T J Collier

Summary

Affiliation: Rush University Medical Center
Country: USA

Publications

  1. ncbi request reprint Striatal trophic factor activity in aging monkeys with unilateral MPTP-induced parkinsonism
    Timothy J Collier
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Exp Neurol 191:S60-7. 2005
  2. ncbi request reprint Reduced cortical noradrenergic neurotransmission is associated with increased neophobia and impaired spatial memory in aged rats
    Timothy J Collier
    Department of Neurological Sciences, Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Tech 2000, Suite 200, 2242 W Harrison St, Chicago, IL 60612, USA
    Neurobiol Aging 25:209-21. 2004
  3. ncbi request reprint Primate models of Parkinson's disease
    Timothy J Collier
    Department of Neurological Sciences, Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Exp Neurol 183:258-62. 2003
  4. ncbi request reprint Cellular models to study dopaminergic injury responses
    Timothy J Collier
    Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    Ann N Y Acad Sci 991:140-51. 2003
  5. ncbi request reprint Embryonic ventral mesencephalic grafts to the substantia nigra of MPTP-treated monkeys: feasibility relevant to multiple-target grafting as a therapy for Parkinson's disease
    Timothy J Collier
    Department of Neurological Sciences, Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    J Comp Neurol 442:320-30. 2002
  6. ncbi request reprint Therapeutic potential of nerve growth factors in Parkinson's disease
    T J Collier
    Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois, USA
    Drugs Aging 14:261-87. 1999
  7. ncbi request reprint Oligodendrocyte-type 2 astrocyte-derived trophic factors increase survival of developing dopamine neurons through the inhibition of apoptotic cell death
    C E Sortwell
    Department of Neurological Sciences and Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    J Comp Neurol 426:143-53. 2000
  8. ncbi request reprint Diminished survival of mesencephalic dopamine neurons grafted into aged hosts occurs during the immediate postgrafting interval
    C E Sortwell
    Department of Neurological Sciences, Research Center for Brain Repair, Rush-Presbyterian-St. Luke's Medical Center, Suite 200, 2242 West Harrison Street, Chicago, Illinois, 60612, USA
    Exp Neurol 169:23-9. 2001
  9. ncbi request reprint A clonal line of mesencephalic progenitor cells converted to dopamine neurons by hematopoietic cytokines: a source of cells for transplantation in Parkinson's disease
    P M Carvey
    Department of Pharmacology, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois, USA
    Exp Neurol 171:98-108. 2001
  10. ncbi request reprint Angiogenic and neurotrophic effects of vascular endothelial growth factor (VEGF165): studies of grafted and cultured embryonic ventral mesencephalic cells
    Mark R Pitzer
    Department of Neurological Sciences and Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Exp Neurol 182:435-45. 2003

