Ashkan Farhadi

Summary

Affiliation: Rush University Medical Center
Country: USA

Publications

  1. ncbi request reprint Heightened responses to stressors in patients with inflammatory bowel disease
    Ashkan Farhadi
    Department of Internal Medicine, Section of Gastroenterology and Nutrition, Rush University Medical Center, Chicago, Illinois 60612, USA
    Am J Gastroenterol 100:1796-804. 2005
  2. ncbi request reprint Mucosal mast cells are pivotal elements in inflammatory bowel disease that connect the dots: stress, intestinal hyperpermeability and inflammation
    Ashkan Farhadi
    World J Gastroenterol 13:3027-30. 2007
  3. ncbi request reprint Intestinal barrier: an interface between health and disease
    Ashkan Farhadi
    Department of Internal Medicine Section of Gastroenterology and Nutrition, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Gastroenterol Hepatol 18:479-97. 2003
  4. pmc Nitric oxide-mediated intestinal injury is required for alcohol-induced gut leakiness and liver damage
    Yueming Tang
    Department of Internal Medicine, Division of Digestive Diseases and Nutrition, Rush University, Chicago, Illinois, USA
    Alcohol Clin Exp Res 33:1220-30. 2009
  5. pmc Effects of aspirin on gastroduodenal permeability in alcoholics and controls
    Ashkan Farhadi
    Department of Medicine, Rush University, Chicago, IL, USA
    Alcohol 44:447-56. 2010
  6. doi request reprint Susceptibility to gut leakiness: a possible mechanism for endotoxaemia in non-alcoholic steatohepatitis
    Ashkan Farhadi
    Department of Medicine, Division of Digestive Diseases and Nutrition, Rush University, Chicago, IL 60612, USA
    Liver Int 28:1026-33. 2008
  7. pmc Lactobacillus GG treatment ameliorates alcohol-induced intestinal oxidative stress, gut leakiness, and liver injury in a rat model of alcoholic steatohepatitis
    Christopher B Forsyth
    Department of Internal Medicine, Division of Digestive Diseases and Nutrition, and Rush University Medical Center, 1725 W Harrison, Suite 206, Chicago, IL 60612, USA
    Alcohol 43:163-72. 2009
  8. pmc Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats
    Ali Keshavarzian
    Department of Internal Medicine, Division of Digestive Disease and Nutrition, Rush University Medical Center, Chicago, IL 60612, USA
    J Hepatol 50:538-47. 2009
  9. ncbi request reprint Reduced immunostaining for c-kit receptors in mucosal mast cells in inflammatory bowel disease
    Ashkan Farhadi
    Section of Gastroenterology and Nutrition, and Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Gastroenterol Hepatol 22:2338-43. 2007
  10. pmc Pattern of alcohol consumption and its effect on gastrointestinal symptoms in inflammatory bowel disease
    Garth R Swanson
    Department Digestive Diseases, Rush University Medical Center, Chicago, IL 60612 3824, USA
    Alcohol 44:223-8. 2010

