Yuesheng Zhang

Summary

Affiliation: Roswell Park Cancer Institute
Country: USA

Publications

  1. pmc The 1,2-benzenedithiole-based cyclocondensation assay: a valuable tool for the measurement of chemopreventive isothiocyanates
    Yuesheng Zhang
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Crit Rev Food Sci Nutr 52:525-32. 2012
  2. pmc The molecular basis that unifies the metabolism, cellular uptake and chemopreventive activities of dietary isothiocyanates
    Yuesheng Zhang
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Carcinogenesis 33:2-9. 2012
  3. pmc Allyl isothiocyanate as a cancer chemopreventive phytochemical
    Yuesheng Zhang
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Mol Nutr Food Res 54:127-35. 2010
  4. ncbi request reprint Discovery and development of sulforaphane as a cancer chemopreventive phytochemical
    Yuesheng Zhang
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Acta Pharmacol Sin 28:1343-54. 2007
  5. ncbi request reprint Induction of GST and NQO1 in cultured bladder cells and in the urinary bladders of rats by an extract of broccoli (Brassica oleracea italica) sprouts
    Yuesheng Zhang
    Department of Chemoprevention, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Agric Food Chem 54:9370-6. 2006
  6. pmc Dithiolethiones for cancer chemoprevention: where do we stand?
    Yuesheng Zhang
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Mol Cancer Ther 7:3470-9. 2008
  7. ncbi request reprint Cancer-preventive isothiocyanates: dichotomous modulators of oxidative stress
    Yuesheng Zhang
    Department of Chemoprevention, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Free Radic Biol Med 38:70-7. 2005
  8. ncbi request reprint Vegetable-derived isothiocyanates: anti-proliferative activity and mechanism of action
    Yuesheng Zhang
    Department of Chemoprevention, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Proc Nutr Soc 65:68-75. 2006
  9. ncbi request reprint Cancer-preventive isothiocyanates: measurement of human exposure and mechanism of action
    Yuesheng Zhang
    Department of Chemoprevention, Roswell Park Cancer Institute, Basic Science 711, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Mutat Res 555:173-90. 2004
  10. ncbi request reprint A strategy for cancer prevention: stimulation of the Nrf2-ARE signaling pathway
    Yuesheng Zhang
    Department of Chemoprevention, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Mol Cancer Ther 3:885-93. 2004

