viral suppression, data comparing inflammatory cytokines and immune activation between HIV/HCV coinfection with chronic hepatitis C (CHC) to HIV/HCV-seropositive patients with cleared HCV are limited...
  20. pmc Microbial translocation and liver disease progression in women coinfected with HIV and hepatitis C virus
    Audrey L French
    Department of Medicine, CORE Center Stroger Hospital of Cook County, Chicago, IL 60612, USA
    J Infect Dis 208:679-89. 2013
    ..We sought to determine whether markers of microbial translocation are associated with liver disease progression during coinfection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV)...
  21. pmc Short-chain fatty acids induce pro-inflammatory cytokine production alone and in combination with toll-like receptor ligands
    Paria Mirmonsef
    Department of Immunology Microbiology, Rush University Medical Center, Chicago, IL, USA
    Am J Reprod Immunol 67:391-400. 2012
    ..We investigated how SCFAs alone or together with Toll-like receptor (TLR) ligands affected pro-inflammatory cytokine secretion...
  22. pmc Comparison of the diversity of the vaginal microbiota in HIV-infected and HIV-uninfected women with or without bacterial vaginosis
    Gregory T Spear
    Department of Immunology Microbiology, Rush University Medical Center, Chicago, Illinois, USA
    J Infect Dis 198:1131-40. 2008
    ..Whether human immunodeficiency virus (HIV) infection is associated with a change in the diversity of genital microbiota in women was investigated...
  23. pmc Positive association between HIV RNA and IL-6 in the genital tract of Rwandan women
    Gregory T Spear
    Department of Immunology Microbiology, Rush University Medical Center, Chicago, Illinois 60612, USA
    AIDS Res Hum Retroviruses 24:973-6. 2008
    ..This association of IL-6 with HIV RNA levels suggests that IL-6 is an indicator for conditions that induce HIV expression and that IL-6 may contribute to induction of HIV expression in the genital tract...
  24. ncbi request reprint Interleukin-7-treated naive T cells can be productively infected by T-cell-adapted and primary isolates of human immunodeficiency virus 1
    Carolyn M Steffens
    Department of Immunology Microbiology at Rush Presbyterian St Luke s Medical Center, Rush University, Chicago, IL 60612, USA
    Blood 99:3310-8. 2002
    ..This information needs to be considered in evaluating IL-7 as an immunomodulator for HIV-infected patients...
  25. ncbi request reprint Activation of plasmacytoid dendritic cells with TLR9 agonists initiates invariant NKT cell-mediated cross-talk with myeloid dendritic cells
    Carlos J Montoya
    Department of Immunology and Microbiology, Rush University Medical Center, Chicago, IL 60612, USA
    J Immunol 177:1028-39. 2006
    ..This interaction supports the notion that iNKT cells can mediate cross-talk between DC subsets known to express mutually exclusive TLR and cytokine profiles...
  26. pmc Human cytomegalovirus and human immunodeficiency virus type-1 co-infection in human cervical tissue
    Andrea M Fox-Canale
    Department of Immunology Microbiology, Rush University Medical Center, 1653 West, Congress Parkway, Chicago, IL 60612, USA
    Virology 369:55-68. 2007
    ..The cervical explants provide an ex vivo human model for examining mechanisms of virus-virus interaction and pathogenesis in clinically relevant tissue...
  27. ncbi request reprint HIV infection of primary CD4+ Th2 cells, defined by expression of the chemoattractant receptor-homologous (CRTH2), induces a Th0 phenotype
    Bouchaib Bahbouhi
    Department of Immunology Microbiology, Rush University Medical Center, 1735 West Harrison Street, Chicago, IL 60612, USA
    AIDS Res Hum Retroviruses 23:269-77. 2007
    ..Collectively, these data indicate that HIV replication in Th2 cells induces a Th0 phenotype. This phenomenon may be a deliberate viral escape mechanism to prevent the skewing of the immune response toward Th1 or Th2...
