Ali Keshavarzian

Summary

Affiliation: Rush University Medical Center
Country: USA

Publications

  1. ncbi request reprint Reactive oxygen species: are they involved in the pathogenesis of GERD, Barrett's esophagus, and the latter's progression toward esophageal cancer?
    Ashkan Farhadi
    Department of Medicine, Rush University Medical Center, Chicago, Illinois 60612, USA
    Am J Gastroenterol 97:22-6. 2002
  2. ncbi request reprint A randomized, placebo-controlled, phase II study of tetomilast in active ulcerative colitis
    Stefan Schreiber
    Department of General Internal Medicine, Christian Albrechts University, Schittenhelmstrasse 12, Kiel Schleswig Holstein 24105, Germany
    Gastroenterology 132:76-86. 2007
  3. ncbi request reprint Reduced immunostaining for c-kit receptors in mucosal mast cells in inflammatory bowel disease
    Ashkan Farhadi
    Section of Gastroenterology and Nutrition, and Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Gastroenterol Hepatol 22:2338-43. 2007
  4. pmc Oats supplementation prevents alcohol-induced gut leakiness in rats by preventing alcohol-induced oxidative tissue damage
    Yueming Tang
    Division of Digestive Disease and Nutrition, Department of Internal Medicine, Rush University, Chicago, IL, USA
    J Pharmacol Exp Ther 329:952-8. 2009
  5. ncbi request reprint Preventing gut leakiness by oats supplementation ameliorates alcohol-induced liver damage in rats
    A Keshavarzian
    Section of Gastroenterology and Nutrition, Division of Digestive Diseases, Department of Internal Medicine, Rush Presbyterian St Lukes Medical Center, Chicago, Illinois 60612, USA
    J Pharmacol Exp Ther 299:442-8. 2001
  6. ncbi request reprint Phosphodiesterase 4 inhibitors and inflammatory bowel disease: emerging therapies in inflammatory bowel disease
    Ali Keshavarzian
    Rush University Medical Center, Department of Internal Medicine Division of Digestive Disease, Pharmacology, Physiology and Molecular Biophysics, Chicago, IL 60612, USA
    Expert Opin Investig Drugs 16:1489-506. 2007
  7. pmc Increases in free radicals and cytoskeletal protein oxidation and nitration in the colon of patients with inflammatory bowel disease
    A Keshavarzian
    Department of Internal Medicine Division of Digestive Diseases, Pharmacology, and Molecular Physiology, Rush University Medical Center, Chicago, IL 60612, USA
    Gut 52:720-8. 2003
  8. pmc Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats
    Ali Keshavarzian
    Department of Internal Medicine, Division of Digestive Disease and Nutrition, Rush University Medical Center, Chicago, IL 60612, USA
    J Hepatol 50:538-47. 2009
  9. pmc Intestinal dysbiosis: a possible mechanism of alcohol-induced endotoxemia and alcoholic steatohepatitis in rats
    Ece Mutlu
    Rush University Medical Center, Division of Digestive Diseases and Nutrition, Nutrition Rush University Medical Center, Chicago, Illinois 60612, USA
    Alcohol Clin Exp Res 33:1836-46. 2009
  10. pmc Nitric oxide-mediated intestinal injury is required for alcohol-induced gut leakiness and liver damage
    Yueming Tang
    Department of Internal Medicine, Division of Digestive Diseases and Nutrition, Rush University, Chicago, Illinois, USA
    Alcohol Clin Exp Res 33:1220-30. 2009

Collaborators

Detail Information

Publications75

  1. ncbi request reprint Reactive oxygen species: are they involved in the pathogenesis of GERD, Barrett's esophagus, and the latter's progression toward esophageal cancer?
    Ashkan Farhadi
    Department of Medicine, Rush University Medical Center, Chicago, Illinois 60612, USA
    Am J Gastroenterol 97:22-6. 2002
  2. ncbi request reprint A randomized, placebo-controlled, phase II study of tetomilast in active ulcerative colitis
    Stefan Schreiber
    Department of General Internal Medicine, Christian Albrechts University, Schittenhelmstrasse 12, Kiel Schleswig Holstein 24105, Germany
    Gastroenterology 132:76-86. 2007
    ..Tetomilast (OPC-6535), a novel thiazole compound, inhibits phosphodiesterase-4 and proinflammatory functions of leukocytes including superoxide production and cytokine release...
  3. ncbi request reprint Reduced immunostaining for c-kit receptors in mucosal mast cells in inflammatory bowel disease
    Ashkan Farhadi
    Section of Gastroenterology and Nutrition, and Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Gastroenterol Hepatol 22:2338-43. 2007
    ..This increased activation of MC in IBD could be due to (i) greater activation of the BGA or (ii) inherited or acquired abnormalities in mucosal MC. In the current study we investigated the latter possibility...
