Research Topics
| Jason P BurgessSummaryAffiliation: RTI International Country: USA Publications
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Detail Information
Publications
Complete 1H and 13C assignments of fluorinated analogs of dehydroepiandrosteroneJason P Burgess
Science and Engineering Group, RTI International, Research Triangle Park NC 27709 2194, USA
Magn Reson Chem 44:1051-3. 2006..Once the proton chemical shifts were assigned, the stereochemistry of the two hydroxylated analogs was determined using 2D ROESY experiments...
Identification of [14C]fluasterone metabolites in urine and feces collected from dogs after subcutaneous and oral administration of [14C]fluasteroneJason P Burgess
Analytical Chemistry and Pharmaceutics Group, RTI International, 3040 Cornwallis Road, Research Triangle Park, NC 27709 2194, USA
Drug Metab Dispos 37:1089-97. 2009....
Conformationally constrained analogues of N-(piperidinyl)-5-(4-chlorophenyl)-1-(2,4- dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716): design, synthesis, computational analysis, and biological evaluationsYanan Zhang
Chemistry and Life Sciences, Research Triangle Institute, Research Triangle Park, NC 27709, USA
J Med Chem 51:3526-39. 2008....- Synthesis, nicotinic acetylcholine receptor binding, and pharmacological properties of 3'-(substituted phenyl)deschloroepibatidine analogsF Ivy Carroll
Organic and Medicinal Chemistry, Research Triangle Institute, PO Box 12194, Research Triangle Park, NC 27709, USA
Bioorg Med Chem 16:746-54. 2008..However, they are potent antagonists in nicotine-induced antinociception in the tail-flick test, but weaker than the corresponding 2'-fluoro-3'-(substituted phenyl)deschloroepibatidines... - Metabolism and disposition of 2-methoxy-4-nitroaniline in male and female Harlan Sprague Dawley rats and B6C3F(1)/N miceJames M Mathews
RTI International, Research Triangle Park, NC, USA
Xenobiotica 42:1213-24. 2012..Following oral administration, the percent of total radioactivity bound in tissues bound was highest in liver (43%) and red blood cells (30%), whereas the radioactivity bound to DNA was highest in cecum (160 pmol/mg DNA)... - Copper-catalyzed cyclization of steroidal acylaminoacetylenes: syntheses of novel 11beta-aryl-17,17- spiro[(4'H,5'-methylene)oxazol]-substituted steroidsChunyang Jin
Organic and Medicinal Chemistry, Science and Engineering Group, Research Triangle Institute, Research Triangle Park, NC 27709, USA
Org Lett 9:1887-90. 2007..The best result was obtained with a catalytic amount of CuI in 1:1 benzene-Et3N at 90 degrees C for 30 min (Ar = 3,4-difluorophenyl; R = ethyl; 97% yield)... - Synthesis, structural identification, and ligand binding of tropane ring analogs of paroxetine and an unexpected aza-bicyclo[3.2.2]nonane rearrangement productScott P Runyon
Chemistry and Life Sciences, Research Triangle Institute, 3040 Cornwallis Road, Research Triangle Park, PO Box 12194, North Carolina, NC 27709-2194, USA
Bioorg Med Chem 13:2439-49. 2005..2.2]nonane derivative 10a... - Discovery of an opioid kappa receptor selective pure antagonist from a library of N-substituted 4beta-methyl-5-(3-hydroxyphenyl)morphansJames B Thomas
Chemistry and Life Sciences, Research Triangle Institute, Research Triangle Park, NC 27709, USA
J Med Chem 45:3524-30. 2002.... - A hexacyclic ent-trachylobane diterpenoid possessing an oxetane ring from Mitrephora glabraChen Li
Natural Products Laboratory, Research Triangle Institute, P.O. Box 12194, Research Triangle Park, North Carolina 27709-2194, USA
Org Lett 7:5709-12. 2005..All compounds were evaluated for cytotoxicity against a panel of cancer cells, where 1 displayed the most potent and broadest activity, and against a battery of antimicrobial assays, where all compounds were approximately equipotent... - Pyrrolizidine alkaloids from Echium glomeratum (Boraginaceae)Feras Q Alali
Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, P O Box 3030, Irbid 22110, Jordan
Phytochemistry 69:2341-6. 2008..All compounds were tested against a human tumor panel for cytotoxicity; no activity was observed (EC50 values>20microg/ml)... - Cytotoxic prenylated xanthones and the unusual compounds anthraquinobenzophenones from Cratoxylum sumatranumEun-Kyoung Seo
Chemistry and Life Sciences Group, Research Triangle Institute, P.O. Box 12194, Research Triangle Park, North Carolina 27709, USA
J Nat Prod 65:299-305. 2002..In addition, two novel anthraquinobenzophenones, cratoxyarborequinones A (7) and B (8), and two known compounds, 2,4,6-trihydroxybenzophenone 4-O-geranyl ether and delta-tocotrienol, were obtained as inactive constituents... - Novel bioactive clerodane diterpenoids from the leaves and twigs of Casearia sylvestrisNicholas H Oberlies
Chemistry and Life Sciences, Research Triangle Institute, P.O. Box 12194, Research Triangle Park, North Carolina 27709-2194, USA
J Nat Prod 65:95-9. 2002..All three compounds displayed promising bioactivity, both in cytotoxicity assays against a panel of tumor cell lines and in antifungal assays via the growth inhibition of Aspergillus niger in a disk diffusion assay...