Jason P Burgess

Summary

Affiliation: RTI International
Country: USA

Publications

  1. ncbi request reprint Complete 1H and 13C assignments of fluorinated analogs of dehydroepiandrosterone
    Jason P Burgess
    Science and Engineering Group, RTI International, Research Triangle Park NC 27709 2194, USA
    Magn Reson Chem 44:1051-3. 2006
  2. pmc Identification of [14C]fluasterone metabolites in urine and feces collected from dogs after subcutaneous and oral administration of [14C]fluasterone
    Jason P Burgess
    Analytical Chemistry and Pharmaceutics Group, RTI International, 3040 Cornwallis Road, Research Triangle Park, NC 27709 2194, USA
    Drug Metab Dispos 37:1089-97. 2009
  3. doi request reprint Conformationally constrained analogues of N-(piperidinyl)-5-(4-chlorophenyl)-1-(2,4- dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716): design, synthesis, computational analysis, and biological evaluations
    Yanan Zhang
    Chemistry and Life Sciences, Research Triangle Institute, Research Triangle Park, NC 27709, USA
    J Med Chem 51:3526-39. 2008
  4. pmc Synthesis, nicotinic acetylcholine receptor binding, and pharmacological properties of 3'-(substituted phenyl)deschloroepibatidine analogs
    F Ivy Carroll
    Organic and Medicinal Chemistry, Research Triangle Institute, PO Box 12194, Research Triangle Park, NC 27709, USA
    Bioorg Med Chem 16:746-54. 2008
  5. doi request reprint Metabolism and disposition of 2-methoxy-4-nitroaniline in male and female Harlan Sprague Dawley rats and B6C3F1/N mice
    James M Mathews
    RTI International, Research Triangle Park, NC, USA
    Xenobiotica 42:1213-24. 2012
  6. ncbi request reprint Copper-catalyzed cyclization of steroidal acylaminoacetylenes: syntheses of novel 11beta-aryl-17,17- spiro[(4'H,5'-methylene)oxazol]-substituted steroids
    Chunyang Jin
    Organic and Medicinal Chemistry, Science and Engineering Group, Research Triangle Institute, Research Triangle Park, NC 27709, USA
    Org Lett 9:1887-90. 2007
  7. ncbi request reprint Synthesis, structural identification, and ligand binding of tropane ring analogs of paroxetine and an unexpected aza-bicyclo[3.2.2]nonane rearrangement product
    Scott P Runyon
    Chemistry and Life Sciences, Research Triangle Institute, 3040 Cornwallis Road, Research Triangle Park, PO Box 12194, North Carolina, NC 27709 2194, USA
    Bioorg Med Chem 13:2439-49. 2005
  8. ncbi request reprint Discovery of an opioid kappa receptor selective pure antagonist from a library of N-substituted 4beta-methyl-5-(3-hydroxyphenyl)morphans
    James B Thomas
    Chemistry and Life Sciences, Research Triangle Institute, Research Triangle Park, NC 27709, USA
    J Med Chem 45:3524-30. 2002
  9. pmc A hexacyclic ent-trachylobane diterpenoid possessing an oxetane ring from Mitrephora glabra
    Chen Li
    Natural Products Laboratory, Research Triangle Institute, P O Box 12194, Research Triangle Park, North Carolina 27709 2194, USA
    Org Lett 7:5709-12. 2005
  10. doi request reprint Pyrrolizidine alkaloids from Echium glomeratum (Boraginaceae)
    Feras Q Alali
    Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, P O Box 3030, Irbid 22110, Jordan
    Phytochemistry 69:2341-6. 2008

Collaborators

  • Brian F Thomas
  • James M Mathews
  • Timothy R Fennell
  • Chunyang Jin
  • F Ivy Carroll
  • Yanan Zhang
  • M I Damaj
  • Hernan A Navarro
  • B R Martin
  • R B Rothman
  • ANITA LEWIN
  • F Q Alali
  • C E Cook
  • Norman R Farnsworth
  • Mansukh C Wani
  • A Douglas Kinghorn
  • Nicholas H Oberlies
  • F Ivy Carroll
  • Chen Li
  • Scott P Runyon
  • Djaja D Soejarto
  • Soedarsono Riswan
  • James B Thomas
  • Monroe E Wall
  • Eun Kyoung Seo
  • Craig R Fairchild
  • Wei Ma
  • Jeffrey R Lee
  • Yasuno Yokota
  • Lawrence E Brieaddy
  • Fransisca M Setyowati
  • Yuka Nakanishi
  • John W Boja
  • Jeffrey Deschamps
  • Michael J Kuhar
  • Kathryn I Keverline-Frantz
  • Joseph O Falkinham
  • Judy Flippen-Anderson
  • Dongho Lee
  • Sharnelle S Phifer
  • Philip Abraham
  • Achmad M Saribi
  • David J Kroll
  • Tyler N Graf
  • Nivedita Namdev
  • Russell W Peterson
  • N Ariane Vinson
  • Rosa Elena Pinos
  • Scott E Fix
  • Leonardus B S Kardono
  • S Wayne Mascarella
  • Christina M Dersch
  • Kenneth M Gigstad
  • Dennis M Zimmerman
  • Kazuko Kawanishi
  • Robert N Atkinson
  • Buddy E Cantrell
  • William C Rose
  • Heng Xu
  • Nam Cheol Kim