  4. pmc Oats supplementation prevents alcohol-induced gut leakiness in rats by preventing alcohol-induced oxidative tissue damage
    Yueming Tang
    Division of Digestive Disease and Nutrition, Department of Internal Medicine, Rush University, Chicago, IL, USA
    J Pharmacol Exp Ther 329:952-8. 2009
    ..This study suggests that oats may be a useful therapeutic agent--a nutraceutical--for the prevention of alcohol-induced oxidative stress and organ dysfunction...
  5. ncbi request reprint Preventing gut leakiness by oats supplementation ameliorates alcohol-induced liver damage in rats
    A Keshavarzian
    Section of Gastroenterology and Nutrition, Division of Digestive Diseases, Department of Internal Medicine, Rush Presbyterian St Lukes Medical Center, Chicago, Illinois 60612, USA
    J Pharmacol Exp Ther 299:442-8. 2001
    ..Further studies are needed to determine whether ALD in humans can be prevented by preventing alcohol-induced gut leakiness, studies that should lead to the development of useful therapeutic agents for the prevention of ALD...
  6. ncbi request reprint Phosphodiesterase 4 inhibitors and inflammatory bowel disease: emerging therapies in inflammatory bowel disease
    Ali Keshavarzian
    Rush University Medical Center, Department of Internal Medicine Division of Digestive Disease, Pharmacology, Physiology and Molecular Biophysics, Chicago, IL 60612, USA
    Expert Opin Investig Drugs 16:1489-506. 2007
    ..The authors detail the clinical development of the compound and report and provide insight into some of the unpublished data from the recently completed multicenter Phase III trials in UC...
  7. pmc Increases in free radicals and cytoskeletal protein oxidation and nitration in the colon of patients with inflammatory bowel disease
    A Keshavarzian
    Department of Internal Medicine Division of Digestive Diseases, Pharmacology, and Molecular Physiology, Rush University Medical Center, Chicago, IL 60612, USA
    Gut 52:720-8. 2003
    ..Our recent findings using monolayers of intestinal cells suggest that the mechanism could be oxidant induced damage to cytoskeletal proteins. However, oxidants and oxidative damage have not been well characterised in IBD mucosa...
  8. pmc Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats
    Ali Keshavarzian
    Department of Internal Medicine, Division of Digestive Disease and Nutrition, Rush University Medical Center, Chicago, IL 60612, USA
    J Hepatol 50:538-47. 2009
    ..Accordingly, the aim of the current study was to determine whether endotoxemia occurs prior to development of ASH and whether gut leakiness is the primary cause of the endotoxemia in an animal model of ASH...
  9. pmc Intestinal dysbiosis: a possible mechanism of alcohol-induced endotoxemia and alcoholic steatohepatitis in rats
    Ece Mutlu
    Rush University Medical Center, Division of Digestive Diseases and Nutrition, Nutrition Rush University Medical Center, Chicago, Illinois 60612, USA
    Alcohol Clin Exp Res 33:1836-46. 2009
    ..Thus, the aim of our study was to interrogate the gut bacterial microbiota in alcohol-fed rats to see if chronic alcohol consumption affects gut bacteria composition...
  10. pmc Nitric oxide-mediated intestinal injury is required for alcohol-induced gut leakiness and liver damage
    Yueming Tang
    Department of Internal Medicine, Division of Digestive Diseases and Nutrition, Rush University, Chicago, Illinois, USA
    Alcohol Clin Exp Res 33:1220-30. 2009
    ..We hypothesized that iNOS inhibitors [NG-nitro-l-arginine methyl ester (l-NAME), l-N(6)-(1-iminoethyl)-lysine (l-NIL)] in vivo will inhibit the above cascade and liver injury in an animal model of alcoholic steatohepatitis (ASH)...
  11. pmc Effects of aspirin on gastroduodenal permeability in alcoholics and controls
    Ashkan Farhadi
    Department of Medicine, Rush University, Chicago, IL, USA
    Alcohol 44:447-56. 2010
    ..Although, acute aspirin and chronic alcohol each increase intestinal permeability in alcoholics, their effects appear to be additive rather than synergistic...
  12. ncbi request reprint Alpha-synuclein in colonic submucosa in early untreated Parkinson's disease
    Kathleen M Shannon
    Departments of Neurological Sciences, Rush Medical College, Chicago, Illinois 60612, USA
    Mov Disord 27:709-15. 2012
    ..3-Nitrotyrosine immunostaining was common in all groups studied, suggesting oxidative stress in the colonic submucosa...
