R W Tyl

Summary

Affiliation: RTI International
Country: USA

Publications

  1. ncbi request reprint Abbreviated assessment of bisphenol A toxicology literature
    Rochelle W Tyl
    RTI International, Hermann 124, 3040 Cornwallis Road, Research Triangle Park, NC 27709 2194, USA Electronic address
    Semin Fetal Neonatal Med 19:195-202. 2014
  2. doi request reprint Commentary on the role of maternal toxicity on developmental toxicity
    Rochelle W Tyl
    Discovery and Analytical Sciences, RTI International, Research Triangle Park, NC 27709 2194, USA
    Birth Defects Res B Dev Reprod Toxicol 95:262-6. 2012
  3. pmc Basic exploratory research versus guideline-compliant studies used for hazard evaluation and risk assessment: bisphenol A as a case study
    Rochelle W Tyl
    RTI International, Research Triangle Park, North Carolina 27709 2194, USA
    Environ Health Perspect 117:1644-51. 2009
  4. ncbi request reprint Two-generation reproductive toxicity study of inhaled tertiary amyl methyl ether (TAME) vapor in CD rats
    R W Tyl
    RTI International, Research Triangle Park, NC 27709 2194, USA
    J Appl Toxicol 23:397-410. 2003
  5. doi request reprint Commentary to the CERHR expert panel report on bisphenol A
    Rochelle W Tyl
    Developmental and Reproductive Toxicology DART, RTI International, 3040 Cornwallis Road, Research Triangle Park, NC 27709 2194, USA
    Birth Defects Res B Dev Reprod Toxicol 83:152. 2008
  6. ncbi request reprint Three-generation evaluation of dietary para-nonylphenol in CD (Sprague-Dawley) rats
    Rochelle W Tyl
    RTI International and Experimental Pathology Laboratories, 3040 Cornwallis Road, Research Triangle Park, NC 27709, USA
    Toxicol Sci 92:295-310. 2006
  7. doi request reprint Two-generation reproductive toxicity study of dietary bisphenol A in CD-1 (Swiss) mice
    Rochelle W Tyl
    Health Sciences Unit, RTI International, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 104:362-84. 2008
  8. ncbi request reprint Identification and interpretation of developmental neurotoxicity effects: a report from the ILSI Research Foundation/Risk Science Institute expert working group on neurodevelopmental endpoints
    Rochelle W Tyl
    RTI International, USA
    Neurotoxicol Teratol 30:349-81. 2008
  9. ncbi request reprint Altered axial skeletal development
    Rochelle W Tyl
    Center for Life Sciences and Toxicology, Research Triangle Institute, Research Triangle Park, North Carolina 27709 2194, USA
    Birth Defects Res B Dev Reprod Toxicol 80:451-72. 2007
  10. ncbi request reprint In honor of the Teratology Society's 50th anniversary: The role of Teratology Society members in the development and evolution of in vivo developmental toxicity test guidelines
    Rochelle W Tyl
    Department of Pharmacology and Toxicology, RTI International, Research Triangle Park, NC 27709 2194, USA
    Birth Defects Res C Embryo Today 90:99-102. 2010

