Aron Buchman

Summary

Affiliation: Rush University Medical Center
Country: USA

Publications

  1. pmc Physical frailty in older persons is associated with Alzheimer disease pathology
    Aron S Buchman
    Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Facility, Suite 1038, 600 S Paulina St, Chicago, IL 60612, USA
    Neurology 71:499-504. 2008
  2. pmc Harm avoidance is associated with progression of parkinsonism in community-dwelling older adults: a prospective cohort study
    Aron S Buchman
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL, USA
    BMC Geriatr 14:54. 2014
  3. pmc Associations between quantitative mobility measures derived from components of conventional mobility testing and Parkinsonian gait in older adults
    Aron S Buchman
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, United States of America
    PLoS ONE 9:e86262. 2014
  4. pmc Total daily activity declines more rapidly with increasing age in older adults
    Aron S Buchman
    Department of Neurological Sciences, Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina, Chicago, IL 60612, USA Electronic address
    Arch Gerontol Geriatr 58:74-9. 2014
  5. pmc Association of total daily physical activity with disability in community-dwelling older persons: a prospective cohort study
    Raj C Shah
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL, USA
    BMC Geriatr 12:63. 2012
  6. pmc Association of cognition with temporal discounting in community based older persons
    Patricia A Boyle
    Rush University Medical Center, Rush Alzheimer s Disease Center, 600 S, Paulina, Suite 1020B, Chicago, IL 60612, USA
    BMC Geriatr 12:48. 2012
  7. pmc Association of brain pathology with the progression of frailty in older adults
    Aron S Buchman
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL, USA
    Neurology 80:2055-61. 2013
  8. pmc Microvascular brain pathology and late-life motor impairment
    Aron S Buchman
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL, USA
    Neurology 80:712-8. 2013
  9. pmc Neuroticism, extraversion, and motor function in community-dwelling older persons
    Aron S Buchman
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Am J Geriatr Psychiatry 21:145-54. 2013
  10. pmc Locus coeruleus neuron density and parkinsonism in older adults without Parkinson's disease
    Aron S Buchman
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA
    Mov Disord 27:1625-31. 2012

