Patricia A Boyle,


Affiliation: Rush University Medical Center
Country: USA


  1. Boyle P, Buchman A, Barnes L, Bennett D. Effect of a purpose in life on risk of incident Alzheimer disease and mild cognitive impairment in community-dwelling older persons. Arch Gen Psychiatry. 2010;67:304-10 pubmed publisher
    ..53-0.95; P = .02) and a slower rate of cognitive decline (mean [SE] global cognition estimate, 0.03 [0.01], P < .01). Greater purpose in life is associated with a reduced risk of AD and MCI in community-dwelling older persons. ..
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    Boyle P, Wilson R, Buchman A, Aggarwal N, Tang Y, Arvanitakis Z, et al. Lower extremity motor function and disability in mild cognitive impairment. Exp Aging Res. 2007;33:355-71 pubmed
    ..These findings suggest that lower extremity motor dysfunction is common and contributes to disability in MCI, but lower extremity motor dysfunction in MCI does not appear to be explained by the vascular factors examined in this study. ..
  3. Boyle P, Buchman A, Wilson R, Leurgans S, Bennett D. Physical frailty is associated with incident mild cognitive impairment in community-based older persons. J Am Geriatr Soc. 2010;58:248-55 pubmed publisher
    ..Physical frailty is associated with risk of MCI and a rapid rate of cognitive decline in aging. ..
  4. Boyle P, Yu L, Buchman A, Laibson D, Bennett D. Cognitive function is associated with risk aversion in community-based older persons. BMC Geriatr. 2011;11:53 pubmed publisher
    ..e., semantic memory, episodic memory, working memory, and perceptual speed); performance on visuospatial abilities was not. A lower level of cognitive ability and female sex are associated with greater risk aversion in advanced age. ..
  5. Boyle P, Yu L, Wilson R, Gamble K, Buchman A, Bennett D. Poor decision making is a consequence of cognitive decline among older persons without Alzheimer's disease or mild cognitive impairment. PLoS ONE. 2012;7:e43647 pubmed publisher
    ..quot; These findings suggest that even very subtle age-related changes in cognition have detrimental effects on judgment. ..
  6. Boyle P, Yu L, Segawa E, Wilson R, Buchman A, Laibson D, et al. Association of cognition with temporal discounting in community based older persons. BMC Geriatr. 2012;12:48 pubmed
    ..These findings have implications regarding the ability of older persons to make decisions that involve delayed rewards but maximize well-being. ..
  7. Boyle P, Yu L, Nag S, Leurgans S, Wilson R, Bennett D, et al. Cerebral amyloid angiopathy and cognitive outcomes in community-based older persons. Neurology. 2015;85:1930-6 pubmed publisher
    ..The associations of CAA with cognitive outcomes were not driven by the presence of capillary involvement. CAA is an important determinant of AD dementia and decline in multiple cognitive systems in old age. ..
  8. Dawe R, Yu L, Leurgans S, Schneider J, Buchman A, Arfanakis K, et al. Postmortem MRI: a novel window into the neurobiology of late life cognitive decline. Neurobiol Aging. 2016;45:169-177 pubmed publisher
  9. Buchman A, Boyle P, Wilson R, James B, Leurgans S, Arnold S, et al. Loneliness and the rate of motor decline in old age: the Rush Memory and Aging Project, a community-based cohort study. BMC Geriatr. 2010;10:77 pubmed publisher
    ..Among community-dwelling older persons, both feeling alone and being alone are associated with more rapid motor decline, underscoring the importance of psychosocial factors and motor decline in old age. ..

More Information


  1. Boyle P, Buchman A, Wilson R, Kelly J, Bennett D. The APOE epsilon4 allele is associated with incident mild cognitive impairment among community-dwelling older persons. Neuroepidemiology. 2010;34:43-9 pubmed publisher
    ..e. episodic memory, semantic memory, working memory and perceptual speed). The presence of the APOE epsilon4 allele is associated with an increased risk of MCI and a more rapid rate of cognitive decline in old age. ..
  2. Boyle P, Buchman A, Bennett D. Purpose in life is associated with a reduced risk of incident disability among community-dwelling older persons. Am J Geriatr Psychiatry. 2010;18:1093-102 pubmed publisher
    ..Purpose in life is thought to be associated with positive health outcomes in old age, but its association with disability is unknown...