Keshav Singh

Summary

Affiliation: Roswell Park Cancer Institute
Country: USA

Publications

  1. ncbi request reprint A colony color method identifies the vulnerability of mitochondria to oxidative damage
    Grace Kim
    Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Bunting Blaustein Cancer Research Building, 1650 Orleans Street Room 143, Baltimore, MD 21231, USA
    Mutagenesis 17:375-81. 2002
  2. ncbi request reprint Genetic determinants of mitochondrial response to arsenic in yeast Saccharomyces cerevisiae
    Marija Vujcic
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 67:9740-9. 2007
  3. pmc Evaluation of cell types for assessment of cytogenetic damage in arsenic exposed population
    Pritha Ghosh
    Molecular and Human Genetics Division, Indian Institute of Chemical Biology, Kolkata 700 032, India
    Mol Cancer 7:45. 2008
  4. pmc hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer
    Renty B Franklin
    Department of Biomedical Sciences, Dental School, University of Maryland, Baltimore, MD, USA
    Mol Cancer 4:32. 2005
  5. pmc Mitochondrial inhibition of uracil-DNA glycosylase is not mutagenic
    Sushant Kachhap
    Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Bunting Blaustein Cancer Research Building, 1650 Orleans St, Baltimore, MD 21231, USA
    Mol Cancer 3:32. 2004
  6. pmc Mutations in mitochondrial DNA polymerase-gamma promote breast tumorigenesis
    Keshav K Singh
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Hum Genet 54:516-24. 2009
  7. ncbi request reprint Inter-genomic cross talk between mitochondria and the nucleus plays an important role in tumorigenesis
    Keshav K Singh
    Department of Cancer Genetics, Cell and Virus Building, Room 247, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Gene 354:140-6. 2005
  8. ncbi request reprint Mitochondria damage checkpoint, aging, and cancer
    Keshav K Singh
    Department of Cancer Genetics, Cell and Virus Building, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Ann N Y Acad Sci 1067:182-90. 2006
  9. ncbi request reprint Mitochondria damage checkpoint in apoptosis and genome stability
    Keshav K Singh
    Department of Cancer Genetics, Cell and Virus Building, Room 247, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    FEMS Yeast Res 5:127-32. 2004
  10. ncbi request reprint Mitochondrial dysfunction is a common phenotype in aging and cancer
    Keshav K Singh
    Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Ann N Y Acad Sci 1019:260-4. 2004

Research Grants

  1. Mitochondria and Mutagenesis
    Keshav K Singh; Fiscal Year: 2010
  2. Mitochondria and Carcinogenesis
    Keshav K Singh; Fiscal Year: 2010
  3. MITDNA MUTAGENESIS BY ENVIRONMENTAL CARCINOGENS
    Keshav Singh; Fiscal Year: 1999
  4. Mitochondria and Mutagenesis
    Keshav Singh; Fiscal Year: 2009
  5. Mitochondria and Carcinogenesis
    Keshav Singh; Fiscal Year: 2009
  6. Loss of FLJ13639 Expression in Acute Leukemia
    Keshav Singh; Fiscal Year: 2009
  7. Mitochondria and Carcinogenesis
    Keshav Singh; Fiscal Year: 2007
  8. Loss of FLJ13639 Expression in Acute Leukemia
    Keshav Singh; Fiscal Year: 2007
  9. MITDNA MUTAGENESIS BY ENVIRONMENTAL CARCINOGENS
    Keshav Singh; Fiscal Year: 2000
  10. MITDNA MUTAGENESIS BY ENVIRONMENTAL CARCINOGENS
    Keshav Singh; Fiscal Year: 2001

