Research Topics
Species | Aron BuchmanSummaryAffiliation: Rush University Medical Center Country: USA Publications
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Publications
Physical frailty in older persons is associated with Alzheimer disease pathologyAron S Buchman
Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Facility, Suite 1038, 600 S Paulina St, Chicago, IL 60612, USA
Neurology 71:499-504. 2008..We examined the extent to which physical frailty in older persons is associated with common age-related brain pathology, including cerebral infarcts, Lewy body pathology, and Alzheimer disease (AD) pathology...- Microvascular brain pathology and late-life motor impairmentAron S Buchman
Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL, USA
Neurology 80:712-8. 2013..To test the hypothesis that microvascular brain pathology is associated with late-life motor impairment... 
Neuroticism, extraversion, and motor function in community-dwelling older personsAron S Buchman
Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL Department of Neurological Sciences, Rush University Medical Center, Chicago, IL Electronic address
Am J Geriatr Psychiatry 21:145-54. 2013..Personality traits are associated with adverse health outcomes in old age, but their association with motor function is unclear. We tested the hypothesis that neuroticism and extraversion are associated with motor decline in older persons...- Locus coeruleus neuron density and parkinsonism in older adults without Parkinson's diseaseAron S Buchman
Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA
Mov Disord 27:1625-31. 2012..In older adults without a clinical diagnosis of PD, neuron density in locus coeruleus nuclei is associated with the severity of parkinsonism and may contribute to late-life motor impairments... - Total daily physical activity and the risk of AD and cognitive decline in older adultsA S Buchman
Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL, USA
Neurology 78:1323-9. 2012..We tested the hypothesis that an objective measure of total daily physical activity predicts incident AD and cognitive decline... - Nigral pathology and parkinsonian signs in elders without Parkinson diseaseAron S Buchman
Rush Alzheimer s Disease Center, Chicago, IL, USA
Ann Neurol 71:258-66. 2012..We tested the hypothesis that nigral pathology is related to parkinsonism in older persons without Parkinson disease (PD)... - Cognitive function is associated with risk aversion in community-based older personsPatricia A Boyle
Rush University Medical Center, Rush Alzheimer s Disease Center, 600 S Paulina, Chicago, IL 60612, USA
BMC Geriatr 11:53. 2011.... - Vibratory thresholds and mobility in older personsAron S Buchman
Rush Alzheimer s Disease Center, Armour Academic Facility, Suite 1038 600 South Paulina, Rush University Medical Center, Chicago, Illinois 60612, USA
Muscle Nerve 39:754-60. 2009..Vibratory thresholds are associated with mobility, supporting the link between peripheral sensory nerve function and mobility in the elderly... - Apolipoprotein E e4 allele is associated with more rapid motor decline in older personsAron S Buchman
Rush Alzheimer s Disease Center, Armour Academic Facility, Rush University Medical Center, Chicago, IL 60612, USA
Alzheimer Dis Assoc Disord 23:63-9. 2009..These results suggest that the presence of epsilon4 allele is a risk factor for more rapid motor decline in the elderly... - Change in frailty and risk of death in older personsA S Buchman
Rush Alzheimer s Disease Center and Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
Exp Aging Res 35:61-82. 2009..Using a continuous measure, the authors document that frailty is progressive in some older persons and that its rate of progression is associated with mortality... - Loneliness and the rate of motor decline in old age: the Rush Memory and Aging Project, a community-based cohort studyAron S Buchman
Department of Neurological Sciences, Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S, Paulina, Chicago, Illinois 60612, USA
BMC Geriatr 10:77. 2010..We tested the hypothesis that feeling alone is associated with the rate of motor decline in community-dwelling older persons... - Association between late-life social activity and motor decline in older adultsAron S Buchman
Departments of Neurological Sciences, Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Facility, Chicago, IL 60612, USA
Arch Intern Med 169:1139-46. 2009..Our objective was to test the hypothesis that late-life social activity is related to the rate of change in motor function in old age... - Kidney function is associated with the rate of cognitive decline in the elderlyAron S Buchman
Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
Neurology 73:920-7. 2009..We tested the hypothesis that impaired kidney function in the elderly is associated with a more rapid rate of cognitive decline... - Pulmonary function, muscle strength, and incident mobility disability in eldersAron S Buchman
Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina Street, Chicago, IL 60612, USA
Proc Am Thorac Soc 6:581-7. 2009..Overall, these findings suggest that lower levels of pulmonary function and muscle strength are relatively independently associated with the development of mobility disability in the elderly... - Combinations of motor measures more strongly predict adverse health outcomes in old age: the rush memory and aging project, a community-based cohort studyAron S Buchman
Department of Neurological Sciences, Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA
BMC Med 9:42. 2011..We tested the hypothesis that combinations of motor constructs more strongly predict adverse health outcomes in older people... - Loss of motor function in preclinical Alzheimer's diseaseAron S Buchman
Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina, Suite 1028, Chicago, IL 60612, USA
Expert Rev Neurother 11:665-76. 2011..Thus, AD may have a much larger impact on the health and wellbeing of our aging population... - Cognitive function is associated with the development of mobility impairments in community-dwelling eldersAron S Buchman
Rush Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
Am J Geriatr Psychiatry 19:571-80. 2011..To examine the association of cognitive function with the risk of incident mobility impairments and the rate of declining mobility in older adults... - Respiratory muscle strength predicts decline in mobility in older personsA S Buchman
Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
Neuroepidemiology 31:174-80. 2008..To test the hypothesis that respiratory muscle strength is associated with the rate of change in mobility even after controlling for leg strength and physical activity... - Pulmonary function, muscle strength and mortality in old ageA S Buchman
Rush Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, United States
Mech Ageing Dev 129:625-31. 2008..Overall, these findings suggest that pulmonary function may partially account for the association of muscle strength and mortality... 
