Jeffrey Kordower

Summary

Affiliation: Rush University Medical Center
Country: USA

Publications

  1. doi request reprint Trophic factor gene therapy for Parkinson's disease
    Jeffrey H Kordower
    Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    Mov Disord 28:96-109. 2013
  2. ncbi request reprint Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease
    J H Kordower
    Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Science 290:767-73. 2000
  3. ncbi request reprint Failure of proteasome inhibitor administration to provide a model of Parkinson's disease in rats and monkeys
    Jeffrey H Kordower
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
    Ann Neurol 60:264-8. 2006
  4. ncbi request reprint Regulatable promoters and gene therapy for Parkinson's disease: is the only thing to fear, fear itself?
    Jeffrey H Kordower
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Exp Neurol 209:34-40. 2008
  5. doi request reprint Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease
    Jeffrey H Kordower
    Department of Neurological Sciences and Center for Brain Repair, Rush University Medical Center, 1735 West Harrison Street, Chicago, Illinois 60612, USA
    Nat Med 14:504-6. 2008
  6. doi request reprint Transplanted dopaminergic neurons develop PD pathologic changes: a second case report
    Jeffrey H Kordower
    Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    Mov Disord 23:2303-6. 2008
  7. pmc Long-term gonadal hormone treatment and endogenous neurogenesis in the dentate gyrus of the adult female monkey
    Jeffrey H Kordower
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Exp Neurol 224:252-7. 2010
  8. pmc Transfer of host-derived α synuclein to grafted dopaminergic neurons in rat
    Jeffrey H Kordower
    Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    Neurobiol Dis 43:552-7. 2011
  9. ncbi request reprint Loss and atrophy of layer II entorhinal cortex neurons in elderly people with mild cognitive impairment
    J H Kordower
    Research Center for Brain Repair, Department of Neurological Sciences, Chicago, IL, USA
    Ann Neurol 49:202-13. 2001
  10. ncbi request reprint In vivo gene delivery of glial cell line--derived neurotrophic factor for Parkinson's disease
    Jeffrey H Kordower
    Department of Neurological Sciences and Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Chicago IL 60612, USA
    Ann Neurol 53:S120-32; discussion S132-4. 2003

Research Grants

  1. DYSKINESIAS IN LENTI-GDNF TREATED PARKINSONIAN MONKEYS
    Jeffrey Kordower; Fiscal Year: 2006
  2. TH and GTPCHI gene therapy for Parkinson's disease
    Jeffrey Kordower; Fiscal Year: 2007
  3. TH and GTPCHI gene therapy for Parkinson's disease
    Jeffrey H Kordower; Fiscal Year: 2010