Collaborators

Detail Information

Publications30

  1. ncbi request reprint A colony color method identifies the vulnerability of mitochondria to oxidative damage
    Grace Kim
    Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Bunting Blaustein Cancer Research Building, 1650 Orleans Street Room 143, Baltimore, MD 21231, USA
    Mutagenesis 17:375-81. 2002
    ....
  2. ncbi request reprint Genetic determinants of mitochondrial response to arsenic in yeast Saccharomyces cerevisiae
    Marija Vujcic
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 67:9740-9. 2007
    ..cerevisiae from arsenic-induced toxicity. Together, our studies suggest that evolutionary conserved mitochondrial networks identified in yeast S. cerevisiae must play an important role in arsenic-induced carcinogenesis in humans...
  3. pmc Evaluation of cell types for assessment of cytogenetic damage in arsenic exposed population
    Pritha Ghosh
    Molecular and Human Genetics Division, Indian Institute of Chemical Biology, Kolkata 700 032, India
    Mol Cancer 7:45. 2008
    ....
  4. pmc hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer
    Renty B Franklin
    Department of Biomedical Sciences, Dental School, University of Maryland, Baltimore, MD, USA
    Mol Cancer 4:32. 2005
    ..hZIP1 expression was also determined in malignant prostate cell lines...
  5. pmc Mitochondrial inhibition of uracil-DNA glycosylase is not mutagenic
    Sushant Kachhap
    Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Bunting Blaustein Cancer Research Building, 1650 Orleans St, Baltimore, MD 21231, USA
    Mol Cancer 3:32. 2004
    ..UDG in human cells is present in both the nucleus and mitochondrial compartments. Although, UDG's role in the nucleus is well established its role in mitochondria is less clear...
  6. pmc Mutations in mitochondrial DNA polymerase-gamma promote breast tumorigenesis
    Keshav K Singh
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Hum Genet 54:516-24. 2009
    ..Together, our study provides the first comprehensive analysis of the POLG gene mutation in human cancer and suggests a function for POLG (1) in decreased OXPHOS in cancers and (2) in promoting tumorigenicity...
  7. ncbi request reprint Inter-genomic cross talk between mitochondria and the nucleus plays an important role in tumorigenesis
    Keshav K Singh
    Department of Cancer Genetics, Cell and Virus Building, Room 247, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Gene 354:140-6. 2005
    ..Taken together, these studies suggest that inter-genomic cross talk between mitochondria and the nucleus plays an important role in tumorigenesis and that APE1 mediates this process...
  8. ncbi request reprint Mitochondria damage checkpoint, aging, and cancer
    Keshav K Singh
    Department of Cancer Genetics, Cell and Virus Building, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Ann N Y Acad Sci 1067:182-90. 2006
    ..Alternatively, mutations occur in the mitochondrial and/or nuclear DNA, resulting in tumorigenesis...
  9. ncbi request reprint Mitochondria damage checkpoint in apoptosis and genome stability
    Keshav K Singh
    Department of Cancer Genetics, Cell and Virus Building, Room 247, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    FEMS Yeast Res 5:127-32. 2004
    ..This study reveals molecular genetic mechanisms underlying a role for mitochondria in carcinogenesis in humans...
  10. ncbi request reprint Mitochondrial dysfunction is a common phenotype in aging and cancer
    Keshav K Singh
    Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Ann N Y Acad Sci 1019:260-4. 2004
    ..These observations suggest that the mitochondrial dysfunction that accompanies aging may exert a major influence on carcinogenesis...
  11. ncbi request reprint Genome-wide analysis of signal transducers and regulators of mitochondrial dysfunction in Saccharomyces cerevisiae
    Keshav K Singh
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Ann N Y Acad Sci 1011:284-98. 2004
    ..Together, our data suggest that gene(s) involved in mitochondria-to-nucleus communication play a role in mutagenesis and may be implicated in carcinogenesis...
  12. pmc p53 regulates mtDNA copy number and mitocheckpoint pathway
    Mariola Kulawiec
    Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, 14263, USA
    J Carcinog 8:8. 2009
    ..We describe a conceptual organization of the mito-checkpoint pathway in which identified roles of p53 in mitochondria are incorporated...
  13. pmc Mitochondrial aconitase and citrate metabolism in malignant and nonmalignant human prostate tissues
    Keshav K Singh
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Mol Cancer 5:14. 2006
    ..To address this issue, the in situ level of m-aconitase enzyme was determined by immunohistochemical analysis of prostate cancer tissue sections and malignant prostate cell lines...
  14. ncbi request reprint Mitochondria and human cancer
    Josephine S Modica-Napolitano
    Department of Cancer Genetics, BLSC Room L3 316, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Curr Mol Med 7:121-31. 2007
    ..The potential use of mitochondria as biomarkers for early detection of cancer, or as unique cellular targets for novel and selective anti-cancer agents is also discussed...
  15. ncbi request reprint Mitochondria as determinant of nucleotide pools and chromosomal stability
    Claus Desler
    Department of Science, Systems and Models, Roskilde University, 4000 Roskilde, Denmark
    Mutat Res 625:112-24. 2007
    ..Our results suggest that mitochondria are central players in maintaining genomic stability and in controlling essential nuclear processes such as upholding a balanced supply of nucleotides...
  16. ncbi request reprint Meeting report: mitochondrial DNA and cancer epidemiology
    Mukesh Verma
    Analytic Epidemiology Research Branch, National Cancer Institute, Rockville, Maryland 20852, USA