Detail Information

Publications33

  1. ncbi request reprint Striatal trophic factor activity in aging monkeys with unilateral MPTP-induced parkinsonism
    Timothy J Collier
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Exp Neurol 191:S60-7. 2005
    ..Third, the aging-related chronic increase in combined striatal trophic activity was not attributable to BDNF or GDNF as these molecules either decreased or did not change with aging...
  2. ncbi request reprint Reduced cortical noradrenergic neurotransmission is associated with increased neophobia and impaired spatial memory in aged rats
    Timothy J Collier
    Department of Neurological Sciences, Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Tech 2000, Suite 200, 2242 W Harrison St, Chicago, IL 60612, USA
    Neurobiol Aging 25:209-21. 2004
    ..The results suggest that an aging-related reduction in cortical NE neurotransmission is associated with the expression of increased neophobia and deficits in spatial learning and memory performance occurring with advanced age in rats...
  3. ncbi request reprint Primate models of Parkinson's disease
    Timothy J Collier
    Department of Neurological Sciences, Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Exp Neurol 183:258-62. 2003
  4. ncbi request reprint Cellular models to study dopaminergic injury responses
    Timothy J Collier
    Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    Ann N Y Acad Sci 991:140-51. 2003
    ..Thus, cell culture models provide an important bidirectional link between mechanistic studies and clinically relevant observations...
  5. ncbi request reprint Embryonic ventral mesencephalic grafts to the substantia nigra of MPTP-treated monkeys: feasibility relevant to multiple-target grafting as a therapy for Parkinson's disease
    Timothy J Collier
    Department of Neurological Sciences, Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    J Comp Neurol 442:320-30. 2002
    ..These results encourage the further development of multiple-target grafting strategies as a means of restoring modulation of anatomically widespread basal ganglia structures relevant to treatment of Parkinson's disease...
  6. ncbi request reprint Therapeutic potential of nerve growth factors in Parkinson's disease
    T J Collier
    Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois, USA
    Drugs Aging 14:261-87. 1999
    ..While the search continues for even more specific, potent and long lasting agents, the single greatest challenge is the development of techniques for targeted delivery of these molecules...
  7. ncbi request reprint Oligodendrocyte-type 2 astrocyte-derived trophic factors increase survival of developing dopamine neurons through the inhibition of apoptotic cell death
    C E Sortwell
    Department of Neurological Sciences and Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    J Comp Neurol 426:143-53. 2000
    ..e., immediately following implantation. Therefore, SO2A-derived trophic factor(s) offers great potential for the augmentation of grafted DA neuron survival...
  8. ncbi request reprint Diminished survival of mesencephalic dopamine neurons grafted into aged hosts occurs during the immediate postgrafting interval
    C E Sortwell
    Department of Neurological Sciences, Research Center for Brain Repair, Rush-Presbyterian-St. Luke's Medical Center, Suite 200, 2242 West Harrison Street, Chicago, Illinois, 60612, USA
    Exp Neurol 169:23-9. 2001
    ....
  9. ncbi request reprint A clonal line of mesencephalic progenitor cells converted to dopamine neurons by hematopoietic cytokines: a source of cells for transplantation in Parkinson's disease
    P M Carvey
    Department of Pharmacology, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois, USA
    Exp Neurol 171:98-108. 2001
    ..When transplanted, these cells provide significant functional benefit in the rat model of PD...
  10. ncbi request reprint Angiogenic and neurotrophic effects of vascular endothelial growth factor (VEGF165): studies of grafted and cultured embryonic ventral mesencephalic cells
    Mark R Pitzer
    Department of Neurological Sciences and Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Exp Neurol 182:435-45. 2003
    ..We conclude that with the proper method of delivery, VEGF165 may prove to be one of several strategies necessary to significantly improve the survival and function of fetal VM tissue grafts...
  11. pmc The synaptic impact of the host immune response in a parkinsonian allograft rat model: Influence on graft-derived aberrant behaviors
    K E Soderstrom
    Department of Neurological Sciences, Rush University, Chicago, IL, USA
    Neurobiol Dis 32:229-42. 2008
