Research Topics
Genomes and Genes | Yuesheng ZhangSummaryAffiliation: Roswell Park Cancer Institute Country: USA Publications
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Publications
The 1,2-benzenedithiole-based cyclocondensation assay: a valuable tool for the measurement of chemopreventive isothiocyanatesYuesheng Zhang
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Crit Rev Food Sci Nutr 52:525-32. 2012..Moreover, detailed discussion is also provided to show how this assay has been used to advance our understanding of the cancer chemopreventive potential and the mechanism of action of ITCs...- The molecular basis that unifies the metabolism, cellular uptake and chemopreventive activities of dietary isothiocyanatesYuesheng Zhang
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Carcinogenesis 33:2-9. 2012..This knowledge deepens our understanding about the biological activities of ITCs and may facilitate further research and development of these compounds for cancer prevention and treatment... 
Cancer-preventive isothiocyanates: dichotomous modulators of oxidative stressYuesheng Zhang
Department of Chemoprevention, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
Free Radic Biol Med 38:70-7. 2005..Ironically, although ITC-induced stress may lead to oxidative damage, it has become increasingly clear that much of the chemoprotective activity of ITCs stems from the response of cells to the stress induced by these compounds...- Vegetable-derived isothiocyanates: anti-proliferative activity and mechanism of actionYuesheng Zhang
Department of Chemoprevention, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Proc Nutr Soc 65:68-75. 2006..Taken together, dietary ITC are highly-promising anti-cancer agents, capable of targetting multiple cellular components that are important for tumour cell survival and proliferation... - Induction of GST and NQO1 in cultured bladder cells and in the urinary bladders of rats by an extract of broccoli (Brassica oleracea italica) sproutsYuesheng Zhang
Department of Chemoprevention, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
J Agric Food Chem 54:9370-6. 2006..In conclusion, broccoli sprout ITC extract is a potent inducer of GST and NQO1 in the bladder and is a promising agent for prevention of bladder cancer... - Cancer-preventive isothiocyanates: measurement of human exposure and mechanism of actionYuesheng Zhang
Department of Chemoprevention, Roswell Park Cancer Institute, Basic Science 711, Elm and Carlton Streets, Buffalo, NY 14263, USA
Mutat Res 555:173-90. 2004..These mechanisms, which are discussed in detail in this review, illustrate the remarkable ability of ITCs to inhibit cancer development-effective against both developing and developed cancer cells... - Discovery and development of sulforaphane as a cancer chemopreventive phytochemicalYuesheng Zhang
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Acta Pharmacol Sin 28:1343-54. 2007.... - Dithiolethiones for cancer chemoprevention: where do we stand?Yuesheng Zhang
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
Mol Cancer Ther 7:3470-9. 2008..Further investigation of these compounds may lead to development of effective and safe agents for cancer prevention in humans... - Allyl isothiocyanate as a cancer chemopreventive phytochemicalYuesheng Zhang
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Mol Nutr Food Res 54:127-35. 2010..Overall, AITC exhibits many desirable attributes of a cancer chemopreventive agent, and further studies are warranted in order to elucidate its mechanism of action and to assess its protective activity in humans... - Selected isothiocyanates rapidly induce growth inhibition of cancer cellsYuesheng Zhang
Arizona Cancer Center and Department of Medicine, College of Medicine, University of Arizona, Tucson, AZ, USA
Mol Cancer Ther 2:1045-52. 2003.... - A strategy for cancer prevention: stimulation of the Nrf2-ARE signaling pathwayYuesheng Zhang
Department of Chemoprevention, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Mol Cancer Ther 3:885-93. 2004..Moreover, many ARE-mediated inducers have been identified, and several of them have shown promising cancer preventive activity... - Identification of an unintended consequence of Nrf2-directed cytoprotection against a key tobacco carcinogen plus a counteracting chemopreventive interventionJoseph D Paonessa