    Cancer Res 67:437-9. 2007
  17. doi request reprint Arsenic-induced health effects and genetic damage in keratotic individuals: involvement of p53 arginine variant and chromosomal aberrations in arsenic susceptibility
    Sujata De Chaudhuri
    Molecular and Human Genetics Division, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Kolkata 700032, India
    Mutat Res 659:118-25. 2008
    ....
  18. ncbi request reprint Proteomic analysis of mitochondria-to-nucleus retrograde response in human cancer
    Mariola Kulawiec
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York, USA
    Cancer Biol Ther 5:967-75. 2006
    ..Our study opens an avenue for identification of retrograde proteins as potential tumor suppressors or oncogenes involved in carcinogenesis...
  19. ncbi request reprint Mitochondria as targets for detection and treatment of cancer
    Josephine S Modica-Napolitano
    Department of Biology, Merrimack College, North Andover, MA 01845, USA
    Expert Rev Mol Med 4:1-19. 2002
    ....
  20. ncbi request reprint Cross talk between mitochondria and superoxide generating NADPH oxidase in breast and ovarian tumors
    Mohamed Mokhtar Desouki
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Biol Ther 4:1367-73. 2005
    ..Furthermore, our studies suggest that mitochondria control Nox1 redox signaling and the loss of control of this signaling contributes to breast and ovarian tumorigenesis...
  21. pmc Nuclear genes involved in mitochondria-to-nucleus communication in breast cancer cells
    Robert Delsite
    Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Bunting Blaustein Cancer Research Building, 1650 Orleans Street, Room 143, Baltimore, MD 21231, USA
    Mol Cancer 1:6. 2002
    ..Mutations in mitochondrial genes encoding the 13 subunits have been reported in a variety of cancers. However, little is known about the nuclear response to impairment of mitochondrial function in human cells...
  22. ncbi request reprint Polymorphisms in genes related to oxidative stress (MPO, MnSOD, CAT) and survival after treatment for breast cancer
    Christine B Ambrosone
    Department of Epidemiology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Res 65:1105-11. 2005
    ..33; 95% confidence interval, 0.13-0.80; P = 0.01). These data indicate that gene variants that impact oxidative stress modify prognosis after treatment for breast cancer...
  23. ncbi request reprint Cellular aging of mitochondrial DNA-depleted cells
    Sun Young Park
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong Kangnam ku, Seoul 135 710, Republic of Korea
    Biochem Biophys Res Commun 325:1399-405. 2004
    ..Features simulating aged cells were also observed in MDA-MB-435 rho(0) cells. These results support the mitochondrial theory of aging, and suggest that rho(0) cells could serve as an in vitro model for aged cells...
  24. ncbi request reprint Mitochondrial impairment is accompanied by impaired oxidative DNA repair in the nucleus
    Robert L Delsite
    Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 212312, USA
    Mutagenesis 18:497-503. 2003
    ..It also provides insights into the development of mitochondrial disease as a consequence of cancer therapy...
  25. pmc Mitochondria-mediated nuclear mutator phenotype in Saccharomyces cerevisiae
    Anne Karin Rasmussen
    Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Bunting Blaustein Cancer Research Building, 1650 Orleans Street, Baltimore, MD 21231, USA
    Nucleic Acids Res 31:3909-17. 2003
    ..Together, our data suggest that mitochondrial dysfunction is mutagenic and multiple pathways are involved in this nuclear mutator phenotype...
  26. ncbi request reprint Mitochondrial impairment in p53-deficient human cancer cells
    Shaoyu Zhou
    Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Bunting Blaustein Cancer Research Building, 1650 Orleans Street, Room 143, Baltimore, MD 21231, USA
    Mutagenesis 18:287-92. 2003
    ..Together, our study suggests that p53 is involved in regulation of COXII at the protein level but not at the mRNA level. p53 does not affect mtDNA mutation or mitochondrial ultrastructure...
  27. ncbi request reprint Xenogenic transfer of isolated murine mitochondria into human rho0 cells can improve respiratory function
    Eyad Katrangi
    Bouve College of Health Sciences, School of Pharmacy, Department of Pharmaceutical Sciences, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA
    Rejuvenation Res 10:561-70. 2007
    ....
  28. pmc Saccharomyces cerevisiae polymerase zeta functions in mitochondria
    Hengshan Zhang
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Genetics 172:2683-8. 2006
    ..Supporting this evidence, both polymerase zeta and Rev1p were found to be localized in the mitochondria. This is the first report demonstrating that the DNA polymerase zeta and Rev1 proteins function in the mitochondria...
  29. ncbi request reprint Loss of p53 function in colon cancer cells results in increased phosphocholine and total choline
    Noriko Mori
    Department of Radiology, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Traylor Building, Baltimore, MD 21205, USA
    Mol Imaging 3:319-23. 2004
    ..These data suggest that the increased malignancy of cancer cells resulting from loss of p53 may be mediated, in part, through the choline phospholipid pathway...
  30. ncbi request reprint Mitochondrial correlation microscopy and nanolaser spectroscopy - new tools for biophotonic detection of cancer in single cells
    Paul L Gourley
    Biomolecular Interfaces and Systems, Sandia National Laboratories, Albuquerque, NM 87185, USA
    Technol Cancer Res Treat 4:585-92. 2005
    ..These optical methods represent powerful new tools that hold promise for detecting cancer at an early stage and may help to limit delays in diagnosis and treatment...

