Research Topics
Species | Yue WuSummaryAffiliation: Roswell Park Cancer Institute Country: USA Publications
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Detail Information
Publications
The antiandrogenic effect of finasteride against a mutant androgen receptorYue Wu
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA
Cancer Biol Ther 11:902-9. 2011..The implication of the above findings is discussed in the context of developing strategies to improve the outcome of androgen deprivation therapy...- Chemotherapeutic sensitization by endoplasmic reticulum stress: increasing the efficacy of taxane against prostate cancerYue Wu
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Cancer Biol Ther 8:146-52. 2009..Both the intrinsic and extrinsic apoptotic pathways were involved in the sensitization mechanism. Our study supports the idea that marshalling ER stress apoptotic response is conducive to chemotherapeutic sensitization... 
Androgen receptor-mTOR crosstalk is regulated by testosterone availability: implication for prostate cancer cell survivalYue Wu
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Anticancer Res 30:3895-901. 2010..Signaling between androgen receptor (AR) and mTOR may be crucial for prostate cancer cells to endure the low androgen and suboptimal nutrient conditions produced by androgen deprivation therapy...
Survival advantage of AMPK activation to androgen-independent prostate cancer cells during energy stressRishi Raj Chhipa
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, United States
Cell Signal 22:1554-61. 2010....- Prx1 enhances androgen receptor function in prostate cancer cells by increasing receptor affinity to dihydrotestosteroneRishi Raj Chhipa
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Mol Cancer Res 7:1543-52. 2009..The above findings led us to believe that Prx1 may be a therapeutic target in blocking the transition of prostate cancer from an androgen-dependent to an androgen-refractory phenotype... - Endoplasmic reticulum stress signal mediators are targets of selenium actionYue Wu
Department of Cancer Chemoprevention, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Cancer Res 65:9073-9. 2005..The present study thus provides strong evidence to support an important role of ER stress response in mediating the anticancer effect of selenium... - Augmented suppression of androgen receptor signaling by a combination of alpha-tocopheryl succinate and methylseleninic acidHaitao Zhang
Department of Cancer Chemoprevention, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Cancer 107:2942-8. 2006..The present study was designed to investigate whether a combination of alphaTS and MSA would produce an additive or a greater than additive effect in suppressing AR level, AR transactivation, and prostate-specific antigen (PSA)... - AMPK-mediated autophagy is a survival mechanism in androgen-dependent prostate cancer cells subjected to androgen deprivation and hypoxiaRishi Raj Chhipa
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Cell Signal 23:1466-72. 2011..g., AMPK or beclin-1, more cells would die by apoptosis. The occurrence of autophagy is thus a survival mechanism for androgen-dependent prostate cancer cells to escape from an androgen-deprived and hypoxic subsistence... - Delineating the mechanism by which selenium deactivates Akt in prostate cancer cellsYue Wu
Department of Cancer Chemoprevention, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
Mol Cancer Ther 5:246-52. 2006..The finding suggests that selenium-mediated dephosphorylation of Akt via calcineurin is likely to be an additional mechanism in regulating the status of phospho-Akt... - The transcriptomics of de novo androgen biosynthesis in prostate cancer cells following androgen reductionJinrong Cheng
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA
Cancer Biol Ther 9:1033-42. 2010..In brief, our results suggest that the VCaP model is an appropriate model for further investigation of targeting the androgen-AR axis to block the emergence of castration-resistant prostate cancer... - Apoptosis induced by t10,c12-conjugated linoleic acid is mediated by an atypical endoplasmic reticulum stress responseLihui Ou
Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY, USA
J Lipid Res 49:985-94. 2008..In summary, our data demonstrate that apoptosis induced by t10,c12-CLA is mediated, at least in part, through an atypical ER stress response that culminates in the induction of CHOP and the cleavage of caspase-12... - Cellular and molecular effects of alpha-tocopheryloxybutyrate: lessons for the design of vitamin E analog for cancer preventionYue Wu
Department of Cancer Chemoprevention, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Anticancer Res 24:3795-802. 2004..The future design of new anticancer tocopherol analogs should incorporate the ether linkage of the side chain for esterase resistance as well as other structural modifications for enhanced blocking of membrane signaling... - Repeat polymorphisms in estrogen metabolism genes and prostate cancer risk: results from the Prostate Cancer Prevention TrialLi Tang
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Carcinogenesis 32:1500-6. 2011....