David A Bennett

Summary

Affiliation: Rush University Medical Center
Country: USA

Publications

  1. pmc Building a pipeline to discover and validate novel therapeutic targets and lead compounds for Alzheimer's disease
    David A Bennett
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL, United States Electronic address
    Biochem Pharmacol 88:617-30. 2014
  2. pmc Cognitive and social lifestyle: links with neuropathology and cognition in late life
    David A Bennett
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL, USA
    Acta Neuropathol 127:137-50. 2014
  3. pmc Association of total daily physical activity with disability in community-dwelling older persons: a prospective cohort study
    Raj C Shah
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL, USA
    BMC Geriatr 12:63. 2012
  4. pmc Relation of neuropathology to cognition in persons without cognitive impairment
    David A Bennett
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Ann Neurol 72:599-609. 2012
  5. pmc Correlates of health and financial literacy in older adults without dementia
    Jarred S Bennett
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL, USA
    BMC Geriatr 12:30. 2012
  6. pmc Overview and findings from the rush Memory and Aging Project
    David A Bennett
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina, Suite 1028, Chicago, IL 60612, USA
    Curr Alzheimer Res 9:646-63. 2012
  7. pmc Overview and findings from the religious orders study
    David A Bennett
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina, Suite 1028, Chicago, IL 60612, USA
    Curr Alzheimer Res 9:628-45. 2012
  8. pmc Effect of a purpose in life on risk of incident Alzheimer disease and mild cognitive impairment in community-dwelling older persons
    Patricia A Boyle
    Rush Alzheimer s Disease Center, 600 S Paulina, Ste 1020B, Chicago, IL 60612, USA
    Arch Gen Psychiatry 67:304-10. 2010
  9. ncbi request reprint Personality and incident disability in older persons
    Kristin R Krueger
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Age Ageing 35:428-33. 2006
  10. ncbi request reprint The Rush Memory and Aging Project: study design and baseline characteristics of the study cohort
    David A Bennett
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina, Suite 1028, Chicago, IL 60612, USA
    Neuroepidemiology 25:163-75. 2005

Collaborators

Detail Information

Publications82

  1. pmc Building a pipeline to discover and validate novel therapeutic targets and lead compounds for Alzheimer's disease
    David A Bennett
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL, United States Electronic address
    Biochem Pharmacol 88:617-30. 2014
    ..Third, we provide an overview of our approach. Finally, we present the details of our planned drug discovery pipeline. ..
  2. pmc Cognitive and social lifestyle: links with neuropathology and cognition in late life
    David A Bennett
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL, USA
    Acta Neuropathol 127:137-50. 2014
    ..Second, effort is needed to identify the molecular substrates of neural reserve as potential mediators of the association of lifestyle factors with cognition. ..
  3. pmc Association of total daily physical activity with disability in community-dwelling older persons: a prospective cohort study
    Raj C Shah
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL, USA
    BMC Geriatr 12:63. 2012
    ..We examined whether greater total daily physical activity was associated with less report of disability in the elderly...
  4. pmc Relation of neuropathology to cognition in persons without cognitive impairment
    David A Bennett
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Ann Neurol 72:599-609. 2012
    ..A study was undertaken to examine the relation of Alzheimer disease (AD) pathology, cerebral infarcts, and Lewy body (LB) pathology to cognition in persons without cognitive impairment...
  5. pmc Correlates of health and financial literacy in older adults without dementia
    Jarred S Bennett
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL, USA
    BMC Geriatr 12:30. 2012
    ..Our study examines the relation of health and financial literacy with health promoting behaviors and health status among community-based older persons...
  6. pmc Overview and findings from the rush Memory and Aging Project
    David A Bennett
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina, Suite 1028, Chicago, IL 60612, USA
    Curr Alzheimer Res 9:646-63. 2012
    ..The findings are discussed and contextualized...
  7. pmc Overview and findings from the religious orders study
    David A Bennett
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina, Suite 1028, Chicago, IL 60612, USA
    Curr Alzheimer Res 9:628-45. 2012
    ....