Detail Information

Publications61

  1. doi request reprint Trophic factor gene therapy for Parkinson's disease
    Jeffrey H Kordower
    Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    Mov Disord 28:96-109. 2013
    ..Similar success has been gleaned in open-label clinical trials, although this has yet to be realized in double-blinded analyses. This work reviews the field of trophic factor gene delivery for PD...
  2. ncbi request reprint Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease
    J H Kordower
    Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Science 290:767-73. 2000
    ..These data indicate that GDNF delivery using a lentiviral vector system can prevent nigrostriatal degeneration and induce regeneration in primate models of PD and might be a viable therapeutic strategy for PD patients...
  3. ncbi request reprint Failure of proteasome inhibitor administration to provide a model of Parkinson's disease in rats and monkeys
    Jeffrey H Kordower
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
    Ann Neurol 60:264-8. 2006
    ..Furthermore, administration of PSI or epoxomicin to monkeys in an attempt to extend the model to a primate species failed. Currently, systemic proteasome inhibition is not a reliable model for Parkinson's disease...
  4. ncbi request reprint Regulatable promoters and gene therapy for Parkinson's disease: is the only thing to fear, fear itself?
    Jeffrey H Kordower
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Exp Neurol 209:34-40. 2008
    ....
  5. doi request reprint Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease
    Jeffrey H Kordower
    Department of Neurological Sciences and Center for Brain Repair, Rush University Medical Center, 1735 West Harrison Street, Chicago, Illinois 60612, USA
    Nat Med 14:504-6. 2008
    ..These findings have implications for cell-based therapies and for understanding the cause of Parkinson's disease...
  6. doi request reprint Transplanted dopaminergic neurons develop PD pathologic changes: a second case report
    Jeffrey H Kordower
    Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    Mov Disord 23:2303-6. 2008
    ..Some grafted cell displayed a loss of tyrosine hydroxylase. These data support the emerging concept that PD-like pathology is seen in young grafted neurons when they survive long term...
  7. pmc Long-term gonadal hormone treatment and endogenous neurogenesis in the dentate gyrus of the adult female monkey
    Jeffrey H Kordower
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Exp Neurol 224:252-7. 2010
    ..7), OVX-E-Cyc (1783+/-415.6), OVX-E-Con+/-P-Cyc (1721+/-229.6), and OVX-Veh (1263+/-106.3), but a trend towards increased BrdU-ir cells was observed in all the experimental groups...
  8. pmc Transfer of host-derived α synuclein to grafted dopaminergic neurons in rat
    Jeffrey H Kordower
    Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    Neurobiol Dis 43:552-7. 2011
    ....
  9. ncbi request reprint Loss and atrophy of layer II entorhinal cortex neurons in elderly people with mild cognitive impairment
    J H Kordower
    Research Center for Brain Repair, Department of Neurological Sciences, Chicago, IL, USA
    Ann Neurol 49:202-13. 2001
    ....
  10. ncbi request reprint In vivo gene delivery of glial cell line--derived neurotrophic factor for Parkinson's disease
    Jeffrey H Kordower
    Department of Neurological Sciences and Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Chicago IL 60612, USA
    Ann Neurol 53:S120-32; discussion S132-4. 2003
    ..Although there are several ways that gene therapy can be applied for PD, this review focuses on in vivo gene delivery of glial cell line-derived neurotrophic factor (GDNF) as a neuroprotective strategy for PD...
  11. ncbi request reprint Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease?
    Yaping Chu
    Department of Neurological Sciences, Rush University Medical Center, 1735 West Harrison Street, Chicago, IL 60612, USA
    Neurobiol Dis 25:134-49. 2007
    ..We further hypothesize that preventing the age-related accumulation of non-aggregated alpha-synuclein might be a simple and potent therapeutic target for patients with PD...
  12. ncbi request reprint Proteasome inhibition and Parkinson's disease modeling
    Jordi Bove
    Department of Neurology, Columbia University, New York, NY, USA
    Ann Neurol 60:260-4. 2006
    ..Although theoretically appealing, this specific model of Parkinson's disease appears to exhibit poor reproducibility...
  13. ncbi request reprint Extensive neuroprotection by choroid plexus transplants in excitotoxin lesioned monkeys
    Dwaine F Emerich
    LCT BioPharma, Providence, RI 02906, USA
    Neurobiol Dis 23:471-80. 2006
    ..43% in controls) and striatum volume (10% decrease vs. 40% in controls). These data indicate that CP transplants might be useful for preventing the degeneration of neurons in HD...
  14. pmc Viral delivery of glial cell line-derived neurotrophic factor improves behavior and protects striatal neurons in a mouse model of Huntington's disease
