Research Topics

Genomes and Genes


David A Bennett


Affiliation: Rush University Medical Center
Country: USA


  1. Buchman A, Wilson R, Leurgans S, Bennett D, Barnes L. Change in motor function and adverse health outcomes in older African-Americans. Exp Gerontol. 2015;70:71-7 pubmed publisher
    ..5-fold higher rate of death and a 3-fold higher rate of developing Katz disability. The rate of declining motor function accelerates with increasing age and its rate of decline predicts adverse health outcomes in older African-Americans. ..
  2. Mostafavi S, Gaiteri C, Sullivan S, White C, Tasaki S, Xu J, et al. A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer's disease. Nat Neurosci. 2018;21:811-819 pubmed publisher
  3. Bennett D, Schneider J, Arvanitakis Z, Wilson R. Overview and findings from the religious orders study. Curr Alzheimer Res. 2012;9:628-45 pubmed
    ..We then discuss and contextualize the study findings. ..
  4. Bennett D, Schneider J, Buchman A, Barnes L, Boyle P, Wilson R. Overview and findings from the rush Memory and Aging Project. Curr Alzheimer Res. 2012;9:646-63 pubmed
    ..The findings are discussed and contextualized. ..
  5. Bennett D, Wilson R, Boyle P, Buchman A, Schneider J. Relation of neuropathology to cognition in persons without cognitive impairment. Ann Neurol. 2012;72:599-609 pubmed publisher
    ..AD pathology and macroscopic infarctions are common in older persons without cognitive impairment and are related to episodic and working memory. ..
  6. Ramos Miguel A, Hercher C, Beasley C, Barr A, Bayer T, Falkai P, et al. Loss of Munc18-1 long splice variant in GABAergic terminals is associated with cognitive decline and increased risk of dementia in a community sample. Mol Neurodegener. 2015;10:65 pubmed publisher
    ..Lower M18L in inhibitory presynaptic terminals may be an early, independent contributor to cognitive decline. ..
  7. Yu L, Dawe R, Buchman A, Boyle P, Schneider J, Arfanakis K, et al. Ex vivo MRI transverse relaxation in community based older persons with and without Alzheimer's dementia. Behav Brain Res. 2017;322:233-240 pubmed publisher
    ..0001). In conclusion, R2 alterations in AD dementia are not solely reflective of common age-related neuropathologies, suggesting that other mechanisms are at work. ..
  8. Wilson R, Bennett D. How Does Psychosocial Behavior Contribute to Cognitive Health in Old Age?. Brain Sci. 2017;7: pubmed publisher
    ..A better understanding of these mechanisms may lead to novel strategies for preserving cognitive health in old age. ..