Malabendu Jana

Summary

Affiliation: Rush University Medical Center
Country: USA

Publications

  1. pmc Induction of lymphotoxin-alpha by interleukin-12 p40 homodimer, the so-called biologically inactive molecule, but not IL-12 p70
    Malabendu Jana
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Immunology 127:312-25. 2009
  2. pmc Interleukin-12 (IL-12), but not IL-23, induces the expression of IL-7 in microglia and macrophages: implications for multiple sclerosis
    Malabendu Jana
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
    Immunology 141:549-63. 2014
  3. pmc IL-12 p40 homodimer, the so-called biologically inactive molecule, induces nitric oxide synthase in microglia via IL-12R beta 1
    Malabendu Jana
    Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    Glia 57:1553-65. 2009
  4. pmc Regulation of cyclic AMP response element binding and hippocampal plasticity-related genes by peroxisome proliferator-activated receptor α
    Avik Roy
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Cell Rep 4:724-37. 2013
  5. pmc Gemfibrozil, a lipid-lowering drug, increases myelin genes in human oligodendrocytes via peroxisome proliferator-activated receptor-β
    Malabendu Jana
    Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Biol Chem 287:34134-48. 2012
  6. pmc Involvement of phosphatidylinositol 3-kinase-mediated up-regulation of I kappa B alpha in anti-inflammatory effect of gemfibrozil in microglia
    Malabendu Jana
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    J Immunol 179:4142-52. 2007
  7. pmc Identification and characterization of PPARα ligands in the hippocampus
    Avik Roy
    Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA
    Nat Chem Biol 12:1075-1083. 2016
  8. pmc IL-12 p40 homodimer, but not IL-12 p70, induces the expression of IL-16 in microglia and macrophages
    Malabendu Jana
    Department of Neurological Sciences, Rush University Medical Center, Cohn Research Building, Suite 320, 1735 West Harrison St, Chicago, IL 60612, United States
    Mol Immunol 46:773-83. 2009
  9. pmc Fibrillar amyloid-beta peptides activate microglia via TLR2: implications for Alzheimer's disease
    Malabendu Jana
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    J Immunol 181:7254-62. 2008
  10. pmc HMG-CoA Reductase Inhibitors Bind to PPARα to Upregulate Neurotrophin Expression in the Brain and Improve Memory in Mice
    Avik Roy
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Cell Metab 22:253-65. 2015

