Giuseppe Sconocchia

Summary

Affiliation: Roswell Park Cancer Institute
Country: USA

Publications

  1. ncbi G-CSF-mobilized CD34+ cells cultured in interleukin-2 and stem cell factor generate a phenotypically novel monocyte
    Giuseppe Sconocchia
    Hematopoietic Stem Cell Transplantation Section, National Heart Lung and Blood Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda MD 20892 0001, USA
    J Leukoc Biol 76:1214-9. 2004
  2. ncbi Identification and in vitro expansion of CD4+ and CD8+ T cells specific for human neutrophil elastase
    Hiroshi Fujiwara
    Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 103:3076-83. 2004
  3. ncbi The antileukemia effect of HLA-matched NK and NK-T cells in chronic myelogenous leukemia involves NKG2D-target-cell interactions
    Giuseppe Sconocchia
    Stem Cell Allotransplantation Section, Hematology Branch, National Heart Lung and Blood Institute, Department of Transfusion Medicine, Clinical Center, National Institutes of Health (NIH, Bethesda, MD 20892, USA
    Blood 106:3666-72. 2005
  4. ncbi Autoreactive, cytotoxic T lymphocytes specific for peptides derived from normal B-cell differentiation antigens in healthy individuals and patients with B-cell malignancies
    Matthias Grube
    Hematology Branch, National Heart-Lung-Blood Institute/NIH, 9000 Rockville Pike, Building 10, Bethesda, MD 20892, USA
    Clin Cancer Res 10:1047-56. 2004
  5. ncbi Clonal dominance of chronic myelogenous leukemia is associated with diminished sensitivity to the antiproliferative effects of neutrophil elastase
    Frank El-Ouriaghli
    Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Blood 102:3786-92. 2003
  6. ncbi Neutrophil elastase enzymatically antagonizes the in vitro action of G-CSF: implications for the regulation of granulopoiesis
    Frank El Ouriaghli
    Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 101:1752-8. 2003
  7. ncbi Functional leukemia-associated antigen-specific memory CD8+ T cells exist in healthy individuals and in patients with chronic myelogenous leukemia before and after stem cell transplantation
    Katayoun Rezvani
    National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 102:2892-900. 2003
  8. ncbi In vitro induction of myeloid leukemia-specific CD4 and CD8 T cells by CD40 ligand-activated B cells gene modified to express primary granule proteins
    Hiroshi Fujiwara
    Stem Cell Allotransplant Section, Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland 20892, USA
    Clin Cancer Res 11:4495-503. 2005
  9. ncbi CD38 ligation plays a direct role in the induction of IL-1beta, IL-6, and IL-10 secretion in resting human monocytes
    Roberto Lande
    Department of Bacteriology and Medical Mycology, Istituto Superiore di Sanita, 00161, Rome, Italy
    Cell Immunol 220:30-8. 2002
  10. ncbi CD16(low/negative) tumor-infiltrating lymphocyte: lymphoid or myeloid in origin?
    Giuseppe Sconocchia
    Clin Cancer Res 13:1620; author reply 1621. 2007

Collaborators

Detail Information

Publications10

  1. ncbi G-CSF-mobilized CD34+ cells cultured in interleukin-2 and stem cell factor generate a phenotypically novel monocyte
    Giuseppe Sconocchia
    Hematopoietic Stem Cell Transplantation Section, National Heart Lung and Blood Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda MD 20892 0001, USA
    J Leukoc Biol 76:1214-9. 2004
    ..The generation of CD56+ cells was negatively regulated by hyaluronic acid and IL-4, indicating that extracellular matrix may play an important role in the commitment of CD34+ cells into CD56 myeloid and lymphoid lineages...
  2. ncbi Identification and in vitro expansion of CD4+ and CD8+ T cells specific for human neutrophil elastase
    Hiroshi Fujiwara
    Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 103:3076-83. 2004
    ..HNE could, therefore, be used in an HLA-unrestricted manner to induce leukemia-reactive CTLs for adoptive immunotherapy...
  3. ncbi The antileukemia effect of HLA-matched NK and NK-T cells in chronic myelogenous leukemia involves NKG2D-target-cell interactions
    Giuseppe Sconocchia
    Stem Cell Allotransplantation Section, Hematology Branch, National Heart Lung and Blood Institute, Department of Transfusion Medicine, Clinical Center, National Institutes of Health (NIH, Bethesda, MD 20892, USA
    Blood 106:3666-72. 2005
    ..However, in vivo, CML cells may avoid NK-cell-mediated immune destruction by immune escape, shedding MICA into the plasma, thereby down-regulating NKG2D on CML CD56(+) cells...
  4. ncbi Autoreactive, cytotoxic T lymphocytes specific for peptides derived from normal B-cell differentiation antigens in healthy individuals and patients with B-cell malignancies
    Matthias Grube
    Hematology Branch, National Heart-Lung-Blood Institute/NIH, 9000 Rockville Pike, Building 10, Bethesda, MD 20892, USA
    Clin Cancer Res 10:1047-56. 2004
    ..They are of low avidity and require high doses of peptide for activation. Strategies to increase T-cell avidity would be necessary for T-cell immunotherapeutic approaches using the peptides studied...
  5. ncbi Clonal dominance of chronic myelogenous leukemia is associated with diminished sensitivity to the antiproliferative effects of neutrophil elastase
    Frank El-Ouriaghli
    Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Blood 102:3786-92. 2003
    ..These results suggest that elastase overproduction by the leukemic clone can change the growth environment by digesting growth factors, thereby giving advantage to Ph+ hematopoiesis...
  6. ncbi Neutrophil elastase enzymatically antagonizes the in vitro action of G-CSF: implications for the regulation of granulopoiesis
    Frank El Ouriaghli
    Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 101:1752-8. 2003
    ..These results support a role for neutrophil elastase in providing negative feedback to granulopoiesis by direct antagonism of G-CSF...
  7. ncbi Functional leukemia-associated antigen-specific memory CD8+ T cells exist in healthy individuals and in patients with chronic myelogenous leukemia before and after stem cell transplantation
    Katayoun Rezvani
    National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 102:2892-900. 2003
    ..The increased response in patients after SCT suggests a quantitative explanation for the greater effect of allogeneic SCT...
  8. ncbi In vitro induction of myeloid leukemia-specific CD4 and CD8 T cells by CD40 ligand-activated B cells gene modified to express primary granule proteins
    Hiroshi Fujiwara
    Stem Cell Allotransplant Section, Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland 20892, USA
    Clin Cancer Res 11:4495-503. 2005
    ..This study emphasizes the clinical potential of PGP for expansion and adoptive transfer of polyclonal leukemia antigen-specific T cells to treat leukemia...
  9. ncbi CD38 ligation plays a direct role in the induction of IL-1beta, IL-6, and IL-10 secretion in resting human monocytes
    Roberto Lande
    Department of Bacteriology and Medical Mycology, Istituto Superiore di Sanita, 00161, Rome, Italy
    Cell Immunol 220:30-8. 2002
    ..The key element for the receptor mediated signaling is represented by surface density of CD38 on resting monocytes...
  10. ncbi CD16(low/negative) tumor-infiltrating lymphocyte: lymphoid or myeloid in origin?
    Giuseppe Sconocchia
    Clin Cancer Res 13:1620; author reply 1621. 2007