David J Kroll

Summary

Affiliation: RTI International
Country: USA

Publications

  1. ncbi request reprint Milk thistle and prostate cancer: differential effects of pure flavonolignans from Silybum marianum on antiproliferative end points in human prostate carcinoma cells
    Paula R Davis-Searles
    Natural Products Laboratory, Research Triangle Institute, Research Triangle Park, North Carolina 27709 2194, USA
    Cancer Res 65:4448-57. 2005
  2. pmc A novel small molecule that selectively inhibits glioblastoma cells expressing EGFRvIII
    Dimitri G Trembath
    Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Mol Cancer 6:30. 2007
  3. ncbi request reprint Milk thistle nomenclature: why it matters in cancer research and pharmacokinetic studies
    David J Kroll
    Natural Products Laboratory, Research Triangle Institute RTI, Research Triangle Park, NC 27709 2194, USA
    Integr Cancer Ther 6:110-9. 2007
  4. pmc Bioactive constituents of the stem bark of Mitrephora glabra
    Chen Li
    Natural Products Laboratory, Research Triangle Institute, P O Box 12194, Research Triangle Park, North Carolina 27709 2194, USA
    J Nat Prod 72:1949-53. 2009
  5. pmc Large-scale isolation of flavonolignans from Silybum marianum extract affords new minor constituents and preliminary structure-activity relationships
    Arlene Sy-Cordero
    Natural Products Laboratory, Research Triangle Institute, Research Triangle Park, North Carolina, USA
    Planta Med 76:644-7. 2010
  6. pmc A hexacyclic ent-trachylobane diterpenoid possessing an oxetane ring from Mitrephora glabra
    Chen Li
    Natural Products Laboratory, Research Triangle Institute, P O Box 12194, Research Triangle Park, North Carolina 27709 2194, USA
    Org Lett 7:5709-12. 2005
  7. ncbi request reprint Gram-scale purification of flavonolignan diastereoisomers from Silybum marianum (Milk Thistle) extract in support of preclinical in vivo studies for prostate cancer chemoprevention
    Tyler N Graf
    Natural Products Laboratory, Research Triangle Institute, Research Triangle Park, NC 27709 2194, USA
    Planta Med 73:1495-501. 2007
  8. pmc Alvaradoins E-N, antitumor and cytotoxic anthracenone C-glycosides from the leaves of Alvaradoa haitiensis
    Sharnelle S Phifer
    Natural Products Laboratory, Research Triangle Institute, P O Box 12194, Research Triangle Park, North Carolina 27709, USA
    J Nat Prod 70:954-61. 2007
  9. ncbi request reprint Diterpene glycosides from Egletes viscosa
    Dongho Lee
    Natural Products Laboratory, Research Triangle Institute, Research Triangle Park, North Carolina 27709, USA
    Planta Med 71:792-4. 2005
  10. doi request reprint Inhibition of paclitaxel metabolism in vitro in human hepatocytes by Ginkgo biloba preparations
    Amy S Etheridge
    Drug Metabolism and Pharmacokinetics, RTI International, Research Triangle Park, North Carolina 27709, USA
    J Diet Suppl 6:104-10. 2009

Research Grants

Collaborators

  • Nicholas H Oberlies
  • Norman R Farnsworth
  • Rajesh Agarwal
  • Nam Cheol Kim
  • James M Mathews
  • Jason P Burgess
  • Robert Wild
  • Geoffrey A Cordell
  • Djaja Doel Soejarto
  • ALAN DOUGLAS KINGHORN
  • F Q Alali
  • W C Rose
  • Tyler N Graf
  • Mansukh C Wani
  • Dongho Lee
  • Yuka Nakanishi
  • Chen Li
  • Gagan Deep
  • Sharnelle S Phifer
  • Fransisca M Setyowati
  • Soedarsono Riswan
  • Joseph O Falkinham
  • Monroe E Wall
  • Arlene Sy-Cordero
  • Amy S Etheridge
  • Dimitri G Trembath
  • Achmad M Saribi
  • Tamara K Nun
  • Meredith T Morgan
  • Paula R Davis-Searles
  • Heather S Shaw
  • Jian Qiao Gu
  • Hernan A Navarro
  • Teatulohi Matainaho
  • Pius Piskaut
  • Ryan J Case
  • Chelsey Hilscher
  • Blossom Damania
  • Ricardo Garcia
  • Robert A Izydore
  • Shou Jian Gao
  • Anita Lal
  • Dirk P Dittmer
  • Eun Kyoung Seo
  • Gregory J Riggins
  • Ling Wang
  • Francisco Jimenez
  • Craig R Fairchild
  • Aaron P Griset
  • Mark W Grinstaff
  • Govindarajan Manikumar
  • Michel Wathier
  • Michael A Carnahan
  • Jose Schunke Vigo
  • James G Graham
  • Fernando Cabieses
  • Leonardus B S Kardono
  • Rachman Ismail
  • Hee Byung Chai
  • Steven M Swanson
  • Katherine B Hobbs
  • Qiuwen Mi
  • Victoria L Seewaldt
  • John M Pezzuto