Detail Information

Publications43

  1. pmc The 1,2-benzenedithiole-based cyclocondensation assay: a valuable tool for the measurement of chemopreventive isothiocyanates
    Yuesheng Zhang
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Crit Rev Food Sci Nutr 52:525-32. 2012
    ..Moreover, detailed discussion is also provided to show how this assay has been used to advance our understanding of the cancer chemopreventive potential and the mechanism of action of ITCs...
  2. pmc The molecular basis that unifies the metabolism, cellular uptake and chemopreventive activities of dietary isothiocyanates
    Yuesheng Zhang
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Carcinogenesis 33:2-9. 2012
    ..This knowledge deepens our understanding about the biological activities of ITCs and may facilitate further research and development of these compounds for cancer prevention and treatment...
  3. pmc Allyl isothiocyanate as a cancer chemopreventive phytochemical
    Yuesheng Zhang
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Mol Nutr Food Res 54:127-35. 2010
    ..Overall, AITC exhibits many desirable attributes of a cancer chemopreventive agent, and further studies are warranted in order to elucidate its mechanism of action and to assess its protective activity in humans...
  4. ncbi request reprint Discovery and development of sulforaphane as a cancer chemopreventive phytochemical
    Yuesheng Zhang
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Acta Pharmacol Sin 28:1343-54. 2007
    ....
  5. ncbi request reprint Induction of GST and NQO1 in cultured bladder cells and in the urinary bladders of rats by an extract of broccoli (Brassica oleracea italica) sprouts
    Yuesheng Zhang
    Department of Chemoprevention, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Agric Food Chem 54:9370-6. 2006
    ..In conclusion, broccoli sprout ITC extract is a potent inducer of GST and NQO1 in the bladder and is a promising agent for prevention of bladder cancer...
  6. pmc Dithiolethiones for cancer chemoprevention: where do we stand?
    Yuesheng Zhang
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Mol Cancer Ther 7:3470-9. 2008
    ..Further investigation of these compounds may lead to development of effective and safe agents for cancer prevention in humans...
  7. ncbi request reprint Cancer-preventive isothiocyanates: dichotomous modulators of oxidative stress
    Yuesheng Zhang
    Department of Chemoprevention, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Free Radic Biol Med 38:70-7. 2005
    ..Ironically, although ITC-induced stress may lead to oxidative damage, it has become increasingly clear that much of the chemoprotective activity of ITCs stems from the response of cells to the stress induced by these compounds...
  8. ncbi request reprint Vegetable-derived isothiocyanates: anti-proliferative activity and mechanism of action
    Yuesheng Zhang
    Department of Chemoprevention, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Proc Nutr Soc 65:68-75. 2006
    ..Taken together, dietary ITC are highly-promising anti-cancer agents, capable of targetting multiple cellular components that are important for tumour cell survival and proliferation...
  9. ncbi request reprint Cancer-preventive isothiocyanates: measurement of human exposure and mechanism of action
    Yuesheng Zhang
    Department of Chemoprevention, Roswell Park Cancer Institute, Basic Science 711, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Mutat Res 555:173-90. 2004
    ..These mechanisms, which are discussed in detail in this review, illustrate the remarkable ability of ITCs to inhibit cancer development-effective against both developing and developed cancer cells...
  10. ncbi request reprint A strategy for cancer prevention: stimulation of the Nrf2-ARE signaling pathway
    Yuesheng Zhang
    Department of Chemoprevention, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Mol Cancer Ther 3:885-93. 2004
    ..Moreover, many ARE-mediated inducers have been identified, and several of them have shown promising cancer preventive activity...
  11. ncbi request reprint Selected isothiocyanates rapidly induce growth inhibition of cancer cells
    Yuesheng Zhang
    Arizona Cancer Center and Department of Medicine, College of Medicine, University of Arizona, Tucson, AZ, USA
    Mol Cancer Ther 2:1045-52. 2003
    ....
  12. pmc Identification of an unintended consequence of Nrf2-directed cytoprotection against a key tobacco carcinogen plus a counteracting chemopreventive intervention
    Joseph D Paonessa
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 71:3904-11. 2011
    ..Thus, CPDT exemplifies a counteracting solution to the dilemma posed by Nrf2...
  13. pmc Cruciferous vegetable intake is inversely associated with lung cancer risk among smokers: a case-control study
    Li Tang
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    BMC Cancer 10:162. 2010
    ..Inverse associations between cruciferous vegetable intake and lung cancer risk have been consistently reported. However, associations within smoking status subgroups have not been consistently addressed...
  14. ncbi request reprint Potent activation of mitochondria-mediated apoptosis and arrest in S and M phases of cancer cells by a broccoli sprout extract
    Li Tang
    Department of Chemoprevention, Roswell Park Cancer Institute, Elm and Carlton Streets, Science 711, Buffalo, NY 14263, USA
    Mol Cancer Ther 5:935-44. 2006
    ..These data show that broccoli sprout isothiocyanate extract is a highly promising substance for cancer prevention/treatment and that its antiproliferative activity is exclusively derived from isothiocyanates...
  15. pmc Mechanism of chemical activation of Nrf2
    Yun Li
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, United States of America