  8. pmc Effect of a purpose in life on risk of incident Alzheimer disease and mild cognitive impairment in community-dwelling older persons
    Patricia A Boyle
    Rush Alzheimer s Disease Center, 600 S Paulina, Ste 1020B, Chicago, IL 60612, USA
    Arch Gen Psychiatry 67:304-10. 2010
    ..Emerging data suggest that psychological and experiential factors are associated with risk of Alzheimer disease (AD), but the association of purpose in life with incident AD is unknown...
  9. ncbi request reprint Personality and incident disability in older persons
    Kristin R Krueger
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Age Ageing 35:428-33. 2006
    ..to examine the relation of personality to the development of disability in old age...
  10. ncbi request reprint The Rush Memory and Aging Project: study design and baseline characteristics of the study cohort
    David A Bennett
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina, Suite 1028, Chicago, IL 60612, USA
    Neuroepidemiology 25:163-75. 2005
    ..Their mean age was 81 years, about a third had 12 or fewer years of education, a third were men, and about 10% were members of a racial or ethnic minority group. More than 950 already have completed their baseline clinical evaluation...
  11. pmc APOE ε4, Alzheimer's disease pathology, cerebrovascular disease, and cognitive change over the years prior to death
    Lei Yu
    Rush Alzheimer s Disease Center, Rush University Medical Center
    Psychol Aging 28:1015-23. 2013
    ..The APOE ε4 allele is an important determinant of late-life change in cognition, including terminal decline, and works primarily through AD pathology...
  12. pmc Neural reserve, neuronal density in the locus ceruleus, and cognitive decline
    Robert S Wilson
    Rush Alzheimer s Disease Center and Departments of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
    Neurology 80:1202-8. 2013
    ..To test the hypothesis that higher neuronal density in brainstem aminergic nuclei contributes to neural reserve...
  13. pmc The association of magnetic resonance imaging measures with cognitive function in a biracial population sample
    Neelum T Aggarwal
    Rush Alzheimer s Disease Center, 600 S Paulina Ave, Ste 1038, Chicago, IL 60612, USA
    Arch Neurol 67:475-82. 2010
    ..White matter hyperintensity volume (WMHV), cerebral infarcts, and total brain volume (TBV) are associated with cognitive function, but few studies have examined these associations in the general population or whether they differ by race...
  14. ncbi request reprint Olfactory identification and incidence of mild cognitive impairment in older age
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina, Ste 1038, Chicago, IL 60612, USA
    Arch Gen Psychiatry 64:802-8. 2007
    ..Mild cognitive impairment (MCI) is often a precursor to Alzheimer disease, but knowledge about factors that predict its development is limited...
  15. ncbi request reprint Correlates of life space in a volunteer cohort of older adults
    Lisa L Barnes
    Rush Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    Exp Aging Res 33:77-93. 2007
    ..The results suggest that the range of environmental movement in older adults is a useful indicator of health in old age and may complement measures of disability...
  16. ncbi request reprint Conscientiousness and the incidence of Alzheimer disease and mild cognitive impairment
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina, Chicago, IL 60612, USA
    Arch Gen Psychiatry 64:1204-12. 2007
    ..The personality trait of conscientiousness has been related to morbidity and mortality in old age, but its association with the development of Alzheimer disease is not known...
  17. pmc Brainstem aminergic nuclei and late-life depressive symptoms
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, Illinois2Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois3Department of Behavioral Sciences, Rush University Medical Center, Chicago, Illinois
    JAMA Psychiatry 70:1320-8. 2013
    ..The neurobiologic basis of late-life depressive symptoms is not well understood...
  18. ncbi request reprint Sex differences in the clinical manifestations of Alzheimer disease pathology
    Lisa L Barnes
    Rush Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    Arch Gen Psychiatry 62:685-91. 2005
    ....
  19. pmc Antiphospholipid antibodies, brain infarcts, and cognitive and motor decline in aging (ABICMA): design of a community-based, longitudinal, clinical-pathological study
    Zoe Arvanitakis
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Neuroepidemiology 40:73-84. 2013
    ....
  20. ncbi request reprint The apolipoprotein E epsilon4 allele and incident Alzheimer's disease in persons with mild cognitive impairment
    Neelum T Aggarwal
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, Illinois 60612 3872, USA
    Neurocase 11:3-7. 2005
    ..02, 2.63). There was a marginally significant reduction in the effect of epsilon4 in older compared to younger participants (p=.053). The results suggest that possession of an epsilon4 allele does increase risk of AD in persons with MCI...
