David A Bennett

Summary

Affiliation: Rush University Medical Center
Country: USA

Publications

  1. pmc ELISA measurement of specific non-antigen-bound antibodies to Aβ1-42 monomer and soluble oligomers in sera from Alzheimer's disease, mild cognitively impaired, and noncognitively impaired subjects
    Andrea C Klaver
    Department of Neurology Research, William Beaumont Hospital Research Institute, Royal Oak, MI 48073, USA
    J Neuroinflammation 8:93. 2011
  2. pmc Plaque complement activation and cognitive loss in Alzheimer's disease
    David A Loeffler
    Neurology Research Laboratory, William Beaumont Hospital Research Institute, Royal Oak, MI 48073, USA
    J Neuroinflammation 5:9. 2008
  3. ncbi request reprint Natural history of mild cognitive impairment in older persons
    D A Bennett
    Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, Rush Presbyterian St Luke s Medical Center, Chicago, IL, USA
    Neurology 59:198-205. 2002
  4. ncbi request reprint Editorial comment on 'Prevalence of dementia in the United States: the aging, demographics, and memory study' by Plassman et al
    David A Bennett
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Neuroepidemiology 29:133-5. 2007
  5. ncbi request reprint Decision rules guiding the clinical diagnosis of Alzheimer's disease in two community-based cohort studies compared to standard practice in a clinic-based cohort study
    David A Bennett
    Rush Alzheimer s Disease Center, Chicago, Ill, USA
    Neuroepidemiology 27:169-76. 2006
  6. ncbi request reprint Apolipoprotein E epsilon4 allele, AD pathology, and the clinical expression of Alzheimer's disease
    D A Bennett
    Rush Alzheimer s Disease Center, Chicago, Illinois 60612, USA
    Neurology 60:246-52. 2003
  7. ncbi request reprint The effect of social networks on the relation between Alzheimer's disease pathology and level of cognitive function in old people: a longitudinal cohort study
    David A Bennett
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Lancet Neurol 5:406-12. 2006
  8. ncbi request reprint Update on mild cognitive impairment
    David A Bennett
    Rush Alzheimer s Disease Center, Rush Presbyterian St Luke s Medical Center, 1645 West Jackson Boulevard, Suite 675, Chicago, IL 60612, USA
    Curr Neurol Neurosci Rep 3:379-84. 2003
  9. ncbi request reprint Education modifies the association of amyloid but not tangles with cognitive function
    D A Bennett
    Rush Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
    Neurology 65:953-5. 2005
  10. pmc Amyloid mediates the association of apolipoprotein E e4 allele to cognitive function in older people
    D A Bennett
    Rush Alzheimer s Disease Center, Armour Academic Center, 600 South Paulina, Suite 1028 Chicago, IL 60612, USA
    J Neurol Neurosurg Psychiatry 76:1194-9. 2005

Collaborators

Detail Information

Publications186 found, 100 shown here

  1. pmc ELISA measurement of specific non-antigen-bound antibodies to Aβ1-42 monomer and soluble oligomers in sera from Alzheimer's disease, mild cognitively impaired, and noncognitively impaired subjects
    Andrea C Klaver
    Department of Neurology Research, William Beaumont Hospital Research Institute, Royal Oak, MI 48073, USA
    J Neuroinflammation 8:93. 2011
    ....
  2. pmc Plaque complement activation and cognitive loss in Alzheimer's disease
    David A Loeffler
    Neurology Research Laboratory, William Beaumont Hospital Research Institute, Royal Oak, MI 48073, USA
    J Neuroinflammation 5:9. 2008
    ..Complement activation is increased in Alzheimer's disease (AD), but its significance is unclear. The objective of this study was to determine the relationship between complement activation and cognition during the development of AD...
  3. ncbi request reprint Natural history of mild cognitive impairment in older persons
    D A Bennett
    Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, Rush Presbyterian St Luke s Medical Center, Chicago, IL, USA
    Neurology 59:198-205. 2002
    ..Few large longitudinal studies have compared the natural history of mild cognitive impairment with similar persons without cognitive impairment...
  4. ncbi request reprint Editorial comment on 'Prevalence of dementia in the United States: the aging, demographics, and memory study' by Plassman et al
    David A Bennett
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Neuroepidemiology 29:133-5. 2007
  5. ncbi request reprint Decision rules guiding the clinical diagnosis of Alzheimer's disease in two community-based cohort studies compared to standard practice in a clinic-based cohort study
    David A Bennett
    Rush Alzheimer s Disease Center, Chicago, Ill, USA
    Neuroepidemiology 27:169-76. 2006
    ..This approach holds promise for reducing the operational costs of epidemiologic studies of aging and AD...
  6. ncbi request reprint Apolipoprotein E epsilon4 allele, AD pathology, and the clinical expression of Alzheimer's disease
    D A Bennett
    Rush Alzheimer s Disease Center, Chicago, Illinois 60612, USA
    Neurology 60:246-52. 2003
    ..To test the hypothesis that the APOE epsilon4 allele is associated with the clinical manifestations of AD through an association with the pathologic hallmarks of disease...
  7. ncbi request reprint The effect of social networks on the relation between Alzheimer's disease pathology and level of cognitive function in old people: a longitudinal cohort study
    David A Bennett
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Lancet Neurol 5:406-12. 2006
    ..Few data are available about how social networks reduce the risk of cognitive impairment in old age. We aimed to measure this effect using data from a large, longitudinal, epidemiological clinicopathological study...