  13. pmc PI3K/AKT signaling is essential for communication between tissue-infiltrating mast cells, macrophages, and epithelial cells in colitis-induced cancer
    Mohammad W Khan
    Robert H Lurie Comprehensive Cancer Center, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Clin Cancer Res 19:2342-54. 2013
    ..We have explored phosphoinositide 3-kinase (PI3K) activity in human inflammatory bowel diseases and mouse colitis models...
  14. pmc Particulate matter air pollution causes oxidant-mediated increase in gut permeability in mice
    Ece A Mutlu
    Department of Medicine, Section of Gastroenterology and Nutrition Rush University Medical College, 1725 W Harrison Street, Chicago, IL 60612, USA
    Part Fibre Toxicol 8:19. 2011
    ..PM can gain access to the gastrointestinal (GI) tract via swallowing of air or secretions from the upper airways or mucociliary clearance of inhaled particles...
  15. pmc Role of intestinal circadian genes in alcohol-induced gut leakiness
    Garth Swanson
    Department of Medicine, Division of Digestive Diseases and Nutrition, Rush University Medical Center, 1725 W Harrison, Chicago, IL 60612, USA
    Alcohol Clin Exp Res 35:1305-14. 2011
    ....
  16. pmc Role of snail activation in alcohol-induced iNOS-mediated disruption of intestinal epithelial cell permeability
    Christopher B Forsyth
    Department of Internal Medicine, Section of Gastroenterology, Rush University Medical Center, Chicago, Illinois 60612, USA
    Alcohol Clin Exp Res 35:1635-43. 2011
    ..As activated Snail disrupts tight junctional proteins, we hypothesized that activation of Snail by iNOS might be one of the key signaling pathways mediating alcohol-stimulated intestinal epithelial cell hyperpermeability...
  17. ncbi request reprint Heightened responses to stressors in patients with inflammatory bowel disease
    Ashkan Farhadi
    Department of Internal Medicine, Section of Gastroenterology and Nutrition, Rush University Medical Center, Chicago, Illinois 60612, USA
    Am J Gastroenterol 100:1796-804. 2005
    ..To test this hypothesis, we determined whether stressor-induced activation of BGA is exaggerated in IBD patients...
  18. pmc Lactobacillus GG treatment ameliorates alcohol-induced intestinal oxidative stress, gut leakiness, and liver injury in a rat model of alcoholic steatohepatitis
    Christopher B Forsyth
    Department of Internal Medicine, Division of Digestive Diseases and Nutrition, and Rush University Medical Center, 1725 W Harrison, Suite 206, Chicago, IL 60612, USA
    Alcohol 43:163-72. 2009
    ..Our study provides a scientific rationale to test probiotics for treatment and/or prevention of alcoholic liver disease in man...
  19. ncbi request reprint Susceptibility to gut leakiness: a possible mechanism for endotoxaemia in non-alcoholic steatohepatitis
    Ashkan Farhadi
    Department of Medicine, Division of Digestive Diseases and Nutrition, Rush University, Chicago, IL 60612, USA
    Liver Int 28:1026-33. 2008
    ..We investigated one possible mechanism for the endotoxaemia--disruption of intestinal barrier integrity...
  20. ncbi request reprint Effect of alcohol on miR-212 expression in intestinal epithelial cells and its potential role in alcoholic liver disease
    Yueming Tang
    Division of Digestive Disease and Nutrition, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois 60612, USA
    Alcohol Clin Exp Res 32:355-64. 2008
    ..Zonula occludens 1 (ZO-1) protein is a major component of tight junctions that regulates intestinal permeability. microRNAs (miRNAs) are recently discovered regulatory molecules that inhibit expression of their target genes...
  21. pmc Increased intestinal permeability correlates with sigmoid mucosa alpha-synuclein staining and endotoxin exposure markers in early Parkinson's disease
    Christopher B Forsyth
    Department of Internal Medicine, Section of Gastroenterology, Rush University Medical Center, Chicago, Illinois, United States of America
    PLoS ONE 6:e28032. 2011
    ..Our study may thus shed new light on PD pathogenesis as well as provide a new method for earlier diagnosis of PD and suggests potential therapeutic targets in PD subjects...
  22. pmc Is moderate red wine consumption safe in inactive inflammatory bowel disease?
    Garth R Swanson
    Department Digestive Diseases, Rush University Medical Center, Chicago, IL 60612 3824, USA
    Digestion 84:238-44. 2011
    ..To test what effects alcohol may have on patients with IBD, we evaluated the effect of moderate daily red wine for 1 week on two factors associated with recurrent IBD disease activity: intestinal permeability and stool calprotectin...
