Christopher G Goetz

..With different primary interests and different etiological views, side by side, they exemplified two models of French medicine at the close of the nineteenth century: medical scientist and scientific physician...

..90 for each part), which support the use of sum scores for each part in preference to a total score of all parts. The combined clinimetric results of this study support the validity of the MDS-UPDRS for rating PD...

..This training program is in English, but as non-English official translations of the MDS-UPDRS are developed, the program can be potentially modified into different languages...

..Revision of the checklist by altering or eliminating the 2 problematic checklist items may improve sensitivity...

..The magnitude and variance of placebo-related changes and the factors that influence them can be helpful in the design of future clinical trials of antidyskinetic agents...

..Furthermore, increased burden of cognitive dysfunction, rather than type of cognitive deficit, may be associated with greater motor impairment in PD-MCI...

..To assess prospectively progression and relationship of hallucinations and sleep disorders over a 10-year longitudinal study of patients with Parkinson disease (PD)...

..Thus, ERC atrophy on MRI may be a potential biomarker for dementia in PD, particularly in the setting of memory impairment...

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..The UDysRS has strong internal consistency and a reliable factor structure, but the important issue of temporal stability has not been established...

..To capture the breadth and severity of hallucinations in chronically hallucinating patients with Parkinson's disease, screening inventories and practice-based interviews must include questions on both visual and nonvisual components...

..Age-related disinhibition may facilitate wider cortical activation in PD and potentiate aberrant signaling that invokes other types of hallucinations besides the classic visual forms...

..Large-scale multicenter randomized clinical trials of dyskinesia treatment are strengthened by a uniform standard of scale application...

..Recognition of factors that impact placebo response rates should be incorporated into individual study designs for PD clinical trials...

..Because Part I collects data on much more extensive information than the UPDRS, and because Part IV is structured differently in the two versions, old ratings for these parts cannot be converted. © 2012 Movement Disorder Society...

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..The UDysRS is a clinimetrically sound rating scale for dyskinesia in PD, demonstrating acceptable levels of internal consistency and inter- and intra-rater reliability. Testing scale responsivity to treatment interventions is planned...

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..We consider a 3-year period a reasonable time frame for published updates and are working to establish a Web-based mechanism to update the report in an ongoing manner...

..In this group of patients with no or mild fluctuations, in spite of pretrial training, patients were inaccurate in separating ON vs. OFF status...

..To monitor progression of "benign hallucinations" in Parkinson disease (PD)...

..Neurologists have long wrestled with the diagnosis of elaborated or feigned disease. Studies have not focused on early techniques utilized to diagnose malingering...

..To analyze Jean-Martin Charcot's studies of mercury-induced tremor...

..Because we found no evidence of seasonal variations, we cannot recommend phototherapy or other strategies affecting chronobiological systems as research priorities to treat PD hallucinations. (c) 2006 Movement Disorder Society...

..ADHD with predominantly inattentive symptoms, rather than hyperactivity symptoms, was associated with lower QOL. To improve QOL, clinicians must consider treatments of co-morbidities among tic patients...

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..Our results suggest that dopaminergic medications have limited benefit in DLB because of the low likelihood of motor improvement and the risk of psychosis exacerbation...

..These strategies also have challenges but have the potential to enhance our understanding of PD psychosis and advance the development of agents that can ultimately be tested in well-designed, randomized, controlled trials...

..The Task Force officially recommended the development of a new scale to assess hallucinations and psychosis in Parkinson's disease. This effort is now ongoing with official endorsement by the Movement Disorder Society...

..Sarizotan 2 mg/day is a safe agent in PD patients with dyskinesia. To test its role in abating dyskinesia, future studies should focus on this dose and will use the composite score of UPDRS Items 32+33 as the primary outcome...

..Trace the medical-legal involvement of the 19th century clinical neurologist Jean-Martin Charcot...

..Although after Charcot's death vibratory therapy was not widely pursued, vibratory appliances are reemerging in 21st century medicine and can be retested using adaptations of Charcot's neurologic protocols...

..The objective of this study is to investigate the relationship between antipsychotic use and weight in tic patients and compare the effects of SGAs to first-generation (typical) antipsychotics (FGAs)...

..The written materials and videotape belong to the Movement Disorder Society and are available by contacting the MDS central office...

..Although most wish they received the active compound being tested, the overall view of participation in placebo-controlled trials is viewed very positively by PD patients...

..Given the relatively high population frequency of the FMR1 premutation, this mutation may be a significant cause of late-onset "idiopathic" progressive tremor...

..To identify outcome measures for clinical trials in progressive supranuclear palsy (PSP), the authors determined the time to key motor impairments in a well-defined patient cohort...

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..Her historic election acknowledged her accomplishments and highlighted the proactive role of the early ANA in forging new medical policies in the United States...

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..In the context of Charcot's extensive discoveries and lasting contributions, the anatomo-clinical method remains the anchor of modern neurological diagnosis and is Charcot's most important contribution to clinical neurology...

..In the context of his time, these elements prompted Marie to enter into controversies and medico-political battles that advanced neurological knowledge, but likely disadvantaged him in his career successes...

..Neurologists should not look to these works as replacements for more seriously composed historical studies, but as enrichments anchored in the imaginative possibilities of Charcot and his fin de siècle era...

..The inclusion criteria can be applied internationally and in multicenter research on treatment interventions, clinicopathological correlations, and studies of cognitive and other nonmotor elements of PD...

..Raters have the greatest difficulty with the mildest impairment, making training especially important to studies of early PD...

..5 increments, this adaptation warrants clinimetric testing. Without such testing, however, the original five-point scales should be maintained...

..These data suggest that neuropathic signs are associated with the fragile X premutation, presumably occurring through the same mechanism proposed for CNS disease, namely, toxicity from expanded-CGG-repeat FMR1 mRNA...

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..New treatments are being developed, but there have been very few large-scale randomized clinical trials to test the relative roles of new or available agents for abating these problematic behaviors...

..The spectrum of medical diseases associated with these four syndromes is reviewed in this article...

..To prospectively assess the relationship of hallucinations to sleep disorders in patients with Parkinson disease (PD) over 6 years...

..Because CCK gene polymorphisms vary across ethnic groups, the presence of similar associations in white PD subjects merits investigation...

..The films demonstrate the variety of dystonic movements appreciated during this period, consider psychogenic, postencephalitic, and hereditary forms, and refer to the treatment of dystonia by surgery and plaster casts...

..Overall, patient awareness of NL side effects is insufficient, and although past exposure to NLs enhances knowledge, it decreases concern...

..004) when compared with adults. Tic phenomenology and severity were similar between children and adults, but pharmacological tic management was different, perhaps reflecting a practice trend to avoid medications in children...

..Movement Disorders has a continuingly growing subscribership and rising impact factor...

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