    Jodi L McBride
    Department of Neurological Sciences, Rush University Medical Center, 1735 West Harrison Street, Suite 300, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 103:9345-50. 2006
    ..These data further support the concept that viral vector delivery of GDNF may be a viable treatment for patients suffering from HD...
  15. ncbi request reprint Neural repair strategies for Parkinson's disease: insights from primate models
    Katherine Soderstrom
    Department of Neurological Science, Research Center for Brain Repair, Rush University Medical Center, Chicago, IL 60612, USA
    Cell Transplant 15:251-65. 2006
    ..Finally, the contribution of primate PD models to our understanding of the etiology and pathology of human PD is discussed...
  16. ncbi request reprint Gene transfer of trophic factors and stem cell grafting as treatments for Parkinson's disease
    Biplob Dass
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60657, USA
    Neurology 66:S89-103. 2006
    ..Long term safety and efficacy trials have not been performed in PD patients and the potential of unanticipated side effects must be addressed. Further, neither treatment is expected to improve the non-dopaminergic features of PD...
  17. ncbi request reprint Age-related alterations in GABA(A) receptor subunits in the nonhuman primate hippocampus
    Robert A Rissman
    Department of Neurobiology and Anatomy, Graduate Program in Neuroscience, MCP Hahnemann University School of Medicine, Philadelphia, PA 19102 1192, USA
    Brain Res 1073:120-30. 2006
    ....
  18. ncbi request reprint Substantia nigra tangles are related to gait impairment in older persons
    Julie A Schneider
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina Street, Chicago, IL, USA
    Ann Neurol 59:166-73. 2006
    ..Our objective was to test the hypothesis that substantia nigra neurofibrillary tangles (NFTs) are related to parkinsonian signs in older persons with and without dementia...
  19. ncbi request reprint Delivery of neurturin by AAV2 (CERE-120)-mediated gene transfer provides structural and functional neuroprotection and neurorestoration in MPTP-treated monkeys
    Jeffrey H Kordower
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
    Ann Neurol 60:706-15. 2006
    ..We tested the hypothesis that gene delivery of the trophic factor neurturin could preserve motor function and protect nigrostriatal circuitry in hemiparkinsonian monkeys...
  20. pmc Aging-related changes in the nigrostriatal dopamine system and the response to MPTP in nonhuman primates: diminished compensatory mechanisms as a prelude to parkinsonism
    Timothy J Collier
    Department of Neurology, University of Cincinnati, PO Box 670525, 265 Albert Sabin Way, Cincinnati, OH 45267, USA
    Neurobiol Dis 26:56-65. 2007
    ....
  21. ncbi request reprint Neurturin gene therapy improves motor function and prevents death of striatal neurons in a 3-nitropropionic acid rat model of Huntington's disease
    Shilpa Ramaswamy
    Department of Neuroscience, Rush University Medical Center, 1735 West Harrison Street, Suite 300, Chicago, IL 60612, USA
    Neurobiol Dis 26:375-84. 2007
    ..Stereological counts revealed a significant protection of NeuN-ir striatal neurons from 3NP toxicity by AAV2-NTN. These data support the concept that AAV2-NTN might be a valuable treatment for patients with Huntington's disease...
  22. ncbi request reprint Role of heparin binding growth factors in nigrostriatal dopamine system development and Parkinson's disease
    Deanna M Marchionini
    Dept Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Brain Res 1147:77-88. 2007
    ..Thus, PTN was identified as a factor that plays a role in the nigrostriatal system during development and in response to disease, and may therefore be useful for neuroprotection or reconstruction of the DA system...
  23. pmc Selective inhibition of NF-kappaB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease
    Anamitra Ghosh
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 104:18754-9. 2007
    ..These findings were specific because mutated NBD peptide had no effect. We conclude that selective inhibition of NF-kappaB activation by NBD peptide may be of therapeutic benefit for PD patients...
  24. ncbi request reprint Deep brain stimulation for treatment of obesity in rats
    Sepehr Sani
    Department of Neurosurgery, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Neurosurg 107:809-13. 2007
    ....
  25. ncbi request reprint Age-related decreases in Nurr1 immunoreactivity in the human substantia nigra
    Yaping Chu
    Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    J Comp Neurol 450:203-14. 2002
    ..These data demonstrate that age-related decline of DA phenotypic markers is associated with down-regulation of Nurr1 expression in the SN...
  26. ncbi request reprint Animal models of Huntington's disease
    Shilpa Ramaswamy
    Department of Neuroscience, Rush University Medical Center, 1735 W Harrison Street, Chicago, IL 60612, USA
