Ali Banan

Summary

Affiliation: Rush University Medical Center
Country: USA

Publications

  1. Banan A, Fields J, Farhadi A, Talmage D, Zhang L, Keshavarzian A. The beta 1 isoform of protein kinase C mediates the protective effects of epidermal growth factor on the dynamic assembly of F-actin cytoskeleton and normalization of calcium homeostasis in human colonic cells. J Pharmacol Exp Ther. 2002;301:852-66 pubmed
    ..EGF normalizes Ca(2+) by enhancing Ca(2+) efflux through PKC-beta1. We have identified novel biologic functions, protection of actin and Ca(2+) homeostasis, among the classical isoforms of PKC. ..
  2. Banan A, Zhang L, Shaikh M, Fields J, Choudhary S, Forsyth C, et al. theta Isoform of protein kinase C alters barrier function in intestinal epithelium through modulation of distinct claudin isotypes: a novel mechanism for regulation of permeability. J Pharmacol Exp Ther. 2005;313:962-82 pubmed
    ..The ability of PKC- to alter the dynamics of permeability protein claudins is a new function not previously ascribed to the novel subfamily of PKC isoforms. ..
  3. Banan A, Fields J, Zhang Y, Keshavarzian A. Key role of PKC and Ca2+ in EGF protection of microtubules and intestinal barrier against oxidants. Am J Physiol Gastrointest Liver Physiol. 2001;280:G828-43 pubmed
    ..In conclusion, EGF protection of microtubules and the intestinal epithelial barrier requires activation of PKC signal transduction and normalization of ([Ca2+](i))...
  4. Banan A, Fields J, Zhang Y, Keshavarzian A. iNOS upregulation mediates oxidant-induced disruption of F-actin and barrier of intestinal monolayers. Am J Physiol Gastrointest Liver Physiol. 2001;280:G1234-46 pubmed
    ..Confirming these mechanisms in vivo would provide a rationale for developing novel anti-RNM therapies for IBD...
  5. Banan A, Fields J, Zhang Y, Keshavarzian A. Phospholipase C-gamma inhibition prevents EGF protection of intestinal cytoskeleton and barrier against oxidants. Am J Physiol Gastrointest Liver Physiol. 2001;281:G412-23 pubmed
    ..Transfected cells also lost EGF protection and showed reduced PLC-gamma phosphorylation and activity. We conclude that EGF protection requires PLC-gamma signaling and that PLC-gamma may be a useful therapeutic target...
  6. Banan A, Zhang L, Fields J, Farhadi A, Talmage D, Keshavarzian A. PKC-zeta prevents oxidant-induced iNOS upregulation and protects the microtubules and gut barrier integrity. Am J Physiol Gastrointest Liver Physiol. 2002;283:G909-22 pubmed
    ..We have thus discovered novel biologic functions, suppression of the iNOS-driven reactions and cytoskeletal oxidation, among the atypical PKC isoforms. ..
  7. Banan A, Zhang L, Farhadi A, Fields J, Shaikh M, Keshavarzian A. PKC-beta1 isoform activation is required for EGF-induced NF-kappaB inactivation and IkappaBalpha stabilization and protection of F-actin assembly and barrier function in enterocyte monolayers. Am J Physiol Cell Physiol. 2004;286:C723-38 pubmed
    ..The ability to inhibit the dynamics of NF-kappaB/IkappaBalpha and F-actin disassembly is a novel mechanism not previously attributed to the classic subfamily of PKC isoforms. ..
  8. Banan A, Zhang L, Shaikh M, Fields J, Farhadi A, Keshavarzian A. Theta-isoform of PKC is required for alterations in cytoskeletal dynamics and barrier permeability in intestinal epithelium: a novel function for PKC-theta. Am J Physiol Cell Physiol. 2004;287:C218-34 pubmed
    ..The ability to alter the cytoskeletal and barrier dynamics is a unique function not previously attributed to PKC-theta. ..
  9. Banan A, Fields J, Talmage D, Zhang Y, Keshavarzian A. PKC-beta1 mediates EGF protection of microtubules and barrier of intestinal monolayers against oxidants. Am J Physiol Gastrointest Liver Physiol. 2001;281:G833-47 pubmed
    ..This mechanism may be useful for development of novel therapies for the treatment of inflammatory gastrointestinal disorders including inflammatory bowel disease...

More Information

Publications10

  1. Banan A, Zhang L, Shaikh M, Fields J, Farhadi A, Keshavarzian A. Key role of PLC-gamma in EGF protection of epithelial barrier against iNOS upregulation and F-actin nitration and disassembly. Am J Physiol Cell Physiol. 2003;285:C977-93 pubmed