Detail Information

Publications21

  1. ncbi request reprint Heightened responses to stressors in patients with inflammatory bowel disease
    Ashkan Farhadi
    Department of Internal Medicine, Section of Gastroenterology and Nutrition, Rush University Medical Center, Chicago, Illinois 60612, USA
    Am J Gastroenterol 100:1796-804. 2005
    ..To test this hypothesis, we determined whether stressor-induced activation of BGA is exaggerated in IBD patients...
  2. ncbi request reprint Mucosal mast cells are pivotal elements in inflammatory bowel disease that connect the dots: stress, intestinal hyperpermeability and inflammation
    Ashkan Farhadi
    World J Gastroenterol 13:3027-30. 2007
    ..Thus, it is not surprising that MC are an important element in the pathogenesis of inflammatory bowel disease and non inflammatory GI disorders such as IBS and mast cell enterocolitis...
  3. ncbi request reprint Intestinal barrier: an interface between health and disease
    Ashkan Farhadi
    Department of Internal Medicine Section of Gastroenterology and Nutrition, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Gastroenterol Hepatol 18:479-97. 2003
    ....
  4. pmc Nitric oxide-mediated intestinal injury is required for alcohol-induced gut leakiness and liver damage
    Yueming Tang
    Department of Internal Medicine, Division of Digestive Diseases and Nutrition, Rush University, Chicago, Illinois, USA
    Alcohol Clin Exp Res 33:1220-30. 2009
    ..We hypothesized that iNOS inhibitors [NG-nitro-l-arginine methyl ester (l-NAME), l-N(6)-(1-iminoethyl)-lysine (l-NIL)] in vivo will inhibit the above cascade and liver injury in an animal model of alcoholic steatohepatitis (ASH)...
  5. pmc Effects of aspirin on gastroduodenal permeability in alcoholics and controls
    Ashkan Farhadi
    Department of Medicine, Rush University, Chicago, IL, USA
    Alcohol 44:447-56. 2010
    ..Although, acute aspirin and chronic alcohol each increase intestinal permeability in alcoholics, their effects appear to be additive rather than synergistic...
  6. doi request reprint Susceptibility to gut leakiness: a possible mechanism for endotoxaemia in non-alcoholic steatohepatitis
    Ashkan Farhadi
    Department of Medicine, Division of Digestive Diseases and Nutrition, Rush University, Chicago, IL 60612, USA
    Liver Int 28:1026-33. 2008
    ..We investigated one possible mechanism for the endotoxaemia--disruption of intestinal barrier integrity...
  7. pmc Lactobacillus GG treatment ameliorates alcohol-induced intestinal oxidative stress, gut leakiness, and liver injury in a rat model of alcoholic steatohepatitis
    Christopher B Forsyth
    Department of Internal Medicine, Division of Digestive Diseases and Nutrition, and Rush University Medical Center, 1725 W Harrison, Suite 206, Chicago, IL 60612, USA
    Alcohol 43:163-72. 2009
    ..Our study provides a scientific rationale to test probiotics for treatment and/or prevention of alcoholic liver disease in man...
  8. pmc Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats
    Ali Keshavarzian
    Department of Internal Medicine, Division of Digestive Disease and Nutrition, Rush University Medical Center, Chicago, IL 60612, USA
    J Hepatol 50:538-47. 2009
    ..Accordingly, the aim of the current study was to determine whether endotoxemia occurs prior to development of ASH and whether gut leakiness is the primary cause of the endotoxemia in an animal model of ASH...
  9. ncbi request reprint Reduced immunostaining for c-kit receptors in mucosal mast cells in inflammatory bowel disease
    Ashkan Farhadi
    Section of Gastroenterology and Nutrition, and Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Gastroenterol Hepatol 22:2338-43. 2007
    ..This increased activation of MC in IBD could be due to (i) greater activation of the BGA or (ii) inherited or acquired abnormalities in mucosal MC. In the current study we investigated the latter possibility...
  10. pmc Pattern of alcohol consumption and its effect on gastrointestinal symptoms in inflammatory bowel disease
    Garth R Swanson
    Department Digestive Diseases, Rush University Medical Center, Chicago, IL 60612 3824, USA
    Alcohol 44:223-8. 2010
    ..Patients with inactive IBD drink alcohol in quantities similar to the general population. Current drinkers with inactive IBD are more likely to report worsening of GI symptoms with alcohol than current drinkers with IBS...
  11. ncbi request reprint Evidence for non-chemical, non-electrical intercellular signaling in intestinal epithelial cells
    Ashkan Farhadi
    Section of Gastroenterology and Nutrition, Rush University Medical Center, Chicago, IL 60612, USA
    Bioelectrochemistry 71:142-8. 2007