    PLoS ONE 7:e35122. 2012
    ..These findings provide significant new insight about Nrf2 activation and suggest that exogenous chemical activators of Nrf2 enter the nucleus to exert most of their inhibitory impact on Nrf2 ubiquitination and degradation...
  16. pmc The principal urinary metabolite of allyl isothiocyanate, N-acetyl-S-(N-allylthiocarbamoyl)cysteine, inhibits the growth and muscle invasion of bladder cancer
    Arup Bhattacharya
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Carcinogenesis 33:394-8. 2012
    ..Furthermore, comparison of the pharmacokinetic and physical properties of NAC-AITC with those of AITC suggests that NAC-AITC is superior to AITC for potential use for prevention and therapy of bladder cancer...
  17. pmc Intake of cruciferous vegetables modifies bladder cancer survival
    Li Tang
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Carlton House Rm 365, Buffalo, NY 14263, USA
    Cancer Epidemiol Biomarkers Prev 19:1806-11. 2010
    ..Due to the potent antiproliferative effects of dietary isothiocyanates on bladder cancer in in vitro and in vivo models, cruciferous vegetable intake may also play a role in survival among patients with bladder cancer...
  18. pmc 5,6-Dihydrocyclopenta[c][1,2]-dithiole-3(4H)-thione is a promising cancer chemopreventive agent in the urinary bladder
    Joseph D Paonessa
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Chem Biol Interact 180:119-26. 2009
    ..In conclusion, CPDT potently and preferentially induces Phase 2 enzymes in the bladder epithelium and Nrf2 is its key mediator...
  19. ncbi request reprint c-jun/AP-1 activation does not affect the antiproliferative activity of phenethyl isothiocyanate, a cruciferous vegetable-derived cancer chemopreventive agent
    Song Yao
    Department of Chemoprevention, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Mol Carcinog 45:605-12. 2006
    ....
  20. pmc Organ-specific exposure and response to sulforaphane, a key chemopreventive ingredient in broccoli: implications for cancer prevention
    Omkara L Veeranki
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Br J Nutr 109:25-32. 2013
    ..These findings may provide a basis for prioritising organs for further chemopreventive study of SF...
  21. pmc Allyl isothiocyanate arrests cancer cells in mitosis, and mitotic arrest in turn leads to apoptosis via Bcl-2 protein phosphorylation
    Feng Geng
    Department of Cancer Prevention and Control, California Institute of Technology, Pasadena, California 91125, USA
    J Biol Chem 286:32259-67. 2011
    ..Taken together, this study has revealed a novel anticancer mechanism of a phytochemical that is commonly present in human diet...
  22. ncbi request reprint Cellular accumulation of dietary anticarcinogenic isothiocyanates is followed by transporter-mediated export as dithiocarbamates
    Eileen C Callaway
    Arizona Cancer Center, College of Medicine, University of Arizona, Tucson, AZ 85724, USA
    Cancer Lett 204:23-31. 2004
    ..These findings are consistent with our previous results regarding cellular export of another anticarcinogenic ITC, sulforaphane, and suggest a common cellular response to ITCs...
  23. ncbi request reprint Involvement of mitogen-activated protein kinases and protein kinase C in regulation of antioxidant response element activity in human keratinocytes
    Ming Zhu
    Translational Genomics Research Institute, Phoenix, AZ, USA
    Cancer Lett 244:220-8. 2006
    ..This suggests that the suppressive effect of UVB on ARE activation by tBHQ is mediated by a JNK pathway(s). These findings provide useful information for developing novel strategies for skin cancer chemoprotection through ARE activation...
  24. ncbi request reprint Mitochondria are the primary target in isothiocyanate-induced apoptosis in human bladder cancer cells
    Li Tang
    Department of Chemoprevention, Roswell Park Cancer Institute, Basic Science 711, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Mol Cancer Ther 4:1250-9. 2005
    ....
  25. pmc High cellular accumulation of sulphoraphane, a dietary anticarcinogen, is followed by rapid transporter-mediated export as a glutathione conjugate
    Yuesheng Zhang
    Arizona Cancer Center, University of Arizona, 1515 N Campbell Avenue, P O Box 245024, Tucson, AZ 85724, U S A
    Biochem J 364:301-7. 2002
    ....
  26. pmc Prolidase directly binds and activates epidermal growth factor receptor and stimulates downstream signaling
    Lu Yang
    Department of Chemoprevention, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    J Biol Chem 288:2365-75. 2013
    ..In conclusion, PEPD is a ligand of EGFR and presents a novel mechanism of EGFR activation...
  27. pmc Allyl isothiocyanate-rich mustard seed powder inhibits bladder cancer growth and muscle invasion
    Arup Bhattacharya
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Carcinogenesis 31:2105-10. 2010
    ..MSP-1 is thus an attractive delivery vehicle for AITC and it strongly inhibits bladder cancer development and progression...
  28. ncbi request reprint Human prx1 gene is a target of Nrf2 and is up-regulated by hypoxia/reoxygenation: implication to tumor biology
    Yun Jeong Kim
    Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 67:546-54. 2007
    ..The above information suggests that the Nrf2-Prx1 axis may be a fruitful target for intervention with respect to inhibiting the malignant progression and/or reducing the treatment resistance of cancer cells...
  29. pmc Inhibition of bladder cancer development by allyl isothiocyanate
    Arup Bhattacharya
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Carcinogenesis 31:281-6. 2010
    ..Moreover, we show that AITC is a multi-targeted agent against bladder cancer. In conclusion, AITC is selectively delivered to bladder cancer tissue through urinary excretion and potently inhibits bladder cancer development and invasion...
