Affiliation: Rush University Medical Center
- Buchman A, Wilson R, Leurgans S, Bennett D, Barnes L. Change in motor function and adverse health outcomes in older African-Americans. Exp Gerontol. 2015;70:71-7 pubmed publisher..5-fold higher rate of death and a 3-fold higher rate of developing Katz disability. The rate of declining motor function accelerates with increasing age and its rate of decline predicts adverse health outcomes in older African-Americans. ..
- Buchman A, Shulman J, Nag S, Leurgans S, Arnold S, Morris M, et al. Nigral pathology and parkinsonian signs in elders without Parkinson disease. Ann Neurol. 2012;71:258-66 pubmed publisher..112; SE, 0.148; p = 0.447), suggesting that neuronal loss may mediate the association of Lewy bodies with global parkinsonism. Nigral pathology is common in persons without PD and may contribute to loss of motor function in old age. ..
- Buchman A, Nag S, Shulman J, Lim A, Vanderhorst V, Leurgans S, et al. Locus coeruleus neuron density and parkinsonism in older adults without Parkinson's disease. Mov Disord. 2012;27:1625-31 pubmed publisher..In older adults without a clinical diagnosis of PD, neuron density in locus coeruleus nuclei is associated with the severity of parkinsonism and may contribute to late-life motor impairments. ..
- Buchman A, Wilson R, Shulman J, Leurgans S, Schneider J, Bennett D. Parkinsonism in Older Adults and Its Association With Adverse Health Outcomes and Neuropathology. J Gerontol A Biol Sci Med Sci. 2016;71:549-56 pubmed publisher..Parkinsonism is common in older adults and is associated with an increased risk of adverse health outcomes and postmortem indices of brain pathology. Its association with age suggests that it will increase in our aging population. ..
- Buchman A, Boyle P, Wilson R, Gu L, Bienias J, Bennett D. Pulmonary function, muscle strength and mortality in old age. Mech Ageing Dev. 2008;129:625-31 pubmed publisher..Overall, these findings suggest that pulmonary function may partially account for the association of muscle strength and mortality. ..
- Buchman A, Wilson R, Bienias J, Bennett D. Change in frailty and risk of death in older persons. Exp Aging Res. 2009;35:61-82 pubmed publisher..Using a continuous measure, the authors document that frailty is progressive in some older persons and that its rate of progression is associated with mortality. ..
- Buchman A, Wilson R, Yu L, James B, Boyle P, Bennett D. Total daily activity declines more rapidly with increasing age in older adults. Arch Gerontol Geriatr. 2014;58:74-9 pubmed publisher..These data suggest that total daily activity in very old adults declines more rapidly with increasing age. Thus, physical inactivity is likely to become a larger problem in our aging population. ..
- Buchman A, Yu L, Wilson R, Shulman J, Boyle P, Bennett D. Harm avoidance is associated with progression of parkinsonism in community-dwelling older adults: a prospective cohort study. BMC Geriatr. 2014;14:54 pubmed publisher..A higher level of the harm avoidance trait is associated with a more rapid progression of parkinsonism in older adults. ..
- Buchman A, Bennett D. Loss of motor function in preclinical Alzheimer's disease. Expert Rev Neurother. 2011;11:665-76 pubmed publisher..Thus, AD may have a much larger impact on the health and wellbeing of our aging population. ..
- Buchman A, Yu L, Boyle P, Schneider J, De Jager P, Bennett D. Higher brain BDNF gene expression is associated with slower cognitive decline in older adults. Neurology. 2016;86:735-41 pubmed publisher..Higher brain BDNF expression is associated with slower cognitive decline and may also reduce the deleterious effects of AD pathology on cognitive decline. ..
- Buchman A, Leurgans S, Yu L, Wilson R, Lim A, James B, et al. Incident parkinsonism in older adults without Parkinson disease. Neurology. 2016;87:1036-44 pubmed publisher..Parkinsonism is common in older adults and increases with age. Identifying modifiable risk factors may decrease the magnitude of this growing public health problem. ..
- Buchman A, Boyle P, Wilson R, Fleischman D, Leurgans S, Bennett D. Association between late-life social activity and motor decline in older adults. Arch Intern Med. 2009;169:1139-46 pubmed publisher..Less frequent participation in social activities is associated with a more rapid rate of motor function decline in old age. ..
- Buchman A, Yu L, Boyle P, Levine S, Nag S, Schneider J, et al. Microvascular brain pathology and late-life motor impairment. Neurology. 2013;80:712-8 pubmed publisher..To test the hypothesis that microvascular brain pathology is associated with late-life motor impairment...
- Buchman A, Leurgans S, Nag S, Bennett D, Schneider J. Cerebrovascular disease pathology and parkinsonian signs in old age. Stroke. 2011;42:3183-9 pubmed publisher..Mild motor symptoms including parkinsonian signs are common in old age, but their underlying neuropathology is unclear. We tested the hypothesis that cerebrovascular pathologies are related to parkinsonian signs...
- Buchman A, Boyle P, Leurgans S, Barnes L, Bennett D. Cognitive function is associated with the development of mobility impairments in community-dwelling elders. Am J Geriatr Psychiatry. 2011;19:571-80 pubmed publisher..Linear mixed-effects models showed that global cognition at baseline was associated with the rate of declining mobility. Among ambulatory elders, cognition is associated with incident mobility impairment and mobility decline. ..
- Buchman A, Boyle P, Wilson R, James B, Leurgans S, Arnold S, et al. Loneliness and the rate of motor decline in old age: the Rush Memory and Aging Project, a community-based cohort study. BMC Geriatr. 2010;10:77 pubmed publisher..Among community-dwelling older persons, both feeling alone and being alone are associated with more rapid motor decline, underscoring the importance of psychosocial factors and motor decline in old age. ..