  23. ncbi request reprint Impact of sleep disturbances in inflammatory bowel disease
    Ziba Ranjbaran
    Division of Digestive Diseases and Nutrition, Department of Medicine, Rush University, Chicago, Illinois, USA
    J Gastroenterol Hepatol 22:1748-53. 2007
    ..The aim of this study was to characterize sleep disturbance in IBD using validated measures of sleep and quality of life...
  24. pmc Role for intestinal CYP2E1 in alcohol-induced circadian gene-mediated intestinal hyperpermeability
    Christopher B Forsyth
    Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA
    Am J Physiol Gastrointest Liver Physiol 305:G185-95. 2013
    ....
  25. pmc New molecular insights into inflammatory bowel disease-induced diarrhea
    Yueming Tang
    Department of Internal Medicine, Division of Digestive Disease and Nutrition, Rush University Medical Center, Chicago, IL 60612, USA
    Expert Rev Gastroenterol Hepatol 5:615-25. 2011
    ....
  26. pmc Colonic microbiome is altered in alcoholism
    Ece A Mutlu
    Department of Medicine, Division of Digestive Diseases and Nutrition, Section of Gastroenterology, Rush University Medical Center, Chicago, Illinois 60612, USA
    Am J Physiol Gastrointest Liver Physiol 302:G966-78. 2012
    ..We show that the colonic mucosa-associated bacterial microbiome is altered in a subset of alcoholics. The altered microbiota composition is persistent and correlates with endotoxemia in a subgroup of alcoholics...
  27. pmc Sleep deprivation worsens inflammation and delays recovery in a mouse model of colitis
    Yueming Tang
    Department of Internal Medicine, Division of Digestive Disease and Nutrition, Rush University Medical Center, 1725 W Harrison, Suite 206, Chicago, IL 60612, USA
    Sleep Med 10:597-603. 2009
    ....
  28. ncbi request reprint Use of herbal preparations in the treatment of oxidant-mediated inflammatory disorders
    Mitchell Kaplan
    Rush University Medical Center, Department of Internal Medicine, Section of Gastroenterology and Nutrition, 1725 West Harrison Street, Suite 206, Chicago, IL 60612 3824, United States
    Complement Ther Med 15:207-16. 2007
    ....
  29. pmc Pattern of alcohol consumption and its effect on gastrointestinal symptoms in inflammatory bowel disease
    Garth R Swanson
    Department Digestive Diseases, Rush University Medical Center, Chicago, IL 60612 3824, USA
    Alcohol 44:223-8. 2010
    ..Patients with inactive IBD drink alcohol in quantities similar to the general population. Current drinkers with inactive IBD are more likely to report worsening of GI symptoms with alcohol than current drinkers with IBS...
  30. ncbi request reprint Evidence for non-chemical, non-electrical intercellular signaling in intestinal epithelial cells
    Ashkan Farhadi
    Section of Gastroenterology and Nutrition, Rush University Medical Center, Chicago, IL 60612, USA
    Bioelectrochemistry 71:142-8. 2007
    ..This signaling system possibly plays a role in synchronous, stimulus-appropriate cell responses to noxious stimuli and may explain a number of cellular behaviors that are hard to explain based only on conventional cell signaling systems...
  31. pmc Ethanol-induced mast cell-mediated inflammation leads to increased susceptibility of intestinal tumorigenesis in the APC Δ468 min mouse model of colon cancer
    Andre L Wimberly
    Department of Pharmacology, Rush University, Chicago, Illinois 60612, USA
    Alcohol Clin Exp Res 37:E199-208. 2013
    ..In this study, we tested our hypothesis that mast cell-mediated inflammation is 1 underlying mechanism by which chronic alcohol promotes intestinal tumorigenesis...
  32. ncbi request reprint Is alpha-synuclein in the colon a biomarker for premotor Parkinson's disease? Evidence from 3 cases
    Kathleen M Shannon
    Department of Neurological Sciences, Rush Medical College, Chicago, Illinois 60612, USA
    Mov Disord 27:716-9. 2012
    ..Alpha-synuclein aggregation underlies Parkinson's disease pathology, and its presence in peripheral tissues may be a reliable disease biomarker...
  33. pmc Alcohol stimulates activation of Snail, epidermal growth factor receptor signaling, and biomarkers of epithelial-mesenchymal transition in colon and breast cancer cells
    Christopher B Forsyth
    Department of Internal Medicine, Section of Gastroenterology, Rush University Medical Center, Chicago, Illinois, USA
    Alcohol Clin Exp Res 34:19-31. 2010
    ....
  34. pmc Chronic alcohol exposure renders epithelial cells vulnerable to bacterial infection
    Stephen Wood
    Department of Immunology Microbiology, Rush University Medical Center, Chicago, Illinois, USA
    PLoS ONE 8:e54646. 2013
    ..Finally, alcohol-treated cells partially regained their ability to withstand infection when ethanol treatment was ceased for two weeks, indicating that alcohol's deleterious effects on cells may be reversible...