Detail Information

Publications12

  1. ncbi request reprint Complete 1H and 13C assignments of fluorinated analogs of dehydroepiandrosterone
    Jason P Burgess
    Science and Engineering Group, RTI International, Research Triangle Park NC 27709 2194, USA
    Magn Reson Chem 44:1051-3. 2006
    ..Once the proton chemical shifts were assigned, the stereochemistry of the two hydroxylated analogs was determined using 2D ROESY experiments...
  2. pmc Identification of [14C]fluasterone metabolites in urine and feces collected from dogs after subcutaneous and oral administration of [14C]fluasterone
    Jason P Burgess
    Analytical Chemistry and Pharmaceutics Group, RTI International, 3040 Cornwallis Road, Research Triangle Park, NC 27709 2194, USA
    Drug Metab Dispos 37:1089-97. 2009
    ....
  3. doi request reprint Conformationally constrained analogues of N-(piperidinyl)-5-(4-chlorophenyl)-1-(2,4- dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716): design, synthesis, computational analysis, and biological evaluations
    Yanan Zhang
    Chemistry and Life Sciences, Research Triangle Institute, Research Triangle Park, NC 27709, USA
    J Med Chem 51:3526-39. 2008
    ....
  4. pmc Synthesis, nicotinic acetylcholine receptor binding, and pharmacological properties of 3'-(substituted phenyl)deschloroepibatidine analogs
    F Ivy Carroll
    Organic and Medicinal Chemistry, Research Triangle Institute, PO Box 12194, Research Triangle Park, NC 27709, USA
    Bioorg Med Chem 16:746-54. 2008
    ..However, they are potent antagonists in nicotine-induced antinociception in the tail-flick test, but weaker than the corresponding 2'-fluoro-3'-(substituted phenyl)deschloroepibatidines...
  5. doi request reprint Metabolism and disposition of 2-methoxy-4-nitroaniline in male and female Harlan Sprague Dawley rats and B6C3F1/N mice
    James M Mathews
    RTI International, Research Triangle Park, NC, USA
    Xenobiotica 42:1213-24. 2012
    ..Following oral administration, the percent of total radioactivity bound in tissues bound was highest in liver (43%) and red blood cells (30%), whereas the radioactivity bound to DNA was highest in cecum (160 pmol/mg DNA)...
  6. ncbi request reprint Copper-catalyzed cyclization of steroidal acylaminoacetylenes: syntheses of novel 11beta-aryl-17,17- spiro[(4'H,5'-methylene)oxazol]-substituted steroids
    Chunyang Jin
    Organic and Medicinal Chemistry, Science and Engineering Group, Research Triangle Institute, Research Triangle Park, NC 27709, USA
    Org Lett 9:1887-90. 2007
    ..The best result was obtained with a catalytic amount of CuI in 1:1 benzene-Et3N at 90 degrees C for 30 min (Ar = 3,4-difluorophenyl; R = ethyl; 97% yield)...
  7. ncbi request reprint Synthesis, structural identification, and ligand binding of tropane ring analogs of paroxetine and an unexpected aza-bicyclo[3.2.2]nonane rearrangement product
    Scott P Runyon
    Chemistry and Life Sciences, Research Triangle Institute, 3040 Cornwallis Road, Research Triangle Park, PO Box 12194, North Carolina, NC 27709 2194, USA
    Bioorg Med Chem 13:2439-49. 2005
    ..2.2]nonane derivative 10a...
  8. ncbi request reprint Discovery of an opioid kappa receptor selective pure antagonist from a library of N-substituted 4beta-methyl-5-(3-hydroxyphenyl)morphans
    James B Thomas
    Chemistry and Life Sciences, Research Triangle Institute, Research Triangle Park, NC 27709, USA
    J Med Chem 45:3524-30. 2002
    ....
  9. pmc A hexacyclic ent-trachylobane diterpenoid possessing an oxetane ring from Mitrephora glabra
    Chen Li
    Natural Products Laboratory, Research Triangle Institute, P O Box 12194, Research Triangle Park, North Carolina 27709 2194, USA
    Org Lett 7:5709-12. 2005
    ..All compounds were evaluated for cytotoxicity against a panel of cancer cells, where 1 displayed the most potent and broadest activity, and against a battery of antimicrobial assays, where all compounds were approximately equipotent...
  10. doi request reprint Pyrrolizidine alkaloids from Echium glomeratum (Boraginaceae)
    Feras Q Alali
    Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, P O Box 3030, Irbid 22110, Jordan
    Phytochemistry 69:2341-6. 2008
    ..All compounds were tested against a human tumor panel for cytotoxicity; no activity was observed (EC50 values>20microg/ml)...
  11. ncbi request reprint Cytotoxic prenylated xanthones and the unusual compounds anthraquinobenzophenones from Cratoxylum sumatranum
    Eun Kyoung Seo
    Chemistry and Life Sciences Group, Research Triangle Institute, P O Box 12194, Research Triangle Park, North Carolina 27709, USA
    J Nat Prod 65:299-305. 2002
    ..In addition, two novel anthraquinobenzophenones, cratoxyarborequinones A (7) and B (8), and two known compounds, 2,4,6-trihydroxybenzophenone 4-O-geranyl ether and delta-tocotrienol, were obtained as inactive constituents...
  12. ncbi request reprint Novel bioactive clerodane diterpenoids from the leaves and twigs of Casearia sylvestris
    Nicholas H Oberlies
    Chemistry and Life Sciences, Research Triangle Institute, P O Box 12194, Research Triangle Park, North Carolina 27709 2194, USA
    J Nat Prod 65:95-9. 2002
    ..All three compounds displayed promising bioactivity, both in cytotoxicity assays against a panel of tumor cell lines and in antifungal assays via the growth inhibition of Aspergillus niger in a disk diffusion assay...