Detail Information

Publications20

  1. ncbi request reprint Milk thistle and prostate cancer: differential effects of pure flavonolignans from Silybum marianum on antiproliferative end points in human prostate carcinoma cells
    Paula R Davis-Searles
    Natural Products Laboratory, Research Triangle Institute, Research Triangle Park, North Carolina 27709 2194, USA
    Cancer Res 65:4448-57. 2005
    ....
  2. pmc A novel small molecule that selectively inhibits glioblastoma cells expressing EGFRvIII
    Dimitri G Trembath
    Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Mol Cancer 6:30. 2007
    ..In this study, we sought small molecule inhibitors specific for cancer cells expressing EGFRvIII, using isogenic parental cells without EGFRvIII as a control...
  3. ncbi request reprint Milk thistle nomenclature: why it matters in cancer research and pharmacokinetic studies
    David J Kroll
    Natural Products Laboratory, Research Triangle Institute RTI, Research Triangle Park, NC 27709 2194, USA
    Integr Cancer Ther 6:110-9. 2007
    ..However, some precautions are advised as high-dose, phase II studies are conducted...
  4. pmc Bioactive constituents of the stem bark of Mitrephora glabra
    Chen Li
    Natural Products Laboratory, Research Triangle Institute, P O Box 12194, Research Triangle Park, North Carolina 27709 2194, USA
    J Nat Prod 72:1949-53. 2009
    ..All compounds were evaluated for their inhibitory activities against a panel of cancer cell lines and a battery of microorganisms...
  5. pmc Large-scale isolation of flavonolignans from Silybum marianum extract affords new minor constituents and preliminary structure-activity relationships
    Arlene Sy-Cordero
    Natural Products Laboratory, Research Triangle Institute, Research Triangle Park, North Carolina, USA
    Planta Med 76:644-7. 2010
    ....
  6. pmc A hexacyclic ent-trachylobane diterpenoid possessing an oxetane ring from Mitrephora glabra
    Chen Li
    Natural Products Laboratory, Research Triangle Institute, P O Box 12194, Research Triangle Park, North Carolina 27709 2194, USA
    Org Lett 7:5709-12. 2005
    ..All compounds were evaluated for cytotoxicity against a panel of cancer cells, where 1 displayed the most potent and broadest activity, and against a battery of antimicrobial assays, where all compounds were approximately equipotent...
  7. ncbi request reprint Gram-scale purification of flavonolignan diastereoisomers from Silybum marianum (Milk Thistle) extract in support of preclinical in vivo studies for prostate cancer chemoprevention
    Tyler N Graf
    Natural Products Laboratory, Research Triangle Institute, Research Triangle Park, NC 27709 2194, USA
    Planta Med 73:1495-501. 2007
    ....
  8. pmc Alvaradoins E-N, antitumor and cytotoxic anthracenone C-glycosides from the leaves of Alvaradoa haitiensis
    Sharnelle S Phifer
    Natural Products Laboratory, Research Triangle Institute, P O Box 12194, Research Triangle Park, North Carolina 27709, USA
    J Nat Prod 70:954-61. 2007
    ..2 mg kg-1 per injection when administered intraperitoneally...
  9. ncbi request reprint Diterpene glycosides from Egletes viscosa
    Dongho Lee
    Natural Products Laboratory, Research Triangle Institute, Research Triangle Park, North Carolina 27709, USA
    Planta Med 71:792-4. 2005
    ..The structures of the new compounds were elucidated by spectroscopic and chemical methods...
  10. doi request reprint Inhibition of paclitaxel metabolism in vitro in human hepatocytes by Ginkgo biloba preparations
    Amy S Etheridge
    Drug Metabolism and Pharmacokinetics, RTI International, Research Triangle Park, North Carolina 27709, USA
    J Diet Suppl 6:104-10. 2009
    ....
  11. ncbi request reprint Camptothecin and taxol: historic achievements in natural products research
    Nicholas H Oberlies
    Natural Products Laboratory, Research Triangle Institute, P O Box 12194, Research Triangle Park, North Carolina 27709 2194, USA
    J Nat Prod 67:129-35. 2004
    ....