  8. ncbi request reprint Update on mild cognitive impairment
    David A Bennett
    Rush Alzheimer s Disease Center, Rush Presbyterian St Luke s Medical Center, 1645 West Jackson Boulevard, Suite 675, Chicago, IL 60612, USA
    Curr Neurol Neurosci Rep 3:379-84. 2003
    ....
  9. ncbi request reprint Education modifies the association of amyloid but not tangles with cognitive function
    D A Bennett
    Rush Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
    Neurology 65:953-5. 2005
    ..02) but not the association of neurofibrillary tangles with level of cognition, suggesting that education is related to factors that reduce the effect of amyloid on cognition...
  10. pmc Amyloid mediates the association of apolipoprotein E e4 allele to cognitive function in older people
    D A Bennett
    Rush Alzheimer s Disease Center, Armour Academic Center, 600 South Paulina, Suite 1028 Chicago, IL 60612, USA
    J Neurol Neurosurg Psychiatry 76:1194-9. 2005
    ..The neurobiological changes underlying the association of the apolipoprotein E (APOE) e4 allele with level of cognition are poorly understood...
  11. ncbi request reprint The Rush Memory and Aging Project: study design and baseline characteristics of the study cohort
    David A Bennett
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina, Suite 1028, Chicago, IL 60612, USA
    Neuroepidemiology 25:163-75. 2005
    ..Their mean age was 81 years, about a third had 12 or fewer years of education, a third were men, and about 10% were members of a racial or ethnic minority group. More than 950 already have completed their baseline clinical evaluation...
  12. pmc Neuropathologic intermediate phenotypes enhance association to Alzheimer susceptibility alleles
    David A Bennett
    Rush Alzheimer s Disease Center, 600 S Paulina, Suite 1028, Chicago, IL 60062, USA
    Neurology 72:1495-503. 2009
    ....
  13. ncbi request reprint Cerebral infarctions and the relationship of depression symptoms to level of cognitive functioning in older persons
    David A Bennett
    Rush Alzheimer s Disease Center, Departments of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Am J Geriatr Psychiatry 12:211-9. 2004
    ....
  14. ncbi request reprint Neurofibrillary tangles mediate the association of amyloid load with clinical Alzheimer disease and level of cognitive function
    David A Bennett
    Rush Alzheimer s Disease Center and the Department of Neurological Sciences Rush University Medical Center, Chicago, IL 60612, USA
    Arch Neurol 61:378-84. 2004
    ..To test the hypothesis that the association of amyloid load with clinical Alzheimer disease (AD) and cognitive impairment is mediated through neurofibrillary tangles...
  15. ncbi request reprint Mild cognitive impairment is related to Alzheimer disease pathology and cerebral infarctions
    D A Bennett
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL, USA
    Neurology 64:834-41. 2005
    ..To examine the extent to which persons with mild cognitive impairment have intermediate levels of Alzheimer disease (AD) pathology, cerebral infarcts, and Lewy body disease...
  16. ncbi request reprint Education modifies the relation of AD pathology to level of cognitive function in older persons
    D A Bennett
    Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, Chicago, IL 60612, USA
    Neurology 60:1909-15. 2003
    ..To test the hypothesis that years of formal education modifies the relation of AD pathology to level of cognitive function...
  17. ncbi request reprint Neuropathology of older persons without cognitive impairment from two community-based studies
    D A Bennett
    Rush Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Neurology 66:1837-44. 2006
    ..To examine the relation of National Institute on Aging-Reagan (NIA-Reagan) neuropathologic criteria of Alzheimer disease (AD) to level of cognitive function in persons without dementia or mild cognitive impairment (MCI)...
  18. ncbi request reprint Dimensionality of parkinsonian signs in aging and Alzheimer's disease
    D A Bennett
    The Rush Alzheimer s Disease Center, Department of Neurological Sciences, Rush University, Chicago 60612, USA
    J Gerontol A Biol Sci Med Sci 54:M191-6. 1999
    ..The extent to which parkinsonian signs in aging and Alzheimer's disease cluster in groups typical of Parkinson's disease has not been investigated previously...
  19. ncbi request reprint Mild cognitive impairment
    David A Bennett
    Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Center, 600 South Paulina, Suite 1028, Chicago, IL 60612, USA
    Clin Geriatr Med 20:15-25. 2004
  20. ncbi request reprint Postmortem indices linking risk factors to cognition: results from the Religious Order Study and the Memory and Aging Project
    David A Bennett
    Rush Alzheimer s Disease Center and Departments of Neurological Sciences, Rush University Medical Center, 600 S Paulina, Chicago, IL 60612, USA
    Alzheimer Dis Assoc Disord 20:S63-8. 2006
    ..The findings to date illustrate the kinds of insights that can be gained into mechanisms of disease through the incorporation of pathologic indices into well-designed, epidemiologic studies of aging and Alzheimer disease...
  21. pmc Relation of neuropathology to cognition in persons without cognitive impairment
    David A Bennett
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Ann Neurol 72:599-609. 2012
    ..A study was undertaken to examine the relation of Alzheimer disease (AD) pathology, cerebral infarcts, and Lewy body (LB) pathology to cognition in persons without cognitive impairment...
