Xiang yang Wang

Summary

Affiliation: Roswell Park Cancer Institute
Country: USA

Publications

  1. ncbi request reprint Development of cancer vaccines using autologous and recombinant high molecular weight stress proteins
    Xiang yang Wang
    Department of Molecular and Cellular Biophysics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Methods 32:13-20. 2004
  2. ncbi request reprint Extracellular targeting of endoplasmic reticulum chaperone glucose-regulated protein 170 enhances tumor immunity to a poorly immunogenic melanoma
    Xiang yang Wang
    Department of Cellular Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Immunol 177:1543-51. 2006
  3. ncbi request reprint Scavenger receptor-A negatively regulates antitumor immunity
    Xiang yang Wang
    Department of Cellular Stress Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 67:4996-5002. 2007
  4. ncbi request reprint Immunization with tumor-derived ER chaperone grp170 elicits tumor-specific CD8+ T-cell responses and reduces pulmonary metastatic disease
    Xiang yang Wang
    Department of Molecular and Cellular Biophysics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Int J Cancer 105:226-31. 2003
  5. ncbi request reprint Targeted immunotherapy using reconstituted chaperone complexes of heat shock protein 110 and melanoma-associated antigen gp100
    Xiang yang Wang
    Department of Molecular and Cellular Biophysics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 63:2553-60. 2003
  6. ncbi request reprint Development of a recombinant HSP110-HER-2/neu vaccine using the chaperoning properties of HSP110
    Masoud H Manjili
    Department of Molecular and Cellular Biophysics, Roswell Park Cancer Institute, Buffalo New York 14263, USA
    Cancer Res 62:1737-42. 2002
  7. ncbi request reprint Hsp110 over-expression increases the immunogenicity of the murine CT26 colon tumor
    Xiang yang Wang
    Department of Molecular and Cellular Biophysics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Immunol Immunother 51:311-9. 2002
  8. pmc Secretable chaperone Grp170 enhances therapeutic activity of a novel tumor suppressor, mda-7/IL-24
    Ping Gao
    Departments of Cellular Stress Biology, Roswell Park Cancer Institute, Buffalo, New York, USA
    Cancer Res 68:3890-8. 2008
  9. ncbi request reprint Chaperoning function of stress protein grp170, a member of the hsp70 superfamily, is responsible for its immunoadjuvant activity
    Jun Eui Park
    Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Res 66:1161-8. 2006
  10. ncbi request reprint The chaperoning properties of mouse grp170, a member of the third family of hsp70 related proteins
    Juneui Park
    Department of Cellular Stress Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Biochemistry 42:14893-902. 2003

Research Grants

  1. Immunochaperone-based gene therapy targeting prostate cancer
    Xiang yang Wang; Fiscal Year: 2007
  2. Scavenger Receptor-A and Immune Regulation
    Xiang yang Wang; Fiscal Year: 2007