    ILAR J 48:356-73. 2007
    ..This article examines the aforementioned models and describes their use in HD research, including aspects of the creation, delivery, pathology, and tested therapies for each model...
  27. ncbi request reprint Neuropathological study 16 years after autologous adrenal medullary transplantation in a Parkinson's disease patient
    Katie Kompoliti
    Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    Mov Disord 22:1630-3. 2007
    ..There were few surviving cells staining with chromogranin A. The absence of TH-staining cells in the transplant 16 years after surgery provides further evidence that adrenal medullary transplants do not survive in the long term...
  28. ncbi request reprint AAV2-mediated delivery of human neurturin to the rat nigrostriatal system: long-term efficacy and tolerability of CERE-120 for Parkinson's disease
    Mehdi Gasmi
    Ceregene Inc, San Diego, CA 92121, USA
    Neurobiol Dis 27:67-76. 2007
    ..These results support the ongoing CERE-120 clinical program in PD patients...
  29. ncbi request reprint Striatal delivery of CERE-120, an AAV2 vector encoding human neurturin, enhances activity of the dopaminergic nigrostriatal system in aged monkeys
    Christopher D Herzog
    Ceregene Inc, San Diego, CA 92121, USA
    Mov Disord 22:1124-32. 2007
    ....
  30. ncbi request reprint Age-related accumulation of Marinesco bodies and lipofuscin in rhesus monkey midbrain dopamine neurons: relevance to selective neuronal vulnerability
    Nicholas M Kanaan
    Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Comp Neurol 502:683-700. 2007
    ..Furthermore, the results begin to characterize the nature of the link between aging and PD, and they support the concept that aged monkeys represent a valuable model for studying specific events preceding PD...
  31. pmc Nurr1 in Parkinson's disease and related disorders
    Yaping Chu
    Department of Neurological Science, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Comp Neurol 494:495-514. 2006
    ..These data demonstrate that Nurr1 deficiency in dopaminergic neurons is associated with the intracellular pathology in both synucleinopathies and tauopathies...
  32. ncbi request reprint Focal not widespread grafts induce novel dyskinetic behavior in parkinsonian rats
    Eleonora Maries
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, N Chicago, IL 60064, USA
    Neurobiol Dis 21:165-80. 2006
    ..The onset of forelimb-facial stereotypy correlated with measures of increased graft function...
  33. ncbi request reprint RET expression does not change with age in the substantia nigra pars compacta of rhesus monkeys
    Biplob Dass
    Department of Neurological Sciences, Rush University Medical Center, 1735 W Harrison Street, Chicago, IL 60657, USA
    Neurobiol Aging 27:857-61. 2006
    ....
  34. ncbi request reprint Knockout of p75NTR does not alter the viability of striatal neurons following a metabolic or excitotoxic injury
    Rose Hanbury
    Research Center for Brain Repair and Department of Neurological Sciences, Rush Presbyterian Medical Center, Chicago, IL 60612, USA
    J Mol Neurosci 20:93-102. 2003
    ..The results indicate that the expression of p75NTR within reactive astrocytes in the mouse striatum is not a key factor in protecting neuronal cell death following metabolic and excitotoxic insults...
  35. ncbi request reprint Structural and functional neuroprotection in a rat model of Huntington's disease by viral gene transfer of GDNF
    Jodi L McBride
    Department of Neurological Sciences, Rush Presbyterian, St Luke s Medical Center, Chicago, IL 60612, USA
    Exp Neurol 181:213-23. 2003
    ..These data indicate that the viral-mediated gene transfer of GDNF into the striatum provides neuroanatomical and behavioral protection in a rodent model of HD...
  36. ncbi request reprint GFAP knockout mice have increased levels of GDNF that protect striatal neurons from metabolic and excitotoxic insults
    Rose Hanbury
    Research Center for Brain Repair and Department of Neurological Sciences, Rush Presbyterian Medical Center, Chicago, Illinois 60612, USA
    J Comp Neurol 461:307-16. 2003
    ..These data strongly suggest that the expression of GFAP is implicated with the production of GDNF to a degree that confers neuroprotection after an excitotoxic or metabolic insult...
  37. ncbi request reprint Inhibitors of cyclooxygenase-2, but not cyclooxygenase-1 provide structural and functional protection against quinolinic acid-induced neurodegeneration
    Heather C Salzberg-Brenhouse
    Division of Biological Research, Alkermes, Inc, 88 Sidney St, Cambridge, MA 02139, USA
    J Pharmacol Exp Ther 306:218-28. 2003
    ....
  38. ncbi request reprint Neuroprotection for Parkinson's disease using viral vector-mediated delivery of GDNF
    Jodi L McBride
    Department of Neurological Sciences, Research Center for Brain Repair, Rush University, 2242 W Harrison Street, Chicago, IL 60612, USA
    Prog Brain Res 138:421-32. 2002