  21. pmc Musculoskeletal pain and incident disability in community-dwelling older adults
    Aron S Buchman
    Rush University Medical Center, Chicago, Illinois 60612, USA
    Arthritis Care Res (Hoboken) 62:1287-93. 2010
    ..To test the hypothesis that the number of areas of musculoskeletal pain reported is related to incident disability...
  22. ncbi request reprint Motor dysfunction in mild cognitive impairment and the risk of incident Alzheimer disease
    Neelum T Aggarwal
    Rush Alzheimer s Disease Center, Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL 60612, USA
    Arch Neurol 63:1763-9. 2006
    ..Little is known about motor function in mild cognitive impairment (MCI) and its relation to the risk of Alzheimer disease (AD)...
  23. ncbi request reprint Parkinsonian signs and functional disability in old age
    Debra A Fleischman
    Rush Alzheimer s Disease Center and Departments of Neurological Sciences and Behavioral Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    Exp Aging Res 33:59-76. 2007
    ....
  24. pmc Ventromedial PFC, parahippocampal, and cerebellar connectivity are associated with temporal discounting in old age
    S Duke Han
    Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL 60612, United States Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, United States Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, United States Mental Health Care Group, VA Long Beach Healthcare System, Long Beach, CA 90822, United States Electronic address
    Exp Gerontol 48:1489-98. 2013
    ..Results support the notion of different brain functional connectivity patterns associated with the dynamic range of temporal discounting in old age. ..
  25. ncbi request reprint Incidence of Alzheimer disease in a biracial urban community: relation to apolipoprotein E allele status
    Denis A Evans
    Rush Institute on Healthy Aging, Chicago, IL, USA
    Arch Neurol 60:185-9. 2003
    ..Few studies compare Alzheimer disease (AD) incidence among black and white subjects...
  26. pmc Vulnerability to stress, anxiety, and development of dementia in old age
    Robert S Wilson
    Rush Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Am J Geriatr Psychiatry 19:327-34. 2011
    ..To identify the components of the neuroticism trait most responsible for its association with cognitive decline and dementia in old age...
  27. pmc Social engagement and cognitive function in old age
    Kristin R Krueger
    Rush Alzheimer s Disease Center and Department of Behavioral Sciences, Rush University Medical Center, Chicago, Illinois, USA
    Exp Aging Res 35:45-60. 2009
    ..The results confirm that higher level of social engagement in old age is associated with better cognitive function but the association varies across domains of social engagement...
  28. pmc Nigral pathology and parkinsonian signs in elders without Parkinson disease
    Aron S Buchman
    Rush Alzheimer s Disease Center, Chicago, IL, USA
    Ann Neurol 71:258-66. 2012
    ..We tested the hypothesis that nigral pathology is related to parkinsonism in older persons without Parkinson disease (PD)...
  29. ncbi request reprint Loneliness and risk of Alzheimer disease
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL 60612, USA
    Arch Gen Psychiatry 64:234-40. 2007
    ..Social isolation in old age has been associated with risk of developing dementia, but the risk associated with perceived isolation, or loneliness, is not well understood...
  30. ncbi request reprint The relation of cigarette smoking to incident Alzheimer's disease in a biracial urban community population
    Neelum T Aggarwal
    Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Center, Chicago, IL 60612, USA
    Neuroepidemiology 26:140-6. 2006
    ....
  31. ncbi request reprint Early and late life cognitive activity and cognitive systems in old age
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Center, 600 South Paulina, Suite 1038, Chicago, IL 60612, USA
    J Int Neuropsychol Soc 11:400-7. 2005
    ..The results suggest that past cognitive activity contributes to current cognition principally through its association with cognitive activity in old age...
  32. ncbi request reprint Relation of blood pressure to risk of incident Alzheimer's disease and change in global cognitive function in older persons
    Raj C Shah
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Neuroepidemiology 26:30-6. 2006
    ..To examine the relation of systolic and diastolic blood pressure to incident Alzheimer's disease (AD) and rate of cognitive change...
  33. pmc Neuropathologic intermediate phenotypes enhance association to Alzheimer susceptibility alleles
    David A Bennett
    Rush Alzheimer s Disease Center, 600 S Paulina, Suite 1028, Chicago, IL 60062, USA
    Neurology 72:1495-503. 2009
    ....