Detail Information

Publications54

  1. pmc Physical frailty in older persons is associated with Alzheimer disease pathology
    Aron S Buchman
    Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Facility, Suite 1038, 600 S Paulina St, Chicago, IL 60612, USA
    Neurology 71:499-504. 2008
    ..We examined the extent to which physical frailty in older persons is associated with common age-related brain pathology, including cerebral infarcts, Lewy body pathology, and Alzheimer disease (AD) pathology...
  2. pmc Harm avoidance is associated with progression of parkinsonism in community-dwelling older adults: a prospective cohort study
    Aron S Buchman
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL, USA
    BMC Geriatr 14:54. 2014
    ..We tested the hypothesis that harm avoidance, a trait associated with behavioral inhibition, is associated with the rate of change in parkinsonism in older adults...
  3. pmc Associations between quantitative mobility measures derived from components of conventional mobility testing and Parkinsonian gait in older adults
    Aron S Buchman
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, United States of America
    PLoS ONE 9:e86262. 2014
    ..To provide objective measures which characterize mobility in older adults assessed in the community setting and to examine the extent to which these measures are associated with parkinsonian gait...
  4. pmc Total daily activity declines more rapidly with increasing age in older adults
    Aron S Buchman
    Department of Neurological Sciences, Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina, Chicago, IL 60612, USA Electronic address
    Arch Gerontol Geriatr 58:74-9. 2014
    ..These data suggest that total daily activity in very old adults declines more rapidly with increasing age. Thus, physical inactivity is likely to become a larger problem in our aging population...
  5. pmc Association of total daily physical activity with disability in community-dwelling older persons: a prospective cohort study
    Raj C Shah
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL, USA
    BMC Geriatr 12:63. 2012
    ..We examined whether greater total daily physical activity was associated with less report of disability in the elderly...
  6. pmc Association of cognition with temporal discounting in community based older persons
    Patricia A Boyle
    Rush University Medical Center, Rush Alzheimer s Disease Center, 600 S, Paulina, Suite 1020B, Chicago, IL 60612, USA
    BMC Geriatr 12:48. 2012
    ..The objective of this study was to test the hypothesis that cognitive function is negatively associated with temporal discounting in old age...
  7. pmc Association of brain pathology with the progression of frailty in older adults
    Aron S Buchman
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL, USA
    Neurology 80:2055-61. 2013
    ..We tested the hypothesis that brain pathology is associated with the rate of progression of physical frailty in older adults...
  8. pmc Microvascular brain pathology and late-life motor impairment
    Aron S Buchman
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL, USA
    Neurology 80:712-8. 2013
    ..To test the hypothesis that microvascular brain pathology is associated with late-life motor impairment...
  9. pmc Neuroticism, extraversion, and motor function in community-dwelling older persons
    Aron S Buchman
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Am J Geriatr Psychiatry 21:145-54. 2013
    ..Personality traits are associated with adverse health outcomes in old age, but their association with motor function is unclear. We tested the hypothesis that neuroticism and extraversion are associated with motor decline in older persons...
  10. pmc Locus coeruleus neuron density and parkinsonism in older adults without Parkinson's disease
    Aron S Buchman
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA
    Mov Disord 27:1625-31. 2012
    ..In older adults without a clinical diagnosis of PD, neuron density in locus coeruleus nuclei is associated with the severity of parkinsonism and may contribute to late-life motor impairments...
  11. pmc Total daily physical activity and the risk of AD and cognitive decline in older adults
    A S Buchman
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL, USA
    Neurology 78:1323-9. 2012
    ..We tested the hypothesis that an objective measure of total daily physical activity predicts incident AD and cognitive decline...
  12. pmc Nigral pathology and parkinsonian signs in elders without Parkinson disease
    Aron S Buchman
    Rush Alzheimer s Disease Center, Chicago, IL, USA
    Ann Neurol 71:258-66. 2012
    ..We tested the hypothesis that nigral pathology is related to parkinsonism in older persons without Parkinson disease (PD)...
  13. pmc Cognitive function is associated with risk aversion in community-based older persons
    Patricia A Boyle
    Rush University Medical Center, Rush Alzheimer s Disease Center, 600 S Paulina, Chicago, IL 60612, USA
    BMC Geriatr 11:53. 2011
    ....
  14. pmc Association between late-life social activity and motor decline in older adults
    Aron S Buchman