Detail Information

Publications29

  1. ncbi request reprint Abbreviated assessment of bisphenol A toxicology literature
    Rochelle W Tyl
    RTI International, Hermann 124, 3040 Cornwallis Road, Research Triangle Park, NC 27709 2194, USA Electronic address
    Semin Fetal Neonatal Med 19:195-202. 2014
    ..The argument rages!..
  2. doi request reprint Commentary on the role of maternal toxicity on developmental toxicity
    Rochelle W Tyl
    Discovery and Analytical Sciences, RTI International, Research Triangle Park, NC 27709 2194, USA
    Birth Defects Res B Dev Reprod Toxicol 95:262-6. 2012
    ..These assays inform mechanism and hazard, but NOT risk. The Environmental Protection Agency currently estimates that these new assays are approximately 70% accurate versus the whole animal tests...
  3. pmc Basic exploratory research versus guideline-compliant studies used for hazard evaluation and risk assessment: bisphenol A as a case study
    Rochelle W Tyl
    RTI International, Research Triangle Park, North Carolina 27709 2194, USA
    Environ Health Perspect 117:1644-51. 2009
    ..They also specifically criticized our published guideline-compliant dietary studies on BPA in rats and mice and 17beta-estradiol (E(2)) in mice...
  4. ncbi request reprint Two-generation reproductive toxicity study of inhaled tertiary amyl methyl ether (TAME) vapor in CD rats
    R W Tyl
    RTI International, Research Triangle Park, NC 27709 2194, USA
    J Appl Toxicol 23:397-410. 2003
    ..The F1 and F2 offspring toxicity was present at 1500 and 3000 ppm. The no-observable-adverse-effect level for adult systemic and offspring toxicity was 250 ppm and 1500 ppm for male reproductive toxicity (females at >3000 ppm)...
  5. doi request reprint Commentary to the CERHR expert panel report on bisphenol A
    Rochelle W Tyl
    Developmental and Reproductive Toxicology DART, RTI International, 3040 Cornwallis Road, Research Triangle Park, NC 27709 2194, USA
    Birth Defects Res B Dev Reprod Toxicol 83:152. 2008
  6. ncbi request reprint Three-generation evaluation of dietary para-nonylphenol in CD (Sprague-Dawley) rats
    Rochelle W Tyl
    RTI International and Experimental Pathology Laboratories, 3040 Cornwallis Road, Research Triangle Park, NC 27709, USA
    Toxicol Sci 92:295-310. 2006
    ....
  7. doi request reprint Two-generation reproductive toxicity study of dietary bisphenol A in CD-1 (Swiss) mice
    Rochelle W Tyl
    Health Sciences Unit, RTI International, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 104:362-84. 2008
    ..Therefore, BPA is not considered a selective reproductive or developmental toxicant in mice...
  8. ncbi request reprint Identification and interpretation of developmental neurotoxicity effects: a report from the ILSI Research Foundation/Risk Science Institute expert working group on neurodevelopmental endpoints
    Rochelle W Tyl
    RTI International, USA
    Neurotoxicol Teratol 30:349-81. 2008
    ..This review provides a framework for the integration of all these types of information in the interpretation of DNT studies...
  9. ncbi request reprint Altered axial skeletal development
    Rochelle W Tyl
    Center for Life Sciences and Toxicology, Research Triangle Institute, Research Triangle Park, North Carolina 27709 2194, USA
    Birth Defects Res B Dev Reprod Toxicol 80:451-72. 2007
    ..Tables of the spontaneous incidence of axial anomalies in both humans and animals are provided...
  10. ncbi request reprint In honor of the Teratology Society's 50th anniversary: The role of Teratology Society members in the development and evolution of in vivo developmental toxicity test guidelines
    Rochelle W Tyl
    Department of Pharmacology and Toxicology, RTI International, Research Triangle Park, NC 27709 2194, USA
    Birth Defects Res C Embryo Today 90:99-102. 2010
    ..Our Society and its journal have played vital roles in the scientific and regulatory accomplishments in birth defects research over the past 50 years and will continue to do so in the future. Happy 50th anniversary!..
