- A deficiency in the region homologous to human 17q21.33-q23.2 causes heart defects in miceY Eugene Yu
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Genetics 173:297-307. 2006..Therefore, we have identified a new dosage-sensitive genomic region that may be critical for normal heart development in both mice and humans...
- Duplication of the entire 22.9 Mb human chromosome 21 syntenic region on mouse chromosome 16 causes cardiovascular and gastrointestinal abnormalitiesZhongyou Li
Department of Cancer Genetics and Center for Genetics and Pharmacology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Hum Mol Genet 16:1359-66. 2007..This new mouse model represents a powerful tool to further understand the molecular and cellular mechanisms of Down syndrome...