  35. ncbi request reprint Dysbiosis in pouchitis: evidence of unique microfloral patterns in pouch inflammation
    Srinadh Komanduri
    Section of Gastroenterology and Nutrition, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    Clin Gastroenterol Hepatol 5:352-60. 2007
    ....
  36. doi request reprint Atopic irritable bowel syndrome: a novel subgroup of irritable bowel syndrome with allergic manifestations
    Mary C Tobin
    Department of Immunology Microbiology, Rush University Medical Center, John H Stoger, Jr Hospital, Chicago, Illinois 60612, USA
    Ann Allergy Asthma Immunol 100:49-53. 2008
    ..Mast cells have a primary role in atopy. Mast cells may play a unique role in a subgroup of patients with irritable bowel syndrome (IBS). This observation suggests a link between atopic disorders and IBS...
  37. ncbi request reprint Intestinal barrier: an interface between health and disease
    Ashkan Farhadi
    Department of Internal Medicine Section of Gastroenterology and Nutrition, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Gastroenterol Hepatol 18:479-97. 2003
    ....
  38. ncbi request reprint Endoscopy in eosinophilic esophagitis: "feline" esophagus and perforation risk
    Mitchell Kaplan
    Section of Gastroenterology and Nutrition, Department of Internal Medicine, Rush University, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612 3824, USA
    Clin Gastroenterol Hepatol 1:433-7. 2003
    ..Idiopathic eosinophilic esophagitis is an underdiagnosed disease with typical endoscopic findings, which have not been well described...
  39. ncbi request reprint Crypt loss is a marker of clinical severity of acute gastrointestinal graft-versus-host disease
    Joshua Melson
    Department of Gastroenterology, Rush University Medical Center, Chicago, Illinois, USA
    Am J Hematol 82:881-6. 2007
    ..Crypt loss is a histological finding in acute gastrointestinal Graft-Versus-Host Disease (GI-GvHD) of undefined clinical significance...
  40. pmc Circadian disorganization alters intestinal microbiota
    ROBIN M VOIGT
    Department of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, Illinois, United States of America
    PLoS ONE 9:e97500. 2014
    ....
  41. pmc A compositional look at the human gastrointestinal microbiome and immune activation parameters in HIV infected subjects
    Ece A Mutlu
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Rush University Medical Center, Chicago, Illinois, United States of America
    PLoS Pathog 10:e1003829. 2014
    ..This is the first report characterizing the terminal ileal and colonic mucosal microbiome in HIV patients with next generation sequencing. Limitations include use of HIV-infected subjects on HAART therapy. ..
  42. pmc Circadian disruption: potential implications in inflammatory and metabolic diseases associated with alcohol
    ROBIN M VOIGT
    Rush University Medical Center, Chicago, Illinois, USA
    Alcohol Res 35:87-96. 2013
    ....
  43. ncbi request reprint Mastocytic enterocolitis: increased mucosal mast cells in chronic intractable diarrhea
    Shriram Jakate
    Department of Pathology, Rush University Medical Center, Chicago, IL 60612, USA
    Arch Pathol Lab Med 130:362-7. 2006
    ..In some adult patients with chronic intractable diarrhea, the diagnosis remains elusive even after detailed evaluations, and colonic or duodenal biopsy specimens may appear unremarkable on routine hematoxylin-eosin staining...
  44. ncbi request reprint Resolution of common dietary sugars from probe sugars for test of intestinal permeability using capillary column gas chromatography
    Ashkan Farhadi
    Department of Internal Medicine, Section of Gastroenterology and Nutrition, Rush University Medical Center, Chicago, IL 60612, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 836:63-8. 2006
    ..The most-widely used sugar probes are sucrose, lactulose, mannitol and sucralose. Measuring these sugars using a sensitive gas chromatographic (GC) method, we noticed interference on the area of the lactulose and mannitol peaks...
  45. ncbi request reprint Gas chromatographic method for detection of urinary sucralose: application to the assessment of intestinal permeability
    Ashkan Farhadi
    Department of Internal Medicine, Division of Digestive Diseases, Rush University Medical Center, 60612, Chicago, IL, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 784:145-54. 2003
    ..Thus, the 24-h urinary concentrations of S and M, or the urinary S/M ratio following an oral dose of a sugar mixture, might be good markers for whole gut permeability...
  46. doi request reprint The role of oral hygiene in inflammatory bowel disease
    Shashideep Singhal
    Department of Internal Medicine, Chicago Medical School at Rosalind Franklin University of Medicine and Science, Chicago, IL, USA
    Dig Dis Sci 56:170-5. 2011
    ..Accordingly, we investigated associations between oral hygiene practices and IBD...
