Research Topics
Genomes and Genes | Khalid Sossey-AlaouiSummaryAffiliation: Roswell Park Cancer Institute Country: USA Publications
Research Grants
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Detail Information
Publications
c-Abl-mediated phosphorylation of WAVE3 is required for lamellipodia formation and cell migrationKhalid Sossey-Alaoui
Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
J Biol Chem 282:26257-65. 2007..Our results show that the activation of WAVE3 to promote actin remodeling is enhanced by the c-Abl-mediated tyrosine phosphorylation of WAVE3...
Down-regulation of WAVE3, a metastasis promoter gene, inhibits invasion and metastasis of breast cancer cellsKhalid Sossey-Alaoui
Roswell Park Cancer Institute, Department of Cancer Genetics, Elm and Carlton Streets, Buffalo, NY 14263, USA
Am J Pathol 170:2112-21. 2007..These studies provide direct evidence that the WAVE3-p38 pathway contributes to breast cancer progression and metastasis...- Molecular characterization of a 7p15-21 homozygous deletion in a Wilms tumorKhalid Sossey-Alaoui
Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Genes Chromosomes Cancer 36:1-6. 2003..This is the only reported homozygous deletion recorded so far in Wilms tumor, and it provides the means to identify the tumor-suppressor gene located in this deletion... - WAVE3 promotes cell motility and invasion through the regulation of MMP-1, MMP-3, and MMP-9 expressionKhalid Sossey-Alaoui
Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
Exp Cell Res 308:135-45. 2005..These findings suggest that WAVE3 regulates actin cytoskeleton, cell motility, and invasion through the p38 MAPK pathway and MMP production... - Genomic organization and expression profile of the human and mouse WAVE gene familyKhalid Sossey-Alaoui
Department of Cancer Genetics, Roswell Park Cancer Institute, 110 C and V Building, Elm and Carlton Streets, Buffalo, New York 14263, USA
Mamm Genome 14:314-22. 2003..It also provides the first steps towards the development of mouse models for the role of the WAVE genes in actin and cytoskeleton organization in general, and in the development of neuroblastoma in particular... - WAVE3-mediated cell migration and lamellipodia formation are regulated downstream of phosphatidylinositol 3-kinaseKhalid Sossey-Alaoui
Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
J Biol Chem 280:21748-55. 2005..The findings of the WAVE3-p85 partnership also suggest a potential regulatory role for p85 in WAVE3-dependent actin-cytoskeleton reorganization and cell migration... - Silencing of the Tropomyosin-1 gene by DNA methylation alters tumor suppressor function of TGF-betaAndrea E Varga
Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Oncogene 24:5043-52. 2005..Together these results suggest that epigenetic suppression of TPM1 may alter TGF-beta tumor suppressor function and contribute to metastatic properties of tumor cells... - Aberrant expression of novel and previously described cell membrane markers in human breast cancer cell lines and tumorsHuayi Huang
Department of Pathology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Clin Cancer Res 11:4357-64. 2005..We also studied the expression of three other cell membrane proteins known to play a role in mammary neoplasia... - EVI5 protein associates with the INCENP-aurora B kinase-survivin chromosomal passenger complex and is involved in the completion of cytokinesisSilviu L Faitar
Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
Exp Cell Res 312:2325-35. 2006..Together, these data provide evidence that EVI5 is an essential component of the protein machinery facilitating the final stages of cell septation at the end of mitosis... - WAVE3, an actin-polymerization gene, is truncated and inactivated as a result of a constitutional t(1;13)(q21;q12) chromosome translocation in a patient with ganglioneuroblastomaKhalid Sossey-Alaoui
Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York, USA
Oncogene 21:5967-74. 2002..From analysis of its expression pattern and function, WAVE3 is a candidate tumor suppressor gene, at least in some forms of neuroblastoma... - The tetraspanin superfamily member NET-6 is a new tumor suppressor geneHuayi Huang
Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
J Cancer Res Clin Oncol 133:761-9. 2007..We now describe the phenotypic and molecular changes induced in MDA-MB-231 breast carcinoma cells by ectopic NET-6 expression... - CLCA2 tumour suppressor gene in 1p31 is epigenetically regulated in breast cancerXiurong Li
Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Oncogene 23:1474-80. 2004..These findings demonstrate that CLCA2 is frequently inactivated in breast cancer by promoter region hypermethylation, which makes it an excellent candidate for the 1p31 breast cancer tumour suppressor gene... - Characterization of FAM10A4, a member of the ST13 tumor suppressor gene family that maps to the 13q14.3 region associated with B-Cell leukemia, multiple myeloma, and prostate cancerKhalid Sossey-Alaoui
Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York, 14263, USA
Genomics 80:5-7. 2002..The characterization of this gene will permit mutation studies in other tumor cell types such as multiple myeloma and prostate cancer, which also show genetic loss in the 13q14 region... - Absence of MeCP2 mutations in patients from the South Carolina autism projectFe Lobo-Menendez
Greenwood Genetic Center, Greenwood, South Carolina, USA
Am J Med Genet B Neuropsychiatr Genet 117:97-101. 2003..The findings from this and other studies suggest that mutations in the coding sequence of the MeCP2 gene are not a significant etiological factor in autism...
Research Grants
- Molecular Cloning of the Wilms tumor Gene from 7p15-21Khalid Sossey Alaoui; Fiscal Year: 2004..Understanding the nature of the genetic events which allow these cells to escape their normal growth regulation may also provide an opportunity for therapeutic intervention. ..