  34. pmc Poor decision making is associated with an increased risk of mortality among community-dwelling older persons without dementia
    Patricia A Boyle
    Rush Alzheimer s Disease Center 600 S Paulina, Suite 1020B, Chicago, IL 60612, USA Patricia_Boyle rush edu
    Neuroepidemiology 40:247-52. 2013
    ..Decision making is thought to be an important determinant of health and well-being across the lifespan, but little is known about the association of decision making with mortality...
  35. pmc Association between cognitive activity and cognitive function in older Hispanics
    Maria J Marquine
    Department of Behavioral Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Int Neuropsychol Soc 18:1041-51. 2012
    ..Thus, interventions aimed at increasing frequency of participation in cognitively stimulating activity may offer a potential target to reduce cognitive impairment in Hispanics...
  36. pmc Loneliness and the rate of motor decline in old age: the Rush Memory and Aging Project, a community-based cohort study
    Aron S Buchman
    Department of Neurological Sciences, Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S, Paulina, Chicago, Illinois 60612, USA
    BMC Geriatr 10:77. 2010
    ..We tested the hypothesis that feeling alone is associated with the rate of motor decline in community-dwelling older persons...
  37. pmc Locus coeruleus neuron density and parkinsonism in older adults without Parkinson's disease
    Aron S Buchman
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA
    Mov Disord 27:1625-31. 2012
    ..In older adults without a clinical diagnosis of PD, neuron density in locus coeruleus nuclei is associated with the severity of parkinsonism and may contribute to late-life motor impairments...
  38. pmc Cognitive decline in prodromal Alzheimer disease and mild cognitive impairment
    Robert S Wilson
    Rush Alzheimer s Disease Center, Department of Neurological Science, Rush University Medical Center, 600 S Paulina Ave, Ste 1038, Chicago, IL 60612, USA
    Arch Neurol 68:351-6. 2011
    ..To characterize the course of cognitive decline during the prodromal phase of Alzheimer disease...
  39. pmc Heritability of different forms of memory in the Late Onset Alzheimer's Disease Family Study
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    J Alzheimers Dis 23:249-55. 2011
    ..This suggests that genetic analyses of memory endophenotypes may help to identify genetic variants associated with AD...
  40. pmc Cerebral amyloid angiopathy pathology and cognitive domains in older persons
    Zoe Arvanitakis
    Rush Alzheimer s Disease Center, Chicago, IL, USA
    Ann Neurol 69:320-7. 2011
    ..To examine the relation of cerebral amyloid angiopathy (CAA) to cognitive domains in older community-dwelling persons with and without dementia...
  41. pmc The APOE epsilon4 allele is associated with incident mild cognitive impairment among community-dwelling older persons
    Patricia A Boyle
    Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Neuroepidemiology 34:43-9. 2010
    ..The apolipoprotein E (APOE) epsilon4 allele is a well-known risk factor for the development of Alzheimer's disease, but little is known about the association of the epsilon4 allele with incident mild cognitive impairment (MCI)...
  42. pmc Relation of late-life social activity with incident disability among community-dwelling older adults
    Bryan D James
    Rush University Medical Center, Room 1038, 600 South Paulina Street, Chicago, IL 60612, USA
    J Gerontol A Biol Sci Med Sci 66:467-73. 2011
    ..We tested the hypothesis that a higher level of social activity was associated with decreased risk of incident disability in older adults...
  43. ncbi request reprint A longitudinal study of implicit and explicit memory in old persons
    Debra A Fleischman
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Psychol Aging 19:617-25. 2004
    ..Findings indicate that explicit memory and priming are dissociable on the basis of age-related change and that mildly reduced priming is not an inevitable consequence of growing older...
  44. ncbi request reprint Change in cognitive function in Alzheimer's disease in African-American and white persons
    Lisa L Barnes
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Neuroepidemiology 26:16-22. 2006
    ..06), perceptual speed (p = 0.07) and naming (p = 0.08). The results suggest that the rate of cognitive decline in AD is slower in African-Americans compared with whites, particularly for episodic memory...
  45. ncbi request reprint The relation of lifetime cognitive activity and lifetime access to resources to late-life cognitive function in older African Americans
    Lisa L Barnes
    Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA
    Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 13:516-28. 2006
    ..The results suggest that both measures are psychometrically sound in a minority population and that lifetime cognitive activity may contribute to current cognitive function in African Americans...
