Research Topics
Genomes and GenesSpecies | Keshav SinghSummaryAffiliation: Roswell Park Cancer Institute Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
A colony color method identifies the vulnerability of mitochondria to oxidative damageGrace Kim
Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Bunting-Blaustein Cancer Research Building, 1650 Orleans Street/Room 143, Baltimore, MD 21231, USA
Mutagenesis 17:375-81. 2002....- Genetic determinants of mitochondrial response to arsenic in yeast Saccharomyces cerevisiaeMarija Vujcic
Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Cancer Res 67:9740-9. 2007..cerevisiae from arsenic-induced toxicity. Together, our studies suggest that evolutionary conserved mitochondrial networks identified in yeast S. cerevisiae must play an important role in arsenic-induced carcinogenesis in humans... 
Evaluation of cell types for assessment of cytogenetic damage in arsenic exposed populationPritha Ghosh
Molecular and Human Genetics Division, Indian Institute of Chemical Biology, Kolkata 700 032, India
Mol Cancer 7:45. 2008....
hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancerRenty B Franklin
Department of Biomedical Sciences, Dental School, University of Maryland, Baltimore, MD, USA
Mol Cancer 4:32. 2005..hZIP1 expression was also determined in malignant prostate cell lines...- Mitochondrial inhibition of uracil-DNA glycosylase is not mutagenicSushant Kachhap
Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Bunting Blaustein Cancer Research Building, 1650 Orleans St, Baltimore, MD 21231, USA
Mol Cancer 3:32. 2004..UDG in human cells is present in both the nucleus and mitochondrial compartments. Although, UDG's role in the nucleus is well established its role in mitochondria is less clear... - Mutations in mitochondrial DNA polymerase-gamma promote breast tumorigenesisKeshav K Singh
Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
J Hum Genet 54:516-24. 2009..Together, our study provides the first comprehensive analysis of the POLG gene mutation in human cancer and suggests a function for POLG (1) in decreased OXPHOS in cancers and (2) in promoting tumorigenicity... - Inter-genomic cross talk between mitochondria and the nucleus plays an important role in tumorigenesisKeshav K Singh
Department of Cancer Genetics, Cell and Virus Building, Room 247, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
Gene 354:140-6. 2005..Taken together, these studies suggest that inter-genomic cross talk between mitochondria and the nucleus plays an important role in tumorigenesis and that APE1 mediates this process... - Mitochondria damage checkpoint, aging, and cancerKeshav K Singh
Department of Cancer Genetics, Cell and Virus Building, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Ann N Y Acad Sci 1067:182-90. 2006..Alternatively, mutations occur in the mitochondrial and/or nuclear DNA, resulting in tumorigenesis... - Mitochondria damage checkpoint in apoptosis and genome stabilityKeshav K Singh
Department of Cancer Genetics, Cell and Virus Building, Room 247, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
FEMS Yeast Res 5:127-32. 2004..This study reveals molecular genetic mechanisms underlying a role for mitochondria in carcinogenesis in humans... - Mitochondrial dysfunction is a common phenotype in aging and cancerKeshav K Singh
Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
Ann N Y Acad Sci 1019:260-4. 2004..These observations suggest that the mitochondrial dysfunction that accompanies aging may exert a major influence on carcinogenesis... - Genome-wide analysis of signal transducers and regulators of mitochondrial dysfunction in Saccharomyces cerevisiaeKeshav K Singh
Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Ann N Y Acad Sci 1011:284-98. 2004..Together, our data suggest that gene(s) involved in mitochondria-to-nucleus communication play a role in mutagenesis and may be implicated in carcinogenesis... - p53 regulates mtDNA copy number and mitocheckpoint pathwayMariola Kulawiec
Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, 14263, USA
