Brahm Segal

Summary

Affiliation: Roswell Park Cancer Institute
Country: USA

Publications

  1. ncbi request reprint Aspergillus fumigatus extract differentially regulates antigen-specific CD4+ and CD8+ T cell responses to promote host immunity
    Jianming Tao
    Department of Immunology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    J Leukoc Biol 80:529-37. 2006
  2. ncbi request reprint Review of epidemiology, diagnosis, and treatment of invasive mould infections in allogeneic hematopoietic stem cell transplant recipients
    Zahida Bhatti
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA
    Mycopathologia 162:1-15. 2006
  3. ncbi request reprint Prevention and treatment of cancer-related infections
    Brahm H Segal
    Roswell Park Cancer Institute, USA
    J Natl Compr Canc Netw 6:122-74. 2008
  4. ncbi request reprint Aspergillosis
    Brahm H Segal
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    N Engl J Med 360:1870-84. 2009
  5. pmc Myeloid-derived suppressor cells modulate immune responses independently of NADPH oxidase in the ovarian tumor microenvironment in mice
    Heidi E Godoy
    Department of Gynecology, Roswell Park Cancer Institute, Buffalo, New York, United States of America
    PLoS ONE 8:e69631. 2013
  6. pmc Role of NADPH oxidase versus neutrophil proteases in antimicrobial host defense
    R Robert Vethanayagam
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York, United States of America
    PLoS ONE 6:e28149. 2011
  7. pmc NETosis and NADPH oxidase: at the intersection of host defense, inflammation, and injury
    Nikolaos G Almyroudis
    Division of Infectious Diseases, Department of Medicine, University at Buffalo School of Medicine Buffalo, NY, USA Department of Medicine, Roswell Park Cancer Institute Buffalo, NY, USA
    Front Immunol 4:45. 2013
  8. ncbi request reprint Antibacterial prophylaxis in patients with neutropenia
    Brahm H Segal
    Division of Infectious Diseases, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    J Natl Compr Canc Netw 5:235-42. 2007
  9. ncbi request reprint Combination antifungals: an update
    Brahm H Segal
    Roswell Park Cancer Institute, Division of Infectious Diseases, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Expert Rev Anti Infect Ther 5:883-92. 2007
  10. ncbi request reprint Heat shock proteins as vaccine adjuvants in infections and cancer
    Brahm H Segal
    Department of Medicine, Immunology, Cellular Stress Biology, and Urologic Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Drug Discov Today 11:534-40. 2006