    ..This signaling system possibly plays a role in synchronous, stimulus-appropriate cell responses to noxious stimuli and may explain a number of cellular behaviors that are hard to explain based only on conventional cell signaling systems...
  12. ncbi request reprint Resolution of common dietary sugars from probe sugars for test of intestinal permeability using capillary column gas chromatography
    Ashkan Farhadi
    Department of Internal Medicine, Section of Gastroenterology and Nutrition, Rush University Medical Center, Chicago, IL 60612, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 836:63-8. 2006
    ..The most-widely used sugar probes are sucrose, lactulose, mannitol and sucralose. Measuring these sugars using a sensitive gas chromatographic (GC) method, we noticed interference on the area of the lactulose and mannitol peaks...
  13. doi request reprint The role of oral hygiene in inflammatory bowel disease
    Shashideep Singhal
    Department of Internal Medicine, Chicago Medical School at Rosalind Franklin University of Medicine and Science, Chicago, IL, USA
    Dig Dis Sci 56:170-5. 2011
    ..Accordingly, we investigated associations between oral hygiene practices and IBD...
  14. ncbi request reprint Gas chromatographic method for detection of urinary sucralose: application to the assessment of intestinal permeability
    Ashkan Farhadi
    Department of Internal Medicine, Division of Digestive Diseases, Rush University Medical Center, 60612, Chicago, IL, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 784:145-54. 2003
    ..Thus, the 24-h urinary concentrations of S and M, or the urinary S/M ratio following an oral dose of a sugar mixture, might be good markers for whole gut permeability...
  15. ncbi request reprint Reactive oxygen species: are they involved in the pathogenesis of GERD, Barrett's esophagus, and the latter's progression toward esophageal cancer?
    Ashkan Farhadi
    Department of Medicine, Rush University Medical Center, Chicago, Illinois 60612, USA
    Am J Gastroenterol 97:22-6. 2002
  16. ncbi request reprint Impact of sleep disturbances in inflammatory bowel disease
    Ziba Ranjbaran
    Division of Digestive Diseases and Nutrition, Department of Medicine, Rush University, Chicago, Illinois, USA
    J Gastroenterol Hepatol 22:1748-53. 2007
    ..The aim of this study was to characterize sleep disturbance in IBD using validated measures of sleep and quality of life...
  17. doi request reprint Atopic irritable bowel syndrome: a novel subgroup of irritable bowel syndrome with allergic manifestations
    Mary C Tobin
    Department of Immunology Microbiology, Rush University Medical Center, John H Stoger, Jr Hospital, Chicago, Illinois 60612, USA
    Ann Allergy Asthma Immunol 100:49-53. 2008
    ..Mast cells have a primary role in atopy. Mast cells may play a unique role in a subgroup of patients with irritable bowel syndrome (IBS). This observation suggests a link between atopic disorders and IBS...
  18. ncbi request reprint New developments in the treatment of inflammatory bowel disease
    Ece A Mutlu
    Rush University, Rush Presbyterian St Luke s Medical Center, Professional Building, 1725 W Harrison, Suite 206, Chicago, IL 60612, USA
    Expert Opin Investig Drugs 11:365-85. 2002
    ....
  19. ncbi request reprint Acute effects of carprofen and meloxicam on canine gastrointestinal permeability and mucosal absorptive capacity
    Melanie Craven
    Royal Dick School of Veterinary Studies, University of Edinburgh, UK
    J Vet Intern Med 21:917-23. 2007
    ..Their beneficial actions can be offset by gastrointestinal (GI) toxicosis. Endoscopy has traditionally been employed to detect GI lesions, but alterations in GI permeability precede the development of mucosal damage...
  20. ncbi request reprint Biological variability and targeted delivery of therapeutics for inflammatory bowel diseases: an in silico approach
    Nahor Haddish-Berhane
    Department of Agricultural and Biological Engineering, Purdue University, West Lafayette, IN 47907 2093, USA
    Inflamm Allergy Drug Targets 6:47-55. 2007
    ..It also could be used by the pharmaceutical industry to improve their medicine efficacy by altering the design...
  21. ncbi request reprint A multi-scale stochastic drug release model for polymer-coated targeted drug delivery systems
    Nahor Haddish-Berhane
    Purdue University, Department of Agricultural and Biological Engineering, 225 S University Street, Room 315, West Lafayette, IN 47907 2093, USA
    J Control Release 110:314-22. 2006
    ..This research shows that in silico experiments using mechanistic models and stochastic approaches can be used for drug design and optimization and as a decision making tool for physicians...