Affiliation: Rush University Medical Center
- Heightened responses to stressors in patients with inflammatory bowel diseaseAshkan Farhadi
Department of Internal Medicine, Section of Gastroenterology and Nutrition, Rush University Medical Center, Chicago, Illinois 60612, USA
Am J Gastroenterol 100:1796-804. 2005..To test this hypothesis, we determined whether stressor-induced activation of BGA is exaggerated in IBD patients...
- Mucosal mast cells are pivotal elements in inflammatory bowel disease that connect the dots: stress, intestinal hyperpermeability and inflammationAshkan Farhadi
World J Gastroenterol 13:3027-30. 2007..Thus, it is not surprising that MC are an important element in the pathogenesis of inflammatory bowel disease and non inflammatory GI disorders such as IBS and mast cell enterocolitis...
- Intestinal barrier: an interface between health and diseaseAshkan Farhadi
Department of Internal Medicine Section of Gastroenterology and Nutrition, Rush University Medical Center, Chicago, Illinois 60612, USA
J Gastroenterol Hepatol 18:479-97. 2003....
- Nitric oxide-mediated intestinal injury is required for alcohol-induced gut leakiness and liver damageYueming Tang
Department of Internal Medicine, Division of Digestive Diseases and Nutrition, Rush University, Chicago, Illinois, USA
Alcohol Clin Exp Res 33:1220-30. 2009..We hypothesized that iNOS inhibitors [NG-nitro-l-arginine methyl ester (l-NAME), l-N(6)-(1-iminoethyl)-lysine (l-NIL)] in vivo will inhibit the above cascade and liver injury in an animal model of alcoholic steatohepatitis (ASH)...
- Effects of aspirin on gastroduodenal permeability in alcoholics and controlsAshkan Farhadi
Department of Medicine, Rush University, Chicago, IL, USA
Alcohol 44:447-56. 2010..Although, acute aspirin and chronic alcohol each increase intestinal permeability in alcoholics, their effects appear to be additive rather than synergistic...
- Susceptibility to gut leakiness: a possible mechanism for endotoxaemia in non-alcoholic steatohepatitisAshkan Farhadi
Department of Medicine, Division of Digestive Diseases and Nutrition, Rush University, Chicago, IL 60612, USA
Liver Int 28:1026-33. 2008..We investigated one possible mechanism for the endotoxaemia--disruption of intestinal barrier integrity...
- Lactobacillus GG treatment ameliorates alcohol-induced intestinal oxidative stress, gut leakiness, and liver injury in a rat model of alcoholic steatohepatitisChristopher B Forsyth
Department of Internal Medicine, Division of Digestive Diseases and Nutrition, and Rush University Medical Center, 1725 W Harrison, Suite 206, Chicago, IL 60612, USA
Alcohol 43:163-72. 2009..Our study provides a scientific rationale to test probiotics for treatment and/or prevention of alcoholic liver disease in man...
- Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in ratsAli Keshavarzian
Department of Internal Medicine, Division of Digestive Disease and Nutrition, Rush University Medical Center, Chicago, IL 60612, USA
J Hepatol 50:538-47. 2009..Accordingly, the aim of the current study was to determine whether endotoxemia occurs prior to development of ASH and whether gut leakiness is the primary cause of the endotoxemia in an animal model of ASH...
- Reduced immunostaining for c-kit receptors in mucosal mast cells in inflammatory bowel diseaseAshkan Farhadi
Section of Gastroenterology and Nutrition, and Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, Illinois 60612, USA
J Gastroenterol Hepatol 22:2338-43. 2007..This increased activation of MC in IBD could be due to (i) greater activation of the BGA or (ii) inherited or acquired abnormalities in mucosal MC. In the current study we investigated the latter possibility...
- Pattern of alcohol consumption and its effect on gastrointestinal symptoms in inflammatory bowel diseaseGarth R Swanson
Department Digestive Diseases, Rush University Medical Center, Chicago, IL 60612 3824, USA
Alcohol 44:223-8. 2010..Patients with inactive IBD drink alcohol in quantities similar to the general population. Current drinkers with inactive IBD are more likely to report worsening of GI symptoms with alcohol than current drinkers with IBS...