    Departments of Neurological Sciences, Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Facility, Chicago, IL 60612, USA
    Arch Intern Med 169:1139-46. 2009
    ..Our objective was to test the hypothesis that late-life social activity is related to the rate of change in motor function in old age...
  15. pmc Kidney function is associated with the rate of cognitive decline in the elderly
    Aron S Buchman
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Neurology 73:920-7. 2009
    ..We tested the hypothesis that impaired kidney function in the elderly is associated with a more rapid rate of cognitive decline...
  16. pmc Pulmonary function, muscle strength, and incident mobility disability in elders
    Aron S Buchman
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina Street, Chicago, IL 60612, USA
    Proc Am Thorac Soc 6:581-7. 2009
    ..Overall, these findings suggest that lower levels of pulmonary function and muscle strength are relatively independently associated with the development of mobility disability in the elderly...
  17. ncbi Physical activity and motor decline in older persons
    A S Buchman
    Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Facility, Suite 1038, 600 South Paulina Street, Chicago, Illinois 60612, USA
    Muscle Nerve 35:354-62. 2007
    ..Thus, higher levels of physical activity are associated with a slower rate of motor decline in older persons...
  18. pmc Cognitive function is associated with the development of mobility impairments in community-dwelling elders
    Aron S Buchman
    Rush Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Am J Geriatr Psychiatry 19:571-80. 2011
    ..To examine the association of cognitive function with the risk of incident mobility impairments and the rate of declining mobility in older adults...
  19. pmc Loss of motor function in preclinical Alzheimer's disease
    Aron S Buchman
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina, Suite 1028, Chicago, IL 60612, USA
    Expert Rev Neurother 11:665-76. 2011
    ..Thus, AD may have a much larger impact on the health and wellbeing of our aging population...
  20. pmc Combinations of motor measures more strongly predict adverse health outcomes in old age: the rush memory and aging project, a community-based cohort study
    Aron S Buchman
    Department of Neurological Sciences, Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA
    BMC Med 9:42. 2011
    ..We tested the hypothesis that combinations of motor constructs more strongly predict adverse health outcomes in older people...
  21. pmc Vibratory thresholds and mobility in older persons
    Aron S Buchman
    Rush Alzheimer s Disease Center, Armour Academic Facility, Suite 1038 600 South Paulina, Rush University Medical Center, Chicago, Illinois 60612, USA
    Muscle Nerve 39:754-60. 2009
    ..Vibratory thresholds are associated with mobility, supporting the link between peripheral sensory nerve function and mobility in the elderly...
  22. pmc Apolipoprotein E e4 allele is associated with more rapid motor decline in older persons
    Aron S Buchman
    Rush Alzheimer s Disease Center, Armour Academic Facility, Rush University Medical Center, Chicago, IL 60612, USA
    Alzheimer Dis Assoc Disord 23:63-9. 2009
    ..These results suggest that the presence of epsilon4 allele is a risk factor for more rapid motor decline in the elderly...
  23. pmc Change in frailty and risk of death in older persons
    A S Buchman
    Rush Alzheimer s Disease Center and Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Exp Aging Res 35:61-82. 2009
    ..Using a continuous measure, the authors document that frailty is progressive in some older persons and that its rate of progression is associated with mortality...
  24. pmc Cerebrovascular disease pathology and parkinsonian signs in old age
    Aron S Buchman
    Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Facility, Suite 1022, 600 South Paulina Street, Chicago, IL 60612, USA
    Stroke 42:3183-9. 2011
    ..Mild motor symptoms including parkinsonian signs are common in old age, but their underlying neuropathology is unclear. We tested the hypothesis that cerebrovascular pathologies are related to parkinsonian signs...
  25. ncbi Change in body mass index and risk of incident Alzheimer disease
    A S Buchman
    Rush Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Neurology 65:892-7. 2005
    ..To examine the association of change in body mass index (BMI) with risk of Alzheimer disease (AD)...
  26. ncbi Body mass index in older persons is associated with Alzheimer disease pathology
    A S Buchman
    Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Facility, Suite 1038, 600 S Paulina St, Chicago, IL 60612, USA
    Neurology 67:1949-54. 2006
    ....
  27. ncbi Change in motor function and risk of mortality in older persons
    Aron S Buchman
    Rush Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    J Am Geriatr Soc 55:11-9. 2007
    ..To assess the association between change in motor function and mortality...
  28. ncbi Frailty is associated with incident Alzheimer's disease and cognitive decline in the elderly
    Aron S Buchman