  46. pmc Total daily activity declines more rapidly with increasing age in older adults
    Aron S Buchman
    Department of Neurological Sciences, Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina, Chicago, IL 60612, USA Electronic address
    Arch Gerontol Geriatr 58:74-9. 2014
    ..These data suggest that total daily activity in very old adults declines more rapidly with increasing age. Thus, physical inactivity is likely to become a larger problem in our aging population...
  47. pmc Association of cognition with temporal discounting in community based older persons
    Patricia A Boyle
    Rush University Medical Center, Rush Alzheimer s Disease Center, 600 S, Paulina, Suite 1020B, Chicago, IL 60612, USA
    BMC Geriatr 12:48. 2012
    ..The objective of this study was to test the hypothesis that cognitive function is negatively associated with temporal discounting in old age...
  48. pmc Life-span cognitive activity, neuropathologic burden, and cognitive aging
    Robert S Wilson
    Rush Alzheimer s Disease Center and Departments of Neurological Sciences, Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA
    Neurology 81:314-21. 2013
    ..To test the hypothesis that cognitive activity across the life span is related to late-life cognitive decline not linked to common neuropathologic disorders...
  49. pmc A random change point model for cognitive decline in Alzheimer's disease and mild cognitive impairment
    Lei Yu
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA lei_yu rush edu
    Neuroepidemiology 39:73-83. 2012
    ....
  50. ncbi request reprint The apolipoprotein E epsilon 4 allele and decline in different cognitive systems during a 6-year period
    Robert S Wilson
    Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, 1645 W Jackson Blvd, Suite 675, Chicago, IL 60612, USA
    Arch Neurol 59:1154-60. 2002
    ..The apolipoprotein E (APOE) epsilon 4 allele is known to influence risk of AD but it has been difficult to establish whether it affects episodic memory differently from other cognitive functions...
  51. ncbi request reprint Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease
    Peleg M Horowitz
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 24:7895-902. 2004
    ..Collectively, these results suggest a role for caspase-6 and N-terminal truncation of tau during neurofibrillary tangle evolution and the progression of Alzheimer's disease...
  52. ncbi request reprint Design of the Chicago Health and Aging Project (CHAP)
    Julia L Bienias
    Rush Institute for Healthy Aging, Rush University, Chicago, IL 60612, USA
    J Alzheimers Dis 5:349-55. 2003
    ..The results from these waves must be combined for effective analysis of the relation among risk factors and incident disease...
  53. ncbi request reprint Chronic distress, age-related neuropathology, and late-life dementia
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina, Suite 1038, Chicago, IL 60612, USA
    Psychosom Med 69:47-53. 2007
    ..The objective of this study was to test whether common age-related neuropathology could account for the relation of chronic distress to dementia...
  54. pmc Effect of purpose in life on the relation between Alzheimer disease pathologic changes on cognitive function in advanced age
    Patricia A Boyle
    Rush Alzheimer s Disease Center, 600 S Paulina Ave, Ste 1020B, Chicago, IL 60612, USA
    Arch Gen Psychiatry 69:499-505. 2012
    ..Purpose in life is associated with a substantially reduced risk of Alzheimer disease (AD), but the neurobiologic basis of this protective effect remains unknown...
  55. pmc Physical frailty is associated with incident mild cognitive impairment in community-based older persons
    Patricia A Boyle
    Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Facility, Suite 1020B, 600 South Paulina Street, Chicago, IL 60612, USA
    J Am Geriatr Soc 58:248-55. 2010
    ..To test the hypothesis that physical frailty is associated with risk of mild cognitive impairment (MCI)...
  56. pmc Combinations of motor measures more strongly predict adverse health outcomes in old age: the rush memory and aging project, a community-based cohort study
    Aron S Buchman
    Department of Neurological Sciences, Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA
    BMC Med 9:42. 2011
    ..We tested the hypothesis that combinations of motor constructs more strongly predict adverse health outcomes in older people...
  57. pmc Repetition priming and change in functional ability in older persons without dementia
    Debra A Fleischman
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Neuropsychology 23:98-104. 2009
    ..The results are discussed in terms of a common biological substrate in the inferotemporal neocortex, supporting efficient processing of meaningful visual-perceptual experience and proficient performance of activities of daily living...