  12. ncbi request reprint Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia
    Jian Qiao Gu
    Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA
    J Nat Prod 67:1156-61. 2004
    ..Plumbagin (1) and maritinone (2) were evaluated also for in vivo antitumor activity in the hollow fiber assay, but both were found to be inactive...
  13. ncbi request reprint Delayed-type hypersensitivity reaction with iscador M given in combination with cytotoxic chemotherapy
    Heather S Shaw
    J Clin Oncol 22:4432-4. 2004
  14. doi request reprint Pyrrolizidine alkaloids from Echium glomeratum (Boraginaceae)
    Feras Q Alali
    Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, P O Box 3030, Irbid 22110, Jordan
    Phytochemistry 69:2341-6. 2008
    ..All compounds were tested against a human tumor panel for cytotoxicity; no activity was observed (EC50 values>20microg/ml)...
  15. doi request reprint Identifying the differential effects of silymarin constituents on cell growth and cell cycle regulatory molecules in human prostate cancer cells
    Gagan Deep
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Denver, Denver, CO 80262, USA
    Int J Cancer 123:41-50. 2008
    ..This study provided further evidence for differential anticancer potential among each silymarin constituent, which would have potential implications in devising better formulations of silymarin against prostate and other cancers...
  16. ncbi request reprint New colchicinoids from a native Jordanian meadow saffron, colchicum brachyphyllum: isolation of the first naturally occurring dextrorotatory colchicinoid
    Feras Q Alali
    Medicinal Chemistry and Pharmacognosy Department, Faculty of Pharmacy, Jordan University of Science and Technology, P O Box 3030, Irbid 22110, Jordan
    J Nat Prod 68:173-8. 2005
    ....
  17. pmc Development of a fluorescence-based assay to screen antiviral drugs against Kaposi's sarcoma associated herpesvirus
    Tamara K Nun
    Department of Microbiology and Immunology, Lineberger Cancer Center, University of North Carolina at Chapel Hill, North Carolina, NC 27599, USA
    Mol Cancer Ther 6:2360-70. 2007
    ....
  18. ncbi request reprint Phytochemical studies and cytotoxicity evaluations of Colchicum tunicatum Feinbr and Colchicum hierosolymitanum Feinbr (Colchicaceae): two native Jordanian meadow saffrons
    Feras Q Alali
    Faculty of Pharmacy, Department of Medicinal Chemistry and Pharmacognosy, Jordan University of Science and Technology, PO Box 3030, Irbid 22110, Jordan
    Nat Prod Res 20:558-66. 2006
    ..Colchicine (I) and (-)-cornigerine (III) were found to be the most bioactive of the identified compounds with EC50 values in the range of 0.016-0.097 microM...
  19. ncbi request reprint Dendrimer-encapsulated camptothecins: increased solubility, cellular uptake, and cellular retention affords enhanced anticancer activity in vitro
    Meredith T Morgan
    Department of Chemistry, Duke University, Durham, North Carolina, USA
    Cancer Res 66:11913-21. 2006
    ..Cellular uptake and efflux measurements in MCF-7 cells show an increase of 16-fold for cellular uptake and an increase in drug retention within the cell when using the dendrimer vehicle...
  20. ncbi request reprint Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostate cancer LNCaP and 22Rv1 cells
    Gagan Deep
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Center, Denver, CO, USA
    Carcinogenesis 28:1533-42. 2007
    ..Together, this study for the first time identified that isosilybin B and isosilybin A, two diastereoisomers isolated from silymarin, have anti-PCA activity that is mediated via cell cycle arrest and apoptosis induction...

Research Grants1

  1. Formulation Dependent Help Interactions with Chemothera*
    David Kroll; Fiscal Year: 2005
    ..These studies are designed in the interest of public health and the spirit that cancer patients should be steered away from harmful herbal products while being assured safe access to alternative formulations of the same herb. ..