Genomes and Genes
Affiliation: Roswell Park Cancer Institute
- Segal B. Role of macrophages in host defense against aspergillosis and strategies for immune augmentation. Oncologist. 2007;12 Suppl 2:7-13 pubmed..Macrophages are therefore a target for immune augmentation strategies that include administration of cytokines, colony-stimulating factors, and pathogen recognition receptor ligands...
- Segal B, Han W, Bushey J, Joo M, Bhatti Z, Feminella J, et al. NADPH oxidase limits innate immune responses in the lungs in mice. PLoS ONE. 2010;5:e9631 pubmed publisher..These studies support a model in which NADPH oxidase-dependent, redox-mediated signaling is critical for termination of lung inflammation and suggest new potential therapeutic targets for CGD. ..
- Mayor P, Eng K, Singel K, Abrams S, Odunsi K, Moysich K, et al. Cancer in primary immunodeficiency diseases: Cancer incidence in the United States Immune Deficiency Network Registry. J Allergy Clin Immunol. 2018;141:1028-1035 pubmed publisher..These data point to a restricted role of the immune system in protecting from specific cancers. ..
- Szender J, Emmons T, Belliotti S, Dickson D, Khan A, Morrell K, et al. Impact of ascites volume on clinical outcomes in ovarian cancer: A cohort study. Gynecol Oncol. 2017;146:491-497 pubmed publisher..If these findings are confirmed in independent studies, consideration should be made to add the presence of large volume ascites at diagnosis to the staging criteria for ovarian cancer. ..