David A Bennett

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..Complement activation is increased in Alzheimer's disease (AD), but its significance is unclear. The objective of this study was to determine the relationship between complement activation and cognition during the development of AD...

..02) but not the association of neurofibrillary tangles with level of cognition, suggesting that education is related to factors that reduce the effect of amyloid on cognition...

..Few large longitudinal studies have compared the natural history of mild cognitive impairment with similar persons without cognitive impairment...

..The neurobiological changes underlying the association of the apolipoprotein E (APOE) e4 allele with level of cognition are poorly understood...

..Their mean age was 81 years, about a third had 12 or fewer years of education, a third were men, and about 10% were members of a racial or ethnic minority group. More than 950 already have completed their baseline clinical evaluation...

..To examine the extent to which persons with mild cognitive impairment have intermediate levels of Alzheimer disease (AD) pathology, cerebral infarcts, and Lewy body disease...

..To test the hypothesis that years of formal education modifies the relation of AD pathology to level of cognitive function...

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..To test the hypothesis that the association of amyloid load with clinical Alzheimer disease (AD) and cognitive impairment is mediated through neurofibrillary tangles...

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..To test the hypothesis that the APOE epsilon4 allele is associated with the clinical manifestations of AD through an association with the pathologic hallmarks of disease...

..The findings to date illustrate the kinds of insights that can be gained into mechanisms of disease through the incorporation of pathologic indices into well-designed, epidemiologic studies of aging and Alzheimer disease...

..This approach holds promise for reducing the operational costs of epidemiologic studies of aging and AD...

..The extent to which parkinsonian signs in aging and Alzheimer's disease cluster in groups typical of Parkinson's disease has not been investigated previously...

..To examine the relation of National Institute on Aging-Reagan (NIA-Reagan) neuropathologic criteria of Alzheimer disease (AD) to level of cognitive function in persons without dementia or mild cognitive impairment (MCI)...

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..Few data are available about how social networks reduce the risk of cognitive impairment in old age. We aimed to measure this effect using data from a large, longitudinal, epidemiological clinicopathological study...

..A study was undertaken to examine the relation of Alzheimer disease (AD) pathology, cerebral infarcts, and Lewy body (LB) pathology to cognition in persons without cognitive impairment...

..Emerging data suggest that psychological and experiential factors are associated with risk of Alzheimer disease (AD), but the association of purpose in life with incident AD is unknown...

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..Mild cognitive impairment (MCI) is often a precursor to Alzheimer disease, but knowledge about factors that predict its development is limited...

..Little is known about motor function in mild cognitive impairment (MCI) and its relation to the risk of Alzheimer disease (AD)...

..The personality trait of conscientiousness has been related to morbidity and mortality in old age, but its association with the development of Alzheimer disease is not known...

..White matter hyperintensity volume (WMHV), cerebral infarcts, and total brain volume (TBV) are associated with cognitive function, but few studies have examined these associations in the general population or whether they differ by race...

..The results suggest that the range of environmental movement in older adults is a useful indicator of health in old age and may complement measures of disability...

..to examine the relation of personality to the development of disability in old age...

..To test the hypothesis that the number of areas of musculoskeletal pain reported is related to incident disability...

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..02, 2.63). There was a marginally significant reduction in the effect of epsilon4 in older compared to younger participants (p=.053). The results suggest that possession of an epsilon4 allele does increase risk of AD in persons with MCI...

..Few studies compare Alzheimer disease (AD) incidence among black and white subjects...

..The apolipoprotein E (APOE) epsilon 4 allele is known to influence risk of AD but it has been difficult to establish whether it affects episodic memory differently from other cognitive functions...

..To examine the relation of systolic and diastolic blood pressure to incident Alzheimer's disease (AD) and rate of cognitive change...

..We tested the hypothesis that nigral pathology is related to parkinsonism in older persons without Parkinson disease (PD)...

..Social isolation in old age has been associated with risk of developing dementia, but the risk associated with perceived isolation, or loneliness, is not well understood...

..The results confirm that higher level of social engagement in old age is associated with better cognitive function but the association varies across domains of social engagement...