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Development of cancer vaccines using autologous and recombinant high molecular weight stress proteins
    Xiang yang Wang
    Department of Molecular and Cellular Biophysics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Methods 32:13-20. 2004
    ..purification of hsp110 and grp170 from tumor tissue or cell lines; II. generation and characterization of in vitro HSP-antigen complexes by heat shock using recombinant HSPs derived from a baculovirus protein expression system...
  2. ncbi request reprint Extracellular targeting of endoplasmic reticulum chaperone glucose-regulated protein 170 enhances tumor immunity to a poorly immunogenic melanoma
    Xiang yang Wang
    Department of Cellular Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Immunol 177:1543-51. 2006
    ....
  3. ncbi request reprint Scavenger receptor-A negatively regulates antitumor immunity
    Xiang yang Wang
    Department of Cellular Stress Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 67:4996-5002. 2007
    ..This is the first report illustrating that SR-A negatively regulates antigen-specific antitumor immunity, which has important clinical implications in vaccine design for cancer immunotherapy...
  4. ncbi request reprint Immunization with tumor-derived ER chaperone grp170 elicits tumor-specific CD8+ T-cell responses and reduces pulmonary metastatic disease
    Xiang yang Wang
    Department of Molecular and Cellular Biophysics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Int J Cancer 105:226-31. 2003
    ..These observations have strong clinical implications for using tumor-derived grp170 as a therapeutic vaccine against metastatic diseases...
  5. ncbi request reprint Targeted immunotherapy using reconstituted chaperone complexes of heat shock protein 110 and melanoma-associated antigen gp100
    Xiang yang Wang
    Department of Molecular and Cellular Biophysics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 63:2553-60. 2003
    ..Thus, the use of hsp110 to form natural chaperone complexes with tumor protein antigens such as gp100 represents a powerful approach to therapeutic vaccine formulation with significant potential for clinical application...
  6. ncbi request reprint Development of a recombinant HSP110-HER-2/neu vaccine using the chaperoning properties of HSP110
    Masoud H Manjili
    Department of Molecular and Cellular Biophysics, Roswell Park Cancer Institute, Buffalo New York 14263, USA
    Cancer Res 62:1737-42. 2002
    ..The use of recombinant HSP110 to form natural chaperone complexes with large protein antigens represents a new and powerful approach for the design of protein-targeted cancer vaccines...
  7. ncbi request reprint Hsp110 over-expression increases the immunogenicity of the murine CT26 colon tumor
    Xiang yang Wang
    Department of Molecular and Cellular Biophysics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Immunol Immunother 51:311-9. 2002
    ..These observations demonstrate that manipulation of hsp110 expression in tumors, specifically when combined with GM-CSF, represents a potentially powerful approach to cancer vaccine formulation...
  8. pmc Secretable chaperone Grp170 enhances therapeutic activity of a novel tumor suppressor, mda-7/IL-24
    Ping Gao
    Departments of Cellular Stress Biology, Roswell Park Cancer Institute, Buffalo, New York, USA
    Cancer Res 68:3890-8. 2008
    ..Given multiple undefined antigens present endogenously within prostate cancer, these data provide a rationale for combining sgrp170-based vaccine strategy with mda-7/IL-24-targeted cancer therapy to induce durable systemic immunity...
  9. ncbi request reprint Chaperoning function of stress protein grp170, a member of the hsp70 superfamily, is responsible for its immunoadjuvant activity
    Jun Eui Park
    Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Res 66:1161-8. 2006
    ....
  10. ncbi request reprint The chaperoning properties of mouse grp170, a member of the third family of hsp70 related proteins
    Juneui Park
    Department of Cellular Stress Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Biochemistry 42:14893-902. 2003
    ..The ability of the C-terminal region to bind peptides is a unique feature of grp170...
  11. ncbi request reprint HSP110-HER2/neu chaperone complex vaccine induces protective immunity against spontaneous mammary tumors in HER-2/neu transgenic mice
    Masoud H Manjili
    Department of Molecular and Cellular Biophysics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Immunol 171:4054-61. 2003
    ....
  12. ncbi request reprint Evaluation of renal cell carcinoma vaccines targeting carbonic anhydrase IX using heat shock protein 110
    Hyung L Kim
    Department of Urologic Oncology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Immunol Immunother 56:1097-105. 2007
    ..Hsp110 + CA9 decreased tumor growth compared to control vaccinations. These studies suggest that recombinant hsp110 complexed to CA9 should be evaluated for treatment of RCC...
  13. ncbi request reprint Immunotherapy of cancer using heat shock proteins
    Masoud H Manjili
    Department of Molecular and Cellular Biophysics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Front Biosci 7:d43-52. 2002
    ..Lastly, means of further enhancing the already potent activity of stress protein vaccines are presented, specifically the use of hyperthermia or CTLA-4 blockade as adjuvants...
  14. ncbi request reprint Cancer immunotherapy and heat-shock proteins: promises and challenges
    Masoud H Manjili
    Department of Cellular Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Expert Opin Biol Ther 4:363-73. 2004
    ..These points should also clarify the conflicting findings about HSPs and promote our knowledge about other immuologically important components that may be present in HSP preparations...
  15. pmc Pattern recognition scavenger receptor SRA/CD204 down-regulates Toll-like receptor 4 signaling-dependent CD8 T-cell activation
    Huanfa Yi
    Department of Cellular Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Blood 113:5819-28. 2009
    ....
  16. pmc Carbonic anhydrase IX has chaperone-like functions and is an immunoadjuvant
    Yanping Wang
    Department of Urologic Oncology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Mol Cancer Ther 7:3867-77. 2008
    ..CA9 has chaperone-like functions and CA9 shed from tumors may play a direct role in stimulating an adaptive immune response...
  17. pmc Secretion of stress protein grp170 promotes immune-mediated inhibition of murine prostate tumor
    Ping Gao
    Department of Cellular Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Immunol Immunother 58:1319-28. 2009
    ....
  18. ncbi request reprint Heat shock proteins as vaccine adjuvants in infections and cancer
    Brahm H Segal
    Department of Medicine, Immunology, Cellular Stress Biology, and Urologic Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Drug Discov Today 11:534-40. 2006
    ..Their roles in priming multiple host defense pathways are being exploited in vaccine development for cancer and infectious diseases...
  19. ncbi request reprint Generation of anti-tumor immunity using mammalian heat shock protein 70 DNA vaccines for cancer immunotherapy
    Ying Li
    Department of Immunology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Vaccine 24:5360-70. 2006
    ..Functional domain mapping and orientation of the E7 and Hsp70 in the fusion gene may have clinical implications for the design and optimization of Hsp70-based DNA vaccines...
  20. ncbi request reprint Heat shock proteins and scavenger receptors: role in adaptive immune responses
    John G Facciponte
    Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York, USA
    Immunol Invest 34:325-42. 2005
    ..A better understanding of this interaction between HSPs and APCs may further unravel mechanisms of immunoadjuvant function of HSPs...
  21. ncbi request reprint Heat shock proteins HSP70 and GP96: structural insights
    John G Facciponte
    Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Cancer Immunol Immunother 55:339-46. 2006
    ..Here, we review the studies that address the role of structural domains or regions of the immunochaperones HSP70 and GP96 that may be involved in the induction of adaptive or innate immune responses...
  22. pmc Peroxiredoxin 1 stimulates secretion of proinflammatory cytokines by binding to TLR4
    Jonah R Riddell
    Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Immunol 184:1022-30. 2010
    ..These findings suggest that Prx1 may act as danger signal similar to other TLR4-binding chaperone molecules such as HSP72...
  23. ncbi request reprint Hsp110 and Grp170, members of the Hsp70 superfamily, bind to scavenger receptor-A and scavenger receptor expressed by endothelial cells-I
    John G Facciponte
    Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Eur J Immunol 37:2268-79. 2007
    ..Thus, SR-A and SREC-I appear to contribute to the binding of hsp110 and grp170 on APC. Scavenger receptors, in general, contribute to the cross-presentation of hsp110-chaperoned protein antigen...

Research Grants3

  1. Immunochaperone-based gene therapy targeting prostate cancer
    Xiang yang Wang; Fiscal Year: 2007
    ..The proposed research could lead to the design of a clinical trial for patients with prostate cancer in the very near future. ..
  2. Scavenger Receptor-A and Immune Regulation
    Xiang yang Wang; Fiscal Year: 2007
    ..Further, successful testing of SR-A-silenced dendritic cells as a vaccine to break tolerance against tumor- associated self-antigens will provide a novel immunotherapeutic approach targeting the inhibitory innate receptor. ..