  47. pmc β-Catenin promotes colitis and colon cancer through imprinting of proinflammatory properties in T cells
    Shilpa Keerthivasan
    Gwen Knapp Center for Lupus and Immunology Research, The University of Chicago, Chicago, IL 60637, USA
    Sci Transl Med 6:225ra28. 2014
    ..On the basis of these findings, we conclude that activation of Wnt/β-catenin signaling in effector T cells and/or Tregs is causatively linked with the imprinting of proinflammatory properties and the promotion of colon cancer...
  48. doi request reprint Histopathology predictors of medically refractory ulcerative colitis
    Joshua E Melson
    Division of Digestive Diseases, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois 60612, USA
    Dis Colon Rectum 53:1280-6. 2010
    ..The ability of ulcerative colitis histology to predict medically refractory disease was evaluated...
  49. ncbi request reprint Effect of body mass index on nonalcoholic fatty liver disease in patients undergoing minimally invasive bariatric surgery
    Constantine T Frantzides
    Department of Surgery, Evanston Northwestern Healthcare, Chicago, Illinois, USA
    J Gastrointest Surg 8:849-55. 2004
    ..Body mass index was a positive risk factor for liver disease in younger patients but a negative risk factor in the older patients...
  50. ncbi request reprint An initial report of sleep disturbance in inactive inflammatory bowel disease
    Laurie Keefer
    Division of Digestive Diseases and Nutrition, Rush University Medical Center, Chicago, IL, USA
    J Clin Sleep Med 2:409-16. 2006
    ..This is the first study to comprehensively examine sleep concerns in patients with IBD...
  51. ncbi request reprint Intestinal permeation and gastrointestinal disease
    Mark T Demeo
    Division of Gastroenterology and Nutrition, Rush University, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    J Clin Gastroenterol 34:385-96. 2002
    ....
  52. doi request reprint The role of matrix metalloproteinases in intestinal epithelial wound healing during normal and inflammatory states
    Dana M Hayden
    Department of General Surgery, Rush University Medical Center, Chicago, Illinois, USA
    J Surg Res 168:315-24. 2011
    ..Healing of the epithelium is a key consideration in gastrointestinal surgery. Inflammation is one factor innate to patients with inflammatory bowel disease that poses a risk of delayed healing of the intestinal epithelium postoperatively...
  53. pmc Progression of intestinal permeability changes and alpha-synuclein expression in a mouse model of Parkinson's disease
    Leo P Kelly
    Department of Neurosurgery, Rush University, Chicago, Illinois, USA Department of Pharmacology, The Graduate College, Rush University, Chicago, Illinois, USA
    Mov Disord 29:999-1009. 2014
    ..2013 International Parkinson and Movement Disorder Society. ..
  54. pmc Sleep disturbances and inflammatory bowel disease: a potential trigger for disease flare?
    Garth R Swanson
    Department of Digestive Diseases, Rush University Medical Center, 1725 West Harrison Street, Suite 207, Chicago, IL 60612 3824, USA
    Expert Rev Clin Immunol 7:29-36. 2011
    ..Further research is needed to clarify the role of disturbances in IBD...
  55. ncbi request reprint Differential effects of T-cell activation on gastric and small bowel permeability in alcohol-consuming mice
    Ziad Alnadjim
    Department of Medicine, Section of Gastroenterology, Feingerg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Alcohol Clin Exp Res 26:1436-43. 2002
    ..A number of variables influence the effect(s) of alcohol on distinct segments of the intestine. In these studies, we examined the effect of T-cell activation on gastric and small bowel permeability in alcohol-fed mice...
  56. ncbi request reprint Prevalence and significance of autoantibodies in patients with non-alcoholic steatohepatitis
    Scott J Cotler
    University of Illinois at Chicago, Chicago, Illinois, USA
    J Clin Gastroenterol 38:801-4. 2004
    ..The aim of this study is to evaluate the prevalence and the clinical and histologic correlates of autoantibodies in patients with nonalcoholic steatohepatitis (NASH)...
  57. ncbi request reprint Diagnostic medical radiation in inflammatory bowel disease: how to limit risk and maximize benefit
    Garth Swanson
    Department Digestive Diseases, Rush University Medical Center, Chicago, Illinois
    Inflamm Bowel Dis 19:2501-8. 2013
    ..Alternative forms of imaging should be carefully considered when evaluating patients, in particularly those with identifiable risk factors for an aggressive disease course...