..Findings indicate that explicit memory and priming are dissociable on the basis of age-related change and that mildly reduced priming is not an inevitable consequence of growing older...

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..The results suggest that past cognitive activity contributes to current cognition principally through its association with cognitive activity in old age...

..To identify the components of the neuroticism trait most responsible for its association with cognitive decline and dementia in old age...

..The results from these waves must be combined for effective analysis of the relation among risk factors and incident disease...

..The findings are discussed and contextualized...

..We tested the hypothesis that feeling alone is associated with the rate of motor decline in community-dwelling older persons...

..The objective of this study was to test whether common age-related neuropathology could account for the relation of chronic distress to dementia...

..To characterize the course of cognitive decline during the prodromal phase of Alzheimer disease...

..Depressive symptoms in Alzheimer's disease appear to follow a more predictable pattern of expression than previously described...

..We tested the hypothesis that a higher level of social activity was associated with decreased risk of incident disability in older adults...

..06), perceptual speed (p = 0.07) and naming (p = 0.08). The results suggest that the rate of cognitive decline in AD is slower in African-Americans compared with whites, particularly for episodic memory...

..To examine the relation of cerebral amyloid angiopathy (CAA) to cognitive domains in older community-dwelling persons with and without dementia...

..This suggests that genetic analyses of memory endophenotypes may help to identify genetic variants associated with AD...

..The apolipoprotein E (APOE) epsilon4 allele is a well-known risk factor for the development of Alzheimer's disease, but little is known about the association of the epsilon4 allele with incident mild cognitive impairment (MCI)...

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..The objective of this study was to test the hypothesis that cognitive function is negatively associated with temporal discounting in old age...

..Purpose in life is associated with a substantially reduced risk of Alzheimer disease (AD), but the neurobiologic basis of this protective effect remains unknown...

..We tested the hypothesis that combinations of motor constructs more strongly predict adverse health outcomes in older people...

..The results suggest that impaired odor identification is associated with more rapid progression of parkinsonism in old age, particularly parkinsonian gait disturbance...

..The results are discussed in terms of a common biological substrate in the inferotemporal neocortex, supporting efficient processing of meaningful visual-perceptual experience and proficient performance of activities of daily living...

..The results suggest that both measures are psychometrically sound in a minority population and that lifetime cognitive activity may contribute to current cognitive function in African Americans...

..Parkinsonianlike signs are common in older persons, but little is known about how their severity or rate of progression is related to the development of Alzheimer disease (AD) or decline in cognition...

..To test the hypothesis that physical frailty is associated with risk of mild cognitive impairment (MCI)...

..Collectively, these results suggest a role for caspase-6 and N-terminal truncation of tau during neurofibrillary tangle evolution and the progression of Alzheimer's disease...

..Declining strength in old age is associated with an increased risk of AD...

..While decreased hemoglobin concentration is common in the elderly, the relationship of the entire range of hemoglobin concentrations with cognitive function is not well understood...

..To examine the association of cognitive function with the risk of incident mobility impairments and the rate of declining mobility in older adults...

..Furthermore, we were able to compare conformational signatures of tau among different lesion types and determine that the molecular profile of tau is lesion-specific...

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..The purpose of this study was to examine the association of blood pressure (BP) with change in lower limb function in older persons...

..The findings indicate that Lewy body disease impairs late life olfactory function even in otherwise asymptomatic individuals...

..CONCLUSION: In this community population where BP treatment was common, there was no association of either high systolic or high diastolic BP at the beginning of the observation interval with 6-year cognitive decline...

..These findings suggest that the rate of atrophy of mesial temporal lobe structures can differentiate healthy from pathological aging...

..Information regarding the prevalence of dizziness and its association with functional disability among African American and white residents from defined community populations is limited...

..no use: mean difference = 0.12; p trend = 0.03). Overall, we found no relation between regular aspirin use and cognitive decline, but long-term use of ibuprofen may be related to decreased rates of cognitive decline in older persons...

..These data suggest that although both the EC and hippocampal formation degenerate before the onset of overt dementia, EC volume is a better predictor of conversion...