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Cancer Res 71:3904-11. 2011..Thus, CPDT exemplifies a counteracting solution to the dilemma posed by Nrf2... - Cruciferous vegetable intake is inversely associated with lung cancer risk among smokers: a case-control studyLi Tang
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
BMC Cancer 10:162. 2010..Inverse associations between cruciferous vegetable intake and lung cancer risk have been consistently reported. However, associations within smoking status subgroups have not been consistently addressed... - Potent activation of mitochondria-mediated apoptosis and arrest in S and M phases of cancer cells by a broccoli sprout extractLi Tang
Department of Chemoprevention, Roswell Park Cancer Institute, Elm and Carlton Streets, Science 711, Buffalo, NY 14263, USA
Mol Cancer Ther 5:935-44. 2006..These data show that broccoli sprout isothiocyanate extract is a highly promising substance for cancer prevention/treatment and that its antiproliferative activity is exclusively derived from isothiocyanates... - Mechanism of chemical activation of Nrf2Yun Li
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, United States of America
PLoS ONE 7:e35122. 2012..These findings provide significant new insight about Nrf2 activation and suggest that exogenous chemical activators of Nrf2 enter the nucleus to exert most of their inhibitory impact on Nrf2 ubiquitination and degradation... - The principal urinary metabolite of allyl isothiocyanate, N-acetyl-S-(N-allylthiocarbamoyl)cysteine, inhibits the growth and muscle invasion of bladder cancerArup Bhattacharya
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Carcinogenesis 33:394-8. 2012..Furthermore, comparison of the pharmacokinetic and physical properties of NAC-AITC with those of AITC suggests that NAC-AITC is superior to AITC for potential use for prevention and therapy of bladder cancer... - Intake of cruciferous vegetables modifies bladder cancer survivalLi Tang
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Carlton House Rm 365, Buffalo, NY 14263, USA
Cancer Epidemiol Biomarkers Prev 19:1806-11. 2010..Due to the potent antiproliferative effects of dietary isothiocyanates on bladder cancer in in vitro and in vivo models, cruciferous vegetable intake may also play a role in survival among patients with bladder cancer... - 5,6-Dihydrocyclopenta[c][1,2]-dithiole-3(4H)-thione is a promising cancer chemopreventive agent in the urinary bladderJoseph D Paonessa
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
Chem Biol Interact 180:119-26. 2009..In conclusion, CPDT potently and preferentially induces Phase 2 enzymes in the bladder epithelium and Nrf2 is its key mediator... - c-jun/AP-1 activation does not affect the antiproliferative activity of phenethyl isothiocyanate, a cruciferous vegetable-derived cancer chemopreventive agentSong Yao
Department of Chemoprevention, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Mol Carcinog 45:605-12. 2006.... - Organ-specific exposure and response to sulforaphane, a key chemopreventive ingredient in broccoli: implications for cancer preventionOmkara L Veeranki
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
Br J Nutr 109:25-32. 2013..These findings may provide a basis for prioritising organs for further chemopreventive study of SF... - Allyl isothiocyanate arrests cancer cells in mitosis, and mitotic arrest in turn leads to apoptosis via Bcl-2 protein phosphorylationFeng Geng
Department of Cancer Prevention and Control, California Institute of Technology, Pasadena, California 91125, USA
J Biol Chem 286:32259-67. 2011..Taken together, this study has revealed a novel anticancer mechanism of a phytochemical that is commonly present in human diet... - Mitochondria are the primary target in isothiocyanate-induced apoptosis in human bladder cancer cellsLi Tang
Department of Chemoprevention, Roswell Park Cancer Institute, Basic Science 711, Elm and Carlton Streets, Buffalo, NY 14263, USA
