Christopher B Forsyth

Summary

Affiliation: Rush University Medical Center
Country: USA

Publications

  1. ncbi Increased intestinal permeability correlates with sigmoid mucosa alpha-synuclein staining and endotoxin exposure markers in early Parkinson's disease
    Christopher B Forsyth
    Department of Internal Medicine, Section of Gastroenterology, Rush University Medical Center, Chicago, Illinois, United States of America
    PLoS ONE 6:e28032. 2011
  2. ncbi Regulation of oxidant-induced intestinal permeability by metalloprotease-dependent epidermal growth factor receptor signaling
    C B Forsyth
    Department of Internal Medicine, Section of Gastroenterology, Rush University Medical Center, 1725 W Harrison, Suite 206, Chicago, IL 60612, USA
    J Pharmacol Exp Ther 321:84-97. 2007
  3. ncbi Role of snail activation in alcohol-induced iNOS-mediated disruption of intestinal epithelial cell permeability
    Christopher B Forsyth
    Department of Internal Medicine, Section of Gastroenterology, Rush University Medical Center, Chicago, Illinois 60612, USA
    Alcohol Clin Exp Res 35:1635-43. 2011
  4. ncbi Nitric oxide-mediated intestinal injury is required for alcohol-induced gut leakiness and liver damage
    Yueming Tang
    Department of Internal Medicine, Division of Digestive Diseases and Nutrition, Rush University, Chicago, Illinois, USA
    Alcohol Clin Exp Res 33:1220-30. 2009
  5. ncbi Oats supplementation prevents alcohol-induced gut leakiness in rats by preventing alcohol-induced oxidative tissue damage
    Yueming Tang
    Division of Digestive Disease and Nutrition, Department of Internal Medicine, Rush University, Chicago, IL, USA
    J Pharmacol Exp Ther 329:952-8. 2009
  6. ncbi Intestinal dysbiosis: a possible mechanism of alcohol-induced endotoxemia and alcoholic steatohepatitis in rats
    Ece Mutlu
    Rush University Medical Center, Division of Digestive Diseases and Nutrition, Nutrition Rush University Medical Center, Chicago, Illinois 60612, USA
    Alcohol Clin Exp Res 33:1836-46. 2009
  7. ncbi Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats
    Ali Keshavarzian
    Department of Internal Medicine, Division of Digestive Disease and Nutrition, Rush University Medical Center, Chicago, IL 60612, USA
    J Hepatol 50:538-47. 2009
  8. ncbi Alcohol stimulates activation of Snail, epidermal growth factor receptor signaling, and biomarkers of epithelial-mesenchymal transition in colon and breast cancer cells
    Christopher B Forsyth
    Department of Internal Medicine, Section of Gastroenterology, Rush University Medical Center, Chicago, Illinois, USA
    Alcohol Clin Exp Res 34:19-31. 2010
  9. ncbi Role of intestinal circadian genes in alcohol-induced gut leakiness
    Garth Swanson
    Department of Medicine, Division of Digestive Diseases and Nutrition, Rush University Medical Center, 1725 W Harrison, Chicago, IL 60612, USA
    Alcohol Clin Exp Res 35:1305-14. 2011
  10. ncbi Lactobacillus GG treatment ameliorates alcohol-induced intestinal oxidative stress, gut leakiness, and liver injury in a rat model of alcoholic steatohepatitis
    Christopher B Forsyth
    Department of Internal Medicine, Division of Digestive Diseases and Nutrition, and Rush University Medical Center, 1725 W Harrison, Suite 206, Chicago, IL 60612, USA
    Alcohol 43:163-72. 2009