  30. ncbi request reprint Dietary isothiocyanates inhibit the growth of human bladder carcinoma cells
    Li Tang
    Department of Chemoprevention, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Nutr 134:2004-10. 2004
    ..However, further increases in ITC concentrations abolished their activities, described above. These findings show that urinary ITC concentrations may need to be maintained at low micromolar concentrations for bladder cancer prevention...
  31. pmc Sulforaphane inhibits 4-aminobiphenyl-induced DNA damage in bladder cells and tissues
    Yi Ding
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Carcinogenesis 31:1999-2003. 2010
    ....
  32. ncbi request reprint Phase II enzyme inducer, sulforaphane, inhibits UVB-induced AP-1 activation in human keratinocytes by a novel mechanism
    Ming Zhu
    Arizona Cancer Center, The University of Arizona, Tucson, Arizona 85724 5024, USA
    Mol Carcinog 41:179-86. 2004
    ..This direct effect of SF on AP-1 DNA binding is a novel mechanism for the action of a drug inhibitor of AP-1 activation...
  33. ncbi request reprint Effects of glutathione S-transferase A1 (GSTA1) genotype and potential modifiers on breast cancer risk
    Jiyoung Ahn
    Department of Epidemiology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Carcinogenesis 27:1876-82. 2006
    ..These data indicate that GSTA1 genotypes related to reduced GSTA1 expression are associated with increased breast cancer primarily among women with lower consumption of cruciferous vegetables and among current smokers...
  34. doi request reprint Consumption of raw cruciferous vegetables is inversely associated with bladder cancer risk
    Li Tang
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Cancer Epidemiol Biomarkers Prev 17:938-44. 2008
    ..93, respectively). These data suggest that cruciferous vegetables, when consumed raw, may reduce the risk of bladder cancer, an effect consistent with the role of dietary isothiocyanates as chemopreventive agents against bladder cancer...
  35. ncbi request reprint The principal urinary metabolites of dietary isothiocyanates, N-acetylcysteine conjugates, elicit the same anti-proliferative response as their parent compounds in human bladder cancer cells
    Li Tang
    Department of Chemoprevention, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Anticancer Drugs 17:297-305. 2006
    ..These data show that the NAC-ITCs are biologically similar to their parent compounds and are highly effective against human bladder cancer cells...
  36. ncbi request reprint Expression and regulation of glutathione S-transferase P1-1 in cultured human epidermal cells
    Yuesheng Zhang
    Department of Medicine, College of Medicine, Arizona Cancer Center, University of Arizona, Room 4985A, 1515 N Campbell Avenue, Tucson, AZ 85724, USA
    J Dermatol Sci 30:205-14. 2002
    ..Moreover, although ras has been shown to stimulate the expression of human GSTP1-1, the effect of c-Ha-ras on GSTP1-1 expression in HaCaT cells appears limited...
  37. ncbi request reprint Isothiocyanates in the chemoprevention of bladder cancer
    Li Tang
    Department of Chemoprevention, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Curr Drug Metab 5:193-201. 2004
    ..As a result, potential systemic adverse effects of ITCs may be minimized when using ITCs for chemoprevention of bladder carcinogenesis. Taken together, ITCs may be especially useful for the prevention of bladder cancer...
  38. ncbi request reprint Enhanced inhibition of urinary bladder cancer growth and muscle invasion by allyl isothiocyanate and celecoxib in combination
    Arup Bhattacharya
    Departments of Chemoprevention, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Carcinogenesis . 2013
    ..These data show that AITC and celecoxib complement each other for inhibition of bladder cancer and provide a novel combination approach for potential use for prevention or treatment of human bladder cancer...
  39. ncbi request reprint Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans
    Lingxiang Ye
    Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, 725 N Wolfe Street, Baltimore, MD 21205, USA
    Clin Chim Acta 316:43-53. 2002
    ....
  40. ncbi request reprint Evaluation of isothiocyanates as potent inducers of carcinogen-detoxifying enzymes in the urinary bladder: critical nature of in vivo bioassay
    Rex Munday
    AgResearch, Ruakura Agricultural Centre, Hamilton, New Zealand
    Nutr Cancer 54:223-31. 2006
    ....
  41. doi request reprint Inhibition of urinary bladder carcinogenesis by broccoli sprouts
    Rex Munday
    AgResearch Limited, Ruakura Agricultural Research Center, Hamilton, New Zealand
    Cancer Res 68:1593-600. 2008
    ..In conclusion, broccoli sprout extract is a highly promising substance for bladder cancer prevention and the isothiocyanates in the extract are selectively delivered to the bladder epithelium through urinary excretion...
  42. pmc Structure-activity relationships and organ specificity in the induction of GST and NQO1 by alkyl-aryl isothiocyanates
    Rex Munday
    Ruakura Agricultural Research Centre, AgResearch, Private Bag 3123, Hamilton, New Zealand
    Pharm Res 25:2164-70. 2008
    ....
  43. ncbi request reprint Structure-activity relationships in the induction of Phase II enzymes by derivatives of 3H-1,2-dithiole-3-thione in rats
    Rex Munday
    AgResearch, Ruakura Agricultural Research Centre, Private Bag 3123, Hamilton, New Zealand
    Chem Biol Interact 160:115-22. 2006
    ..In view of the evidence that Phase II enzyme induction plays a major role in the chemoprotective action of dithiolethiones, evaluation of the anti-cancer activity of the more potent inducers identified in this study would be of interest...