Research Grants20

  1. Mitochondria and Mutagenesis
    Keshav K Singh; Fiscal Year: 2010
    ..abstract_text> ..
  2. Mitochondria and Carcinogenesis
    Keshav K Singh; Fiscal Year: 2010
    ..The proposed study will help determine the contribution of mutant mtDNA to the development of human cancer. ..
  3. MITDNA MUTAGENESIS BY ENVIRONMENTAL CARCINOGENS
    Keshav Singh; Fiscal Year: 1999
    ..The proposed study will fill a major gap in our understanding of the mechanisms of mitDNA mutagenesis induced by environmental carcinogens which has direct relevance in on the induction of mitochondrial diseases. ..
  4. Mitochondria and Mutagenesis
    Keshav Singh; Fiscal Year: 2009
    ..abstract_text> ..
  5. Mitochondria and Carcinogenesis
    Keshav Singh; Fiscal Year: 2009
    ..The proposed study will help determine the contribution of mutant mtDNA to the development of human cancer. ..
  6. Loss of FLJ13639 Expression in Acute Leukemia
    Keshav Singh; Fiscal Year: 2009
    ..Confirmation of the role of the loss of FLJ13639 in leukemia prognosis, increase of chemo resistance should lead us and others, to develop new prognostic tools as well as novel, innovative therapeutic strategies. ..
  7. Mitochondria and Carcinogenesis
    Keshav Singh; Fiscal Year: 2007
    ..The proposed study will help determine the contribution of mutant mtDNA to the development of human cancer. ..
  8. Loss of FLJ13639 Expression in Acute Leukemia
    Keshav Singh; Fiscal Year: 2007
    ..Confirmation of the role of the loss of FLJ13639 in leukemia prognosis, increase of chemo resistance should lead us and others, to develop new prognostic tools as well as novel, innovative therapeutic strategies. ..
  9. MITDNA MUTAGENESIS BY ENVIRONMENTAL CARCINOGENS
    Keshav Singh; Fiscal Year: 2000
    ..The proposed study will fill a major gap in our understanding of the mechanisms of mitDNA mutagenesis induced by environmental carcinogens which has direct relevance in on the induction of mitochondrial diseases. ..
  10. MITDNA MUTAGENESIS BY ENVIRONMENTAL CARCINOGENS
    Keshav Singh; Fiscal Year: 2001
    ..The proposed study will fill a major gap in our understanding of the mechanisms of mitDNA mutagenesis induced by environmental carcinogens which has direct relevance in on the induction of mitochondrial diseases. ..
  11. MITDNA MUTAGENESIS BY ENVIRONMENTAL CARCINOGENS
    Keshav Singh; Fiscal Year: 2001
    ..The proposed study will fill a major gap in our understanding of the mechanisms of mitDNA mutagenesis induced by environmental carcinogens which has direct relevance in on the induction of mitochondrial diseases. ..
  12. MITDNA MUTAGENESIS BY ENVIRONMENTAL CARCINOGENS
    Keshav Singh; Fiscal Year: 2002
    ..The proposed study will fill a major gap in our understanding of the mechanisms of mitDNA mutagenesis induced by environmental carcinogens which has direct relevance in on the induction of mitochondrial diseases. ..
  13. MITDNA MUTAGENESIS BY ENVIRONMENTAL CARCINOGENS
    Keshav Singh; Fiscal Year: 2003
    ..The proposed study will fill a major gap in our understanding of the mechanisms of mitDNA mutagenesis induced by environmental carcinogens which has direct relevance in on the induction of mitochondrial diseases. ..
  14. Mitochondria and Mutagenesis
    Keshav Singh; Fiscal Year: 2006
    ....
  15. Mitochondria and Mutagenesis
    Keshav Singh; Fiscal Year: 2007
    ....
  16. Mitochondria and Carcinogenesis
    Keshav Singh; Fiscal Year: 2006
    ..The proposed study will help determine the contribution of mutant mtDNA to the development of human cancer. ..
  17. Loss of FLJ13639 Expression in Acute Leukemia
    Keshav K Singh; Fiscal Year: 2010
    ..Confirmation of the role of the loss of FLJ13639 in leukemia prognosis, increase of chemo resistance should lead us and others, to develop new prognostic tools as well as novel, innovative therapeutic strategies. ..