Khalid Sossey-Alaoui

Summary

Affiliation: Roswell Park Cancer Institute
Country: USA

Publications

  1. ncbi request reprint c-Abl-mediated phosphorylation of WAVE3 is required for lamellipodia formation and cell migration
    Khalid Sossey-Alaoui
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    J Biol Chem 282:26257-65. 2007
  2. pmc Down-regulation of WAVE3, a metastasis promoter gene, inhibits invasion and metastasis of breast cancer cells
    Khalid Sossey-Alaoui
    Roswell Park Cancer Institute, Department of Cancer Genetics, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Am J Pathol 170:2112-21. 2007
  3. ncbi request reprint Molecular characterization of a 7p15-21 homozygous deletion in a Wilms tumor
    Khalid Sossey-Alaoui
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Genes Chromosomes Cancer 36:1-6. 2003
  4. ncbi request reprint WAVE3 promotes cell motility and invasion through the regulation of MMP-1, MMP-3, and MMP-9 expression
    Khalid Sossey-Alaoui
    Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Exp Cell Res 308:135-45. 2005
  5. ncbi request reprint Genomic organization and expression profile of the human and mouse WAVE gene family
    Khalid Sossey-Alaoui
    Department of Cancer Genetics, Roswell Park Cancer Institute, 110 C and V Building, Elm and Carlton Streets, Buffalo, New York 14263, USA
    Mamm Genome 14:314-22. 2003
  6. ncbi request reprint WAVE3-mediated cell migration and lamellipodia formation are regulated downstream of phosphatidylinositol 3-kinase
    Khalid Sossey-Alaoui
    Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    J Biol Chem 280:21748-55. 2005
  7. ncbi request reprint Silencing of the Tropomyosin-1 gene by DNA methylation alters tumor suppressor function of TGF-beta
    Andrea E Varga
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Oncogene 24:5043-52. 2005
  8. ncbi request reprint Aberrant expression of novel and previously described cell membrane markers in human breast cancer cell lines and tumors
    Huayi Huang
    Department of Pathology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Clin Cancer Res 11:4357-64. 2005
  9. ncbi request reprint EVI5 protein associates with the INCENP-aurora B kinase-survivin chromosomal passenger complex and is involved in the completion of cytokinesis
    Silviu L Faitar
    Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Exp Cell Res 312:2325-35. 2006
  10. ncbi request reprint WAVE3, an actin-polymerization gene, is truncated and inactivated as a result of a constitutional t(1;13)(q21;q12) chromosome translocation in a patient with ganglioneuroblastoma
    Khalid Sossey-Alaoui
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York, USA
    Oncogene 21:5967-74. 2002