  39. pmc Etiology of Parkinson's disease: Genetics and environment revisited
    Kathy Steece-Collier
    Department of Neurological Sciences, Rush Presbyterian Medical Center, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 99:13972-4. 2002
  40. ncbi request reprint Lentivirally delivered glial cell line-derived neurotrophic factor increases the number of striatal dopaminergic neurons in primate models of nigrostriatal degeneration
    Stephane Palfi
    Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    J Neurosci 22:4942-54. 2002
    ..Thus, GDNF may mediate plasticity in the dopamine-depleted primate brain, which may serve to compensate for cell loss by converting striatal neurons to a dopaminergic phenotype...
  41. ncbi request reprint Excitotoxic and metabolic damage to the rodent striatum: role of the P75 neurotrophin receptor and glial progenitors
    Rose Hanbury
    Research Center for Brain Repair and Department of Neurological Sciences, Rush Presbyterian Medical Center, 2242 West Harrison Street, Chicago, IL 60612, USA
    J Comp Neurol 444:291-305. 2002
    ..The expression of the p75(NTR) receptor after these chemical lesions support the concept that this receptor plays a role in the initiation of endogenous cellular events associated with CNS injury...
  42. ncbi request reprint Behavioral and morphological comparison of two nonhuman primate models of Huntington's disease
    Ben Zion Roitberg
    Department of Neurosurgery, University of Illinois, 912 S Wood Street, M C 799, Chicago, IL 60612, USA
    Neurosurgery 50:137-45; discussion 145-6. 2002
    ..No effective treatment exists, and thus stable primate models could aid in the development of novel therapies...
  43. ncbi request reprint Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment
    Steven T DeKosky
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Ann Neurol 51:145-55. 2002
    ..The upregulation in frontal cortex and hippocampal ChAT activity could be an important factor in preventing the transition of MCI subjects to AD...
  44. ncbi request reprint Loss of basal forebrain P75(NTR) immunoreactivity in subjects with mild cognitive impairment and Alzheimer's disease
    Elliott J Mufson
    Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    J Comp Neurol 443:136-53. 2002
    ..Although there was no difference in p75(NTR) CBF cell reduction between MCI and AD, it remains to be determined whether these findings lend support to the hypothesis that MCI is a prodromal stage of AD...
  45. ncbi request reprint A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease
    C Warren Olanow
    Department of Neurology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Ann Neurol 54:403-14. 2003
    ..Fetal nigral transplantation currently cannot be recommended as a therapy for PD based on these results...
  46. ncbi request reprint Human neural stem cell transplants improve motor function in a rat model of Huntington's disease
    Jodi L McBride
    Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Comp Neurol 475:211-9. 2004
    ..Taken together, these data demonstrate that striatal transplants of human fetal stem cells elicit behavioral and anatomical recovery in a rodent model of Huntington's disease...
  47. ncbi request reprint Effects of estrogen replacement therapy on cholinergic basal forebrain neurons and cortical cholinergic innervation in young and aged ovariectomized rhesus monkeys
    Katie Kompoliti
    Department of Neurological Sciences, Rush University Medical Center, Rush University, Chicago, Illinois 60612, USA
    J Comp Neurol 472:193-207. 2004
    ....
  48. ncbi request reprint Striatal trophic factor activity in aging monkeys with unilateral MPTP-induced parkinsonism
    Timothy J Collier
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Exp Neurol 191:S60-7. 2005
    ..Third, the aging-related chronic increase in combined striatal trophic activity was not attributable to BDNF or GDNF as these molecules either decreased or did not change with aging...
  49. ncbi request reprint A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease
    Mark H Tuszynski
    Department of Neurosciences, University of California at San Diego, La Jolla 92093, USA
    Nat Med 11:551-5. 2005
    ..05) increases in cortical 18-fluorodeoxyglucose after treatment. Brain autopsy from one subject suggested robust growth responses to NGF. Additional clinical trials of NGF for Alzheimer disease are warranted...
  50. ncbi request reprint Estrogen replacement increases spinophilin-immunoreactive spine number in the prefrontal cortex of female rhesus monkeys
    Yong Tang
    Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cereb Cortex 14:215-23. 2004
    ....
  51. ncbi request reprint Primate models of Parkinson's disease
    Timothy J Collier
    Department of Neurological Sciences, Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Exp Neurol 183:258-62. 2003
  52. ncbi request reprint RNA amplification of bromodeoxyuridine labeled newborn neurons in the monkey hippocampus
    Scott E Counts
