Yue Wu

Summary

Affiliation: Roswell Park Cancer Institute
Country: USA

Publications

  1. pmc The antiandrogenic effect of finasteride against a mutant androgen receptor
    Yue Wu
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA
    Cancer Biol Ther 11:902-9. 2011
  2. pmc Chemotherapeutic sensitization by endoplasmic reticulum stress: increasing the efficacy of taxane against prostate cancer
    Yue Wu
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Biol Ther 8:146-52. 2009
  3. doi request reprint The direct inhibitory effect of dutasteride or finasteride on androgen receptor activity is cell line specific
    Rishi Raj Chhipa
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, USA
    Prostate 73:1483-94. 2013
  4. ncbi request reprint Androgen receptor-mTOR crosstalk is regulated by testosterone availability: implication for prostate cancer cell survival
    Yue Wu
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Anticancer Res 30:3895-901. 2010
  5. doi request reprint Survival advantage of AMPK activation to androgen-independent prostate cancer cells during energy stress
    Rishi Raj Chhipa
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, United States
    Cell Signal 22:1554-61. 2010
  6. pmc Prx1 enhances androgen receptor function in prostate cancer cells by increasing receptor affinity to dihydrotestosterone
    Rishi Raj Chhipa
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Mol Cancer Res 7:1543-52. 2009
  7. pmc Augmented suppression of androgen receptor signaling by a combination of alpha-tocopheryl succinate and methylseleninic acid
    Haitao Zhang
    Department of Cancer Chemoprevention, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer 107:2942-8. 2006
  8. ncbi request reprint Endoplasmic reticulum stress signal mediators are targets of selenium action
    Yue Wu
    Department of Cancer Chemoprevention, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 65:9073-9. 2005
  9. doi request reprint Prostate cancer cells differ in testosterone accumulation, dihydrotestosterone conversion, and androgen receptor signaling response to steroid 5α-reductase inhibitors
    Yue Wu
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Prostate 73:1470-82. 2013
  10. pmc AMPK-mediated autophagy is a survival mechanism in androgen-dependent prostate cancer cells subjected to androgen deprivation and hypoxia
    Rishi Raj Chhipa
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Cell Signal 23:1466-72. 2011

Collaborators

Detail Information

Publications15

  1. pmc The antiandrogenic effect of finasteride against a mutant androgen receptor
    Yue Wu
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA
    Cancer Biol Ther 11:902-9. 2011
    ..The implication of the above findings is discussed in the context of developing strategies to improve the outcome of androgen deprivation therapy...
  2. pmc Chemotherapeutic sensitization by endoplasmic reticulum stress: increasing the efficacy of taxane against prostate cancer
    Yue Wu
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Biol Ther 8:146-52. 2009
    ..Both the intrinsic and extrinsic apoptotic pathways were involved in the sensitization mechanism. Our study supports the idea that marshalling ER stress apoptotic response is conducive to chemotherapeutic sensitization...
  3. doi request reprint The direct inhibitory effect of dutasteride or finasteride on androgen receptor activity is cell line specific
    Rishi Raj Chhipa
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, USA
    Prostate 73:1483-94. 2013
    ..These drugs may possess off-target effects on the androgen receptor (AR) due to their structural similarity to DHT...
  4. ncbi request reprint Androgen receptor-mTOR crosstalk is regulated by testosterone availability: implication for prostate cancer cell survival
    Yue Wu
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Anticancer Res 30:3895-901. 2010
    ..Signaling between androgen receptor (AR) and mTOR may be crucial for prostate cancer cells to endure the low androgen and suboptimal nutrient conditions produced by androgen deprivation therapy...
  5. doi request reprint Survival advantage of AMPK activation to androgen-independent prostate cancer cells during energy stress
    Rishi Raj Chhipa
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, United States
    Cell Signal 22:1554-61. 2010
    ....
  6. pmc Prx1 enhances androgen receptor function in prostate cancer cells by increasing receptor affinity to dihydrotestosterone
    Rishi Raj Chhipa
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Mol Cancer Res 7:1543-52. 2009
    ..The above findings led us to believe that Prx1 may be a therapeutic target in blocking the transition of prostate cancer from an androgen-dependent to an androgen-refractory phenotype...
  7. pmc Augmented suppression of androgen receptor signaling by a combination of alpha-tocopheryl succinate and methylseleninic acid
    Haitao Zhang
    Department of Cancer Chemoprevention, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer 107:2942-8. 2006
    ..The present study was designed to investigate whether a combination of alphaTS and MSA would produce an additive or a greater than additive effect in suppressing AR level, AR transactivation, and prostate-specific antigen (PSA)...
  8. ncbi request reprint Endoplasmic reticulum stress signal mediators are targets of selenium action
    Yue Wu
    Department of Cancer Chemoprevention, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 65:9073-9. 2005
    ..The present study thus provides strong evidence to support an important role of ER stress response in mediating the anticancer effect of selenium...
  9. doi request reprint Prostate cancer cells differ in testosterone accumulation, dihydrotestosterone conversion, and androgen receptor signaling response to steroid 5α-reductase inhibitors
    Yue Wu
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Prostate 73:1470-82. 2013
    ..Factors affecting intracellular androgen levels and the androgen receptor (AR) signaling axis need to be examined systematically in order to fully understand the outcome of interventions using these drugs...
  10. pmc AMPK-mediated autophagy is a survival mechanism in androgen-dependent prostate cancer cells subjected to androgen deprivation and hypoxia
    Rishi Raj Chhipa
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Cell Signal 23:1466-72. 2011
    ..g., AMPK or beclin-1, more cells would die by apoptosis. The occurrence of autophagy is thus a survival mechanism for androgen-dependent prostate cancer cells to escape from an androgen-deprived and hypoxic subsistence...
  11. ncbi request reprint Delineating the mechanism by which selenium deactivates Akt in prostate cancer cells
    Yue Wu
    Department of Cancer Chemoprevention, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Mol Cancer Ther 5:246-52. 2006
    ..The finding suggests that selenium-mediated dephosphorylation of Akt via calcineurin is likely to be an additional mechanism in regulating the status of phospho-Akt...
  12. pmc The transcriptomics of de novo androgen biosynthesis in prostate cancer cells following androgen reduction
    Jinrong Cheng
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA
    Cancer Biol Ther 9:1033-42. 2010
    ..In brief, our results suggest that the VCaP model is an appropriate model for further investigation of targeting the androgen-AR axis to block the emergence of castration-resistant prostate cancer...
  13. pmc Apoptosis induced by t10,c12-conjugated linoleic acid is mediated by an atypical endoplasmic reticulum stress response
    Lihui Ou
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY, USA
    J Lipid Res 49:985-94. 2008
    ..In summary, our data demonstrate that apoptosis induced by t10,c12-CLA is mediated, at least in part, through an atypical ER stress response that culminates in the induction of CHOP and the cleavage of caspase-12...
  14. pmc Repeat polymorphisms in estrogen metabolism genes and prostate cancer risk: results from the Prostate Cancer Prevention Trial
    Li Tang
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Carcinogenesis 32:1500-6. 2011
    ....
  15. ncbi request reprint Cellular and molecular effects of alpha-tocopheryloxybutyrate: lessons for the design of vitamin E analog for cancer prevention
    Yue Wu
    Department of Cancer Chemoprevention, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Anticancer Res 24:3795-802. 2004
    ..The future design of new anticancer tocopherol analogs should incorporate the ether linkage of the side chain for esterase resistance as well as other structural modifications for enhanced blocking of membrane signaling...