Collaborators

Detail Information

Publications16

  1. ncbi Increased intestinal permeability correlates with sigmoid mucosa alpha-synuclein staining and endotoxin exposure markers in early Parkinson's disease
    Christopher B Forsyth
    Department of Internal Medicine, Section of Gastroenterology, Rush University Medical Center, Chicago, Illinois, United States of America
    PLoS ONE 6:e28032. 2011
    ..Our study may thus shed new light on PD pathogenesis as well as provide a new method for earlier diagnosis of PD and suggests potential therapeutic targets in PD subjects. TRIAL REGISTRATION: Clinicaltrials.gov NCT01155492...
  2. ncbi Regulation of oxidant-induced intestinal permeability by metalloprotease-dependent epidermal growth factor receptor signaling
    C B Forsyth
    Department of Internal Medicine, Section of Gastroenterology, Rush University Medical Center, 1725 W Harrison, Suite 206, Chicago, IL 60612, USA
    J Pharmacol Exp Ther 321:84-97. 2007
    ..These data could have a significant effect on our view of IBD pathogenesis and provide new therapeutic targets for IBD treatment...
  3. ncbi Role of snail activation in alcohol-induced iNOS-mediated disruption of intestinal epithelial cell permeability
    Christopher B Forsyth
    Department of Internal Medicine, Section of Gastroenterology, Rush University Medical Center, Chicago, Illinois 60612, USA
    Alcohol Clin Exp Res 35:1635-43. 2011
    ..As activated Snail disrupts tight junctional proteins, we hypothesized that activation of Snail by iNOS might be one of the key signaling pathways mediating alcohol-stimulated intestinal epithelial cell hyperpermeability...
  4. ncbi Nitric oxide-mediated intestinal injury is required for alcohol-induced gut leakiness and liver damage
    Yueming Tang
    Department of Internal Medicine, Division of Digestive Diseases and Nutrition, Rush University, Chicago, Illinois, USA
    Alcohol Clin Exp Res 33:1220-30. 2009
    ..We hypothesized that iNOS inhibitors [NG-nitro-l-arginine methyl ester (l-NAME), l-N(6)-(1-iminoethyl)-lysine (l-NIL)] in vivo will inhibit the above cascade and liver injury in an animal model of alcoholic steatohepatitis (ASH)...
  5. ncbi Oats supplementation prevents alcohol-induced gut leakiness in rats by preventing alcohol-induced oxidative tissue damage
    Yueming Tang
    Division of Digestive Disease and Nutrition, Department of Internal Medicine, Rush University, Chicago, IL, USA
    J Pharmacol Exp Ther 329:952-8. 2009
    ..This study suggests that oats may be a useful therapeutic agent--a nutraceutical--for the prevention of alcohol-induced oxidative stress and organ dysfunction...
  6. ncbi Intestinal dysbiosis: a possible mechanism of alcohol-induced endotoxemia and alcoholic steatohepatitis in rats
    Ece Mutlu
    Rush University Medical Center, Division of Digestive Diseases and Nutrition, Nutrition Rush University Medical Center, Chicago, Illinois 60612, USA
    Alcohol Clin Exp Res 33:1836-46. 2009
    ..Thus, the aim of our study was to interrogate the gut bacterial microbiota in alcohol-fed rats to see if chronic alcohol consumption affects gut bacteria composition...
  7. ncbi Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats
    Ali Keshavarzian
    Department of Internal Medicine, Division of Digestive Disease and Nutrition, Rush University Medical Center, Chicago, IL 60612, USA
    J Hepatol 50:538-47. 2009
    ..Accordingly, the aim of the current study was to determine whether endotoxemia occurs prior to development of ASH and whether gut leakiness is the primary cause of the endotoxemia in an animal model of ASH...
  8. ncbi Alcohol stimulates activation of Snail, epidermal growth factor receptor signaling, and biomarkers of epithelial-mesenchymal transition in colon and breast cancer cells
    Christopher B Forsyth
    Department of Internal Medicine, Section of Gastroenterology, Rush University Medical Center, Chicago, Illinois, USA
    Alcohol Clin Exp Res 34:19-31. 2010
    ....
  9. ncbi Role of intestinal circadian genes in alcohol-induced gut leakiness
    Garth Swanson
    Department of Medicine, Division of Digestive Diseases and Nutrition, Rush University Medical Center, 1725 W Harrison, Chicago, IL 60612, USA
    Alcohol Clin Exp Res 35:1305-14. 2011
    ....
  10. ncbi Lactobacillus GG treatment ameliorates alcohol-induced intestinal oxidative stress, gut leakiness, and liver injury in a rat model of alcoholic steatohepatitis
    Christopher B Forsyth
    Department of Internal Medicine, Division of Digestive Diseases and Nutrition, and Rush University Medical Center, 1725 W Harrison, Suite 206, Chicago, IL 60612, USA
    Alcohol 43:163-72. 2009
    ..Our study provides a scientific rationale to test probiotics for treatment and/or prevention of alcoholic liver disease in man...
  11. ncbi Effects of aspirin on gastroduodenal permeability in alcoholics and controls
    Ashkan Farhadi
    Department of Medicine, Rush University, Chicago, IL, USA
    Alcohol 44:447-56. 2010
    ..Although, acute aspirin and chronic alcohol each increase intestinal permeability in alcoholics, their effects appear to be additive rather than synergistic...
  12. ncbi Particulate matter air pollution causes oxidant-mediated increase in gut permeability in mice
    Ece A Mutlu
    Department of Medicine, Section of Gastroenterology and Nutrition Rush University Medical College, 1725 W Harrison Street, Chicago, IL 60612, USA
    Part Fibre Toxicol 8:19. 2011
    ..PM can gain access to the gastrointestinal (GI) tract via swallowing of air or secretions from the upper airways or mucociliary clearance of inhaled particles...
  13. ncbi New molecular insights into inflammatory bowel disease-induced diarrhea
    Yueming Tang
    Department of Internal Medicine, Division of Digestive Disease and Nutrition, Rush University Medical Center, Chicago, IL 60612, USA
    Expert Rev Gastroenterol Hepatol 5:615-25. 2011
    ....
  14. ncbi Effect of alcohol on miR-212 expression in intestinal epithelial cells and its potential role in alcoholic liver disease
    Yueming Tang
    Division of Digestive Disease and Nutrition, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois 60612, USA
    Alcohol Clin Exp Res 32:355-64. 2008
    ..The aims of our study were: (i) to investigate the effect of alcohol on miRNA-212 (miR-212) and on expression of its predicted target gene, ZO-1, (ii) to study the potential role of miR-212 in the pathophysiology of ALD in man...
  15. ncbi Loss of p120 catenin upregulates transcription of pro-inflammatory adhesion molecules in human endothelial cells
    James J O'Donnell
    Department of Pharmacology, Rush University Medical Center, Chicago, IL, USA
    Microvasc Res 82:105-12. 2011
    ..We conclude that p120ctn functions to suppress transcription, which is an important and novel regulation in vascular endothelium...
  16. ncbi Ethanol-induced mast cell-mediated inflammation leads to increased susceptibility of intestinal tumorigenesis in the APC Δ468 min mouse model of colon cancer
    Andre L Wimberly
    Department of Pharmacology, Rush University, Chicago, Illinois 60612, USA
    Alcohol Clin Exp Res 37:E199-208. 2013
    ..In this study, we tested our hypothesis that mast cell-mediated inflammation is 1 underlying mechanism by which chronic alcohol promotes intestinal tumorigenesis...