Research Topics
Genomes and Genes | Xiang yang WangSummaryAffiliation: Roswell Park Cancer Institute Country: USA Publications
Research Grants
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Detail Information
Publications
Development of cancer vaccines using autologous and recombinant high molecular weight stress proteinsXiang yang Wang
Department of Molecular and Cellular Biophysics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Methods 32:13-20. 2004..purification of hsp110 and grp170 from tumor tissue or cell lines; II. generation and characterization of in vitro HSP-antigen complexes by heat shock using recombinant HSPs derived from a baculovirus protein expression system...- Scavenger receptor-A negatively regulates antitumor immunityXiang yang Wang
Department of Cellular Stress Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Cancer Res 67:4996-5002. 2007..This is the first report illustrating that SR-A negatively regulates antigen-specific antitumor immunity, which has important clinical implications in vaccine design for cancer immunotherapy... - Extracellular targeting of endoplasmic reticulum chaperone glucose-regulated protein 170 enhances tumor immunity to a poorly immunogenic melanomaXiang yang Wang
Department of Cellular Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
J Immunol 177:1543-51. 2006.... - Immunization with tumor-derived ER chaperone grp170 elicits tumor-specific CD8+ T-cell responses and reduces pulmonary metastatic diseaseXiang yang Wang
Department of Molecular and Cellular Biophysics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Int J Cancer 105:226-31. 2003..These observations have strong clinical implications for using tumor-derived grp170 as a therapeutic vaccine against metastatic diseases... - Hsp110 over-expression increases the immunogenicity of the murine CT26 colon tumorXiang yang Wang
Department of Molecular and Cellular Biophysics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
Cancer Immunol Immunother 51:311-9. 2002..These observations demonstrate that manipulation of hsp110 expression in tumors, specifically when combined with GM-CSF, represents a potentially powerful approach to cancer vaccine formulation... 
Secretable chaperone Grp170 enhances therapeutic activity of a novel tumor suppressor, mda-7/IL-24Ping Gao
Departments of Cellular Stress Biology, Roswell Park Cancer Institute, Buffalo, New York, USA
Cancer Res 68:3890-8. 2008..Given multiple undefined antigens present endogenously within prostate cancer, these data provide a rationale for combining sgrp170-based vaccine strategy with mda-7/IL-24-targeted cancer therapy to induce durable systemic immunity...- Chaperoning function of stress protein grp170, a member of the hsp70 superfamily, is responsible for its immunoadjuvant activityJun Eui Park
Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
Cancer Res 66:1161-8. 2006.... - The chaperoning properties of mouse grp170, a member of the third family of hsp70 related proteinsJuneui Park
Department of Cellular Stress Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Biochemistry 42:14893-902. 2003..The ability of the C-terminal region to bind peptides is a unique feature of grp170... - HSP110-HER2/neu chaperone complex vaccine induces protective immunity against spontaneous mammary tumors in HER-2/neu transgenic miceMasoud H Manjili
Department of Molecular and Cellular Biophysics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
J Immunol 171:4054-61. 2003.... - Evaluation of renal cell carcinoma vaccines targeting carbonic anhydrase IX using heat shock protein 110Hyung L Kim
Department of Urologic Oncology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
Cancer Immunol Immunother 56:1097-105. 2007..Hsp110 + CA9 decreased tumor growth compared to control vaccinations. These studies suggest that recombinant hsp110 complexed to CA9 should be evaluated for treatment of RCC... - Cancer immunotherapy and heat-shock proteins: promises and challengesMasoud H Manjili
Department of Cellular Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
Expert Opin Biol Ther 4:363-73. 2004..These points should also clarify the conflicting findings about HSPs and promote our knowledge about other immuologically important components that may be present in HSP preparations... - Pattern recognition scavenger receptor SRA/CD204 down-regulates Toll-like receptor 4 signaling-dependent CD8 T-cell activationHuanfa Yi
Department of Cellular Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Blood 113:5819-28. 2009.... - Carbonic anhydrase IX has chaperone-like functions and is an immunoadjuvantYanping Wang
