Research Topics
Genomes and GenesSpecies | Li TangSummaryAffiliation: Roswell Park Cancer Institute Country: USA Publications
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Publications
Consumption of raw cruciferous vegetables is inversely associated with bladder cancer riskLi Tang
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Cancer Epidemiol Biomarkers Prev 17:938-44. 2008..93, respectively). These data suggest that cruciferous vegetables, when consumed raw, may reduce the risk of bladder cancer, an effect consistent with the role of dietary isothiocyanates as chemopreventive agents against bladder cancer...
Cruciferous vegetable intake is inversely associated with lung cancer risk among smokers: a case-control studyLi Tang
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
BMC Cancer 10:162. 2010..Inverse associations between cruciferous vegetable intake and lung cancer risk have been consistently reported. However, associations within smoking status subgroups have not been consistently addressed...- Repeat polymorphisms in estrogen metabolism genes and prostate cancer risk: results from the Prostate Cancer Prevention TrialLi Tang
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Carcinogenesis 32:1500-6. 2011.... - Intake of cruciferous vegetables modifies bladder cancer survivalLi Tang
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Carlton House Rm 365, Buffalo, NY 14263, USA
Cancer Epidemiol Biomarkers Prev 19:1806-11. 2010..Due to the potent antiproliferative effects of dietary isothiocyanates on bladder cancer in in vitro and in vivo models, cruciferous vegetable intake may also play a role in survival among patients with bladder cancer... - Serum estrogen levels and prostate cancer risk in the prostate cancer prevention trial: a nested case-control studySong Yao
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA
Cancer Causes Control 22:1121-31. 2011..Finasteride reduces prostate cancer risk by blocking the conversion of testosterone to dihydrotestosterone. However, whether finasteride affects estrogens levels or change in estrogens affects prostate cancer risk is unknown... - Allyl isothiocyanate arrests cancer cells in mitosis, and mitotic arrest in turn leads to apoptosis via Bcl-2 protein phosphorylationFeng Geng
Department of Cancer Prevention and Control, California Institute of Technology, Pasadena, California 91125, USA
J Biol Chem 286:32259-67. 2011..Taken together, this study has revealed a novel anticancer mechanism of a phytochemical that is commonly present in human diet... 
Potent activation of mitochondria-mediated apoptosis and arrest in S and M phases of cancer cells by a broccoli sprout extractLi Tang
Department of Chemoprevention, Roswell Park Cancer Institute, Elm and Carlton Streets, Science 711, Buffalo, NY 14263, USA
Mol Cancer Ther 5:935-44. 2006..These data show that broccoli sprout isothiocyanate extract is a highly promising substance for cancer prevention/treatment and that its antiproliferative activity is exclusively derived from isothiocyanates...- Mitochondria are the primary target in isothiocyanate-induced apoptosis in human bladder cancer cellsLi Tang
Department of Chemoprevention, Roswell Park Cancer Institute, Basic Science 711, Elm and Carlton Streets, Buffalo, NY 14263, USA
Mol Cancer Ther 4:1250-9. 2005.... - Discovery and development of sulforaphane as a cancer chemopreventive phytochemicalYuesheng Zhang
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Acta Pharmacol Sin 28:1343-54. 2007.... - Selected isothiocyanates rapidly induce growth inhibition of cancer cellsYuesheng Zhang
Arizona Cancer Center and Department of Medicine, College of Medicine, University of Arizona, Tucson, AZ, USA
Mol Cancer Ther 2:1045-52. 2003.... - The principal urinary metabolites of dietary isothiocyanates, N-acetylcysteine conjugates, elicit the same anti-proliferative response as their parent compounds in human bladder cancer cellsLi Tang
Department of Chemoprevention, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Anticancer Drugs 17:297-305. 2006..These data show that the NAC-ITCs are biologically similar to their parent compounds and are highly effective against human bladder cancer cells... - Cancer-preventive isothiocyanates: dichotomous modulators of oxidative stressYuesheng Zhang
Department of Chemoprevention, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
Free Radic Biol Med 38:70-7. 2005..Ironically, although ITC-induced stress may lead to oxidative damage, it has become increasingly clear that much of the chemoprotective activity of ITCs stems from the response of cells to the stress induced by these compounds... - Dietary isothiocyanates inhibit the growth of human bladder carcinoma cellsLi Tang
Department of Chemoprevention, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
J Nutr 134:2004-10. 2004..However, further increases in ITC concentrations abolished their activities, described above. These findings show that urinary ITC concentrations may need to be maintained at low micromolar concentrations for bladder cancer prevention... - Inhibition of bladder cancer development by allyl isothiocyanateArup Bhattacharya