J Carcinog 8:8. 2009..We describe a conceptual organization of the mito-checkpoint pathway in which identified roles of p53 in mitochondria are incorporated... - Mitochondrial aconitase and citrate metabolism in malignant and nonmalignant human prostate tissuesKeshav K Singh
Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Mol Cancer 5:14. 2006..To address this issue, the in situ level of m-aconitase enzyme was determined by immunohistochemical analysis of prostate cancer tissue sections and malignant prostate cell lines... - Mitochondria and human cancerJosephine S Modica Napolitano
Department of Cancer Genetics, BLSC Room L3 316, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
Curr Mol Med 7:121-31. 2007..The potential use of mitochondria as biomarkers for early detection of cancer, or as unique cellular targets for novel and selective anti-cancer agents is also discussed... - Mitochondria as determinant of nucleotide pools and chromosomal stabilityClaus Desler
Department of Science, Systems and Models, Roskilde University, 4000 Roskilde, Denmark
Mutat Res 625:112-24. 2007..Our results suggest that mitochondria are central players in maintaining genomic stability and in controlling essential nuclear processes such as upholding a balanced supply of nucleotides... - Meeting report: mitochondrial DNA and cancer epidemiologyMukesh Verma
Analytic Epidemiology Research Branch, National Cancer Institute, Rockville, Maryland 20852, USA
Cancer Res 67:437-9. 2007 
Arsenic-induced health effects and genetic damage in keratotic individuals: involvement of p53 arginine variant and chromosomal aberrations in arsenic susceptibilitySujata De Chaudhuri
Molecular and Human Genetics Division, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Kolkata 700032, India
Mutat Res 659:118-25. 2008....- Proteomic analysis of mitochondria-to-nucleus retrograde response in human cancerMariola Kulawiec
Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York, USA
Cancer Biol Ther 5:967-75. 2006..Our study opens an avenue for identification of retrograde proteins as potential tumor suppressors or oncogenes involved in carcinogenesis... - Mitochondria as targets for detection and treatment of cancerJosephine S Modica-Napolitano
Department of Biology, Merrimack College, North Andover, MA 01845, USA
Expert Rev Mol Med 4:1-19. 2002.... - Cross talk between mitochondria and superoxide generating NADPH oxidase in breast and ovarian tumorsMohamed Mokhtar Desouki
Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Cancer Biol Ther 4:1367-73. 2005..Furthermore, our studies suggest that mitochondria control Nox1 redox signaling and the loss of control of this signaling contributes to breast and ovarian tumorigenesis... - Nuclear genes involved in mitochondria-to-nucleus communication in breast cancer cellsRobert Delsite
Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Bunting Blaustein Cancer Research Building, 1650 Orleans Street, Room 143, Baltimore, MD 21231, USA
Mol Cancer 1:6. 2002..Mutations in mitochondrial genes encoding the 13 subunits have been reported in a variety of cancers. However, little is known about the nuclear response to impairment of mitochondrial function in human cells... - Polymorphisms in genes related to oxidative stress (MPO, MnSOD, CAT) and survival after treatment for breast cancerChristine B Ambrosone
Department of Epidemiology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
Cancer Res 65:1105-11. 2005..33; 95% confidence interval, 0.13-0.80; P = 0.01). These data indicate that gene variants that impact oxidative stress modify prognosis after treatment for breast cancer... - Cellular aging of mitochondrial DNA-depleted cellsSun Young Park
Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong Kangnam-ku, Seoul 135-710, Republic of Korea
Biochem Biophys Res Commun 325:1399-405. 2004..Features simulating aged cells were also observed in MDA-MB-435 rho(0) cells. These results support the mitochondrial theory of aging, and suggest that rho(0) cells could serve as an in vitro model for aged cells... - Mitochondrial impairment is accompanied by impaired oxidative DNA repair in the nucleusRobert L Delsite
Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 212312, USA
