Patricia A Boyle,

..The objective of this study was to test the hypothesis that poor decision making is a consequence of cognitive decline among older persons without Alzheimer's disease or mild cognitive impairment...

..The objective of this study was to test the hypothesis that cognitive function is negatively associated with temporal discounting in old age...

..Purpose in life is associated with a substantially reduced risk of Alzheimer disease (AD), but the neurobiologic basis of this protective effect remains unknown...

..We tested the hypothesis that combinations of motor constructs more strongly predict adverse health outcomes in older people...

..We tested the hypothesis that feeling alone is associated with the rate of motor decline in community-dwelling older persons...

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..These findings suggest that lower extremity motor dysfunction is common and contributes to disability in MCI, but lower extremity motor dysfunction in MCI does not appear to be explained by the vascular factors examined in this study...

..Purpose in life is thought to be associated with positive health outcomes in old age, but its association with disability is unknown...

..Emerging data suggest that psychological and experiential factors are associated with risk of Alzheimer disease (AD), but the association of purpose in life with incident AD is unknown...

..To test the hypothesis that physical frailty is associated with risk of mild cognitive impairment (MCI)...

..If this is an effective compensatory strategy, then involvement of additional cognitive systems may help maintain function in other cognitive systems despite the accumulation of pathology...

..The apolipoprotein E (APOE) epsilon4 allele is a well-known risk factor for the development of Alzheimer's disease, but little is known about the association of the epsilon4 allele with incident mild cognitive impairment (MCI)...

..To assess the association between purpose in life and all-cause mortality in community-dwelling elderly persons...

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..To examine the extent to which persons with mild cognitive impairment (MCI) have an increased risk of Alzheimer disease (AD) and a more rapid rate of decline in cognitive function compared to similar persons without cognitive impairment...

..To examine the association between life space, a measure of functional status that describes the range of movement through the environment covered during daily functioning, and the risk of mortality in older community-based persons...

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..To assess the contribution of dementia-related neuropathologic lesions to age-related and disease-related change in cognitive function...

..Overall, these findings suggest that pulmonary function may partially account for the association of muscle strength and mortality...

..To test the hypothesis that respiratory muscle strength is associated with the rate of change in mobility even after controlling for leg strength and physical activity...

..We tested the hypothesis that impaired kidney function in the elderly is associated with a more rapid rate of cognitive decline...

..To test the hypothesis that frequent cognitive activity predicts slower cognitive decline before dementia onset in Alzheimer disease (AD) and faster decline thereafter...

..Thus, higher levels of physical activity are associated with a slower rate of motor decline in older persons...

..Here we test the hypothesis that chronic psychological distress is associated with increased incidence of MCI in old age...

..To study the relationship between Alzheimer disease (AD) pathology and memory complaints proximate to death...

..To test the hypothesis that the number of areas of musculoskeletal pain reported is related to incident disability...

..To characterize the course of cognitive decline during the prodromal phase of Alzheimer disease...

..Overall, these findings suggest that lower levels of pulmonary function and muscle strength are relatively independently associated with the development of mobility disability in the elderly...

..Basic lexical skills are hypothesised to be relatively preserved in mild dementia, but clinical studies have reported inconsistent results...

..We tested the hypothesis that a higher level of social activity was associated with decreased risk of incident disability in older adults...

..We tested the hypothesis that musculoskeletal pain is associated with first occurrence of severe mobility disability...

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..Our objective was to test the hypothesis that late-life social activity is related to the rate of change in motor function in old age...

..To assess the association between change in motor function and mortality...

..Examine the effects of subcortical infarcts with Alzheimer's disease (AD) pathology on dementia, episodic memory, and other cognitive abilities in older persons...

..Mild cognitive impairment (MCI) is often a precursor to Alzheimer disease, but knowledge about factors that predict its development is limited...

..To assess the extent to which physical activity and leg strength are associated with change in mobility in older persons...

..Declining strength in old age is associated with an increased risk of AD...

..To assess the association between frailty and incident Alzheimer's disease (AD) and cognitive decline. Frailty is common in older persons and associated with adverse health outcomes...

..These results suggest that the presence of epsilon4 allele is a risk factor for more rapid motor decline in the elderly...

..The purpose of this study is to investigate associations between executive dysfunction, neuroimaging findings, and functional impairment in patients with vascular dementia (VaD)...

..These findings suggest that different aspects of frontal and executive functions may be related to IADLs, depending on the type of assessment instrument used. Key words: activities of daily living, executive function, older adults..

..The purpose of this study was to examine the extent to which executive cognitive dysfunction and frontally-mediated behavioral disturbances are associated with functional impairment in patients with mild-to-moderate Alzheimer disease (AD)...

..The emerging role of frontal system dysfunction as an important determinant of ADL impairment is discussed, and recommendations for clinical practice and future research are provided...

..These findings demonstrate that baseline executive dysfunction is a significant and powerful predictor of future functional decline in individuals with VaD...

..Also, the potential use of executive dysfunction as a marker for instrumental activities of daily living impairment is discussed and recommendations for clinical practice and future research are provided...

..Patients with VaD display diverse cognitive and motor deficits, however, and relationships between these impairments and independent living abilities remain unclear...

..The potential benefits of other pharmacologic agents and combined pharmacologic-behavioral interventions are also discussed, and recommendations for future research are provided...

..The results from this study indicate that age bias is not as serious a problem among neuropsychologists as many psychologists once believed...

..The association between SH and antidepressant treatment response in depressed geriatric outpatients remains unclear and deserves further investigation...

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..These findings suggest that caregiver interventions aimed to reduce burden may benefit from the incorporation of specific strategies to increase self-efficacy and decrease depressive symptoms...

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