    ..These features were exacerbated in rats with the highest immune activation and correlated statistically with GID-like behaviors, suggesting that immune-mediated aberrant synaptology may contribute to graft-induced aberrant behaviors...
  12. ncbi request reprint Interference with anoikis-induced cell death of dopamine neurons: implications for augmenting embryonic graft survival in a rat model of Parkinson's disease
    Deanna M Marchionini
    Department of Neurological Sciences, Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, 2422 West Harrison St, Chicago, Illinois 60612, USA
    J Comp Neurol 464:172-9. 2003
    ....
  13. ncbi request reprint Tumor necrosis factor alpha is toxic to embryonic mesencephalic dopamine neurons
    S O McGuire
    Department of Pharmacology, Rush Presbyterian St. Luke's Medical Center, Chicago, IL 60612, USA
    Exp Neurol 169:219-30. 2001
    ..These data strongly suggest that TNFalpha mediates cell death in a sensitive population of DA neurons and support the potential involvement of proinflammatory cytokines in the degeneration of DA neurons in PD...
  14. ncbi request reprint Age-related accumulation of Marinesco bodies and lipofuscin in rhesus monkey midbrain dopamine neurons: relevance to selective neuronal vulnerability
    Nicholas M Kanaan
    Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Comp Neurol 502:683-700. 2007
    ..Furthermore, the results begin to characterize the nature of the link between aging and PD, and they support the concept that aged monkeys represent a valuable model for studying specific events preceding PD...
  15. pmc Impact of dendritic spine preservation in medium spiny neurons on dopamine graft efficacy and the expression of dyskinesias in parkinsonian rats
    Katherine E Soderstrom
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Eur J Neurosci 31:478-90. 2010
    ..Taken together, these results demonstrate that even with grafting suboptimal numbers of cells, maintaining normal spine density on target MSNs results in overall superior behavioral efficacy of dopamine grafts...
  16. ncbi request reprint Galanin inhibits tyrosine hydroxylase expression in midbrain dopaminergic neurons
    Scott E Counts
    Department of Neurological Sciences and Pharmacology, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    J Neurochem 83:442-51. 2002
    ..GAL inhibition of midbrain DA activity may involve a GALR1- mediated reduction of TH in midbrain dopaminergic neurons...
  17. ncbi request reprint Pattern of synaptophysin immunoreactivity within mesencephalic grafts following transplantation in a parkinsonian primate model
    C E Sortwell
    Department of Neuroscience, Chicago Medical School, North Chicago, IL 60064, USA
    Brain Res 791:117-24. 1998
    ....
  18. ncbi request reprint An in vitro interval before transplantation of mesencephalic reaggregates does not compromise survival or functionality
    Caryl E Sortwell
    Department of Neurological Sciences, Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Exp Neurol 187:58-64. 2004
    ..This ex vivo reaggregate system allows for extended pretreatment (3 days) of mesencephalic cells with survival-promoting agents and immunological screening of tissue before transplantation...
  19. pmc Age-related changes in glial cells of dopamine midbrain subregions in rhesus monkeys
    Nicholas M Kanaan
    Rush University Medical Center, Department of Neurological Sciences, Chicago, IL 60612, USA nicholas
    Neurobiol Aging 31:937-52. 2010
    ..Our results suggest advancing age is associated with chronic mild inflammation in the vtSN, which may render these DA neurons more vulnerable to degeneration...
  20. ncbi request reprint Embryonic mesencephalic grafts increase levodopa-induced forelimb hyperkinesia in parkinsonian rats
    Kathy Steece-Collier
    Department of Neurological Science, Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    Mov Disord 18:1442-54. 2003
    ....
  21. ncbi request reprint Role of heparin binding growth factors in nigrostriatal dopamine system development and Parkinson's disease
    Deanna M Marchionini
    Dept Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Brain Res 1147:77-88. 2007
    ..Thus, PTN was identified as a factor that plays a role in the nigrostriatal system during development and in response to disease, and may therefore be useful for neuroprotection or reconstruction of the DA system...
  22. ncbi request reprint Failure of proteasome inhibitor administration to provide a model of Parkinson's disease in rats and monkeys
    Jeffrey H Kordower
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
    Ann Neurol 60:264-8. 2006
