J A Block
Affiliation: Rush University Medical Center
- Osteogenic protein 1 in synovial fluid from patients with rheumatoid arthritis or osteoarthritis: relationship with disease and levels of hyaluronan and antigenic keratan sulfateSusan Chubinskaya
Department of Biochemistry, Rush University Medical Center, Chicago, Illinois, USA
Arthritis Res Ther 8:R73. 2006..In conclusion, the results of this study suggest that measurement of OP-1 in joint fluid may have value in the clinical evaluation of joint disease processes...
- The effects of oral glucosamine on joint health: is a change in research approach needed?J A Block
Department of Internal Medicine Rheumatology, Rush University Medical Center, Chicago IL 60612, USA
Osteoarthritis Cartilage 18:5-11. 2010..Here, we review the state of knowledge concerning the biology of GlcN as it relates to OA, and discuss a framework for future research directions...
- The biomechanics of osteoarthritis: implications for therapyJoel A Block
Section of Rheumatology, Rush Medical College, Rush University Medical Center, Chicago, IL 60612, USA
Curr Rheumatol Rep 11:15-22. 2009..These new therapies may ultimately be shown to retard disease progression and palliate pain. This article reviews some of these strategies...
- Lower limb osteoarthritis: biomechanical alterations and implications for therapyJoel A Block
Section of Rheumatology, Rush Medical College, Rush University Medical Center, Chicago, Illinois, USA
Curr Opin Rheumatol 22:544-50. 2010..To review the role of biomechanics in the pathogenesis of lower-extremity osteoarthritis and recent advances in biomechanically active intervention strategies for osteoarthritis...
- Raynaud's phenomenonJ A Block
Section of Rheumatology, Rush Medical College, Rush Presbyterian St Luke s Medical Center, 1725 West Harrison Street, Chicago, IL 60612, USA
Lancet 357:2042-8. 2001....
- The biomechanical effects of focused muscle training on medial knee loads in OA of the knee: a pilot, proof of concept studyL E Thorp
Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA
J Musculoskelet Neuronal Interact 10:166-73. 2010..This study examined the biomechanical effects of a lower extremity exercise regimen, emphasizing training of hip abductor musculature, on dynamic knee loads in individuals with knee OA...
- Increased knee joint loads during walking are present in subjects with knee osteoarthritisA J Baliunas
Department of Orthopedic Surgery, Rush Medical College of Rush University, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
Osteoarthritis Cartilage 10:573-9. 2002..Additionally, this study tests if changes in the knee angles, such as a reduced midstance knee flexion angle, or reduced sagittal plane moments previously identified by others as load reducing mechanisms are present in this OA group...
- Knee pain and joint loading in subjects with osteoarthritis of the kneeD E Hurwitz
Department of Orthopedic Surgery, Section of Rheumatology, Rush Presbyterian St Luke s Medical Cente, Chicago, Illinois 60612, USA
J Orthop Res 18:572-9. 2000..Additional long-term prospective studies are needed to determine whether increased loading during walking actually results in accelerated progression of the disease...
- Bone density, dynamic joint loading and joint degeneration. A reviewD E Hurwitz
Department of Orthopedic Surgery, Rush Medical College of Rush University, Rush Presbyterian St Luke s Medical Center, Chicago Ill 60612, USA
Cells Tissues Organs 169:201-9. 2001..Major questions yet to be answered are how joint loading and bone density interact in the development and progression of joint degeneration...
- Bone mineral density in the proximal tibia varies as a function of static alignment and knee adduction angular momentum in individuals with medial knee osteoarthritisL E Thorp
Department of Anatomy and Cell Biology, Rush University Medical Center, 600 S Paulina, Chicago, IL 60612, USA
Bone 39:1116-22. 2006....
- Pain and its relationship with muscle strength and proprioception in knee OA: results of an 8-week home exercise pilot studyN Shakoor
Section of Rheumatology, Rush Medical College of Rush University Medical Center, Chicago, IL 60612, USA
J Musculoskelet Neuronal Interact 8:35-42. 2008..41, p=0.01) with exercise. The association of pain with both muscle strength and proprioception should prompt future studies to consider and adjust for the influence of pain on neuromuscular factors in knee OA...
- Patient reported outcomes and analgesia use in osteoarthritis of the kneeS Mody
Rush University Medical Center, Chicago, IL 60612, USA
Osteoarthritis Cartilage 16:1294-9. 2008..Here, we assess the relationship of pain, physical function, and HRQoL to NOA use in symptomatic knee OA...
- Osteoarticular tuberculosis: current diagnosis and treatmentW Sequeira
Cook County Hospital and Rush Medical College of Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
Am J Ther 7:393-8. 2000..Partial synovectomy and other surgical procedures should be restricted to joints with severe cartilage destruction, large abscesses, joint deformity, multiple drug resistance, or atypical mycobacteria...
- Etanercept therapy in patients with a positive tuberculin skin testA M Manadan
John H Stroger Hospital of Cook County Hospital, Chicago, USA
Clin Exp Rheumatol 25:743-5. 2007..In this study, we attempted to evaluate the frequency of latent TB reactivation among patients treated with etanercept...
- The knee adduction moment during gait in subjects with knee osteoarthritis is more closely correlated with static alignment than radiographic disease severity, toe out angle and painD E Hurwitz
Department of Orthopedic Surgery, Rush Presbyterian St Luke s Medical Center, Rush Medical College of Rush University, Chicago, IL 60612, USA
J Orthop Res 20:101-7. 2002..Understanding which clinical measures of OA are most closely associated with the dynamic knee joint loads may ultimately result in a better understanding of the disease process and the development of therapeutic interventions...
- The effect of chemonucleolysis on serum keratan sulfate levels in humansJ A Block
Department of Internal Medicine, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612 3864
Arthritis Rheum 32:100-4. 1989..By measuring serum KS levels both pre- and post-CN, we have demonstrated that serum KS levels rise predictably after CN, in a manner that reflects major catabolic events of cartilage...
- Mycobacteria tuberculosis peritonitis associated with etanercept therapyA M Manadan
Clin Exp Rheumatol 21:526. 2003