  58. pmc Regulatory B cell frequency correlates with markers of HIV disease progression and attenuates anti-HIV CD8⁺ T cell function in vitro
    Basile Siewe
    Rush University Medical Center, Departments of Immunology Microbiology and Internal Medicine, Chicago, Illinois 60612, USA
    J Leukoc Biol 93:811-8. 2013
    ..4791; P=0.0443). Our data indicate that Bregs contribute to HIV-infection associated immune dysfunction by T cell impairment, via IL-10 and possibly PD-L1 expression...
  59. ncbi request reprint New developments in the treatment of inflammatory bowel disease
    Ece A Mutlu
    Rush University, Rush Presbyterian St Luke s Medical Center, Professional Building, 1725 W Harrison, Suite 206, Chicago, IL 60612, USA
    Expert Opin Investig Drugs 11:365-85. 2002
    ....
  60. ncbi request reprint Focal rectal capillaritis: microscopic polyangiitis presenting as painless rectal bleeding
    Srinadh Komanduri
    Department of Internal Medicine, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    J Clin Gastroenterol 35:157-9. 2002
    ..This is the first reported case of microscopic polyangiitis with initial presentation of rectal bleeding and diagnosis made by rectal mucosal biopsy...
  61. ncbi request reprint Feasibility and acceptability of gut-directed hypnosis on inflammatory bowel disease: a brief communication
    Laurie Keefer
    Rush University Medical Center, Chicago, Illinois, USA
    Int J Clin Exp Hypn 55:457-66. 2007
    ..38, p = .01, with a mean improvement in quality of life of 29 points with significant changes in all 4 subscales. No negative effects of treatment were found...
  62. pmc Reconsidering the methodology of "stress" research in inflammatory bowel disease
    Laurie Keefer
    Department of Internal Medicine, Section of Gastroenterology and Nutrition, Rush University Medical Center, 1725 W Harrison, Suite 206 Chicago, IL 60612, United States
    J Crohns Colitis 2:193-201. 2008
    ..The goals of this paper are: 1) to critically review and analyze the methodology of the studies since 1990 linking stress to inflammatory bowel disease; and 2) to make recommendations for future research in this area of research...
  63. ncbi request reprint Current therapeutic approaches in inflammatory bowel disease
    Amir Ali Sohrabpour
    Division of Digestive Diseases, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois 60612, USA
    Curr Pharm Des 16:3668-83. 2010
    ..Furthermore, current basic laboratory research has provided a large number of potential therapeutic targets to treat IBD with new promising highly specific and targeted agents...
  64. ncbi request reprint Gastric heterotopia presenting as a mass in jejunum
    Baishali Bhattacharya
    Department of Pathology, Rush Presbyterian St Luke s Medical Center, Chicago, Ill 60612, USA
    Arch Pathol Lab Med 127:506-7. 2003
  65. ncbi request reprint Hyperalbuminemia and elevated transaminases associated with high-protein diet
    Ece A Mutlu
    Gastroenterology and Nutrition, Rush University Medical College, Chicago, Illinois 60612, USA
    Scand J Gastroenterol 41:759-60. 2006
    ..While the pathogenesis and importance of these abnormalities need further study, the findings raise concerns regarding the safety of high protein diets combined with high intensity exercise...
  66. ncbi request reprint The effects of quinidine and its chiral isolates on erg-1sm potassium current and correlation with gastrointestinal augmentation
    Ivana Cvetanovic
    Department of Pharmacology and Medicine, Rush University Medical Center, Chicago, Illinois, USA
    Am J Ther 14:269-76. 2007
    ..These results suggest that erg1-sm inhibition does not explain gastrointestinal contractile augmentation caused by the quinidine racemate and its chiral isolates...
  67. ncbi request reprint Exposure to ethanol induces oxidative damage in the pituitary gland
    Jian Ching Ren
    The Neuroscience Program, Loyola University Medical Center, Maywood, IL 60153, USA
    Alcohol 35:91-101. 2005
    ..These results provide evidence for ethanol-induced oxidative damage at the pituitary level, which may contribute to pituitary dysfunction...
  68. pmc Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium
    Vishnudutt Purohit
    Division of Metabolism and Health Effects, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5635 Fishers Lane, Room 2035, MSC 9304, Bethesda, MD 20892 9304, USA
    Alcohol 42:349-61. 2008
    ..Thus reducing the number of intestinal Gram-negative bacteria and preserving intestinal permeability to endotoxin may attenuate alcoholic liver and other organ injuries...
  69. ncbi request reprint A multi-scale stochastic drug release model for polymer-coated targeted drug delivery systems
    Nahor Haddish-Berhane
    Purdue University, Department of Agricultural and Biological Engineering, 225 S University Street, Room 315, West Lafayette, IN 47907 2093, USA
    J Control Release 110:314-22. 2006
    ..This research shows that in silico experiments using mechanistic models and stochastic approaches can be used for drug design and optimization and as a decision making tool for physicians...