  28. pmc Interleukin-7 signalling is sufficient to phenotypically and functionally prime human CD4 naive T cells
    Elizabeth Z Managlia
    Department of Immunology and Microbiology, Rush University Medical Center, Chicago, IL 60612, USA
    Immunology 114:322-35. 2005
    ..Collectively, these data indicate that IL-7 signalling is sufficient to phenotypically and functionally prime human CD4(+) naive T cells independent of antigen stimulation...
  29. ncbi request reprint Interleukin-7 induces HIV replication in primary naive T cells through a nuclear factor of activated T cell (NFAT)-dependent pathway
    Elizabeth Z Managlia
    Department of Immunology Microbiology, Rush University Medical Center, 1735 West Harrison Street, 614 Cohn, Chicago, IL 60612, USA
    Virology 350:443-52. 2006
    ..These findings are relevant to the treatment of HIV disease and understanding HIV pathogenesis in the naive CD4+ T cell compartment, especially in light of the vigorous pursuit of IL-7 as an in vivo immune modulator...
  30. pmc IL-22 levels are associated with Trichomonas vaginalis infection in the lower genital tract
    Hadijat Moradeke Makinde
    Department of Immunology Microbiology, Rush University Medical Center, Chicago, IL 60612, USA
    Am J Reprod Immunol 70:38-44. 2013
    ..IL-22 has important functions at mucosal surfaces, including the induction of antimicrobial peptides and maintenance of epithelium. However, IL-22 has not been investigated in the genital tract during TV infection...
  31. pmc TLR2-activated B cells are phenotypically similar to the abnormal circulating B cells seen preceding the diagnosis of AIDS-related NHL diagnosis
    Yu Guo
    UCLA AIDS Institute, Los Angeles, CA The Institution of Viral disease Control and Prevention, CDC, Beijing, China Departments of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, CA Department of Immunology Microbiology, Rush University Medical Center, Chicago, IL Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA Department of Epidemiology, UCLA Jonathan and Karin Fielding School of Public Health, Los Angeles, CA and Jonsson Comprehensive Cancer Center, Los Angeles, CA
    J Acquir Immune Defic Syndr 64:204-10. 2013
    ....
  32. pmc Multiplex immunoassay of lower genital tract mucosal fluid from women attending an urban STD clinic shows broadly increased IL1ß and lactoferrin
    Gregory T Spear
    Department of Immunology Microbiology, Rush University Medical Center, Chicago, Illinois, United States of America
    PLoS ONE 6:e19560. 2011
    ....
  33. ncbi request reprint CD8+ T cells that express CD4 on their surface (CD4dimCD8bright T cells) recognize an antigen-specific target, are detected in vivo, and can be productively infected by T-tropic HIV
    Andrew Zloza
    Department of Immunology and Microbiology, Rush Presbyterian St Luke s Medical Center, 1735 W Harrison Street, 614 Cohn, Chicago, IL 60612, USA
    Blood 102:2156-64. 2003
    ..Collectively, these data suggest a role of CD4dimCD8bright T cells in both normal T-cell biology and HIV pathogenesis...
  34. pmc Early immune senescence in HIV disease
    Seema Desai
    Department of Immunology Microbiology, Rush University Medical Center, 1735 W Harrison Street, Room 660 Cohn, Chicago, IL, 60612, USA
    Curr HIV/AIDS Rep 7:4-10. 2010
    ..Dysfunctional thymic output, along with HIV-mediated disruption of the gastrointestinal barrier leading to microbial translocation, contributes to the circulating antigenic load driving early senescence in HIV disease...
  35. ncbi request reprint Dynamics of cytokine expression in HIV productively infected primary CD4+ T cells
    Bouchaib Bahbouhi
    Department of Immunology Microbiology, Rush University Medical Center, 1653 W Congress Parkway, Chicago, IL 60612, USA
    Blood 103:4581-7. 2004
    ....
  36. pmc Immunophenotypic alterations in acute and early HIV infection
    Lena Al-Harthi
    Department of Immunology Microbiology, Rush University Medical Center, Chicago, IL 60612, USA
    Clin Immunol 125:299-308. 2007
    ....