Research Grants

Detail Information

Publications48

  1. ncbi request reprint Aspergillus fumigatus extract differentially regulates antigen-specific CD4+ and CD8+ T cell responses to promote host immunity
    Jianming Tao
    Department of Immunology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    J Leukoc Biol 80:529-37. 2006
    ..This information suggests that strategies to target CD4+ T cell effector maturation may promote host immunity to Aspergillus and unexpectedly demonstrates the use for Af extract as a CD8+ T cell adjuvant...
  2. ncbi request reprint Review of epidemiology, diagnosis, and treatment of invasive mould infections in allogeneic hematopoietic stem cell transplant recipients
    Zahida Bhatti
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA
    Mycopathologia 162:1-15. 2006
    ..We review the epidemiology, diagnosis, and management of invasive mould infection in HSCT, with a focus on allogeneic recipients. We also discuss options for prevention and early treatment of invasive mould infections...
  3. ncbi request reprint Prevention and treatment of cancer-related infections
    Brahm H Segal
    Roswell Park Cancer Institute, USA
    J Natl Compr Canc Netw 6:122-74. 2008
  4. ncbi request reprint Aspergillosis
    Brahm H Segal
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    N Engl J Med 360:1870-84. 2009
  5. pmc Myeloid-derived suppressor cells modulate immune responses independently of NADPH oxidase in the ovarian tumor microenvironment in mice
    Heidi E Godoy
    Department of Gynecology, Roswell Park Cancer Institute, Buffalo, New York, United States of America
    PLoS ONE 8:e69631. 2013
    ..We speculate that factors inherent to the tumor, tumor microenvironment, or both determine the specific requirement for NADPH oxidase in MDSC accumulation and function...
  6. pmc Role of NADPH oxidase versus neutrophil proteases in antimicrobial host defense
    R Robert Vethanayagam
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York, United States of America
    PLoS ONE 6:e28149. 2011
    ..cepacia, whereas the proteases we evaluated were dispensable. Our results indicate that NADPH oxidase dependent pathways separate from neutrophil serine protease activation are required for host defense against specific pathogens...
  7. pmc NETosis and NADPH oxidase: at the intersection of host defense, inflammation, and injury
    Nikolaos G Almyroudis
    Division of Infectious Diseases, Department of Medicine, University at Buffalo School of Medicine Buffalo, NY, USA Department of Medicine, Roswell Park Cancer Institute Buffalo, NY, USA
    Front Immunol 4:45. 2013
    ..Recent work supports a role for NETosis in both acute lung injury and in autoimmunity. Knowledge gained about mechanisms that modulate NETosis may lead to novel therapeutic approaches to limit inflammation-associated injury...
  8. ncbi request reprint Antibacterial prophylaxis in patients with neutropenia
    Brahm H Segal
    Division of Infectious Diseases, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    J Natl Compr Canc Netw 5:235-42. 2007
    ..However, if such patients develop fever during neutropenia, they should be considered for outpatient empiric therapy with an oral quinolone-containing regimen if they meet criteria for low risk for complications...
  9. ncbi request reprint Combination antifungals: an update
    Brahm H Segal
    Roswell Park Cancer Institute, Division of Infectious Diseases, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Expert Rev Anti Infect Ther 5:883-92. 2007
    ..We review data from in vitro and animal model studies as well as insights from clinical trials to discuss current thoughts and highlight the gaps in our knowledge surrounding combination antifungal therapy...
  10. ncbi request reprint Heat shock proteins as vaccine adjuvants in infections and cancer
    Brahm H Segal
    Department of Medicine, Immunology, Cellular Stress Biology, and Urologic Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Drug Discov Today 11:534-40. 2006
    ..Their roles in priming multiple host defense pathways are being exploited in vaccine development for cancer and infectious diseases...
  11. ncbi request reprint Role of macrophages in host defense against aspergillosis and strategies for immune augmentation
    Brahm H Segal
    Division of Infectious Diseases, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, USA
    Oncologist 12:7-13. 2007
    ..Macrophages are therefore a target for immune augmentation strategies that include administration of cytokines, colony-stimulating factors, and pathogen recognition receptor ligands...
  12. ncbi request reprint Immunotherapy for fungal infections
    Brahm H Segal
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Clin Infect Dis 42:507-15. 2006
    ..g., vaccines). Immunotherapy must be tailored to specific immunocompromised states. Challenges exist in bringing promising immunotherapies from the laboratory to clinical trials...
  13. ncbi request reprint Primary phagocytic disorders of childhood
    B H Segal