  70. pmc Mucosal mast cells are pivotal elements in inflammatory bowel disease that connect the dots: stress, intestinal hyperpermeability and inflammation
    Ashkan Farhadi
    World J Gastroenterol 13:3027-30. 2007
    ..Thus, it is not surprising that MC are an important element in the pathogenesis of inflammatory bowel disease and non inflammatory GI disorders such as IBS and mast cell enterocolitis...
  71. ncbi request reprint Biological variability and targeted delivery of therapeutics for inflammatory bowel diseases: an in silico approach
    Nahor Haddish-Berhane
    Department of Agricultural and Biological Engineering, Purdue University, West Lafayette, IN 47907 2093, USA
    Inflamm Allergy Drug Targets 6:47-55. 2007
    ..It also could be used by the pharmaceutical industry to improve their medicine efficacy by altering the design...
  72. ncbi request reprint Influence of dietary fiber on inflammatory bowel disease and colon cancer: importance of fermentation pattern
    Devin J Rose
    Whistler Center for Carbohydrate Research and Department of Food Science, Purdue University, 760 Agriculture Mall, West Lafayette, IN 47907, USA
    Nutr Rev 65:51-62. 2007
    ..A greater understanding of the relationships between fermentation rate and dietary fiber structure would allow for development of dietary fibers for optimum colonic health...
  73. ncbi request reprint Apoptosis resistance in ulcerative colitis: high expression of decoy receptors by lamina propria T cells
    Raja Fayad
    Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago Medical Center, Maywood, IL 60153, USA
    Eur J Immunol 36:2215-22. 2006
    ....
  74. ncbi request reprint Alcoholic liver disease: is it an "extraintestinal" complication of alcohol-induced intestinal injury?
    Ali Keshavarzian
    J Lab Clin Med 142:285-7. 2003
  75. ncbi request reprint Laparoscopic transgastric esophageal mucosal resection for high-grade dysplasia
    Constantine T Frantzides
    Evanston Northwestern Healthcare, Evanston, Illinois 60201, USA
    J Laparoendosc Adv Surg Tech A 14:261-5. 2004
    ..As a surgical alternative to esophagectomy, we describe for the first time a new option in the treatment of high-grade dysplasia...

Research Grants7

  1. Brain-gut circadian rhythm interactions in alcohol-induced gut leakiness
    Fred W Turek; Fiscal Year: 2010
    ..Identifying how alcohol affects these biological rhythms in these organs may help us design new treatments for alcoholic liver disease and other alcohol related diseases. ..
  2. Alcohol, iNOS upregulation, leaky gut & liver disease
    Ali Keshavarzian; Fiscal Year: 2003
    ..Significance: Showing that ALD requires a leaky gut, & that NO & cytoskeletal pathways are involved, could 1) identify drinkers at risk for LD (sugar test); 2) lead to therapies to prevent LD in those drinkers unable to abstain. ..
  3. Alcohol, iNOS upregulation , leaky gut & liver disease
    Ali Keshavarzian; Fiscal Year: 2004
    ..Significance: Showing that ALD requires a leaky gut, & that NO & cytoskeletal pathways are involved, could 1) identify drinkers at risk for LD (sugar test); 2) lead to therapies to prevent LD in those drinkers unable to abstain. ..
  4. Alcohol, iNOS upregulation , leaky gut & liver disease
    Ali Keshavarzian; Fiscal Year: 2005
    ..Significance: Showing that ALD requires a leaky gut, & that NO & cytoskeletal pathways are involved, could 1) identify drinkers at risk for LD (sugar test); 2) lead to therapies to prevent LD in those drinkers unable to abstain. ..
  5. Alcohol, iNOS upregulation , leaky gut & liver disease
    Ali Keshavarzian; Fiscal Year: 2006
    ..Significance: Showing that ALD requires a leaky gut, & that NO & cytoskeletal pathways are involved, could 1) identify drinkers at risk for LD (sugar test); 2) lead to therapies to prevent LD in those drinkers unable to abstain. ..
  6. Alcohol, iNOS upregulation, leaky gut & liver disease
    Ali Keshavarzian; Fiscal Year: 2007
    ..Significance: Showing that ALD requires a leaky gut, & that NO & cytoskeletal pathways are involved, could 1) identify drinkers at risk for LD (sugar test); 2) lead to therapies to prevent LD in those drinkers unable to abstain. ..
  7. Alcohol, iNOS upregulation, leaky gut & liver disease
    Ali Keshavarzian; Fiscal Year: 2009
    ..Significance: Showing that ALD requires a leaky gut, &that NO &cytoskeletal pathways are involved, could 1) identify drinkers at risk for LD (sugar test);2) lead to therapies to prevent LD in those drinkers unable to abstain. ..