  22. pmc Effect of a purpose in life on risk of incident Alzheimer disease and mild cognitive impairment in community-dwelling older persons
    Patricia A Boyle
    Rush Alzheimer s Disease Center, 600 S Paulina, Ste 1020B, Chicago, IL 60612, USA
    Arch Gen Psychiatry 67:304-10. 2010
    ..Emerging data suggest that psychological and experiential factors are associated with risk of Alzheimer disease (AD), but the association of purpose in life with incident AD is unknown...
  23. ncbi request reprint Sex differences in the clinical manifestations of Alzheimer disease pathology
    Lisa L Barnes
    Rush Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    Arch Gen Psychiatry 62:685-91. 2005
    ....
  24. pmc APOE ε4, Alzheimer's disease pathology, cerebrovascular disease, and cognitive change over the years prior to death
    Lei Yu
    Rush Alzheimer s Disease Center, Rush University Medical Center
    Psychol Aging 28:1015-23. 2013
    ..The APOE ε4 allele is an important determinant of late-life change in cognition, including terminal decline, and works primarily through AD pathology...
  25. pmc Neural reserve, neuronal density in the locus ceruleus, and cognitive decline
    Robert S Wilson
    Rush Alzheimer s Disease Center and Departments of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
    Neurology 80:1202-8. 2013
    ..To test the hypothesis that higher neuronal density in brainstem aminergic nuclei contributes to neural reserve...
  26. ncbi request reprint Correlates of life space in a volunteer cohort of older adults
    Lisa L Barnes
    Rush Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    Exp Aging Res 33:77-93. 2007
    ..The results suggest that the range of environmental movement in older adults is a useful indicator of health in old age and may complement measures of disability...
  27. ncbi request reprint Olfactory identification and incidence of mild cognitive impairment in older age
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina, Ste 1038, Chicago, IL 60612, USA
    Arch Gen Psychiatry 64:802-8. 2007
    ..Mild cognitive impairment (MCI) is often a precursor to Alzheimer disease, but knowledge about factors that predict its development is limited...
  28. ncbi request reprint Motor dysfunction in mild cognitive impairment and the risk of incident Alzheimer disease
    Neelum T Aggarwal
    Rush Alzheimer s Disease Center, Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL 60612, USA
    Arch Neurol 63:1763-9. 2006
    ..Little is known about motor function in mild cognitive impairment (MCI) and its relation to the risk of Alzheimer disease (AD)...
  29. ncbi request reprint Personality and incident disability in older persons
    Kristin R Krueger
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Age Ageing 35:428-33. 2006
    ..to examine the relation of personality to the development of disability in old age...
  30. ncbi request reprint Conscientiousness and the incidence of Alzheimer disease and mild cognitive impairment
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina, Chicago, IL 60612, USA
    Arch Gen Psychiatry 64:1204-12. 2007
    ..The personality trait of conscientiousness has been related to morbidity and mortality in old age, but its association with the development of Alzheimer disease is not known...
  31. pmc The association of magnetic resonance imaging measures with cognitive function in a biracial population sample
    Neelum T Aggarwal
    Rush Alzheimer s Disease Center, 600 S Paulina Ave, Ste 1038, Chicago, IL 60612, USA
    Arch Neurol 67:475-82. 2010
    ..White matter hyperintensity volume (WMHV), cerebral infarcts, and total brain volume (TBV) are associated with cognitive function, but few studies have examined these associations in the general population or whether they differ by race...
  32. pmc Brainstem aminergic nuclei and late-life depressive symptoms
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, Illinois2Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois3Department of Behavioral Sciences, Rush University Medical Center, Chicago, Illinois
    JAMA Psychiatry 70:1320-8. 2013
    ..The neurobiologic basis of late-life depressive symptoms is not well understood...
  33. pmc Antiphospholipid antibodies, brain infarcts, and cognitive and motor decline in aging (ABICMA): design of a community-based, longitudinal, clinical-pathological study
    Zoe Arvanitakis
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Neuroepidemiology 40:73-84. 2013
    ....
  34. pmc Musculoskeletal pain and incident disability in community-dwelling older adults
    Aron S Buchman
    Rush University Medical Center, Chicago, Illinois 60612, USA
    Arthritis Care Res (Hoboken) 62:1287-93. 2010
    ..To test the hypothesis that the number of areas of musculoskeletal pain reported is related to incident disability...
  35. ncbi request reprint The apolipoprotein E epsilon 4 allele and decline in different cognitive systems during a 6-year period
    Robert S Wilson
    Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, 1645 W Jackson Blvd, Suite 675, Chicago, IL 60612, USA
    Arch Neurol 59:1154-60. 2002
    ..The apolipoprotein E (APOE) epsilon 4 allele is known to influence risk of AD but it has been difficult to establish whether it affects episodic memory differently from other cognitive functions...
  36. ncbi request reprint The apolipoprotein E epsilon4 allele and incident Alzheimer's disease in persons with mild cognitive impairment
    Neelum T Aggarwal
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, Illinois 60612 3872, USA
    Neurocase 11:3-7. 2005
    ..02, 2.63). There was a marginally significant reduction in the effect of epsilon4 in older compared to younger participants (p=.053). The results suggest that possession of an epsilon4 allele does increase risk of AD in persons with MCI...