  37. ncbi request reprint Trophoblasts are productively infected by CD4-independent isolate of HIV type 1
    Lena Al-Harthi
    Department of Immunology Microbiology, Rush Presbyterian St Luke s Medical Center, Rush University, Chicago, Illinois 60612, USA
    AIDS Res Hum Retroviruses 18:13-7. 2002
    ..In additional, our data suggest that CD4-independent mechanisms of infection may play a role in promoting in utero HIV-1 transmission...
  38. pmc Evaluating the impact of hepatitis C virus (HCV) on highly active antiretroviral therapy-mediated immune responses in HCV/HIV-coinfected women: role of HCV on expression of primed/memory T cells
    Lena Al-Harthi
    Rush University Medical Center, Chicago, Illinois 60612, USA
    J Infect Dis 193:1202-10. 2006
    ....
  39. pmc HIV type 1 and cytomegalovirus coinfection in the female genital tract
    Nell S Lurain
    Rush University Medical Center, Chicago, Illinois 60612, USA
    J Infect Dis 190:619-23. 2004
    ..More than 1 strain of CMV was detected in specimens from 2 patients. These results suggest mechanisms by which CMV coinfection could affect HIV-1 disease progression...
  40. ncbi request reprint HIV-1-infected antiretroviral-treated patients with prolonged partial viral suppression: clinical, virologic, and immunologic course
    Allan R Tenorio
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Acquir Immune Defic Syndr 34:491-6. 2003
    ..HIV-specific CD4+ T-cell immunity was detected in most subjects with low-level and undetectable viremia and may have a role in controlling viremia in the setting of partial suppression...
  41. ncbi request reprint Immune recovery in HIV disease: role of the thymus and T cell expansion in immune reconstitution strategies
    Lena Al-Harthi
    Department of Immunology Microbiology, Rush University, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    J Hematother Stem Cell Res 11:777-86. 2002
    ..In this review, we will integrate this new information in the context of the current strategies for HIV therapy leading to long-term immune reconstitution...
  42. ncbi request reprint Long-term changes in circulating CD4 T lymphocytes in virologically suppressed patients after 6 years of highly active antiretroviral therapy
    Kimberly Smith
    Department of Infectious Diseases, Rush Medical College of Rush University, Chicago, IL 60612, USA
    AIDS 18:1953-6. 2004
    ..This cohort represents the longest prospective immunological follow-up of virologically suppressed patients on HAART...
  43. doi request reprint The relationship of T-regulatory cell subsets to disease stage, immune activation, and pathogen-specific immunity in HIV infection
    Allan R Tenorio
    Section of Infectious Disease, Department of Medicine, Rush Medical College, Chicago, IL 60612, USA
    J Acquir Immune Defic Syndr 48:577-80. 2008
    ..Human immunodeficiency virus (HIV) infection is associated with abnormalities in T-regulatory (T-reg) cells, but the effect of HIV on the naive (CD45RO-) and memory (CD45RO) CD25+CD127loCD4+ T-reg cell subsets has not been defined...
  44. pmc Dendritic cell activation and maturation induced by mucosal fluid from women with bacterial vaginosis
    Elizabeth P St John
    Department of Immunology and Microbiology, Rush University Medical Center, Cohn Bldg Rm 636a, Chicago, IL 60612, USA
    Clin Immunol 125:95-102. 2007
    ..Healthy flora CVL had little effect in any of the tests. This study suggests that BV, but not healthy flora, affects local dendritic cell function in vivo suggesting a mechanism through which BV affects mucosal immunity...
  45. pmc Cervicovaginal levels of lactoferrin, secretory leukocyte protease inhibitor, and RANTES and the effects of coexisting vaginoses in human immunodeficiency virus (HIV)-seronegative women with a high risk of heterosexual acquisition of HIV infection
    Richard M Novak
    University of Illinois at Chicago, 808 S Wood St, M C 735, Rm 888, Chicago, IL 60612, USA
    Clin Vaccine Immunol 14:1102-7. 2007
    ..However, the increased RANTES levels in a higher-risk subset of high-risk women were reduced after BV treatment...