Research Grants

  1. Molecular Cloning of the Wilms tumor Gene from 7p15-21
    Khalid Sossey Alaoui; Fiscal Year: 2004

Collaborators

Detail Information

Publications14

  1. ncbi request reprint c-Abl-mediated phosphorylation of WAVE3 is required for lamellipodia formation and cell migration
    Khalid Sossey-Alaoui
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    J Biol Chem 282:26257-65. 2007
    ..Our results show that the activation of WAVE3 to promote actin remodeling is enhanced by the c-Abl-mediated tyrosine phosphorylation of WAVE3...
  2. pmc Down-regulation of WAVE3, a metastasis promoter gene, inhibits invasion and metastasis of breast cancer cells
    Khalid Sossey-Alaoui
    Roswell Park Cancer Institute, Department of Cancer Genetics, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Am J Pathol 170:2112-21. 2007
    ..These studies provide direct evidence that the WAVE3-p38 pathway contributes to breast cancer progression and metastasis...
  3. ncbi request reprint Molecular characterization of a 7p15-21 homozygous deletion in a Wilms tumor
    Khalid Sossey-Alaoui
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Genes Chromosomes Cancer 36:1-6. 2003
    ..This is the only reported homozygous deletion recorded so far in Wilms tumor, and it provides the means to identify the tumor-suppressor gene located in this deletion...
  4. ncbi request reprint WAVE3 promotes cell motility and invasion through the regulation of MMP-1, MMP-3, and MMP-9 expression
    Khalid Sossey-Alaoui
    Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Exp Cell Res 308:135-45. 2005
    ..These findings suggest that WAVE3 regulates actin cytoskeleton, cell motility, and invasion through the p38 MAPK pathway and MMP production...
  5. ncbi request reprint Genomic organization and expression profile of the human and mouse WAVE gene family
    Khalid Sossey-Alaoui
    Department of Cancer Genetics, Roswell Park Cancer Institute, 110 C and V Building, Elm and Carlton Streets, Buffalo, New York 14263, USA
    Mamm Genome 14:314-22. 2003
    ..It also provides the first steps towards the development of mouse models for the role of the WAVE genes in actin and cytoskeleton organization in general, and in the development of neuroblastoma in particular...
  6. ncbi request reprint WAVE3-mediated cell migration and lamellipodia formation are regulated downstream of phosphatidylinositol 3-kinase
    Khalid Sossey-Alaoui
    Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    J Biol Chem 280:21748-55. 2005
    ..The findings of the WAVE3-p85 partnership also suggest a potential regulatory role for p85 in WAVE3-dependent actin-cytoskeleton reorganization and cell migration...
  7. ncbi request reprint Silencing of the Tropomyosin-1 gene by DNA methylation alters tumor suppressor function of TGF-beta
    Andrea E Varga
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Oncogene 24:5043-52. 2005
    ..Together these results suggest that epigenetic suppression of TPM1 may alter TGF-beta tumor suppressor function and contribute to metastatic properties of tumor cells...
  8. ncbi request reprint Aberrant expression of novel and previously described cell membrane markers in human breast cancer cell lines and tumors
    Huayi Huang
    Department of Pathology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Clin Cancer Res 11:4357-64. 2005
    ..We also studied the expression of three other cell membrane proteins known to play a role in mammary neoplasia...
  9. ncbi request reprint EVI5 protein associates with the INCENP-aurora B kinase-survivin chromosomal passenger complex and is involved in the completion of cytokinesis
    Silviu L Faitar
    Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Exp Cell Res 312:2325-35. 2006
    ..Together, these data provide evidence that EVI5 is an essential component of the protein machinery facilitating the final stages of cell septation at the end of mitosis...
  10. ncbi request reprint WAVE3, an actin-polymerization gene, is truncated and inactivated as a result of a constitutional t(1;13)(q21;q12) chromosome translocation in a patient with ganglioneuroblastoma
    Khalid Sossey-Alaoui
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York, USA
    Oncogene 21:5967-74. 2002
    ..From analysis of its expression pattern and function, WAVE3 is a candidate tumor suppressor gene, at least in some forms of neuroblastoma...
  11. ncbi request reprint The tetraspanin superfamily member NET-6 is a new tumor suppressor gene
    Huayi Huang
    Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Cancer Res Clin Oncol 133:761-9. 2007
    ..We now describe the phenotypic and molecular changes induced in MDA-MB-231 breast carcinoma cells by ectopic NET-6 expression...
  12. ncbi request reprint CLCA2 tumour suppressor gene in 1p31 is epigenetically regulated in breast cancer
    Xiurong Li
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Oncogene 23:1474-80. 2004
    ..These findings demonstrate that CLCA2 is frequently inactivated in breast cancer by promoter region hypermethylation, which makes it an excellent candidate for the 1p31 breast cancer tumour suppressor gene...
  13. ncbi request reprint Characterization of FAM10A4, a member of the ST13 tumor suppressor gene family that maps to the 13q14.3 region associated with B-Cell leukemia, multiple myeloma, and prostate cancer
    Khalid Sossey-Alaoui
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York, 14263, USA
    Genomics 80:5-7. 2002
    ..The characterization of this gene will permit mutation studies in other tumor cell types such as multiple myeloma and prostate cancer, which also show genetic loss in the 13q14 region...
  14. ncbi request reprint Absence of MeCP2 mutations in patients from the South Carolina autism project
    Fe Lobo-Menendez
    Greenwood Genetic Center, Greenwood, South Carolina, USA
    Am J Med Genet B Neuropsychiatr Genet 117:97-101. 2003
    ..The findings from this and other studies suggest that mutations in the coding sequence of the MeCP2 gene are not a significant etiological factor in autism...

Research Grants1

  1. Molecular Cloning of the Wilms tumor Gene from 7p15-21
    Khalid Sossey Alaoui; Fiscal Year: 2004
    ..Understanding the nature of the genetic events which allow these cells to escape their normal growth regulation may also provide an opportunity for therapeutic intervention. ..