  37. ncbi request reprint Parkinsonian signs and functional disability in old age
    Debra A Fleischman
    Rush Alzheimer s Disease Center and Departments of Neurological Sciences and Behavioral Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    Exp Aging Res 33:59-76. 2007
    ....
  38. ncbi request reprint Incidence of Alzheimer disease in a biracial urban community: relation to apolipoprotein E allele status
    Denis A Evans
    Rush Institute on Healthy Aging, Chicago, IL, USA
    Arch Neurol 60:185-9. 2003
    ..Few studies compare Alzheimer disease (AD) incidence among black and white subjects...
  39. ncbi request reprint Relation of blood pressure to risk of incident Alzheimer's disease and change in global cognitive function in older persons
    Raj C Shah
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Neuroepidemiology 26:30-6. 2006
    ..To examine the relation of systolic and diastolic blood pressure to incident Alzheimer's disease (AD) and rate of cognitive change...
  40. pmc Nigral pathology and parkinsonian signs in elders without Parkinson disease
    Aron S Buchman
    Rush Alzheimer s Disease Center, Chicago, IL, USA
    Ann Neurol 71:258-66. 2012
    ..We tested the hypothesis that nigral pathology is related to parkinsonism in older persons without Parkinson disease (PD)...
  41. ncbi request reprint Loneliness and risk of Alzheimer disease
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL 60612, USA
    Arch Gen Psychiatry 64:234-40. 2007
    ..Social isolation in old age has been associated with risk of developing dementia, but the risk associated with perceived isolation, or loneliness, is not well understood...
  42. ncbi request reprint A longitudinal study of implicit and explicit memory in old persons
    Debra A Fleischman
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Psychol Aging 19:617-25. 2004
    ..Findings indicate that explicit memory and priming are dissociable on the basis of age-related change and that mildly reduced priming is not an inevitable consequence of growing older...
  43. ncbi request reprint Design of the Chicago Health and Aging Project (CHAP)
    Julia L Bienias
    Rush Institute for Healthy Aging, Rush University, Chicago, IL 60612, USA
    J Alzheimers Dis 5:349-55. 2003
    ..The results from these waves must be combined for effective analysis of the relation among risk factors and incident disease...
  44. pmc Social engagement and cognitive function in old age
    Kristin R Krueger
    Rush Alzheimer s Disease Center and Department of Behavioral Sciences, Rush University Medical Center, Chicago, Illinois, USA
    Exp Aging Res 35:45-60. 2009
    ..The results confirm that higher level of social engagement in old age is associated with better cognitive function but the association varies across domains of social engagement...
  45. ncbi request reprint Early and late life cognitive activity and cognitive systems in old age
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Center, 600 South Paulina, Suite 1038, Chicago, IL 60612, USA
    J Int Neuropsychol Soc 11:400-7. 2005
    ..The results suggest that past cognitive activity contributes to current cognition principally through its association with cognitive activity in old age...
  46. pmc Vulnerability to stress, anxiety, and development of dementia in old age
    Robert S Wilson
    Rush Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Am J Geriatr Psychiatry 19:327-34. 2011
    ..To identify the components of the neuroticism trait most responsible for its association with cognitive decline and dementia in old age...
  47. ncbi request reprint The relation of cigarette smoking to incident Alzheimer's disease in a biracial urban community population
    Neelum T Aggarwal
    Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Center, Chicago, IL 60612, USA
    Neuroepidemiology 26:140-6. 2006
    ....
  48. pmc Poor decision making is associated with an increased risk of mortality among community-dwelling older persons without dementia
    Patricia A Boyle
    Rush Alzheimer s Disease Center 600 S Paulina, Suite 1020B, Chicago, IL 60612, USA Patricia_Boyle rush edu
    Neuroepidemiology 40:247-52. 2013
    ..Decision making is thought to be an important determinant of health and well-being across the lifespan, but little is known about the association of decision making with mortality...
  49. pmc Association between cognitive activity and cognitive function in older Hispanics
    Maria J Marquine
    Department of Behavioral Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Int Neuropsychol Soc 18:1041-51. 2012
    ..Thus, interventions aimed at increasing frequency of participation in cognitively stimulating activity may offer a potential target to reduce cognitive impairment in Hispanics...
  50. pmc Locus coeruleus neuron density and parkinsonism in older adults without Parkinson's disease
    Aron S Buchman
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA
    Mov Disord 27:1625-31. 2012
    ..In older adults without a clinical diagnosis of PD, neuron density in locus coeruleus nuclei is associated with the severity of parkinsonism and may contribute to late-life motor impairments...
  51. pmc Overview and findings from the rush Memory and Aging Project
    David A Bennett
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina, Suite 1028, Chicago, IL 60612, USA
    Curr Alzheimer Res 9:646-63. 2012
    ..The findings are discussed and contextualized...
  52. pmc Loneliness and the rate of motor decline in old age: the Rush Memory and Aging Project, a community-based cohort study
    Aron S Buchman
    Department of Neurological Sciences, Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S, Paulina, Chicago, Illinois 60612, USA
    BMC Geriatr 10:77. 2010
    ..We tested the hypothesis that feeling alone is associated with the rate of motor decline in community-dwelling older persons...