    Divisions of Infectious Diseases and Allergy, Immunology, and Rheumatology, State University of New York at Buffalo, Roswell Park Cancer Institute, Buffalo, New York, USA
    Pediatr Clin North Am 47:1311-38. 2000
    ..Prophylactic antibiotics, BMT, and the use of exogenous cytokines, such as IFN-gamma and G-CSF, are appropriate for specific phagocytic disorders. Gene therapy is a promising strategy for several of the phagocytic disorders...
  14. ncbi request reprint Current approaches to diagnosis and treatment of invasive aspergillosis
    Brahm H Segal
    Department of Medicine, SUNY at Buffalo, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Am J Respir Crit Care Med 173:707-17. 2006
    ..In addition, there has been an increased understanding of the immunology of Aspergillus infection, paving the way to novel immune augmentation strategies in animal models that merit evaluation in phase I clinic trials...
  15. doi request reprint Chronic granulomatous disease
    B H Segal
    Departments of Medicine and Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Cell Mol Life Sci 66:553-8. 2009
    ..This model is based on studies in mice and requires correlation in humans...
  16. doi request reprint Invasive aspergillosis in chronic granulomatous disease
    Brahm H Segal
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Med Mycol 47:S282-90. 2009
    ....
  17. pmc Defining responses to therapy and study outcomes in clinical trials of invasive fungal diseases: Mycoses Study Group and European Organization for Research and Treatment of Cancer consensus criteria
    Brahm H Segal
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Clin Infect Dis 47:674-83. 2008
    ..We also discuss potential pitfalls in assessing outcome, such as conflicting clinical, radiological, and/or mycological data and gaps in knowledge...
  18. pmc NADPH oxidase limits innate immune responses in the lungs in mice
    Brahm H Segal
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York, United States of America
    PLoS ONE 5:e9631. 2010
    ..g., inflammatory bowel disease). The mechanisms by which NADPH oxidase regulates inflammation are not well understood...
  19. ncbi request reprint Fungal infections in nontransplant patients with hematologic malignancies
    Brahm H Segal
    Division of Infectious Diseases, SUNY at Buffalo, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Infect Dis Clin North Am 16:935-64, vii. 2002
    ..This article reviews the epidemiology, clinical manifestations, diagnostic evaluation, and treatment of the major fungal pathogens in nontransplant patients with hematologic malignancies...
  20. ncbi request reprint Prevention and early treatment of invasive fungal infection in patients with cancer and neutropenia and in stem cell transplant recipients in the era of newer broad-spectrum antifungal agents and diagnostic adjuncts
    Brahm H Segal
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Clin Infect Dis 44:402-9. 2007
    ..Finally, we discuss the implications of newer antifungal agents and diagnostic adjuncts in the design of future clinical trials to evaluate prophylaxis and early prevention strategies...
  21. ncbi request reprint Invasive filamentous fungal infections in allogeneic hematopoietic stem cell transplant recipients after recovery from neutropenia: clinical, radiologic, and pathologic characteristics
    Aasma Shaukat
    Department of Medicine, School of Medicine and Biochemical Sciences, SUNY at Buffalo, Buffalo 14263, NY, USA
    Mycopathologia 159:181-8. 2005
    ..The predominance of coagulative necrosis in our series may reflect the high doses of corticosteroids used to treat graft-versus-host disease (GVHD), which may have disabled leukocyte trafficking and hyphal killing...
  22. ncbi request reprint Efficacy of high-efficiency particulate air filtration in preventing aspergillosis in immunocompromised patients with hematologic malignancies
    Theresa Hahn
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Infect Control Hosp Epidemiol 23:525-31. 2002
    ..To describe and investigate the cause of an outbreak of 10 cases of nosocomial invasive infection with Aspergillus flavus in a hematologic oncology patient care unit...
  23. pmc Pulmonary aspergillosis: clinical presentation, diagnostic tests, management and complications
    Rami Sherif
    Department of Medicine, Roswell Park Cancer Institute, School of Medicine and Biomedical Sciences, University of Buffalo, Buffalo, New York 14263, USA
    Curr Opin Pulm Med 16:242-50. 2010
    ..We will review insights gained in host defense against Aspergillus species and the immunopathogenesis of Aspergillus-related diseases as well as important advances made in fungal diagnostics and antifungal therapy...
  24. ncbi request reprint Issues related to the design and interpretation of clinical trials of salvage therapy for invasive mold infection
    Nikolaos G Almyroudis
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Clin Infect Dis 43:1449-55. 2006