  46. pmc Susceptibility to human immunodeficiency virus-1 infection of human foreskin and cervical tissue grown in explant culture
    Bruce K Patterson
    Department of Pediatrics, Division of Infectious Diseases, Children s Memorial Hospital, Chicago, Illinois 60614, USA
    Am J Pathol 161:867-73. 2002
    ..Adult foreskin mucosa had greater susceptibility to infection with HIV(bal) than cervical mucosa or the external surface of foreskin tissue. Circumcision likely reduces risk of HIV-1 acquisition in men by decreasing HIV-1 target cells...
  47. ncbi request reprint Effect of etanercept (Enbrel) on interleukin 6, tumor necrosis factor alpha, and markers of immune activation in HIV-infected subjects receiving interleukin 2
    Beverly E Sha
    Section of Infectious Diseases, Department of Medicine, Rush Medical College, Chicago, Illinois 60612 3833, USA
    AIDS Res Hum Retroviruses 18:661-5. 2002
    ..Pretreatment with etanercept may blunt activation of IL-6 and CRP expression induced by rhIL-2. The safety and utility of etanercept in HIV-infected persons should be explored further...
  48. pmc The effects of commensal bacteria on innate immune responses in the female genital tract
    Paria Mirmonsef
    Department of Immunology Microbiology, Rush University Medical Center, Chicago, IL 60612, USA
    Am J Reprod Immunol 65:190-5. 2011
    ..In this review, we will discuss these results, in addition to some recent articles that we believe will enhance our understanding of how microbes might interact with the immune system...
  49. pmc Virological and immunological characteristics of human cytomegalovirus infection associated with Alzheimer disease
    Nell S Lurain
    Department of Immunology Microbiology, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Infect Dis 208:564-72. 2013
    ..HSV-1 infection of HFFs did not induce amyloid-β. These data support an association between CMV and the development of Alzheimer disease. ..
  50. ncbi request reprint Antigen-presenting cells in HIV pathogenesis and therapy: summary of the October 17-18, 2002, Think Tank meeting
    Alan Landay
    Rush Medical College, Chicago, Illinois, USA
    Clin Immunol 103:243-8. 2002
  51. pmc Associations of insulin-like growth factor (IGF)-I and IGF-binding protein-3 with HIV disease progression in women
    Howard D Strickler
    Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Infect Dis 197:319-27. 2008
    ....
  52. doi request reprint Regulatory T cells in HIV infection: pathogenic or protective participants in the immune response?
    Barbara Fazekas de St Groth
    AIDS 22:671-83. 2008
  53. pmc Women with cervicovaginal antibody-dependent cell-mediated cytotoxicity have lower genital HIV-1 RNA loads
    Pratip Nag
    Department of Microbiology and Immunology, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
    J Infect Dis 190:1970-8. 2004
    ..This finding suggests that specific IgG in cervical fluid can mediate ADCC activity that inversely correlates with genital viral load...
  54. doi request reprint Genotyping of urogenital Chlamydia trachomatis in Regional New South Wales, Australia
    David Mossman
    Immunology and Infectious Diseases Unit, John Hunter Hospital, Newcastle, Australia
    Sex Transm Dis 35:614-6. 2008
  55. ncbi request reprint HIV-1 target cells in foreskins of African men with varying histories of sexually transmitted infections
    Betty A Donoval
    Division of Epidemiology, School of Public Health, University of Illinois, Chicago 60612, USA
    Am J Clin Pathol 125:386-91. 2006
    ..The densities and positions of HIV-1 target cells in the foreskin tissue of these Kenyan men indicate that the inner mucosal surface of the human foreskin contains cells that make it highly susceptible to HIV infection...
  56. pmc Valproic acid without intensified antiviral therapy has limited impact on persistent HIV infection of resting CD4+ T cells
    Nancy M Archin
    University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    AIDS 22:1131-5. 2008
    ..Valproic acid and intensified antiretroviral therapy may deplete resting CD4+ T-cell HIV infection. We tested the ability of valproic acid to deplete resting CD4+ T-cell infection in patients receiving standard antiretroviral therapy...