  53. pmc Heritability of different forms of memory in the Late Onset Alzheimer's Disease Family Study
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    J Alzheimers Dis 23:249-55. 2011
    ..This suggests that genetic analyses of memory endophenotypes may help to identify genetic variants associated with AD...
  54. pmc The APOE epsilon4 allele is associated with incident mild cognitive impairment among community-dwelling older persons
    Patricia A Boyle
    Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Neuroepidemiology 34:43-9. 2010
    ..The apolipoprotein E (APOE) epsilon4 allele is a well-known risk factor for the development of Alzheimer's disease, but little is known about the association of the epsilon4 allele with incident mild cognitive impairment (MCI)...
  55. pmc Cognitive decline in prodromal Alzheimer disease and mild cognitive impairment
    Robert S Wilson
    Rush Alzheimer s Disease Center, Department of Neurological Science, Rush University Medical Center, 600 S Paulina Ave, Ste 1038, Chicago, IL 60612, USA
    Arch Neurol 68:351-6. 2011
    ..To characterize the course of cognitive decline during the prodromal phase of Alzheimer disease...
  56. ncbi request reprint Predictors of depressive symptoms in persons with Alzheimer's disease
    David W Gilley
    Rush Institute for Healthy Aging and Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Gerontol B Psychol Sci Soc Sci 59:P75-83. 2004
    ..Depressive symptoms in Alzheimer's disease appear to follow a more predictable pattern of expression than previously described...
  57. ncbi request reprint Change in cognitive function in Alzheimer's disease in African-American and white persons
    Lisa L Barnes
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Neuroepidemiology 26:16-22. 2006
    ..06), perceptual speed (p = 0.07) and naming (p = 0.08). The results suggest that the rate of cognitive decline in AD is slower in African-Americans compared with whites, particularly for episodic memory...
  58. pmc Relation of late-life social activity with incident disability among community-dwelling older adults
    Bryan D James
    Rush University Medical Center, Room 1038, 600 South Paulina Street, Chicago, IL 60612, USA
    J Gerontol A Biol Sci Med Sci 66:467-73. 2011
    ..We tested the hypothesis that a higher level of social activity was associated with decreased risk of incident disability in older adults...
  59. pmc Cerebral amyloid angiopathy pathology and cognitive domains in older persons
    Zoe Arvanitakis
    Rush Alzheimer s Disease Center, Chicago, IL, USA
    Ann Neurol 69:320-7. 2011
    ..To examine the relation of cerebral amyloid angiopathy (CAA) to cognitive domains in older community-dwelling persons with and without dementia...
  60. ncbi request reprint Chronic distress, age-related neuropathology, and late-life dementia
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina, Suite 1038, Chicago, IL 60612, USA
    Psychosom Med 69:47-53. 2007
    ..The objective of this study was to test whether common age-related neuropathology could account for the relation of chronic distress to dementia...
  61. pmc Life-span cognitive activity, neuropathologic burden, and cognitive aging
    Robert S Wilson
    Rush Alzheimer s Disease Center and Departments of Neurological Sciences, Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA
    Neurology 81:314-21. 2013
    ..To test the hypothesis that cognitive activity across the life span is related to late-life cognitive decline not linked to common neuropathologic disorders...
  62. pmc A random change point model for cognitive decline in Alzheimer's disease and mild cognitive impairment
    Lei Yu
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA lei_yu rush edu
    Neuroepidemiology 39:73-83. 2012
    ....
  63. pmc Association of cognition with temporal discounting in community based older persons
    Patricia A Boyle
    Rush University Medical Center, Rush Alzheimer s Disease Center, 600 S, Paulina, Suite 1020B, Chicago, IL 60612, USA
    BMC Geriatr 12:48. 2012
    ..The objective of this study was to test the hypothesis that cognitive function is negatively associated with temporal discounting in old age...
  64. pmc Effect of purpose in life on the relation between Alzheimer disease pathologic changes on cognitive function in advanced age
    Patricia A Boyle
    Rush Alzheimer s Disease Center, 600 S Paulina Ave, Ste 1020B, Chicago, IL 60612, USA
    Arch Gen Psychiatry 69:499-505. 2012
    ..Purpose in life is associated with a substantially reduced risk of Alzheimer disease (AD), but the neurobiologic basis of this protective effect remains unknown...
  65. pmc Combinations of motor measures more strongly predict adverse health outcomes in old age: the rush memory and aging project, a community-based cohort study
    Aron S Buchman
    Department of Neurological Sciences, Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA
    BMC Med 9:42. 2011
    ..We tested the hypothesis that combinations of motor constructs more strongly predict adverse health outcomes in older people...
  66. ncbi request reprint Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease
    Peleg M Horowitz
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 24:7895-902. 2004
    ..Collectively, these results suggest a role for caspase-6 and N-terminal truncation of tau during neurofibrillary tangle evolution and the progression of Alzheimer's disease...
  67. pmc Odor identification and progression of parkinsonian signs in older persons
    Robert S Wilson
    Rush Alzheimer s Disease Center and Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    Exp Aging Res 34:173-87. 2008
    ..The results suggest that impaired odor identification is associated with more rapid progression of parkinsonism in old age, particularly parkinsonian gait disturbance...
  68. pmc Repetition priming and change in functional ability in older persons without dementia
    Debra A Fleischman
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Neuropsychology 23:98-104. 2009
    ..The results are discussed in terms of a common biological substrate in the inferotemporal neocortex, supporting efficient processing of meaningful visual-perceptual experience and proficient performance of activities of daily living...
