Cynthia L Comella
Affiliation: Rush University Medical Center
- Efficacy and safety of incobotulinumtoxinA (NT 201, XEOMIN®, botulinum neurotoxin type A, without accessory proteins) in patients with cervical dystoniaCynthia L Comella
Merz Pharmaceuticals GmbH, Frankfurt, Germany
J Neurol Sci 308:103-9. 2011..The objective of this study was to compare the safety and efficacy of incobotulinumtoxinA (120 U, 240 U; Merz Pharmaceuticals) to placebo in subjects with cervical dystonia (CD)...
- Sleep disorders in Parkinson's diseaseCynthia L Comella
Cynthia L Comella, MD Department of Neurological Sciences, Rush University Medical Center, 1725 West Harrison, Suite 755, Chicago, IL 60612, USA
Curr Treat Options Neurol 10:215-21. 2008..Excessive daytime sleepiness related to the use of direct dopaminergic agonists may improve with dosage reduction or discontinuation. Stimulants such as modafinil may provide modest benefit...
- Sleep disorders in Parkinson's disease: an overviewCynthia L Comella
Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
Mov Disord 22:S367-73. 2007..Appropriate diagnosis of the sleep disturbance affecting a PD patient can lead to specific treatments that can consolidate nocturnal sleep and enhance daytime alertness...
- Association of daytime napping and Parkinsonian signs in Alzheimer's diseaseMargaret Park
Sleep Disorders Center, Rush University Medical Center, 710 South Paulina Street, JRB 6th Floor, Chicago, IL 60612, USA
Sleep Med 7:614-8. 2006..The purpose of this study was to determine whether more Parkinsonian motor signs exist in AD patients with more reported daytime napping compared to AD patients without daytime napping...
- Can families be screened for cervical dystonia using a telephone interview?Cynthia L Comella
Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
Nat Clin Pract Neurol 2:20-1. 2006
- Restless legs syndrome: treatment with dopaminergic agentsCynthia L Comella
Department of Neurological Sciences, Rush Medical Center, Chicago, IL 60612, USA
Neurology 58:S87-92. 2002..Augmentation, although it may be associated with chronic agonist use, is usually mild and responsive to additional dosing. The direct dopamine receptor agonists have largely replaced levodopa as the most effective treatment for RLS...
- Nocturnal activity with nighttime pergolide in Parkinson disease: a controlled study using actigraphyCynthia L Comella
Department of Neurologic Sciences, Rush University Medical Center, 1725 W Harrison, Chicago, IL 60612, USA
Neurology 64:1450-1. 2005..The pergolide group (n = 10) worsened in actigraphic measures of sleep efficiency and sleep fragmentation vs the placebo group (n = 12). Side effects were more frequent in the pergolide group...
- Botulinum toxins in neurological diseaseCynthia L Comella
Department of Neurological Sciences, Rush University Medical Center, 1725 West Harrison, Chicago, Illinois 60612, USA
Muscle Nerve 29:628-44. 2004..This review focuses on the pharmacology, electrophysiology, immunology, and application of botulinum toxin in selected neurological disorders...
- Treatment of dystoniaJennifer G Goldman
Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, 1725 W Harrison Street, Suite 755, Chicago, IL 60612, USA
Clin Neuropharmacol 26:102-8. 2003..Studies in functional outcome and quality of life further support the importance of discovering safe and effective means to treat dystonia. An algorithmic approach may be useful to guide the physician along the various treatment choices...
- Sleep disturbances in Parkinson's diseaseCynthia L Comella
Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Rush Medical College, 1725 West Harrison, Suite 755, Chicago, IL 60612, USA
Curr Neurol Neurosci Rep 3:173-80. 2003..Treatment is aimed toward improving night-time sleep and daytime drowsiness by addressing the causative factors...
- Greater impairment of extension movements as compared to flexion movements in Parkinson's diseaseJulie A Robichaud
Department of Human Movement Sciences M C 194, University of Illinois at Chicago, 901 West Roosevelt Road, Chicago, IL 60608, USA
Exp Brain Res 156:240-54. 2004..The results are consistent with the hypothesis that there is a differential impairment of neural activation of extensor muscles of the arm as compared to flexor muscles in subjects with PD...
- Effect of medication on EMG patterns in individuals with Parkinson's diseaseJulie A Robichaud
School of Kinesiology, University of Illinois at Chicago, Chicago, Illinois 60608, USA
Mov Disord 17:950-60. 2002..These results show that medication does not alter the temporal profile of EMG activation...
- Stimulation-induced parkinsonism after posteroventral deep brain stimulation of the globus pallidus internus for craniocervical dystoniaS Elizabeth Zauber
Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA
J Neurosurg 110:229-33. 2009..Stimulation through dorsal contacts alleviated parkinsonism, but resulted in the return of dystonia. No stimulation parameters could alleviate the dystonia without inducing parkinsonism over the course of his 4-year follow-up...
- Restless legs syndromeIlia Itin
Rush University Medical Center, Section of Movement Disorders, 1725 West Harrison Street, Suite 755, Chicago, IL 60612, USA
Prim Care 32:435-48. 2005..The currently available medications are highly effective in treating RLS. The knowledge of clinical presentation and diagnostic features of RLS will empower the primary care practitioners to effectively treat their patients who have RLS...
- Rating scales for dystonia: a multicenter assessmentCynthia L Comella
Rush Presbyterian St Lukes Medical Center, Suite 755, 1725 West Harrison, Chicago, IL 60612
Mov Disord 18:303-12. 2003..Among scales, the total scores correlated (Pearson's r, 0.977-0.983). Overall, 74% of raters found the GDS the easiest to apply. The GDS with its simplicity and ease of application may be the most useful dystonia rating scale...
- Variability of EMG patterns: a potential neurophysiological marker of Parkinson's disease?Julie A Robichaud
Department of Kinesiology and Nutrition M C 994, University of Illinois at Chicago, 1919 West Taylor Street, 650 AHSB, MC 994, Chicago, IL 60612, USA
Clin Neurophysiol 120:390-7. 2009....