    ..Furthermore, administration of PSI or epoxomicin to monkeys in an attempt to extend the model to a primate species failed. Currently, systemic proteasome inhibition is not a reliable model for Parkinson's disease...
  23. ncbi request reprint Reassessment of caspase inhibition to augment grafted dopamine neuron survival
    Deanna M Marchionini
    Department of Neurological Sciences, Research Center for Brain Repair, Rush University Medical Center, Chicago, IL 60612, USA
    Cell Transplant 13:273-82. 2004
    ..Furthermore, we suggest that cell culture paradigms used to model grafting paradigms must more closely approximate the cell densities of mesencephalic grafts to effectively screen potential augmentative treatments...
  24. ncbi request reprint Exogenous erythropoietin provides neuroprotection of grafted dopamine neurons in a rodent model of Parkinson's disease
    Nicholas M Kanaan
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Brain Res 1068:221-9. 2006
    ..As direct neurotrophic effects of Epo were not observed in vitro, the mechanism of Epo neuroprotection remains to be elucidated...
  25. pmc Age-related changes in dopamine transporters and accumulation of 3-nitrotyrosine in rhesus monkey midbrain dopamine neurons: relevance in selective neuronal vulnerability to degeneration
    N M Kanaan
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
    Eur J Neurosci 27:3205-15. 2008
    ..These findings are consistent with a role for aging-related accrual of nitrative damage in the selective vulnerability of vtSN neurons to degeneration in PD...
  26. pmc Age and region-specific responses of microglia, but not astrocytes, suggest a role in selective vulnerability of dopamine neurons after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure in monkeys
    Nicholas M Kanaan
    Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA
    Glia 56:1199-214. 2008
    ....
  27. ncbi request reprint Focal not widespread grafts induce novel dyskinetic behavior in parkinsonian rats
    Eleonora Maries
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, N Chicago, IL 60064, USA
    Neurobiol Dis 21:165-80. 2006
    ..The onset of forelimb-facial stereotypy correlated with measures of increased graft function...
  28. pmc Increased cell suspension concentration augments the survival rate of grafted tyrosine hydroxylase immunoreactive neurons
    Brian T Terpstra
    Department of Neurology, University of Cincinnati, PO Box 670525, Cincinnati, OH 45267 0525, United States
    J Neurosci Methods 166:13-9. 2007
    ..These data have the potential to identify optimal transplantation parameters that can be applied to procedures utilizing stem cells, neural progenitors, and primary mesencephalic cells...
  29. ncbi request reprint Partial dopamine loss enhances activated caspase-3 activity: differential outcomes in striatal projection systems
    Marjorie A Ariano
    Department of Neuroscience, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064 3095, USA
    J Neurosci Res 82:387-96. 2005
    ..These observations could be capitalized upon to develop therapeutic interventions in the preclinical phases of the disorder...
  30. ncbi request reprint Dietary supplementation with blueberry extract improves survival of transplanted dopamine neurons
    Susan O McGuire
    Department of Pathology, Loyola University Medical School, Loyola University Chicago, Maywood, IL 60153, USA
    Nutr Neurosci 9:251-8. 2006
    ..These findings provide support for the potential of dietary phytochemicals as an easily administered and well-tolerated therapy that can be used to improve the effectiveness of DA neuron replacement...
  31. pmc Aging-related changes in the nigrostriatal dopamine system and the response to MPTP in nonhuman primates: diminished compensatory mechanisms as a prelude to parkinsonism
    Timothy J Collier
    Department of Neurology, University of Cincinnati, PO Box 670525, 265 Albert Sabin Way, Cincinnati, OH 45267, USA
    Neurobiol Dis 26:56-65. 2007
    ....
  32. pmc Effects of ex vivo transduction of mesencephalic reaggregates with bcl-2 on grafted dopamine neuron survival
    Caryl E Sortwell
    Department of Neurology University of Cincinnati, PO Box 670537, ML0537, Cincinnati, OH 45267 0537, USA
    Brain Res 1134:33-44. 2007
    ..Even with highly efficient viral vector-mediated transduction, our results demonstrate that ex vivo gene transfer of bcl-2 to mesencephalic reaggregates is ineffective in increasing grafted DA neuron survival...
  33. ncbi request reprint The role of alpha-synuclein in Parkinson's disease: insights from animal models
    Eleonora Maries
    Department of Neuroscience, The Chicago Medical School, 3333 Green Bay Road, N Chicago, Illinois 60064, USA
    Nat Rev Neurosci 4:727-38. 2003