David A Bennett
Affiliation: Rush University Medical Center
Bennett D, Schneider J, Buchman A, Mendes de Leon C, Bienias J, Wilson R. The Rush Memory and Aging Project: study design and baseline characteristics of the study cohort. Neuroepidemiology. 2005;25:163-75 pubmed
..Their mean age was 81 years, about a third had 12 or fewer years of education, a third were men, and about 10% were members of a racial or ethnic minority group. More than 950 already have completed their baseline clinical evaluation. ..
Bennett D, Schneider J, Bienias J, Evans D, Wilson R. Mild cognitive impairment is related to Alzheimer disease pathology and cerebral infarctions. Neurology. 2005;64:834-41 pubmed
..04). Only 3 (8.1%) persons with mild cognitive impairment had Lewy body disease. These data suggest that mild cognitive impairment may be the earliest clinical manifestation of common age-related neurologic diseases. ..
Bihlmeyer N, Brody J, Smith A, Lunetta K, Nalls M, Smith J, et al
. Genetic diversity is a predictor of mortality in humans. BMC Genet. 2014;15:159 pubmed publisher
..57%. This effect was consistent between European and African ancestry cohorts, men and women, and major causes of death (cancer and cardiovascular disease), demonstrating the broad positive impact of genomic diversity on human survival. ..
Buchman A, Boyle P, Wilson R, James B, Leurgans S, Arnold S, et al
. Loneliness and the rate of motor decline in old age: the Rush Memory and Aging Project, a community-based cohort study. BMC Geriatr. 2010;10:77 pubmed publisher
..Among community-dwelling older persons, both feeling alone and being alone are associated with more rapid motor decline, underscoring the importance of psychosocial factors and motor decline in old age. ..
Bennett D, Schneider J, Wilson R, Bienias J, Berry Kravis E, Arnold S. Amyloid mediates the association of apolipoprotein E e4 allele to cognitive function in older people. J Neurol Neurosurg Psychiatry. 2005;76:1194-9 pubmed
..These findings are consistent with a sequence of events whereby the e4 allele works through amyloid deposition and subsequent tangle formation to cause cognitive impairment. ..
Bennett D, De Jager P, Leurgans S, Schneider J. Neuropathologic intermediate phenotypes enhance association to Alzheimer susceptibility alleles. Neurology. 2009;72:1495-503 pubmed publisher
..Discovery efforts for susceptibility loci for Alzheimer disease could benefit from the use of neuropathologic intermediate phenotypes as a complement to other approaches. ..
Bennett D, Wilson R, Schneider J, Evans D, Aggarwal N, Arnold S, et al
. Apolipoprotein E epsilon4 allele, AD pathology, and the clinical expression of Alzheimer's disease. Neurology. 2003;60:246-52 pubmed
..The APOE epsilon4 allele appears to be associated with the clinical manifestations of AD through an association with the pathologic hallmarks of AD rather than another mechanism. ..