Christopher B Forsyth
Affiliation: Rush University Medical Center
Forsyth C, Shannon K, Kordower J, VOIGT R, Shaikh M, Jaglin J, et al
. Increased intestinal permeability correlates with sigmoid mucosa alpha-synuclein staining and endotoxin exposure markers in early Parkinson's disease. PLoS ONE. 2011;6:e28032 pubmed publisher
..Our study may thus shed new light on PD pathogenesis as well as provide a new method for earlier diagnosis of PD and suggests potential therapeutic targets in PD subjects. Clinicaltrials.gov NCT01155492. ..
Forsyth C, VOIGT R, Burgess H, Swanson G, Keshavarzian A. Circadian rhythms, alcohol and gut interactions. Alcohol. 2015;49:389-98 pubmed publisher
..Taken together our data support circadian mechanisms for alcohol-induced gut leakiness that could provide new therapeutic targets for ALD. ..
Shaikh M, Rajan K, Forsyth C, VOIGT R, Keshavarzian A. Simultaneous gas-chromatographic urinary measurement of sugar probes to assess intestinal permeability: use of time course analysis to optimize its use to assess regional gut permeability. Clin Chim Acta. 2015;442:24-32 pubmed publisher
..This was also found to be true in a Parkinson's disease model. ..
Forsyth C, Tang Y, Shaikh M, Zhang L, Keshavarzian A. Role of snail activation in alcohol-induced iNOS-mediated disruption of intestinal epithelial cell permeability. Alcohol Clin Exp Res. 2011;35:1635-43 pubmed publisher
Forsyth C, VOIGT R, Shaikh M, Tang Y, Cederbaum A, Turek F, et al
. Role for intestinal CYP2E1 in alcohol-induced circadian gene-mediated intestinal hyperpermeability. Am J Physiol Gastrointest Liver Physiol. 2013;305:G185-95 pubmed publisher
Forsyth C, VOIGT R, Keshavarzian A. Intestinal CYP2E1: A mediator of alcohol-induced gut leakiness. Redox Biol. 2014;3:40-6 pubmed publisher
..Taken together our data support a novel Cyp2e1-circadian clock protein mechanism for alcohol-induced gut leakiness that could provide new avenues for therapy of ALD. ..