Mol Cancer Ther 4:1250-9. 2005.... - Cellular accumulation of dietary anticarcinogenic isothiocyanates is followed by transporter-mediated export as dithiocarbamatesEileen C Callaway
Arizona Cancer Center, College of Medicine, University of Arizona, Tucson, AZ 85724, USA
Cancer Lett 204:23-31. 2004..These findings are consistent with our previous results regarding cellular export of another anticarcinogenic ITC, sulforaphane, and suggest a common cellular response to ITCs... - High cellular accumulation of sulphoraphane, a dietary anticarcinogen, is followed by rapid transporter-mediated export as a glutathione conjugateYuesheng Zhang
Arizona Cancer Center, University of Arizona, 1515 N Campbell Avenue, P O Box 245024, Tucson, AZ 85724, U S A
Biochem J 364:301-7. 2002.... - Involvement of mitogen-activated protein kinases and protein kinase C in regulation of antioxidant response element activity in human keratinocytesMing Zhu
Translational Genomics Research Institute, Phoenix, AZ, USA
Cancer Lett 244:220-8. 2006..This suggests that the suppressive effect of UVB on ARE activation by tBHQ is mediated by a JNK pathway(s). These findings provide useful information for developing novel strategies for skin cancer chemoprotection through ARE activation... - Prolidase directly binds and activates epidermal growth factor receptor and stimulates downstream signalingLu Yang
Department of Chemoprevention, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
J Biol Chem 288:2365-75. 2013..In conclusion, PEPD is a ligand of EGFR and presents a novel mechanism of EGFR activation... - Allyl isothiocyanate-rich mustard seed powder inhibits bladder cancer growth and muscle invasionArup Bhattacharya
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Carcinogenesis 31:2105-10. 2010..MSP-1 is thus an attractive delivery vehicle for AITC and it strongly inhibits bladder cancer development and progression... - Human prx1 gene is a target of Nrf2 and is up-regulated by hypoxia/reoxygenation: implication to tumor biologyYun Jeong Kim
Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Cancer Res 67:546-54. 2007..The above information suggests that the Nrf2-Prx1 axis may be a fruitful target for intervention with respect to inhibiting the malignant progression and/or reducing the treatment resistance of cancer cells... - Inhibition of bladder cancer development by allyl isothiocyanateArup Bhattacharya
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Carcinogenesis 31:281-6. 2010..Moreover, we show that AITC is a multi-targeted agent against bladder cancer. In conclusion, AITC is selectively delivered to bladder cancer tissue through urinary excretion and potently inhibits bladder cancer development and invasion... - Dietary isothiocyanates inhibit the growth of human bladder carcinoma cellsLi Tang
Department of Chemoprevention, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
J Nutr 134:2004-10. 2004..However, further increases in ITC concentrations abolished their activities, described above. These findings show that urinary ITC concentrations may need to be maintained at low micromolar concentrations for bladder cancer prevention... - Phase II enzyme inducer, sulforaphane, inhibits UVB-induced AP-1 activation in human keratinocytes by a novel mechanismMing Zhu
Arizona Cancer Center, The University of Arizona, Tucson, Arizona 85724-5024, USA
Mol Carcinog 41:179-86. 2004..This direct effect of SF on AP-1 DNA binding is a novel mechanism for the action of a drug inhibitor of AP-1 activation... - Sulforaphane inhibits 4-aminobiphenyl-induced DNA damage in bladder cells and tissuesYi Ding
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Carcinogenesis 31:1999-2003. 2010.... - Effects of glutathione S-transferase A1 (GSTA1) genotype and potential modifiers on breast cancer riskJiyoung Ahn
Department of Epidemiology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Carcinogenesis 27:1876-82. 2006..These data indicate that GSTA1 genotypes related to reduced GSTA1 expression are associated with increased breast cancer primarily among women with lower consumption of cruciferous vegetables and among current smokers... 