    ..Given that randomized studies are unrealistic, studies involving carefully selected, matched, contemporaneous control subjects are likely to be the most useful alternative...
  25. ncbi request reprint Long-term use of oral beclomethasone dipropionate for the treatment of gastrointestinal graft-versus-host disease
    Renuka V Iyer
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Biol Blood Marrow Transplant 11:587-92. 2005
    ..Multiple courses may be necessary to achieve or maintain response in some patients, and prolonged BDP therapy is a feasible alternative to prolonged systemic corticosteroids...
  26. ncbi request reprint Antifungal agents in hematopoietic stem cell transplantation
    G Iyer Parameswaran
    Division of Infectious Diseases, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Curr Pharm Des 14:2011-21. 2008
    ..Finally there has been increasing interest on combination therapy for invasive aspergillosis due to the high rate of failure of the currently available antifungals, especially in the profoundly immunocompromised host...
  27. ncbi request reprint Broad-spectrum antifungal prophylaxis in patients with cancer at high risk for invasive mold infections: point
    Antonio V Gonzalez
    The Division of Infectious Diseases, Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA
    J Natl Compr Canc Netw 6:175-82. 2008
    ....
  28. pmc Effect of amphotericin B and micafungin combination on survival, histopathology, and fungal burden in experimental aspergillosis in the p47phox-/- mouse model of chronic granulomatous disease
    Carly G Dennis
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Antimicrob Agents Chemother 50:422-7. 2006
    ..fumigatus challenge and also demonstrated unique features of CGD mice as a model for experimental aspergillosis...
  29. ncbi request reprint Infection control measures to prevent invasive mould diseases in hematopoietic stem cell transplant recipients
    Kimberly Partridge-Hinckley
    Division of Infection Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Mycopathologia 168:329-37. 2009
    ....
  30. ncbi request reprint Ganciclovir inhibits lymphocyte proliferation by impairing DNA synthesis
    Minoo Battiwalla
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York 14202, USA
    Biol Blood Marrow Transplant 13:765-70. 2007
    ..Collectively, these results show that ganciclovir suppresses T-lymphocyte proliferation in vitro by inhibiting DNA synthesis; with implications for T-lymphocyte function following allogeneic BMT...
  31. ncbi request reprint Posaconazole as salvage therapy in patients with chronic granulomatous disease and invasive filamentous fungal infection
    Brahm H Segal
    Department of Medicine, Division of Infectious Diseases, Roswell Park Cancer Institute, Buffalo, NY, USA
    Clin Infect Dis 40:1684-8. 2005
    ..In this preliminary study, salvage treatment with posaconazole was safe and effective...
  32. ncbi request reprint Prevention and treatment of invasive fungal diseases in neutropenic patients
    Nikolaos G Almyroudis
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Curr Opin Infect Dis 22:385-93. 2009
    ..Despite advances in the diagnosis and management, invasive fungal diseases contribute substantially to the morbidity and mortality of patients with prolonged neutropenia...
  33. pmc Altered granulopoietic profile and exaggerated acute neutrophilic inflammation in mice with targeted deficiency in the sialyltransferase ST6Gal I
    Mehrab Nasirikenari
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Blood 108:3397-405. 2006
    ..Together, our study demonstrated a role for ST6Gal-1, possibly from extramedullary sources (eg, produced in liver) in regulating inflammation, circulating neutrophil homeostasis, and replenishing granulocyte numbers...
  34. ncbi request reprint Invasive pulmonary filamentous fungal infection in a patient receiving inhaled corticosteroid therapy
    Elvis Peter
    Department of Medicine, School of Medicine and Biochemical Sciences, State University of New York, Buffalo, NY, USA
    Clin Infect Dis 35:e54-6. 2002
    ..This case demonstrates the potential risk for opportunistic fungal infections in patients treated with high-potency lipophilic inhaled corticosteroids...
  35. pmc Modeling the combination of amphotericin B, micafungin, and nikkomycin Z against Aspergillus fumigatus in vitro using a novel response surface paradigm
    Yseult F Brun
    Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Antimicrob Agents Chemother 51:1804-12. 2007
    ..Applying this response surface method to a huge data set for a three-antifungal-agent combination is novel. This new paradigm has the potential to significantly advance the field of combination antifungal pharmacology...
  36. ncbi request reprint Acid aspiration-induced lung inflammation and injury are exacerbated in NADPH oxidase-deficient mice
    Brahm H Segal
    Department of Medicine, Roswell Park Cancer Institute, University at Buffalo State University of New York, Buffalo, NY 14214 3013, USA
    Am J Physiol Lung Cell Mol Physiol 292:L760-8. 2007