  69. pmc Physical frailty is associated with incident mild cognitive impairment in community-based older persons
    Patricia A Boyle
    Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Facility, Suite 1020B, 600 South Paulina Street, Chicago, IL 60612, USA
    J Am Geriatr Soc 58:248-55. 2010
    ..To test the hypothesis that physical frailty is associated with risk of mild cognitive impairment (MCI)...
  70. ncbi request reprint Parkinsonianlike signs and risk of incident Alzheimer disease in older persons
    Robert S Wilson
    Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging and the Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Arch Neurol 60:539-44. 2003
    ..Parkinsonianlike signs are common in older persons, but little is known about how their severity or rate of progression is related to the development of Alzheimer disease (AD) or decline in cognition...
  71. ncbi request reprint The relation of lifetime cognitive activity and lifetime access to resources to late-life cognitive function in older African Americans
    Lisa L Barnes
    Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA
    Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 13:516-28. 2006
    ..The results suggest that both measures are psychometrically sound in a minority population and that lifetime cognitive activity may contribute to current cognitive function in African Americans...
  72. ncbi request reprint Grip strength and the risk of incident Alzheimer's disease
    Aron S Buchman
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Neuroepidemiology 29:66-73. 2007
    ..Declining strength in old age is associated with an increased risk of AD...
  73. ncbi request reprint Blood pressure and lower limb function in older persons
    Raj C Shah
    Department of Family Medicine, Rush Alzheimer s Disease Center, 710 South Paulina, Suite 8 North, Chicago, IL 60612, USA
    J Gerontol A Biol Sci Med Sci 61:839-43. 2006
    ..The purpose of this study was to examine the association of blood pressure (BP) with change in lower limb function in older persons...
  74. ncbi request reprint Tau conformational changes correspond to impairments of episodic memory in mild cognitive impairment and Alzheimer's disease
    Nupur Ghoshal
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Exp Neurol 177:475-93. 2002
    ..Furthermore, we were able to compare conformational signatures of tau among different lesion types and determine that the molecular profile of tau is lesion-specific...
  75. pmc Relation of hemoglobin to level of cognitive function in older persons
    Raj C Shah
    Rush Alzheimer s Disease Center, Chicago, Ill 60612, USA
    Neuroepidemiology 32:40-6. 2009
    ..While decreased hemoglobin concentration is common in the elderly, the relationship of the entire range of hemoglobin concentrations with cognitive function is not well understood...
  76. pmc Lewy bodies and olfactory dysfunction in old age
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina Avenue, Chicago, IL 60612, USA
    Chem Senses 36:367-73. 2011
    ..The findings indicate that Lewy body disease impairs late life olfactory function even in otherwise asymptomatic individuals...
  77. ncbi request reprint Physical activity is associated with incident disability in community-based older persons
    Patricia A Boyle
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Am Geriatr Soc 55:195-201. 2007
    ....
  78. pmc Cognitive function is associated with the development of mobility impairments in community-dwelling elders
    Aron S Buchman
    Rush Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Am J Geriatr Psychiatry 19:571-80. 2011
    ..To examine the association of cognitive function with the risk of incident mobility impairments and the rate of declining mobility in older adults...
  79. ncbi request reprint Blood pressure and late-life cognitive function change: a biracial longitudinal population study
    L E Hebert
    Rush Institute on Healthy Aging, Rush University Medical Center, Chicago, IL 60612, USA
    Neurology 62:2021-4. 2004
    ..To examine the relation of blood pressure (BP) to subsequent decline in cognitive function among persons age 65 or over...
  80. pmc Rate of entorhinal and hippocampal atrophy in incipient and mild AD: relation to memory function
    T R Stoub
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Neurobiol Aging 31:1089-98. 2010
    ..These findings suggest that the rate of atrophy of mesial temporal lobe structures can differentiate healthy from pathological aging...
  81. ncbi request reprint The prevalence of dizziness and its association with functional disability in a biracial community population
    N T Aggarwal
    Department of Neurological Sciences, Rush University and Rush Presbyterian St Luke s Medical Center, Chicago, Illinois, USA
    J Gerontol A Biol Sci Med Sci 55:M288-92. 2000
    ..Information regarding the prevalence of dizziness and its association with functional disability among African American and white residents from defined community populations is limited...
  82. pmc Anti-inflammatory agents and cognitive decline in a bi-racial population
    Francine Grodstein
    Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL, USA
    Neuroepidemiology 30:45-50. 2008
    ..no use: mean difference = 0.12; p trend = 0.03). Overall, we found no relation between regular aspirin use and cognitive decline, but long-term use of ibuprofen may be related to decreased rates of cognitive decline in older persons...
  83. ncbi request reprint MRI-derived entorhinal and hippocampal atrophy in incipient and very mild Alzheimer's disease
    B C Dickerson
    Department of Neurological Sciences, Rush University, Chicago, IL 60612, USA
    Neurobiol Aging 22:747-54. 2001
    ..These data suggest that although both the EC and hippocampal formation degenerate before the onset of overt dementia, EC volume is a better predictor of conversion...