Change in body mass index and risk of incident Alzheimer diseaseA S Buchman
Rush Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
Neurology 65:892-7. 2005..To examine the association of change in body mass index (BMI) with risk of Alzheimer disease (AD)...- Cerebrovascular disease pathology and parkinsonian signs in old ageAron S Buchman
Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Facility, Suite 1022, 600 South Paulina Street, Chicago, IL 60612, USA
Stroke 42:3183-9. 2011..Mild motor symptoms including parkinsonian signs are common in old age, but their underlying neuropathology is unclear. We tested the hypothesis that cerebrovascular pathologies are related to parkinsonian signs... - Body mass index in older persons is associated with Alzheimer disease pathologyA S Buchman
Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Facility, Suite 1038, 600 S Paulina St, Chicago, IL 60612, USA
Neurology 67:1949-54. 2006.... - Change in motor function and risk of mortality in older personsAron S Buchman
Rush Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
J Am Geriatr Soc 55:11-9. 2007..To assess the association between change in motor function and mortality... - Physical activity and motor decline in older personsA S Buchman
Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Facility, Suite 1038, 600 South Paulina Street, Chicago, Illinois 60612, USA
Muscle Nerve 35:354-62. 2007..Thus, higher levels of physical activity are associated with a slower rate of motor decline in older persons... - Frailty is associated with incident Alzheimer's disease and cognitive decline in the elderlyAron S Buchman
Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
Psychosom Med 69:483-9. 2007..To assess the association between frailty and incident Alzheimer's disease (AD) and cognitive decline. Frailty is common in older persons and associated with adverse health outcomes... - Total daily activity is associated with cognition in older personsAron S Buchman
Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
Am J Geriatr Psychiatry 16:697-701. 2008..The authors tested the hypothesis that total daily physical activity is related to the level of cognition in older persons... - Physical activity and leg strength predict decline in mobility performance in older personsAron S Buchman
Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
J Am Geriatr Soc 55:1618-23. 2007..To assess the extent to which physical activity and leg strength are associated with change in mobility in older persons... - Grip strength and the risk of incident Alzheimer's diseaseAron S Buchman
Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
Neuroepidemiology 29:66-73. 2007..Declining strength in old age is associated with an increased risk of AD... - Olfactory impairment in presymptomatic Alzheimer's diseaseRobert S Wilson
Department of Neurological Sciences, Rush Alzheimer s Disease Center, Rush University Medical Cetner, Chicago, Illinois 60612, USA
Ann N Y Acad Sci 1170:730-5. 2009.... - Purpose in life is associated with mortality among community-dwelling older personsPatricia A Boyle
Rush Alzheimer s Disease Center, Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL 60612, USA
Psychosom Med 71:574-9. 2009..To assess the association between purpose in life and all-cause mortality in community-dwelling elderly persons... - Odor identification and progression of parkinsonian signs in older personsRobert S Wilson
Rush Alzheimer s Disease Center and Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
Exp Aging Res 34:173-87. 2008..The results suggest that impaired odor identification is associated with more rapid progression of parkinsonism in old age, particularly parkinsonian gait disturbance... - Visuoperceptual repetition priming and progression of parkinsonian signs in agingDebra A Fleischman
Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL, USA
Neurobiol Aging 30:441-9. 2009..Reduced visuoperceptual priming in aging may be an early signal of vulnerability in a corticostrial circuit that contributes to sensorimotor integration... - Correlates of life space in a volunteer cohort of older adultsLisa L Barnes
Rush Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
Exp Aging Res 33:77-93. 2007..The results suggest that the range of environmental movement in older adults is a useful indicator of health in old age and may complement measures of disability... - Harm avoidance and disability in old ageRobert S Wilson
Rush Alzheimer s Disease Center and Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
Exp Aging Res 32:243-61. 2006..The results suggest that harm avoidance is associated with disability in old age... - The Rush Memory and Aging Project: study design and baseline characteristics of the study cohortDavid A Bennett
Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina, Suite 1028, Chicago, IL 60612, USA