..CONCLUSION: In nondemented individuals, entorhinal cortex atrophy is associated with risk of Alzheimer disease...

..08). CONCLUSION: Diabetes may be a previously unrecognized risk factor for progression of parkinsonian-like signs in older persons...

..Little is known about factors that predict transition from mild cognitive impairment to Alzheimer's disease (AD)...

..In contrast, the loss of trkA mRNA in MCI and AD was significantly correlated with function on a variety of episodic memory tests...

..To examine the relation of nonsteroidal anti-inflammatory drugs (NSAIDs) to incident Alzheimer disease (AD), change in cognition, and AD pathology...

..To examine the relation of statins to incident Alzheimer disease (AD) and change in cognition and neuropathology...

..CONCLUSION: We found a relation between diabetes and cerebral infarction but not between diabetes and Alzheimer disease pathology in older persons...

..Frequent participation in cognitively stimulating activities has been hypothesized to reduce risk of Alzheimer disease (AD), but prospective data regarding an association are lacking...

..To assess the association between change in motor function and mortality...

..Individual differences in retest effects were substantial but not consistent across cognitive measures. The results suggest that retest-based improvement in cognitive test performance can be substantial and persistent...

..The authors tested the hypothesis that total daily physical activity is related to the level of cognition in older persons...

..Prospective studies have established an association between depressive symptoms and risk of dementia, but how depressive symptoms change during the evolution of dementia is uncertain...

..To test the hypothesis that rate of cognitive decline accelerates in the last years of life...

..To assess the association between frailty and incident Alzheimer's disease (AD) and cognitive decline. Frailty is common in older persons and associated with adverse health outcomes...

..These results suggest that the presence of epsilon4 allele is a risk factor for more rapid motor decline in the elderly...

..Vibratory thresholds are associated with mobility, supporting the link between peripheral sensory nerve function and mobility in the elderly...

..Overall, these findings suggest that lower levels of pulmonary function and muscle strength are relatively independently associated with the development of mobility disability in the elderly...

..059) after controlling for depressive symptoms. The results suggest that the tendency to experience psychological distress is associated with increased cognitive decline in old age...

..To examine the prevalence of perceived discrimination in an older biracial population and to examine its correlation with depressive symptoms...

..Basic lexical skills are hypothesised to be relatively preserved in mild dementia, but clinical studies have reported inconsistent results...

..Little is known about the role of microinfarcts in dementia and cognition. We examined microinfarcts and dementia, global cognition, and 5 cognitive systems in community-dwelling older persons...

..Dietary n-3 polyunsaturated fatty acids improve brain functioning in animal studies, but there is limited study of whether this type of fat protects against Alzheimer disease...

..3 million in 2002 by the Aging, Demographics, and Memory Study (ADAMS), which is almost 50% less than the estimate of 4.5 million in 2000 derived from the Chicago Health and Aging Project...

..Oxidative processes have been suggested as elements in the development of Alzheimer disease (AD), but whether dietary intake of vitamin E and other antioxidant nutrients prevents its development is unknown...

..The cross-sectional association between blood pressure and cognitive functions is small and curvilinear and more apparent in persons with cardiovascular conditions...

..These results suggest that age-associated decreases in memory ability may be due to decreased frontal-lobe contributions to the initial encoding of experience...

..The results of the proposed study could lay the foundation for a series of studies that address these and other aspects of economic decision making in older persons without dementia. ..

..Even relatively small reductions of risk from common disabling conditions will have a major public health impact for future generations. ..

..PERFORMANCE SITE(S) (organization ..

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..The proposed study to identify novel epigenetic marks associated with risk of dementia is a timely and important study that could provide new knowledge critical to public health. ..

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..Further, understanding the biologic pathways linking risk factors to clinical disease is essential for developing therapeutic interventions to treat and ultimately prevent AD. ..

..The findings from the proposed study could have important implications for therapeutic intervention and the prevention of Alzheimer's disease. ..

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..Even relatively small reductions of risk from common disabling conditions will have a major public health impact for future generations. ..

..The proposed study to identify novel epigenetic marks associated with risk of dementia is a timely and important study that could provide new knowledge critical to public health. ..