- Evidence for non-chemical, non-electrical intercellular signaling in intestinal epithelial cellsAshkan Farhadi
Section of Gastroenterology and Nutrition, Rush University Medical Center, Chicago, IL 60612, USA
Bioelectrochemistry 71:142-8. 2007..This signaling system possibly plays a role in synchronous, stimulus-appropriate cell responses to noxious stimuli and may explain a number of cellular behaviors that are hard to explain based only on conventional cell signaling systems...
- Resolution of common dietary sugars from probe sugars for test of intestinal permeability using capillary column gas chromatographyAshkan Farhadi
Department of Internal Medicine, Section of Gastroenterology and Nutrition, Rush University Medical Center, Chicago, IL 60612, USA
J Chromatogr B Analyt Technol Biomed Life Sci 836:63-8. 2006..The most-widely used sugar probes are sucrose, lactulose, mannitol and sucralose. Measuring these sugars using a sensitive gas chromatographic (GC) method, we noticed interference on the area of the lactulose and mannitol peaks...
- The role of oral hygiene in inflammatory bowel diseaseShashideep Singhal
Department of Internal Medicine, Chicago Medical School at Rosalind Franklin University of Medicine and Science, Chicago, IL, USA
Dig Dis Sci 56:170-5. 2011..Accordingly, we investigated associations between oral hygiene practices and IBD...
- Gas chromatographic method for detection of urinary sucralose: application to the assessment of intestinal permeabilityAshkan Farhadi
Department of Internal Medicine, Division of Digestive Diseases, Rush University Medical Center, 60612, Chicago, IL, USA
J Chromatogr B Analyt Technol Biomed Life Sci 784:145-54. 2003..Thus, the 24-h urinary concentrations of S and M, or the urinary S/M ratio following an oral dose of a sugar mixture, might be good markers for whole gut permeability...
- Reactive oxygen species: are they involved in the pathogenesis of GERD, Barrett's esophagus, and the latter's progression toward esophageal cancer?Ashkan Farhadi
Department of Medicine, Rush University Medical Center, Chicago, Illinois 60612, USA
Am J Gastroenterol 97:22-6. 2002
- Impact of sleep disturbances in inflammatory bowel diseaseZiba Ranjbaran
Division of Digestive Diseases and Nutrition, Department of Medicine, Rush University, Chicago, Illinois, USA
J Gastroenterol Hepatol 22:1748-53. 2007..The aim of this study was to characterize sleep disturbance in IBD using validated measures of sleep and quality of life...
- Atopic irritable bowel syndrome: a novel subgroup of irritable bowel syndrome with allergic manifestationsMary C Tobin
Department of Immunology Microbiology, Rush University Medical Center, John H Stoger, Jr Hospital, Chicago, Illinois 60612, USA
Ann Allergy Asthma Immunol 100:49-53. 2008..Mast cells have a primary role in atopy. Mast cells may play a unique role in a subgroup of patients with irritable bowel syndrome (IBS). This observation suggests a link between atopic disorders and IBS...
- New developments in the treatment of inflammatory bowel diseaseEce A Mutlu
Rush University, Rush Presbyterian St Luke s Medical Center, Professional Building, 1725 W Harrison, Suite 206, Chicago, IL 60612, USA
Expert Opin Investig Drugs 11:365-85. 2002....
- Acute effects of carprofen and meloxicam on canine gastrointestinal permeability and mucosal absorptive capacityMelanie Craven
Royal Dick School of Veterinary Studies, University of Edinburgh, UK
J Vet Intern Med 21:917-23. 2007..Their beneficial actions can be offset by gastrointestinal (GI) toxicosis. Endoscopy has traditionally been employed to detect GI lesions, but alterations in GI permeability precede the development of mucosal damage...
- Biological variability and targeted delivery of therapeutics for inflammatory bowel diseases: an in silico approachNahor Haddish-Berhane
Department of Agricultural and Biological Engineering, Purdue University, West Lafayette, IN 47907 2093, USA
Inflamm Allergy Drug Targets 6:47-55. 2007..It also could be used by the pharmaceutical industry to improve their medicine efficacy by altering the design...
- A multi-scale stochastic drug release model for polymer-coated targeted drug delivery systemsNahor Haddish-Berhane
Purdue University, Department of Agricultural and Biological Engineering, 225 S University Street, Room 315, West Lafayette, IN 47907 2093, USA
J Control Release 110:314-22. 2006..This research shows that in silico experiments using mechanistic models and stochastic approaches can be used for drug design and optimization and as a decision making tool for physicians...