Neuroepidemiology 25:163-75. 2005..Their mean age was 81 years, about a third had 12 or fewer years of education, a third were men, and about 10% were members of a racial or ethnic minority group. More than 950 already have completed their baseline clinical evaluation... - Relation of late-life social activity with incident disability among community-dwelling older adultsBryan D James
Rush University Medical Center, Room 1038, 600 South Paulina Street, Chicago, IL 60612, USA
J Gerontol A Biol Sci Med Sci 66:467-73. 2011..We tested the hypothesis that a higher level of social activity was associated with decreased risk of incident disability in older adults... - Lewy bodies and olfactory dysfunction in old ageRobert S Wilson
Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina Avenue, Chicago, IL 60612, USA
Chem Senses 36:367-73. 2011..The findings indicate that Lewy body disease impairs late life olfactory function even in otherwise asymptomatic individuals... - Physical activity is associated with incident disability in community-based older personsPatricia A Boyle
Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA
J Am Geriatr Soc 55:195-201. 2007.... - Association of muscle strength with the risk of Alzheimer disease and the rate of cognitive decline in community-dwelling older personsPatricia A Boyle
Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
Arch Neurol 66:1339-44. 2009.... - The APOE epsilon4 allele is associated with incident mild cognitive impairment among community-dwelling older personsPatricia A Boyle
Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL 60612, USA
Neuroepidemiology 34:43-9. 2010..The apolipoprotein E (APOE) epsilon4 allele is a well-known risk factor for the development of Alzheimer's disease, but little is known about the association of the epsilon4 allele with incident mild cognitive impairment (MCI)... - Physical frailty is associated with incident mild cognitive impairment in community-based older personsPatricia A Boyle
Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Facility, Suite 1020B, 600 South Paulina Street, Chicago, IL 60612, USA
J Am Geriatr Soc 58:248-55. 2010..To test the hypothesis that physical frailty is associated with risk of mild cognitive impairment (MCI)... - Effect of a purpose in life on risk of incident Alzheimer disease and mild cognitive impairment in community-dwelling older personsPatricia A Boyle
Rush Alzheimer s Disease Center, 600 S Paulina, Ste 1020B, Chicago, IL 60612, USA
Arch Gen Psychiatry 67:304-10. 2010..Emerging data suggest that psychological and experiential factors are associated with risk of Alzheimer disease (AD), but the association of purpose in life with incident AD is unknown... - Purpose in life is associated with a reduced risk of incident disability among community-dwelling older personsPatricia A Boyle
From the Rush Alzheimer s Disease Center, Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA
Am J Geriatr Psychiatry 18:1093-102. 2010..Purpose in life is thought to be associated with positive health outcomes in old age, but its association with disability is unknown... - Association between life space and risk of mortality in advanced agePatricia A Boyle
Rush Alzheimer s Disease Center, Chicago, Illinois 60612, USA
J Am Geriatr Soc 58:1925-30. 2010..To examine the association between life space, a measure of functional status that describes the range of movement through the environment covered during daily functioning, and the risk of mortality in older community-based persons... - Musculoskeletal pain is associated with incident mobility disability in community-dwelling eldersRaj C Shah
Rush Alzheimer s Disease Center, 600 South Paulina, Suite 1038, Chicago, IL 60612, USA
J Gerontol A Biol Sci Med Sci 66:82-8. 2011..We tested the hypothesis that musculoskeletal pain is associated with first occurrence of severe mobility disability... - Musculoskeletal pain and incident disability in community-dwelling older adultsAron S Buchman
Rush University Medical Center, Chicago, Illinois 60612, USA
Arthritis Care Res (Hoboken) 62:1287-93. 2010..To test the hypothesis that the number of areas of musculoskeletal pain reported is related to incident disability... - Eosinophilia, myositis, and myasthenia gravis associated with a thymomaIrit Avni
Internal Medicine D, Sheba Medical Center, Tel Hashomer, 52621, Israel
Muscle Nerve 34:242-5. 2006..Thymoma-associated T-cell abnormalities may well have contributed to this rare association. This case underscores the need to reevaluate constantly the presumed cause of clinical complaints, as more than one cause may be present... - Botulinum toxin injections for children with excessive droolingSharon Hassin-Baer
Department of Neurology, Chaim Sheba Medical Center, Tel Hashomer, Israel
J Child Neurol 20:120-3. 2005..These results underscore the need for further studies to establish the efficacy of this treatment in children...
Research Grants
- Risk Factors and the Neurobiologic Substrate of FrailtyAron Buchman; Fiscal Year: 2007....
- Risk Factors and the Neurobiologic Substrate of FrailtyAron Buchman; Fiscal Year: 2009..abstract_text> ..