Mutagenesis 18:497-503. 2003..It also provides insights into the development of mitochondrial disease as a consequence of cancer therapy... - Mitochondria-mediated nuclear mutator phenotype in Saccharomyces cerevisiaeAnne Karin Rasmussen
Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Bunting-Blaustein Cancer Research Building, 1650 Orleans Street, Baltimore, MD 21231, USA
Nucleic Acids Res 31:3909-17. 2003..Together, our data suggest that mitochondrial dysfunction is mutagenic and multiple pathways are involved in this nuclear mutator phenotype... - Mitochondrial impairment in p53-deficient human cancer cellsShaoyu Zhou
Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Bunting-Blaustein Cancer Research Building, 1650 Orleans Street, Room 143, Baltimore, MD 21231, USA
Mutagenesis 18:287-92. 2003..Together, our study suggests that p53 is involved in regulation of COXII at the protein level but not at the mRNA level. p53 does not affect mtDNA mutation or mitochondrial ultrastructure... - Xenogenic transfer of isolated murine mitochondria into human rho0 cells can improve respiratory functionEyad Katrangi
Bouve College of Health Sciences, School of Pharmacy, Department of Pharmaceutical Sciences, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA
Rejuvenation Res 10:561-70. 2007.... - Saccharomyces cerevisiae polymerase zeta functions in mitochondriaHengshan Zhang
Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Genetics 172:2683-8. 2006..Supporting this evidence, both polymerase zeta and Rev1p were found to be localized in the mitochondria. This is the first report demonstrating that the DNA polymerase zeta and Rev1 proteins function in the mitochondria... - Loss of p53 function in colon cancer cells results in increased phosphocholine and total cholineNoriko Mori
Department of Radiology, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Traylor Building, Baltimore, MD 21205, USA
Mol Imaging 3:319-23. 2004..These data suggest that the increased malignancy of cancer cells resulting from loss of p53 may be mediated, in part, through the choline phospholipid pathway... - Mitochondrial correlation microscopy and nanolaser spectroscopy - new tools for biophotonic detection of cancer in single cellsPaul L Gourley
Biomolecular Interfaces and Systems, Sandia National Laboratories, Albuquerque, NM 87185, USA
Technol Cancer Res Treat 4:585-92. 2005..These optical methods represent powerful new tools that hold promise for detecting cancer at an early stage and may help to limit delays in diagnosis and treatment...
Research Grants
- Mitochondria and MutagenesisKeshav K Singh; Fiscal Year: 2010..abstract_text> ..
- Loss of FLJ13639 Expression in Acute LeukemiaKeshav Singh; Fiscal Year: 2009..Confirmation of the role of the loss of FLJ13639 in leukemia prognosis, increase of chemo resistance should lead us and others, to develop new prognostic tools as well as novel, innovative therapeutic strategies. ..
- Mitochondria and CarcinogenesisKeshav K Singh; Fiscal Year: 2010..The proposed study will help determine the contribution of mutant mtDNA to the development of human cancer. ..
- Mitochondria and CarcinogenesisKeshav Singh; Fiscal Year: 2007..The proposed study will help determine the contribution of mutant mtDNA to the development of human cancer. ..
- Loss of FLJ13639 Expression in Acute LeukemiaKeshav Singh; Fiscal Year: 2007..Confirmation of the role of the loss of FLJ13639 in leukemia prognosis, increase of chemo resistance should lead us and others, to develop new prognostic tools as well as novel, innovative therapeutic strategies. ..
- MITDNA MUTAGENESIS BY ENVIRONMENTAL CARCINOGENSKeshav Singh; Fiscal Year: 2003..The proposed study will fill a major gap in our understanding of the mechanisms of mitDNA mutagenesis induced by environmental carcinogens which has direct relevance in on the induction of mitochondrial diseases. ..
- Mitochondria and MutagenesisKeshav Singh; Fiscal Year: 2007....
- Loss of FLJ13639 Expression in Acute LeukemiaKeshav K Singh; Fiscal Year: 2010..Confirmation of the role of the loss of FLJ13639 in leukemia prognosis, increase of chemo resistance should lead us and others, to develop new prognostic tools as well as novel, innovative therapeutic strategies. ..