    Department of Neurological Sciences, Alla and Solomon Jesmer Chair in Aging, Rush University Medical Center, 1735 W Harrison Street, Suite 300, Chicago, IL, USA
    J Neurosci Methods 144:197-201. 2005
    ..The present study demonstrates for the first time that BrdU immunohistochemisty is compatable with gene array technology in the primate hippocampus to evaluate subclasses of genes in newborn neurons...
  53. ncbi request reprint Estrogen increases the number of spinophilin-immunoreactive spines in the hippocampus of young and aged female rhesus monkeys
    Jiandong Hao
    Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Comp Neurol 465:540-50. 2003
    ....
  54. ncbi request reprint Prenatal 3,4-methylenedioxymethamphetamine (ecstasy) alters exploratory behavior, reduces monoamine metabolism, and increases forebrain tyrosine hydroxylase fiber density of juvenile rats
    James B Koprich
    Department of Neurological Sciences, Rush University, Rush Presbyterian St Luke s Medical Center, 2242 West Harrison Street, Suite 265, Chicago, IL 60612, USA
    Neurotoxicol Teratol 25:509-17. 2003
    ..Further investigation is warranted to elucidate possible mechanisms of action and to monitor children gestationally exposed to MDMA...
  55. ncbi request reprint Early changes in Huntington's disease patient brains involve alterations in cytoskeletal and synaptic elements
    Nicholas A DiProspero
    Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA
    J Neurocytol 33:517-33. 2004
    ..We propose that mutant huntingtin affects proteins involved in synaptic function and cytoskeletal integrity before symptoms develop which may influence early disease onset and/or progression...
  56. ncbi request reprint The role of alpha-synuclein in Parkinson's disease: insights from animal models
    Eleonora Maries
    Department of Neuroscience, The Chicago Medical School, 3333 Green Bay Road, N Chicago, Illinois 60064, USA
    Nat Rev Neurosci 4:727-38. 2003
  57. ncbi request reprint The immunophilin ligand GPI-1046 does not have neuroregenerative effects in MPTP-treated monkeys
    Jamie L Eberling
    Department of Neurology and Center for Neuroscience, University of California, Davis, 95616, USA
    Exp Neurol 178:236-42. 2002
    ..These findings show that GPI-1046 does not have regenerative effects in MPTP-treated primates and suggest that there may be species differences with respect to the trophic effects of GPI-1046 on nigrostriatal DA neurons...
  58. ncbi request reprint Chronic ischemic stroke model in cynomolgus monkeys: behavioral, neuroimaging and anatomical study
    Ben Roitberg
    Department of Neurosurgery M C 799, University of Illinois at Chicago, 912 S Wood St, Chicago, IL 60612, USA
    Neurol Res 25:68-78. 2003
    ..Our model may be particularly suitable for studies testing the effects of therapeutic strategies involving neural or stem cell transplantation, trophic factors or gene therapy...
  59. ncbi request reprint Huntington's disease: pathological mechanisms and therapeutic strategies
    Shilpa Ramaswamy
    Department of Neuroscience, Rush University Medical Center, Chicago, IL 60612, USA
    Cell Transplant 16:301-12. 2007
    ..This review describes the disease pathology in HD and addresses many of the past and emerging therapeutic strategies...
  60. ncbi request reprint Survival and early differentiation of human neural stem cells transplanted in a nonhuman primate model of stroke
    Ben Z Roitberg
    Department of Neurosurgery, University of Illinois, Chicago, Illinois 60612, USA
    J Neurosurg 105:96-102. 2006
    ..Neural cell transplantation has been proposed as a treatment after stroke. The purpose of this study was to establish if human neural stem cells (HNSCs) could survive in the nonhuman primate brain after an ischemic event...
  61. ncbi request reprint Distribution of high affinity choline transporter immunoreactivity in the primate central nervous system
    Laura Kus
    Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612
    J Comp Neurol 463:341-57. 2003
    ..The present observations indicate that the present CHT antibody labels cholinergic structures within the primate CNS and provides an additional marker for the investigation of cholinergic neuronal function in aging and disease...

Research Grants10

  1. DYSKINESIAS IN LENTI-GDNF TREATED PARKINSONIAN MONKEYS
    Jeffrey Kordower; Fiscal Year: 2006
    ..This application will determine whether potent dopaminergic gene therapies influence dyskinesias in the best animal model of PD. ..
  2. TH and GTPCHI gene therapy for Parkinson's disease
    Jeffrey Kordower; Fiscal Year: 2007
    ..These studies will determine the safety and efficacy of gene delivery of LDOPA and determine whether this approach is appropriate for clinical trials. ..
  3. TH and GTPCHI gene therapy for Parkinson's disease
    Jeffrey H Kordower; Fiscal Year: 2010
    ..These studies will determine the safety and efficacy of gene delivery of LDOPA and determine whether this approach is appropriate for clinical trials. ..