  58. pmc Association between late-life social activity and motor decline in older adults
    Aron S Buchman
    Departments of Neurological Sciences, Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Facility, Chicago, IL 60612, USA
    Arch Intern Med 169:1139-46. 2009
    ..Our objective was to test the hypothesis that late-life social activity is related to the rate of change in motor function in old age...
  59. ncbi request reprint Predictors of depressive symptoms in persons with Alzheimer's disease
    David W Gilley
    Rush Institute for Healthy Aging and Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Gerontol B Psychol Sci Soc Sci 59:P75-83. 2004
    ..Depressive symptoms in Alzheimer's disease appear to follow a more predictable pattern of expression than previously described...
  60. ncbi request reprint Implicit memory and Alzheimer's disease neuropathology
    Debra A Fleischman
    Rush Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
    Brain 128:2006-15. 2005
    ..The results suggest that hallmark indices of Alzheimer's disease neuropathology are associated with performance on priming tests to the extent that conceptual, but not perceptual, processing resources are required...
  61. pmc The Minority Aging Research Study: ongoing efforts to obtain brain donation in African Americans without dementia
    Lisa L Barnes
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 S Paulina, Suite 1038, Chicago, IL 60612, USA
    Curr Alzheimer Res 9:734-45. 2012
    ..The implications of these efforts are discussed...
  62. pmc Emotional neglect in childhood and cerebral infarction in older age
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL, USA
    Neurology 79:1534-9. 2012
    ..The purpose of the study was to test the hypothesis that a higher level of childhood adversity is associated with increased risk of cerebral infarction in old age...
  63. ncbi request reprint Physical activity is associated with incident disability in community-based older persons
    Patricia A Boyle
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Am Geriatr Soc 55:195-201. 2007
    ....
  64. pmc Relation of hemoglobin to level of cognitive function in older persons
    Raj C Shah
    Rush Alzheimer s Disease Center, Chicago, Ill 60612, USA
    Neuroepidemiology 32:40-6. 2009
    ..While decreased hemoglobin concentration is common in the elderly, the relationship of the entire range of hemoglobin concentrations with cognitive function is not well understood...
  65. pmc Odor identification and progression of parkinsonian signs in older persons
    Robert S Wilson
    Rush Alzheimer s Disease Center and Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    Exp Aging Res 34:173-87. 2008
    ..The results suggest that impaired odor identification is associated with more rapid progression of parkinsonism in old age, particularly parkinsonian gait disturbance...
  66. pmc Anti-inflammatory agents and cognitive decline in a bi-racial population
    Francine Grodstein
    Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL, USA
    Neuroepidemiology 30:45-50. 2008
    ..no use: mean difference = 0.12; p trend = 0.03). Overall, we found no relation between regular aspirin use and cognitive decline, but long-term use of ibuprofen may be related to decreased rates of cognitive decline in older persons...
  67. pmc Lewy bodies and olfactory dysfunction in old age
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, 600 South Paulina Avenue, Chicago, IL 60612, USA
    Chem Senses 36:367-73. 2011
    ..The findings indicate that Lewy body disease impairs late life olfactory function even in otherwise asymptomatic individuals...
  68. ncbi request reprint Grip strength and the risk of incident Alzheimer's disease
    Aron S Buchman
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Neuroepidemiology 29:66-73. 2007
    ..Declining strength in old age is associated with an increased risk of AD...
  69. pmc Visuoperceptual repetition priming and progression of parkinsonian signs in aging
    Debra A Fleischman
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL, USA
    Neurobiol Aging 30:441-9. 2009
    ..Reduced visuoperceptual priming in aging may be an early signal of vulnerability in a corticostrial circuit that contributes to sensorimotor integration...
  70. pmc Cognitive function is associated with the development of mobility impairments in community-dwelling elders
    Aron S Buchman
    Rush Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Am J Geriatr Psychiatry 19:571-80. 2011
    ..To examine the association of cognitive function with the risk of incident mobility impairments and the rate of declining mobility in older adults...
  71. pmc Cognitive function is associated with risk aversion in community-based older persons
    Patricia A Boyle
    Rush University Medical Center, Rush Alzheimer s Disease Center, 600 S Paulina, Chicago, IL 60612, USA
    BMC Geriatr 11:53. 2011
    ....