    ..We speculate that this downmodulating effect may be mediated by promoting the transition from production of cytokines and chemokines involved in neutrophilic infiltration to a less injurious, chronic inflammatory response...
  37. pmc Linezolid-resistant Enterococcus faecalis isolated from a cord blood transplant recipient
    Imad Dibo
    Department of Medicine, Roswell Park Cancer Institute, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York, USA
    J Clin Microbiol 42:1843-5. 2004
    ..Sequencing showed a G2576U mutation in the 23S rRNA gene. Because of the important niche of linezolid in cancer treatment, linezolid-resistant E. faecalis is noteworthy...
  38. ncbi request reprint Immunotherapy for fungal infections with special emphasis on central nervous system infections
    Iyer G Parameswaran
    Division of Infectious Diseases, University at Buffalo School of Medicine, Buffalo, NY, USA
    Neurol India 55:260-6. 2007
    ..This notion is only partially accurate. Immune-based therapies for fungal CNS disease are at an exploratory level and merit further evaluation in clinical trials...
  39. pmc Altered eosinophil profile in mice with ST6Gal-1 deficiency: an additional role for ST6Gal-1 generated by the P1 promoter in regulating allergic inflammation
    Mehrab Nasirikenari
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York, USA
    J Leukoc Biol 87:457-66. 2010
    ....
  40. ncbi request reprint Multicenter, noncomparative study of caspofungin in combination with other antifungals as salvage therapy in adults with invasive aspergillosis
    Johan Maertens
    Department of Hematology, University Hospital Gasthuisberg, Leuven, Belgium
    Cancer 107:2888-97. 2006
    ..Interest remains as to whether caspofungin, in combination with other antifungal classes, can improve the efficacy against IA...
  41. doi request reprint Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America
    Thomas J Walsh
    Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA
    Clin Infect Dis 46:327-60. 2008
  42. doi request reprint Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease
    Luigina Romani
    Department of Experimental Medicine, University of Perugia, 06126 Perugia, Italy
    Nature 451:211-5. 2008
    ..Yet, this condition can be reverted by reactivating the pathway downstream of the superoxide-dependent step...
  43. ncbi request reprint Dapsone-induced methemoglobinemia after hematopoietic stem cell transplantation
    Lauren M Dunford
    Biol Blood Marrow Transplant 12:241-2. 2006
  44. ncbi request reprint Antibacterial prophylaxis in patients with cancer and neutropenia
    Nikolaos G Almyroudis
    N Engl J Med 354:90-4; author reply 90-4. 2006
  45. ncbi request reprint Treatment of invasive aspergillosis with posaconazole in patients who are refractory to or intolerant of conventional therapy: an externally controlled trial
    Thomas J Walsh
    Immunocompromised Host Section, National Cancer Institute, Bethesda, MD 20892, USA
    Clin Infect Dis 44:2-12. 2007
    ..Current treatments provide limited benefit. Posaconazole is an extended-spectrum triazole with in vitro and in vivo activity against Aspergillus species...
  46. ncbi request reprint p47phox deficiency impairs NF-kappa B activation and host defense in Pseudomonas pneumonia
    Ruxana T Sadikot
    Department of Veterans Affairs and Division of Allergy, Pulmonary and Critical Care, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 172:1801-8. 2004
    ..These data indicate that the NADPH oxidase-dependent respiratory burst stimulated by Pseudomonas infection contributes to host defense by modulating redox-dependent signaling through the NF-kappaB pathway...
  47. ncbi request reprint Clinical research in the lay press: irresponsible journalism raises a huge dose of doubt
    Elias J Anaissie
    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Clin Infect Dis 43:1031-9. 2006
  48. pmc Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) C
    Ben de Pauw
    Department of Blood Transfusion Service and Transplant Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Infect Dis 46:1813-21. 2008
    ..Clarity and uniformity in defining these infections are important factors in improving the quality of clinical studies. A standard set of definitions strengthens the consistency and reproducibility of such studies...

Research Grants2

  1. Role of NADPH Oxidase in Regulating Inflammation
    Brahm Segal; Fiscal Year: 2009
    ..Our proposal will evaluate mechanisms by which NADPH oxidase regulates inflammation that will be important to our understanding of CGD, and will be broadly relevant to pathologic conditions, such as inflammatory disorders and cancer. ..
  2. Role of NADPH Oxidase in Regulating Inflammation
    Brahm H Segal; Fiscal Year: 2010
    ..Our proposal will evaluate mechanisms by which NADPH oxidase regulates inflammation that will be important to our understanding of CGD, and will be broadly relevant to pathologic conditions, such as inflammatory disorders and cancer. ..