Consumption of raw cruciferous vegetables is inversely associated with bladder cancer riskLi Tang
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Cancer Epidemiol Biomarkers Prev 17:938-44. 2008..93, respectively). These data suggest that cruciferous vegetables, when consumed raw, may reduce the risk of bladder cancer, an effect consistent with the role of dietary isothiocyanates as chemopreventive agents against bladder cancer...- The principal urinary metabolites of dietary isothiocyanates, N-acetylcysteine conjugates, elicit the same anti-proliferative response as their parent compounds in human bladder cancer cellsLi Tang
Department of Chemoprevention, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Anticancer Drugs 17:297-305. 2006..These data show that the NAC-ITCs are biologically similar to their parent compounds and are highly effective against human bladder cancer cells... - Isothiocyanates in the chemoprevention of bladder cancerLi Tang
Department of Chemoprevention, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Curr Drug Metab 5:193-201. 2004..As a result, potential systemic adverse effects of ITCs may be minimized when using ITCs for chemoprevention of bladder carcinogenesis. Taken together, ITCs may be especially useful for the prevention of bladder cancer... - Expression and regulation of glutathione S-transferase P1-1 in cultured human epidermal cellsYuesheng Zhang
Department of Medicine, College of Medicine, Arizona Cancer Center, University of Arizona, Room 4985A, 1515 N Campbell Avenue, Tucson, AZ 85724, USA
J Dermatol Sci 30:205-14. 2002..Moreover, although ras has been shown to stimulate the expression of human GSTP1-1, the effect of c-Ha-ras on GSTP1-1 expression in HaCaT cells appears limited... - Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humansLingxiang Ye
Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, USA
Clin Chim Acta 316:43-53. 2002.... - Inhibition of urinary bladder carcinogenesis by broccoli sproutsRex Munday
AgResearch Limited, Ruakura Agricultural Research Center, Hamilton, New Zealand
Cancer Res 68:1593-600. 2008..In conclusion, broccoli sprout extract is a highly promising substance for bladder cancer prevention and the isothiocyanates in the extract are selectively delivered to the bladder epithelium through urinary excretion... - Structure-activity relationships and organ specificity in the induction of GST and NQO1 by alkyl-aryl isothiocyanatesRex Munday
Ruakura Agricultural Research Centre, AgResearch, Private Bag 3123, Hamilton, New Zealand
Pharm Res 25:2164-70. 2008.... - Evaluation of isothiocyanates as potent inducers of carcinogen-detoxifying enzymes in the urinary bladder: critical nature of in vivo bioassayRex Munday
AgResearch, Ruakura Agricultural Centre, Hamilton, New Zealand
Nutr Cancer 54:223-31. 2006.... - Structure-activity relationships in the induction of Phase II enzymes by derivatives of 3H-1,2-dithiole-3-thione in ratsRex Munday
AgResearch, Ruakura Agricultural Research Centre, Private Bag 3123, Hamilton, New Zealand
Chem Biol Interact 160:115-22. 2006..In view of the evidence that Phase II enzyme induction plays a major role in the chemoprotective action of dithiolethiones, evaluation of the anti-cancer activity of the more potent inducers identified in this study would be of interest...
Research Grants
- Bladder Cancer Chemoprevention with Allyl IsothiocyanateYuesheng Zhang; Fiscal Year: 2010....
- Bladder Cancer Chemoprevention with Allyl IsothiocyanateYuesheng Zhang; Fiscal Year: 2009....
- Novel Dithiolethiones for Bladder Cancer PreventionYuesheng Zhang; Fiscal Year: 2009....
- Novel Dithiolethiones for Bladder Cancer PreventionYuesheng Zhang; Fiscal Year: 2007....
- Isothiocyanates in the Chemoprevention of Bladder CancerYuesheng Zhang; Fiscal Year: 2007..Aim 5 will determine the efficacy of an orally administered ITC in inhibiting N-butyl-N- (4-hydroxybutyl)-nitrosamine-induced bladder tumorigenesis in F344 rats. ..
- Prevention of Bladder Cancer with Broccoli SproutsYuesheng Zhang; Fiscal Year: 2004..Tumor incidence, tumor multiplicity, and the nature of each tumor will be determined. ..
- CANCER CHEMOPREVENTION MECHANISMS OF ISOTHIOCYANATESYuesheng Zhang; Fiscal Year: 2002..Finally, Aim 3 is proposed to determine how cellular accumulation levels of these compounds affect their potencies in inducing apoptosis. ..
- Novel Dithiolethiones for Bladder Cancer PreventionYuesheng Zhang; Fiscal Year: 2010....