  11. ncbi request reprint Developmental toxicity evaluation of sodium thioglycolate administered topically to Sprague-Dawley (CD) rats and New Zealand White rabbits
    R W Tyl
    RTI International, Center for Life Sciences and Toxicology, Research Triangle Park, North Carolina 27709 2194, USA
    Birth Defects Res B Dev Reprod Toxicol 68:144-61. 2003
    ..Sodium thioglycolate, which has widespread occupational and consumer exposure to women from cosmetics and hair-care products, was evaluated for developmental toxicity by topical exposure during the embryonic and fetal periods of pregnancy..
  12. doi request reprint Validation of the intact rat weanling uterotrophic assay with notes on the formulation and analysis of the positive control chemical in vehicle
    Rochelle W Tyl
    RTI International, Research Triangle Park, NC 27709 2194, USA
    J Appl Toxicol 30:694-8. 2010
    ..0 µg kg⁻¹ per day. Therefore, this intact weanling uterotrophic assay is validated in our laboratory for use under US and European endocrine toxicity testing programs/legislation...
  13. ncbi request reprint Effects of acrylamide on rodent reproductive performance
    Rochelle W Tyl
    RTI, Center for Life Sciences and Toxicology, PO Box 12194, 3040 Cornwallis Road, Research Triangle Park, NC 27709 2194, USA
    Reprod Toxicol 17:1-13. 2003
    ..Glycidamide-induced mutations appear to play no role in reproductive or neurologic toxicity...
  14. ncbi request reprint Three-generation reproductive toxicity study of dietary bisphenol A in CD Sprague-Dawley rats
    R W Tyl
    RTI, Research Triangle Park, North Carolina 27709 2194, USA
    Toxicol Sci 68:121-46. 2002
    ..001-5 mg/kg/day) on any parameters and no evidence of nonmonotonic dose-response curves across generations for either sex. BPA should not be considered a selective reproductive toxicant, based on the results of this study...
  15. ncbi request reprint Rat two-generation reproduction and dominant lethal study of acrylamide in drinking water
    R W Tyla
    Bushy Run Research Center Union Carbide Corp, Export, PA, USA
    Reprod Toxicol 14:385-401. 2000
    ..The NOEL for prenatal DL was 2.0 mg/kg/day; the NOEL for adult systemic toxicity, including neurotoxicity, was < or = 0.5 mg/kg/day. Therefore, neurotoxicity and DL were differentially affected...
  16. ncbi request reprint Relationship between acrylamide reproductive and neurotoxicity in male rats
    R W Tyl
    Research Triangle Institute, PO Box 12194, Research Triangle Park, NC 27709 2194, USA
    Reprod Toxicol 14:147-57. 2000
    ..Therefore, epididymal sperm, mating, and neurotoxic effects were observed at AM doses that also resulted in increased postimplantation loss, possibly by different mechanisms...
  17. ncbi request reprint Two-generation reproductive toxicity study of inhaled toluene diisocyanate vapor in CD rats
    R W Tyl
    Bushy Run Research Center, Export, Pennsylvania, USA
    Toxicol Sci 52:258-68. 1999
    ..Therefore, under the conditions of this study, a no observed adverse effect level (NOAEL) was not determined for adult toxicity; the NOAEL for reproductive toxicity was at least 0.3 ppm, and the NOAEL for postnatal toxicity was 0.02 ppm...
  18. ncbi request reprint Developmental toxicity evaluation of inhaled toluene diisocyanate vapor in CD rats
    R W Tyl
    Bushy Run Research Center, Export, Pennsylvania, USA
    Toxicol Sci 52:248-57. 1999
    ..50 ppm no observed adverse effect level (NOAEL) for maternal and developmental toxicity was 0.10 ppm. No treatment-related embryotoxicity or teratogenicity was observed...
  19. doi request reprint One-generation reproductive toxicity study of dietary 17beta-estradiol (E2; CAS No. 50-28-2) in CD-1 (Swiss) mice
    Rochelle W Tyl
    Health Sciences Unit, RTI International, Research Triangle Park, NC 27709 2194, United States
    Reprod Toxicol 25:144-60. 2008
    ..At 0.05 ppm: no F0 reproductive effects, increased F1 weanling UCVW; delayed PPS. The NOEL was 0.005 ppm ( approximately 1 microg/kg/day)...
  20. ncbi request reprint A review of adverse pregnancy outcomes and formaldehyde exposure in human and animal studies
    J J Collins
    Solutia Inc, Pittsburgh, Pennsylvania, USA