  57. ncbi request reprint Increased IFN-gamma production by NK and CD3+/CD56+ cells in sexually HIV-1-exposed but uninfected individuals
    Carlos Julio Montoya
    Group of Immunovirology, Biogenesis Corporation, University of Antioquia, Medellin, Colombia
    Clin Immunol 120:138-46. 2006
    ....
  58. pmc VACUTAINER CPT and Ficoll density gradient separation perform equivalently in maintaining the quality and function of PBMC from HIV seropositive blood samples
    Joyce J Ruitenberg
    BD Biosciences, San Jose, CA, USA
    BMC Immunol 7:11. 2006
    ..The pre- and post- cryopreservation performance of samples collected by these two methods were compared by assessment of antigen-specific IFNgamma expression in CD8+ and CD8- T cells, cellular viability, and cellular recovery...
  59. pmc Depletion of latent HIV-1 infection in vivo: a proof-of-concept study
    Ginger Lehrman
    University of Texas Southwestern Medical Center at Dallas, Department of Medicine, Division of Infectious Diseases, 5323 Harry Hines Boulevard, Dallas, TX 753901, USA
    Lancet 366:549-55. 2005
    ..Since the chromatin remodeling enzyme histone deacetylase 1 (HDAC1) maintains latency of integrated HIV, we tested the ability of the HDAC inhibitor valproic acid to deplete persistent, latent infection in resting CD4+ T cells...
  60. ncbi request reprint Saliva can mediate HIV-1-specific antibody-dependent cell-mediated cytotoxicity
    Jenney S Kim
    Department of Microbiology and Immunology, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA
    FEMS Immunol Med Microbiol 48:267-73. 2006
    ..These studies demonstrate that HIV-specific ADCC activity can be present in saliva. This activity may contribute to host defence against initial infection with HIV...
  61. pmc PDL-1 upregulation on monocytes and T cells by HIV via type I interferon: restricted expression of type I interferon receptor by CCR5-expressing leukocytes
    Adriano Boasso
    Experimental Immunology Branch, National Cancer Institute NCI, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Clin Immunol 129:132-44. 2008
    ..Finally, T cell proliferation was improved by PDL-1 blockade in HIV-treated PBMC. In the setting of HIV infection, IFN-alpha may negatively affect T cell responses by inducing PDL-1...
  62. ncbi request reprint Innate immune defenses in HIV-1 infection: prospects for a novel immune therapy
    Carlos J Montoya
    University of Antioquia, Group of Immunovirology Biogenesis, Medellin, Colombia
    Expert Rev Anti Infect Ther 4:767-80. 2006
    ....
  63. ncbi request reprint Recent observations on HIV type-1 infection in the genital tract of men and women
    Robert W Coombs
    Departments of Laboratory Medicine and Medicine, University of Washington, Seattle, Washington, USA
    AIDS 17:455-80. 2003
  64. ncbi request reprint Long-term mitochondrial toxicity in HIV-uninfected infants born to HIV-infected mothers
    Miriam C Poirier
    Carcinogen DNA Interactions Section, National Cancer Institute, National Institutes of Health, Building 37, Room 4032, 37 Convent Drive, Bethesda, MD 20892 4255, USA
    J Acquir Immune Defic Syndr 33:175-83. 2003
    ..The study shows that children of HIV+ mothers are at risk for mitochondrial damage that is further increased in infants of mothers receiving AZT during pregnancy...
  65. ncbi request reprint Antibody-dependent cell-mediated cytotoxicity in cervical lavage fluids of human immunodeficiency virus type 1--infected women
    Kimberly Battle-Miller
    Department of Microbiology and Immunology, Finch University of Health Sciences The Chicago Medical School, North Chicago, IL 60064, USA
    J Infect Dis 185:439-47. 2002
    ..ADCC antibodies are present in the cervicovaginal fluids, which indicates that this form of innate immunity can contribute to mucosal defense against HIV-1...

Research Grants3

  1. FEMALE GENITAL TRACT IN HIV PATHOGENESIS
    Alan Landay; Fiscal Year: 2006
    ..abstract_text> ..