Department of Urologic Oncology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
Mol Cancer Ther 7:3867-77. 2008..CA9 has chaperone-like functions and CA9 shed from tumors may play a direct role in stimulating an adaptive immune response... - Secretion of stress protein grp170 promotes immune-mediated inhibition of murine prostate tumorPing Gao
Department of Cellular Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
Cancer Immunol Immunother 58:1319-28. 2009.... - Heat shock proteins HSP70 and GP96: structural insightsJohn G Facciponte
Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Cancer Immunol Immunother 55:339-46. 2006..Here, we review the studies that address the role of structural domains or regions of the immunochaperones HSP70 and GP96 that may be involved in the induction of adaptive or innate immune responses... - Heat shock proteins as vaccine adjuvants in infections and cancerBrahm H Segal
Department of Medicine, Immunology, Cellular Stress Biology, and Urologic Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Drug Discov Today 11:534-40. 2006..Their roles in priming multiple host defense pathways are being exploited in vaccine development for cancer and infectious diseases... - Targeted immunotherapy using reconstituted chaperone complexes of heat shock protein 110 and melanoma-associated antigen gp100Xiang-Yang Wang
Department of Molecular and Cellular Biophysics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Cancer Res 63:2553-60. 2003..Thus, the use of hsp110 to form natural chaperone complexes with tumor protein antigens such as gp100 represents a powerful approach to therapeutic vaccine formulation with significant potential for clinical application... - Hsp110 and Grp170, members of the Hsp70 superfamily, bind to scavenger receptor-A and scavenger receptor expressed by endothelial cells-IJohn G Facciponte
Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Eur J Immunol 37:2268-79. 2007..Thus, SR-A and SREC-I appear to contribute to the binding of hsp110 and grp170 on APC. Scavenger receptors, in general, contribute to the cross-presentation of hsp110-chaperoned protein antigen... - Peroxiredoxin 1 stimulates secretion of proinflammatory cytokines by binding to TLR4Jonah R Riddell
Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
J Immunol 184:1022-30. 2010..These findings suggest that Prx1 may act as danger signal similar to other TLR4-binding chaperone molecules such as HSP72... - Development of a recombinant HSP110-HER-2/neu vaccine using the chaperoning properties of HSP110Masoud H Manjili
Department of Molecular and Cellular Biophysics, Roswell Park Cancer Institute, Buffalo New York 14263, USA
Cancer Res 62:1737-42. 2002..The use of recombinant HSP110 to form natural chaperone complexes with large protein antigens represents a new and powerful approach for the design of protein-targeted cancer vaccines... - Generation of anti-tumor immunity using mammalian heat shock protein 70 DNA vaccines for cancer immunotherapyYing Li
Department of Immunology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
Vaccine 24:5360-70. 2006..Functional domain mapping and orientation of the E7 and Hsp70 in the fusion gene may have clinical implications for the design and optimization of Hsp70-based DNA vaccines... - Immunotherapy of cancer using heat shock proteinsMasoud H Manjili
Department of Molecular and Cellular Biophysics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Front Biosci 7:d43-52. 2002..Lastly, means of further enhancing the already potent activity of stress protein vaccines are presented, specifically the use of hyperthermia or CTLA-4 blockade as adjuvants... - Heat shock proteins and scavenger receptors: role in adaptive immune responsesJohn G Facciponte
Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York, USA
Immunol Invest 34:325-42. 2005..A better understanding of this interaction between HSPs and APCs may further unravel mechanisms of immunoadjuvant function of HSPs...
Research Grants
- Immunochaperone-based gene therapy targeting prostate cancerXiang yang Wang; Fiscal Year: 2007..The proposed research could lead to the design of a clinical trial for patients with prostate cancer in the very near future. ..
- Scavenger Receptor-A and Immune RegulationXiang yang Wang; Fiscal Year: 2007..Further, successful testing of SR-A-silenced dendritic cells as a vaccine to break tolerance against tumor- associated self-antigens will provide a novel immunotherapeutic approach targeting the inhibitory innate receptor. ..