  72. ncbi request reprint Subcortical infarcts, Alzheimer's disease pathology, and memory function in older persons
    Julie A Schneider
    Rush Alzheimer s Disease Center and Rush Institute for Healthy Aging, Department of Neurological Sciences, Rush University Medical Center, 600 South Paulina Street, Chicago, IL 60612, USA
    Ann Neurol 62:59-66. 2007
    ..Examine the effects of subcortical infarcts with Alzheimer's disease (AD) pathology on dementia, episodic memory, and other cognitive abilities in older persons...
  73. ncbi request reprint Decision rules guiding the clinical diagnosis of Alzheimer's disease in two community-based cohort studies compared to standard practice in a clinic-based cohort study
    David A Bennett
    Rush Alzheimer s Disease Center, Chicago, Ill, USA
    Neuroepidemiology 27:169-76. 2006
    ..This approach holds promise for reducing the operational costs of epidemiologic studies of aging and AD...
  74. pmc Functional connectivity variations in mild cognitive impairment: associations with cognitive function
    S Duke Han
    Department of Behavioral Sciences, Rush University Medical Center, 1645 W Jackson Blvd, Chicago, IL 60612, USA
    J Int Neuropsychol Soc 18:39-48. 2012
    ..Results suggest functional connectivity values in regions of difference are associated with cognitive function and may reflect the presence of AD pathology and increased risk of developing clinical AD...
  75. pmc The neuropathology of probable Alzheimer disease and mild cognitive impairment
    Julie A Schneider
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL, USA
    Ann Neurol 66:200-8. 2009
    ..The objective of this study was to investigate single and mixed common age-related neuropathologies in persons with probable AD and MCI...
  76. ncbi request reprint Physical activity and leg strength predict decline in mobility performance in older persons
    Aron S Buchman
    Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Am Geriatr Soc 55:1618-23. 2007
    ..To assess the extent to which physical activity and leg strength are associated with change in mobility in older persons...
  77. pmc Vibratory thresholds and mobility in older persons
    Aron S Buchman
    Rush Alzheimer s Disease Center, Armour Academic Facility, Suite 1038 600 South Paulina, Rush University Medical Center, Chicago, Illinois 60612, USA
    Muscle Nerve 39:754-60. 2009
    ..Vibratory thresholds are associated with mobility, supporting the link between peripheral sensory nerve function and mobility in the elderly...
  78. ncbi request reprint Personality and mortality in old age
    Robert S Wilson
    Rush Institute for Healthy Aging and Rush Alzheimer s Disease Center, Chicago, Illinois 60612, USA
    J Gerontol B Psychol Sci Soc Sci 59:P110-6. 2004
    ..Findings for extraversion were mixed, and neither agreeableness nor openness was strongly related to mortality. The results suggest that personality is associated with mortality in old age...
  79. ncbi request reprint Blood pressure and lower limb function in older persons
    Raj C Shah
    Department of Family Medicine, Rush Alzheimer s Disease Center, 710 South Paulina, Suite 8 North, Chicago, IL 60612, USA
    J Gerontol A Biol Sci Med Sci 61:839-43. 2006
    ..The purpose of this study was to examine the association of blood pressure (BP) with change in lower limb function in older persons...
  80. ncbi request reprint Early life socioeconomic status and late life risk of Alzheimer's disease
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Neuroepidemiology 25:8-14. 2005
    ..The results suggest that early life socioeconomic level is related to level of cognition in late life but not to rate of cognitive decline or risk of AD...
  81. ncbi request reprint The effect of social networks on the relation between Alzheimer's disease pathology and level of cognitive function in old people: a longitudinal cohort study
    David A Bennett
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    Lancet Neurol 5:406-12. 2006
    ..Few data are available about how social networks reduce the risk of cognitive impairment in old age. We aimed to measure this effect using data from a large, longitudinal, epidemiological clinicopathological study...
  82. pmc The neuropathology of older persons with and without dementia from community versus clinic cohorts
    Julie A Schneider
    Department of Pathology Neuropathology and Neurological Sciences, Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Center, 600 South Paulina Street, Suite 1022F, Chicago, IL 60612, USA
    J Alzheimers Dis 18:691-701. 2009
    ..Overall, clinic-based persons have more Lewy bodies and atypical pathologies. The spectrum of pathologies underlying cognitive impairment in clinic-based cohorts differs from community-based cohorts...