  84. ncbi request reprint Diabetes mellitus and progression of rigidity and gait disturbance in older persons
    Z Arvanitakis
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina, Suite 1020E, Chicago, IL 60612, USA
    Neurology 63:996-1001. 2004
    ..Few risk factors for these signs have been identified. Diabetes mellitus, also a common chronic condition in old age and known to be associated with physical and neurologic disability, may be associated with parkinsonian-like signs...
  85. ncbi request reprint MRI predictors of risk of incident Alzheimer disease: a longitudinal study
    T R Stoub
    Department of Neurologic Sciences, Rush University Medical Center, Chicago, IL, USA
    Neurology 64:1520-4. 2005
    ..To determine if baseline entorhinal and hippocampal volumes and their rate of atrophy could predict the risk of incident Alzheimer disease (AD)...
  86. doi request reprint Relation of NSAIDs to incident AD, change in cognitive function, and AD pathology
    Z Arvanitakis
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Neurology 70:2219-25. 2008
    ..To examine the relation of nonsteroidal anti-inflammatory drugs (NSAIDs) to incident Alzheimer disease (AD), change in cognition, and AD pathology...
  87. ncbi request reprint Down-regulation of trkA mRNA within nucleus basalis neurons in individuals with mild cognitive impairment and Alzheimer's disease
    Y Chu
    Department of Neurological Sciences and Rush Alzheimer's Disease Center, Rush Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612, USA
    J Comp Neurol 437:296-307. 2001
    ..In contrast, the loss of trkA mRNA in MCI and AD was significantly correlated with function on a variety of episodic memory tests...
  88. pmc Mild cognitive impairment in different functional domains and incident Alzheimer's disease
    N T Aggarwal
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    J Neurol Neurosurg Psychiatry 76:1479-84. 2005
    ..Little is known about factors that predict transition from mild cognitive impairment to Alzheimer's disease (AD)...
  89. doi request reprint Statins, incident Alzheimer disease, change in cognitive function, and neuropathology
    Z Arvanitakis
    Rush Alzheimer s Disease Center, Department of Neurological Sciences, 600 S Paulina, Suite 1020, Rush University Medical Center, Chicago, IL 60612, USA
    Neurology 70:1795-802. 2008
    ..To examine the relation of statins to incident Alzheimer disease (AD) and change in cognition and neuropathology...
  90. ncbi request reprint Diabetes is related to cerebral infarction but not to AD pathology in older persons
    Z Arvanitakis
    Rush Alzheimer s Disease Center, 600 S Paulina, Suite 1020, Rush University Medical Center, Chicago, IL 60612, USA
    Neurology 67:1960-5. 2006
    ..To examine the potential relation of diabetes to common neuropathologic causes of dementia, cerebral infarction and Alzheimer disease (AD) neuropathology...
  91. pmc Apolipoprotein E e4 allele is associated with more rapid motor decline in older persons
    Aron S Buchman
    Rush Alzheimer s Disease Center, Armour Academic Facility, Rush University Medical Center, Chicago, IL 60612, USA
    Alzheimer Dis Assoc Disord 23:63-9. 2009
    ..These results suggest that the presence of epsilon4 allele is a risk factor for more rapid motor decline in the elderly...
  92. pmc The neuropathology of probable Alzheimer disease and mild cognitive impairment
    Julie A Schneider
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL, USA
    Ann Neurol 66:200-8. 2009
    ..The objective of this study was to investigate single and mixed common age-related neuropathologies in persons with probable AD and MCI...
  93. pmc Diabetes and cognitive systems in older black and white persons
    Zoe Arvanitakis
    Department of Neurological Sciences and Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA
    Alzheimer Dis Assoc Disord 24:37-42. 2010
    ..We found similar effects of diabetes on cognition in both racial groups. Because diabetes is twice as common in blacks, the burden of diabetes on cognition is higher in black than white persons...
  94. doi request reprint Change in depressive symptoms during the prodromal phase of Alzheimer disease
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina, Ste 1038, Chicago, IL 60612, USA
    Arch Gen Psychiatry 65:439-45. 2008
    ..Prospective studies have established an association between depressive symptoms and risk of dementia, but how depressive symptoms change during the evolution of dementia is uncertain...
  95. ncbi request reprint Terminal cognitive decline: accelerated loss of cognition in the last years of life
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, Suite 1038, Chicago, IL 60612, USA
    Psychosom Med 69:131-7. 2007
    ..To test the hypothesis that rate of cognitive decline accelerates in the last years of life...
  96. ncbi request reprint Frailty is associated with incident Alzheimer's disease and cognitive decline in the elderly
    Aron S Buchman
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Psychosom Med 69:483-9. 2007
    ..To assess the association between frailty and incident Alzheimer's disease (AD) and cognitive decline. Frailty is common in older persons and associated with adverse health outcomes...
  97. pmc Pulmonary function, muscle strength, and incident mobility disability in elders
    Aron S Buchman
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina Street, Chicago, IL 60612, USA
    Proc Am Thorac Soc 6:581-7. 2009
    ..Overall, these findings suggest that lower levels of pulmonary function and muscle strength are relatively independently associated with the development of mobility disability in the elderly...
  98. pmc Loss of basic lexical knowledge in old age
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina Ave, Suite 1038, Chicago, IL 60612, USA
    J Neurol Neurosurg Psychiatry 82:369-72. 2011
    ..Basic lexical skills are hypothesised to be relatively preserved in mild dementia, but clinical studies have reported inconsistent results...