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Psychosom Med 69:483-9. 2007
    ..To assess the association between frailty and incident Alzheimer's disease (AD) and cognitive decline. Frailty is common in older persons and associated with adverse health outcomes...
  29. ncbi Physical activity and leg strength predict decline in mobility performance in older persons
    Aron S Buchman
    Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Am Geriatr Soc 55:1618-23. 2007
    ..To assess the extent to which physical activity and leg strength are associated with change in mobility in older persons...
  30. ncbi Grip strength and the risk of incident Alzheimer's disease
    Aron S Buchman
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Neuroepidemiology 29:66-73. 2007
    ..Declining strength in old age is associated with an increased risk of AD...
  31. ncbi Total daily activity is associated with cognition in older persons
    Aron S Buchman
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Am J Geriatr Psychiatry 16:697-701. 2008
    ..The authors tested the hypothesis that total daily physical activity is related to the level of cognition in older persons...
  32. pmc Pulmonary function, muscle strength and mortality in old age
    A S Buchman
    Rush Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, United States
    Mech Ageing Dev 129:625-31. 2008
    ..Overall, these findings suggest that pulmonary function may partially account for the association of muscle strength and mortality...
  33. pmc Respiratory muscle strength predicts decline in mobility in older persons
    A S Buchman
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Neuroepidemiology 31:174-80. 2008
    ..To test the hypothesis that respiratory muscle strength is associated with the rate of change in mobility even after controlling for leg strength and physical activity...
  34. pmc Loneliness and the rate of motor decline in old age: the Rush Memory and Aging Project, a community-based cohort study
    Aron S Buchman
    Department of Neurological Sciences, Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S, Paulina, Chicago, Illinois 60612, USA
    BMC Geriatr 10:77. 2010
    ..We tested the hypothesis that feeling alone is associated with the rate of motor decline in community-dwelling older persons...
  35. pmc Visuoperceptual repetition priming and progression of parkinsonian signs in aging
    Debra A Fleischman
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL, USA
    Neurobiol Aging 30:441-9. 2009
    ..Reduced visuoperceptual priming in aging may be an early signal of vulnerability in a corticostrial circuit that contributes to sensorimotor integration...
  36. pmc Relation of late-life social activity with incident disability among community-dwelling older adults
    Bryan D James
    Rush University Medical Center, Room 1038, 600 South Paulina Street, Chicago, IL 60612, USA
    J Gerontol A Biol Sci Med Sci 66:467-73. 2011
    ..We tested the hypothesis that a higher level of social activity was associated with decreased risk of incident disability in older adults...
  37. pmc Lewy bodies and olfactory dysfunction in old age
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina Avenue, Chicago, IL 60612, USA
    Chem Senses 36:367-73. 2011
    ..The findings indicate that Lewy body disease impairs late life olfactory function even in otherwise asymptomatic individuals...
  38. pmc Musculoskeletal pain is associated with incident mobility disability in community-dwelling elders
    Raj C Shah
    Rush Alzheimer s Disease Center, 600 South Paulina, Suite 1038, Chicago, IL 60612, USA
    J Gerontol A Biol Sci Med Sci 66:82-8. 2011
    ..We tested the hypothesis that musculoskeletal pain is associated with first occurrence of severe mobility disability...
  39. ncbi Harm avoidance and disability in old age
    Robert S Wilson
    Rush Alzheimer s Disease Center and Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    Exp Aging Res 32:243-61. 2006
    ..The results suggest that harm avoidance is associated with disability in old age...
  40. ncbi Correlates of life space in a volunteer cohort of older adults
    Lisa L Barnes
    Rush Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    Exp Aging Res 33:77-93. 2007
    ..The results suggest that the range of environmental movement in older adults is a useful indicator of health in old age and may complement measures of disability...
  41. ncbi Physical activity is associated with incident disability in community-based older persons
    Patricia A Boyle
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Am Geriatr Soc 55:195-201. 2007
    ....
  42. pmc Odor identification and progression of parkinsonian signs in older persons
    Robert S Wilson
    Rush Alzheimer s Disease Center and Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    Exp Aging Res 34:173-87. 2008
    ..The results suggest that impaired odor identification is associated with more rapid progression of parkinsonism in old age, particularly parkinsonian gait disturbance...
  43. pmc Purpose in life is associated with mortality among community-dwelling older persons
    Patricia A Boyle