    Regul Toxicol Pharmacol 34:17-34. 2001
    ..However, information from experimental studies and studies of metabolism indicate reproductive impacts are unlikely at formaldehyde exposures levels observed in the epidemiology studies...
  21. ncbi request reprint Reproductive toxicity evaluation of dietary butyl benzyl phthalate (BBP) in rats
    Rochelle W Tyl
    RTI International, 245 HLB MCB, P O Box 12194, 3040 Cornwallis Road, Research Triangle Park, NC, USA
    Reprod Toxicol 18:241-64. 2004
    ..The offspring toxicity no observable effect level (NOEL) was 750 ppm, based on the presence of reduced AGD in F1 and F2 males at birth at 3750 ppm, but no effects on reproductive development, structures, or functions...
  22. ncbi request reprint Developmental toxicity evaluation of Bendectin in CD rats
    R W Tyl
    Research Triangle Institute, Research Triangle Park, North Carolina 27709
    Teratology 37:539-52. 1988
    ..In conclusion, the incidence of litters with one or more malformed fetuses was increased only at a dose of Bendectin which produced maternal mortality (17.1%) and other indices of maternal and developmental toxicity (see Discussion)...
  23. doi request reprint Two-generation reproductive toxicity evaluation of dietary 17beta-estradiol (E2; CAS No. 50-28-2) in CD-1 (Swiss) mice
    Rochelle W Tyl
    Health Sciences Unit, RTI International, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 102:392-412. 2008
    ..The no observable effect level was 0.005 ppm E2 ( approximately 1 mug/kg/day). Therefore, the mouse model is sensitive to E2 by oral administration, with effects on reproductive development at doses of 10- 100 mug/kg/day...
  24. ncbi request reprint Developmental toxicity evaluation of inhaled tertiary amyl methyl ether in mice and rats
    Frank Welsch
    CIIT Centers for Health Research, 6 Davis Drive PO Box 12137, Research Triangle Park, NC 27709 2137, USA
    J Appl Toxicol 23:387-95. 2003
    ..Therefore, the NOAEL for the mouse maternal and developmental toxicity was 250 ppm under the conditions of this study...
  25. ncbi request reprint Transmission of mutations in the lacI transgene to the offspring of ENU-treated Big Blue male mice
    Lois B Barnett
    RTI International, Research Triangle Park, North Carolina, USA
    Environ Mol Mutagen 40:251-7. 2002
    ..These data provide preliminary evidence for the biological validity of assessing induced, heritable mutations using transgenic mice, without the need for generating an F(1) generation...
  26. pmc Bisphenol A: findings of a multigenerational rat study
    Rochelle W Tyl
    Environ Health Perspect 111:A632. 2003
  27. doi request reprint Environmental factors and puberty timing: expert panel research needs
    Germaine M Buck Louis
    Epidemiology Branch, Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, 6100 Executive Blvd, Room 7B03, Rockville, MD 20852, USA
    Pediatrics 121:S192-207. 2008
    ..Coupled with comparative species studies, such research may provide insight regarding the causal ordering of events that underlie pubertal onset and progression and their role in the pathway of adult-onset disease...
  28. ncbi request reprint Current and potential rodent screens and tests for thyroid toxicants
    R Thomas Zoeller
    Biology Department, Morrill Science Center, University of Massachusetts Amherst, Amherst, Massachusetts 01003, USA
    Crit Rev Toxicol 37:55-95. 2007
    ..Finally, the importance of understanding the relationship between timing of exposure, duration of dose, and time of acquisition of the endpoints in interpreting the results of the in vivo assays is emphasized...
  29. ncbi request reprint Occupational exposure to glycol ethers and human congenital malformations
    George Maldonado
    School of Public Health, University of Minnesota, 420 Delaware St SE, Mayo Mail Code 807, Minneapolis, MN 55455 0392, USA
    Int Arch Occup Environ Health 76:405-23. 2003
    ..This commentary reviews toxicological information and critically evaluates epidemiological information on the relationship between glycol ethers and congenital malformations...