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Carcinogenesis 31:281-6. 2010..Moreover, we show that AITC is a multi-targeted agent against bladder cancer. In conclusion, AITC is selectively delivered to bladder cancer tissue through urinary excretion and potently inhibits bladder cancer development and invasion... - Variants in the vitamin D pathway, serum levels of vitamin D, and estrogen receptor negative breast cancer among African-American women: a case-control studySong Yao
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
Breast Cancer Res 14:R58. 2012..We hypothesized that racial differences in 25OHD levels, as well as in inherited genetic variations, may contribute, in part, to the differences in tumor characteristics... - Isothiocyanates in the chemoprevention of bladder cancerLi Tang
Department of Chemoprevention, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Curr Drug Metab 5:193-201. 2004..As a result, potential systemic adverse effects of ITCs may be minimized when using ITCs for chemoprevention of bladder carcinogenesis. Taken together, ITCs may be especially useful for the prevention of bladder cancer... - Myeloperoxidase genotypes and enhanced efficacy of chemotherapy for early-stage breast cancer in SWOG-8897Christine B Ambrosone
Roswell Park Cancer Institute, Department of Cancer Prevention and Control, Buffalo, NY 14263, USA
J Clin Oncol 27:4973-9. 2009.... - Oxidative stress as a component of chromium-induced cytotoxicity in rat calvarial osteoblastsJun Fu
Key Laboratory of Oral Biomedical Engineering of Chinese Ministry of Education, West China College of Stomatology, Sichuan University, Chengdu, Sichuan 610041, People s Republic of China
Cell Biol Toxicol 24:201-12. 2008..Cr3+ (5-20 microM) have no significant cytotoxicity in osteoblasts based on the results of this study... - Generation of novel epothilone analogs with cytotoxic activity by biotransformationLi Tang
Kosan Biosciences, Inc, 3832 Bay Center Place, Hayward, CA 94545, USA
J Antibiot (Tokyo) 56:16-23. 2003..The compounds generated by biotransformation exert differential effects on tubulin polymerization, which correlate with their biological activities... - Characterization of a novel C-type lectin-like gene, LSECtin: demonstration of carbohydrate binding and expression in sinusoidal endothelial cells of liver and lymph nodeWanli Liu
Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine, Chinese Human Genome Center at Beijing, 27 Taiping Road, Beijing 100850, People s Republic of China
J Biol Chem 279:18748-58. 2004..Our results indicate that LSECtin is a novel member of a family of proteins comprising CD23, DC-SIGN, and DC-SIGNR and might function in vivo as a lectin receptor... - Enhanced tolerance of transgenic potato plants expressing both superoxide dismutase and ascorbate peroxidase in chloroplasts against oxidative stress and high temperatureLi Tang
Environmental Biotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology, Yuseong, Daejeon, 305-806, Korea
Plant Cell Rep 25:1380-6. 2006..These results suggest that the manipulation of the antioxidative mechanism of the chloroplasts may be applied in the development of industrial transgenic crop plants with increased tolerance to multiple environmental stresses... - A DNA vaccine against chimeric AFP enhanced by HSP70 suppresses growth of hepatocellular carcinomaYing Hua Lan
Key Laboratory of Molecular Biology for Infectious Diseases, Ministry of Education, Institute for Viral Hepatitis, Second Affiliated Hospital, Chongqing Medical University, 400010 Chongqing, People s Republic of China
Cancer Immunol Immunother 56:1009-16. 2007..It is anticipated that vaccine strategies such as this may contribute to the effective future treatment of hepatocellular carcinoma... - [Expression of cyclin B1 and cyclin-dependent kanasel in ectopic and eutopic endometrium tissues of patients with endometriosis]Li Tang
Department of Reproductive Endocrinology, Women s Hospital, School of Medicine, Zhejiang University, Zhejiang 310006, China
Zhonghua Yi Xue Za Zhi 87:179-83. 2007..To investigate the possible roles of cyclin B1 and cyclin-dependent kanase1 cyclin-dependent kanase1 play in the pathogenesis and development of endometriosis and their association with the ovarian hormones... - Inhibition of urinary bladder carcinogenesis by broccoli sproutsRex Munday
AgResearch Limited, Ruakura Agricultural Research Center, Hamilton, New Zealand
Cancer Res 68:1593-600. 2008..In conclusion, broccoli sprout extract is a highly promising substance for bladder cancer prevention and the isothiocyanates in the extract are selectively delivered to the bladder epithelium through urinary excretion... - Enhanced tolerance of transgenic potato plants overexpressing nucleoside diphosphate kinase 2 against multiple environmental stressesLi Tang
Environmental Biotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology, 52 Eoeun dong, Yuseong Gu, Daejeon, Korea
Transgenic Res 17:705-15. 2008..These results indicate that overexpression of NDPK2 under the stress-inducible SWPA2 promoter might efficiently regulate the oxidative stress derived from various environmental stresses... - A new cytotoxic epothilone from modified polyketide synthases heterologously expressed in Myxococcus xanthusRobert L Arslanian
Kosan Biosciences, Inc, 3832 Bay Center Place, Hayward, California 94545, USA
J Nat Prod 65:1061-4. 2002..The cytotoxicity of 5 against a panel of tumor cell lines, including several with multidrug resistance, and its effect on tubulin polymerization were comparable to epothilone D (4)...