Research Grants16

  1. Bladder Cancer Chemoprevention with Allyl Isothiocyanate
    Yuesheng Zhang; Fiscal Year: 2010
    ....
  2. Bladder Cancer Chemoprevention with Allyl Isothiocyanate
    Yuesheng Zhang; Fiscal Year: 2009
    ....
  3. Novel Dithiolethiones for Bladder Cancer Prevention
    Yuesheng Zhang; Fiscal Year: 2009
    ....
  4. Novel Dithiolethiones for Bladder Cancer Prevention
    Yuesheng Zhang; Fiscal Year: 2007
    ....
  5. Isothiocyanates in the Chemoprevention of Bladder Cancer
    Yuesheng Zhang; Fiscal Year: 2007
    ..Aim 5 will determine the efficacy of an orally administered ITC in inhibiting N-butyl-N- (4-hydroxybutyl)-nitrosamine-induced bladder tumorigenesis in F344 rats. ..
  6. Prevention of Bladder Cancer with Broccoli Sprouts
    Yuesheng Zhang; Fiscal Year: 2004
    ..Tumor incidence, tumor multiplicity, and the nature of each tumor will be determined. ..
  7. CANCER CHEMOPREVENTION MECHANISMS OF ISOTHIOCYANATES
    Yuesheng Zhang; Fiscal Year: 2002
    ..Finally, Aim 3 is proposed to determine how cellular accumulation levels of these compounds affect their potencies in inducing apoptosis. ..
  8. Novel Dithiolethiones for Bladder Cancer Prevention
    Yuesheng Zhang; Fiscal Year: 2010
    ....