Collaborators

Detail Information

Publications15

  1. pmc Induction of lymphotoxin-alpha by interleukin-12 p40 homodimer, the so-called biologically inactive molecule, but not IL-12 p70
    Malabendu Jana
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Immunology 127:312-25. 2009
    ..These studies delineate a novel biological function of p40(2) that is absent in IL-12...
  2. pmc Interleukin-12 (IL-12), but not IL-23, induces the expression of IL-7 in microglia and macrophages: implications for multiple sclerosis
    Malabendu Jana
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
    Immunology 141:549-63. 2014
    ..These studies delineate a novel biological function of IL-12 that is absent in IL-23 and other p40 family members...
  3. pmc IL-12 p40 homodimer, the so-called biologically inactive molecule, induces nitric oxide synthase in microglia via IL-12R beta 1
    Malabendu Jana
    Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    Glia 57:1553-65. 2009
    ..This study delineates a new role of IL-12R beta 1 and IL-12R beta 2 for the expression of iNOS and production of NO in microglia that may participate in the pathogenesis of neuroinflammatory diseases...
  4. pmc Regulation of cyclic AMP response element binding and hippocampal plasticity-related genes by peroxisome proliferator-activated receptor α
    Avik Roy
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Cell Rep 4:724-37. 2013
    ....
  5. pmc Gemfibrozil, a lipid-lowering drug, increases myelin genes in human oligodendrocytes via peroxisome proliferator-activated receptor-β
    Malabendu Jana
    Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Biol Chem 287:34134-48. 2012
    ..These results suggest that gemfibrozil stimulates the expression of myelin genes via PPAR-β and that gemfibrozil, a prescribed drug for humans, may find further therapeutic use in demyelinating diseases...
  6. pmc Involvement of phosphatidylinositol 3-kinase-mediated up-regulation of I kappa B alpha in anti-inflammatory effect of gemfibrozil in microglia
    Malabendu Jana
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    J Immunol 179:4142-52. 2007
    ....
  7. pmc Identification and characterization of PPARα ligands in the hippocampus
    Avik Roy
    Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA
    Nat Chem Biol 12:1075-1083. 2016
    ..Moreover, these ligands activated PPARα and upregulated the synaptic function of hippocampal neurons. These results highlight the discovery of hippocampal ligands of PPARα capable of modulating synaptic functions...
  8. pmc IL-12 p40 homodimer, but not IL-12 p70, induces the expression of IL-16 in microglia and macrophages
    Malabendu Jana
    Department of Neurological Sciences, Rush University Medical Center, Cohn Research Building, Suite 320, 1735 West Harrison St, Chicago, IL 60612, United States
    Mol Immunol 46:773-83. 2009
    ..These results delineate a novel biological function of p40(2) and raise the possibility that biological function of IL-12 p40(2) may be different from IL-12 p70...
  9. pmc Fibrillar amyloid-beta peptides activate microglia via TLR2: implications for Alzheimer's disease
    Malabendu Jana
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    J Immunol 181:7254-62. 2008
    ..Taken together, these studies delineate a novel role of TLR2 signaling pathway in mediating fibrillar Abeta peptide-induced activation of microglia...
  10. pmc HMG-CoA Reductase Inhibitors Bind to PPARα to Upregulate Neurotrophin Expression in the Brain and Improve Memory in Mice
    Avik Roy
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Cell Metab 22:253-65. 2015
    ....
  11. pmc Gemfibrozil, a lipid lowering drug, inhibits the activation of primary human microglia via peroxisome proliferator-activated receptor β
    Malabendu Jana
    Department of Neurological Sciences, Rush University Medical Center, 1735 West Harrison St, Suite 320, Chicago, IL 60612, USA
    Neurochem Res 37:1718-29. 2012
    ....
  12. pmc MAPK p38 regulates transcriptional activity of NF-kappaB in primary human astrocytes via acetylation of p65
    Ramendra N Saha
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    J Immunol 179:7101-9. 2007
    ..Taken together, this study illuminates a novel regulatory role of p38 during neuroinflammation where this MAP kinase controls acetylation of NF-kappaB p65 by regulating acetyltransferase activity of coactivator p300...
  13. pmc Sodium Benzoate, a Metabolite of Cinnamon and a Food Additive, Upregulates Ciliary Neurotrophic Factor in Astrocytes and Oligodendrocytes
    Khushbu K Modi
    Department of Neurological Sciences, Rush University Medical Center, 1735 West Harrison St, Suite Cohn 320, Chicago, IL, 60612, USA
    Neurochem Res 40:2333-47. 2015
    ..These results highlight a novel myelinogenic property of NaB and cinnamon, which may be of benefit for MS and other demyelinating disorders. ..
  14. pmc A simplified method for isolating highly purified neurons, oligodendrocytes, astrocytes, and microglia from the same human fetal brain tissue
    Malabendu Jana
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Neurochem Res 32:2015-22. 2007
    ..The availability of highly purified human brain cells will increase the possibility of developing therapies for different neurodegenerative disorders...
  15. pmc Gemfibrozil ameliorates relapsing-remitting experimental autoimmune encephalomyelitis independent of peroxisome proliferator-activated receptor-alpha
    Subhajit Dasgupta
    Department of Neurological Sciences, Rush University Medical Center, Cohn Research Building, Suite 320, 1735 West Harrison St, Chicago, IL 60612, USA
    Mol Pharmacol 72:934-46. 2007
    ..Taken together, our results suggest gemfibrozil, an approved drug for hyperlipidemia in humans, may find further therapeutic use in multiple sclerosis...