    Rush Alzheimer s Disease Center, Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Psychosom Med 71:574-9. 2009
    ..To assess the association between purpose in life and all-cause mortality in community-dwelling elderly persons...
  44. pmc Olfactory impairment in presymptomatic Alzheimer's disease
    Robert S Wilson
    Department of Neurological Sciences, Rush Alzheimer s Disease Center, Rush University Medical Cetner, Chicago, Illinois 60612, USA
    Ann N Y Acad Sci 1170:730-5. 2009
    ....
  45. pmc Association of muscle strength with the risk of Alzheimer disease and the rate of cognitive decline in community-dwelling older persons
    Patricia A Boyle
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Arch Neurol 66:1339-44. 2009
    ....
  46. pmc The APOE epsilon4 allele is associated with incident mild cognitive impairment among community-dwelling older persons
    Patricia A Boyle
    Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Neuroepidemiology 34:43-9. 2010
    ..The apolipoprotein E (APOE) epsilon4 allele is a well-known risk factor for the development of Alzheimer's disease, but little is known about the association of the epsilon4 allele with incident mild cognitive impairment (MCI)...
  47. pmc Physical frailty is associated with incident mild cognitive impairment in community-based older persons
    Patricia A Boyle
    Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Facility, Suite 1020B, 600 South Paulina Street, Chicago, IL 60612, USA
    J Am Geriatr Soc 58:248-55. 2010
    ..To test the hypothesis that physical frailty is associated with risk of mild cognitive impairment (MCI)...
  48. pmc Effect of a purpose in life on risk of incident Alzheimer disease and mild cognitive impairment in community-dwelling older persons
    Patricia A Boyle
    Rush Alzheimer s Disease Center, 600 S Paulina, Ste 1020B, Chicago, IL 60612, USA
    Arch Gen Psychiatry 67:304-10. 2010
    ..Emerging data suggest that psychological and experiential factors are associated with risk of Alzheimer disease (AD), but the association of purpose in life with incident AD is unknown...
  49. pmc Purpose in life is associated with a reduced risk of incident disability among community-dwelling older persons
    Patricia A Boyle
    From the Rush Alzheimer s Disease Center, Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA
    Am J Geriatr Psychiatry 18:1093-102. 2010
    ..Purpose in life is thought to be associated with positive health outcomes in old age, but its association with disability is unknown...
  50. pmc Association between life space and risk of mortality in advanced age
    Patricia A Boyle
    Rush Alzheimer s Disease Center, Chicago, Illinois 60612, USA
    J Am Geriatr Soc 58:1925-30. 2010
    ..To examine the association between life space, a measure of functional status that describes the range of movement through the environment covered during daily functioning, and the risk of mortality in older community-based persons...
  51. pmc Musculoskeletal pain and incident disability in community-dwelling older adults
    Aron S Buchman
    Rush University Medical Center, Chicago, Illinois 60612, USA
    Arthritis Care Res (Hoboken) 62:1287-93. 2010
    ..To test the hypothesis that the number of areas of musculoskeletal pain reported is related to incident disability...
  52. ncbi The Rush Memory and Aging Project: study design and baseline characteristics of the study cohort
    David A Bennett
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina, Suite 1028, Chicago, IL 60612, USA
    Neuroepidemiology 25:163-75. 2005
    ..Their mean age was 81 years, about a third had 12 or fewer years of education, a third were men, and about 10% were members of a racial or ethnic minority group. More than 950 already have completed their baseline clinical evaluation...
  53. ncbi Botulinum toxin injections for children with excessive drooling
    Sharon Hassin-Baer
    Department of Neurology, Chaim Sheba Medical Center, Tel Hashomer, Israel
    J Child Neurol 20:120-3. 2005
    ..These results underscore the need for further studies to establish the efficacy of this treatment in children...
  54. ncbi Eosinophilia, myositis, and myasthenia gravis associated with a thymoma
    Irit Avni
    Internal Medicine D, Sheba Medical Center, Tel Hashomer, 52621, Israel
    Muscle Nerve 34:242-5. 2006
    ..Thymoma-associated T-cell abnormalities may well have contributed to this rare association. This case underscores the need to reevaluate constantly the presumed cause of clinical complaints, as more than one cause may be present...

Research Grants6

  1. Risk Factors and the Neurobiologic Substrate of Frailty
    Aron Buchman; Fiscal Year: 2005
    ..abstract_text> ..
  2. Risk Factors and the Neurobiologic Substrate of Frailty
    Aron Buchman; Fiscal Year: 2006
    ..abstract_text> ..
  3. Risk Factors and the Neurobiologic Substrate of Frailty
    Aron Buchman; Fiscal Year: 2007
    ..abstract_text> ..
  4. Risk Factors and the Neurobiologic Substrate of Frailty
    Aron Buchman; Fiscal Year: 2007
    ....
  5. Risk Factors and the Neurobiologic Substrate of Frailty
    Aron Buchman; Fiscal Year: 2009
    ..abstract_text> ..