Xinjiang Wang

Summary

Affiliation: Roswell Park Cancer Institute
Country: USA

Publications

  1. ncbi Mdm2 and MdmX partner to regulate p53
    Xinjiang Wang
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    FEBS Lett 586:1390-6. 2012
  2. ncbi MdmX protein is essential for Mdm2 protein-mediated p53 polyubiquitination
    Xinjiang Wang
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    J Biol Chem 286:23725-34. 2011
  3. ncbi p53 regulation: teamwork between RING domains of Mdm2 and MdmX
    Xinjiang Wang
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY, USA
    Cell Cycle 10:4225-9. 2011

Detail Information

Publications3

  1. ncbi Mdm2 and MdmX partner to regulate p53
    Xinjiang Wang
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    FEBS Lett 586:1390-6. 2012
    ..Unsurprisingly, stress signals target MdmX to disengage the p53/Mdm2 feedback loop for timely and appropriate p53 responses to these stresses...
  2. ncbi MdmX protein is essential for Mdm2 protein-mediated p53 polyubiquitination
    Xinjiang Wang
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    J Biol Chem 286:23725-34. 2011
    ..Together, our findings provide a biochemical basis for the requirement of both Mdm2 and MdmX in the dynamic regulation of p53 stability...
  3. ncbi p53 regulation: teamwork between RING domains of Mdm2 and MdmX
    Xinjiang Wang
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY, USA
    Cell Cycle 10:4225-9. 2011
    ..The new advance of the field assigned an essential role of the RING domain of MdmX in negative regulation of p53 in vivo, just like Mdm2 RING domain, through p53 degradation...