  99. pmc Vibratory thresholds and mobility in older persons
    Aron S Buchman
    Rush Alzheimer s Disease Center, Armour Academic Facility, Suite 1038 600 South Paulina, Rush University Medical Center, Chicago, Illinois 60612, USA
    Muscle Nerve 39:754-60. 2009
    ..Vibratory thresholds are associated with mobility, supporting the link between peripheral sensory nerve function and mobility in the elderly...
  100. pmc Microinfarct pathology, dementia, and cognitive systems
    Zoe Arvanitakis
    Rush Alzheimer s Disease Center, 600 S Paulina, Suite 1020, Rush University Medical Center, Chicago, IL 60612, USA
    Stroke 42:722-7. 2011
    ..Little is known about the role of microinfarcts in dementia and cognition. We examined microinfarcts and dementia, global cognition, and 5 cognitive systems in community-dwelling older persons...
  101. doi request reprint Total daily activity is associated with cognition in older persons
    Aron S Buchman
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Am J Geriatr Psychiatry 16:697-701. 2008
    ..The authors tested the hypothesis that total daily physical activity is related to the level of cognition in older persons...

Research Grants30

  1. Degraded Rationality: Subclinical Neuropathology and Neuroeconomic Behavior in Ol
    David Bennett; Fiscal Year: 2007
    ..The results of the proposed study could lay the foundation for a series of studies that address these and other aspects of economic decision making in older persons without dementia. ..
  2. EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGING
    David Bennett; Fiscal Year: 2007
    ..Even relatively small reductions of risk from common disabling conditions will have a major public health impact for future generations. ..
  3. Rush Alzheimer's Disease Core Center
    David Bennett; Fiscal Year: 2007
    ..PERFORMANCE SITE(S) (organization ..
  4. Epidemiologic Study of Neural Reserve and Neurobiology of Aging
    David Bennett; Fiscal Year: 2009
    ....
  5. RISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF AD
    David Bennett; Fiscal Year: 2009
    ..Further, understanding the biologic pathways linking risk factors to clinical disease is essential for developing therapeutic interventions to treat and ultimately prevent AD. ..
  6. Exploring the Role of the Brain Epigenome: Cognitive Decline and Life Experiences
    David Bennett; Fiscal Year: 2009
    ..The proposed study to identify novel epigenetic marks associated with risk of dementia is a timely and important study that could provide new knowledge critical to public health. ..
  7. Epidemiologic Study of Neural Reserve and Neurobiology of Aging
    David A Bennett; Fiscal Year: 2010
    ....
  8. RISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF AD
    David A Bennett; Fiscal Year: 2010
    ..Further, understanding the biologic pathways linking risk factors to clinical disease is essential for developing therapeutic interventions to treat and ultimately prevent AD. ..
  9. RISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF AD
    David Bennett; Fiscal Year: 2007
    ..The findings from the proposed study could have important implications for therapeutic intervention and the prevention of Alzheimer's disease. ..
  10. RISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF AD
    David Bennett; Fiscal Year: 2006
    ..The findings from the proposed study could have important implications for therapeutic intervention and the prevention of Alzheimer's disease. ..
  11. RISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF AD
    David Bennett; Fiscal Year: 1999
    ....
  12. RISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF AD
    David Bennett; Fiscal Year: 1999
    ....
  13. RISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF AD
    David Bennett; Fiscal Year: 2000
    ....
  14. EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGING
    David Bennett; Fiscal Year: 2001
    ..Even relatively small reductions of risk from common disabling conditions will have a major public health impact for future generations. ..
  15. RISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF AD
    David Bennett; Fiscal Year: 2001
    ....
  16. RISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF AD
    David Bennett; Fiscal Year: 2002
    ....
  17. EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGING
    David Bennett; Fiscal Year: 2002
    ..Even relatively small reductions of risk from common disabling conditions will have a major public health impact for future generations. ..
  18. EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGING
    David Bennett; Fiscal Year: 2003
    ..Even relatively small reductions of risk from common disabling conditions will have a major public health impact for future generations. ..
  19. RISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF AD
    David Bennett; Fiscal Year: 2003
    ..The findings from the proposed study could have important implications for therapeutic intervention and the prevention of Alzheimer's disease. ..
  20. EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGING
    David Bennett; Fiscal Year: 2004
    ..Even relatively small reductions of risk from common disabling conditions will have a major public health impact for future generations. ..
  21. RISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF AD
    David Bennett; Fiscal Year: 2004
    ..The findings from the proposed study could have important implications for therapeutic intervention and the prevention of Alzheimer's disease. ..
  22. RISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF AD
    David Bennett; Fiscal Year: 2005
    ..The findings from the proposed study could have important implications for therapeutic intervention and the prevention of Alzheimer's disease. ..
  23. EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGING
    David Bennett; Fiscal Year: 2005
    ..Even relatively small reductions of risk from common disabling conditions will have a major public health impact for future generations. ..
  24. Exploring the Role of the Brain Epigenome: Cognitive Decline and Life Experiences
    David A Bennett; Fiscal Year: 2010
    ..The proposed study to identify novel epigenetic marks associated with risk of dementia is a timely and important study that could provide new knowledge critical to public health. ..