Sheila N J Sait

Summary

Affiliation: Roswell Park Cancer Institute
Country: USA

Publications

  1. ncbi request reprint Translocation (4;11)(p12;q23) with rearrangement of FRYL and MLL in therapy-related acute myeloid leukemia
    Sheila N J Sait
    Clinical Cytogenetics Laboratory, DNA Microarray and Genomics Facility, Departments of Pathology and Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Genet Cytogenet 177:143-6. 2007
  2. pmc Smoking adversely affects survival in acute myeloid leukemia patients
    Ramya Varadarajan
    Department of Medicine, Leukemia Section, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Int J Cancer 130:1451-8. 2012
  3. doi request reprint Is obesity a prognostic factor for acute myeloid leukemia outcome?
    Hun Ju Lee
    Leukemia Section, Department of Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Ann Hematol 91:359-65. 2012
  4. pmc Phase 1 study of arsenic trioxide, high-dose cytarabine, and idarubicin to down-regulate constitutive signal transducer and activator of transcription 3 activity in patients aged <60 years with acute myeloid leukemia
    Meir Wetzler
    Leukemia Section, Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer 117:4861-8. 2011
  5. pmc Myeloid blastic transformation of myeloproliferative neoplasms--a review of 112 cases
    Syed J Noor
    Leukemia Section, Department of Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Leuk Res 35:608-13. 2011
  6. doi request reprint Genomic, immunophenotypic, and NPM1/FLT3 mutational studies on 17 patients with normal karyotype acute myeloid leukemia (AML) followed by aberrant karyotype AML at relapse
    Eunice S Wang
    Leukemia Service, Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Cancer Genet Cytogenet 202:101-7. 2010
  7. doi request reprint Hypoxia-inducible factor-1α protein expression is associated with poor survival in normal karyotype adult acute myeloid leukemia
    George Deeb
    Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA
    Leuk Res 35:579-84. 2011
  8. ncbi request reprint Acute myeloid leukemia developing during imatinib mesylate therapy for chronic myeloid leukemia in the absence of new cytogenetic abnormalities
    Attaphol Pawarode
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Leuk Res 31:1589-92. 2007
  9. pmc Recurrent deletion of 9q34 in adult normal karyotype precursor B-cell acute lymphoblastic leukemia
    Norma J Nowak
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Cancer Genet Cytogenet 199:15-20. 2010
  10. pmc Metachronous and synchronous presentation of acute myeloid leukemia and lung cancer
    Ramya Varadarajan
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Leuk Res 33:1208-11. 2009

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Translocation (4;11)(p12;q23) with rearrangement of FRYL and MLL in therapy-related acute myeloid leukemia
    Sheila N J Sait
    Clinical Cytogenetics Laboratory, DNA Microarray and Genomics Facility, Departments of Pathology and Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Genet Cytogenet 177:143-6. 2007
    ..Thus, t(4;11)(p12;q23) with MLL and FRYL involvement represents a new recurring 11q23 translocation, to date seen only in therapy-related acute leukemias...
  2. pmc Smoking adversely affects survival in acute myeloid leukemia patients
    Ramya Varadarajan
    Department of Medicine, Leukemia Section, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Int J Cancer 130:1451-8. 2012
    ..In summary, cigarette smoking has a deleterious effect on OS in AML...
  3. doi request reprint Is obesity a prognostic factor for acute myeloid leukemia outcome?
    Hun Ju Lee
    Leukemia Section, Department of Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Ann Hematol 91:359-65. 2012
    ..We conclude that high BMI should not be a barrier to administer high-dose cytarabine-containing regimens for AML induction...
  4. pmc Phase 1 study of arsenic trioxide, high-dose cytarabine, and idarubicin to down-regulate constitutive signal transducer and activator of transcription 3 activity in patients aged <60 years with acute myeloid leukemia
    Meir Wetzler
    Leukemia Section, Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer 117:4861-8. 2011
    ..In vitro treatment of AML blasts with arsenic trioxide (ATO) down-regulated STAT3 activity within 6 hours associated with a reduced viability within 48 hours...
  5. pmc Myeloid blastic transformation of myeloproliferative neoplasms--a review of 112 cases
    Syed J Noor
    Leukemia Section, Department of Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Leuk Res 35:608-13. 2011
    ..Finally, allogeneic transplantation represents the only chance for long-term survival in these patients...
  6. doi request reprint Genomic, immunophenotypic, and NPM1/FLT3 mutational studies on 17 patients with normal karyotype acute myeloid leukemia (AML) followed by aberrant karyotype AML at relapse
    Eunice S Wang
    Leukemia Service, Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Cancer Genet Cytogenet 202:101-7. 2010
    ..Additional studies are needed to confirm whether AK AML cells represent selection of rare preexisting clones below aCGH detection and to further characterize the molecular lesions found at time of AK AML relapse...
  7. doi request reprint Hypoxia-inducible factor-1α protein expression is associated with poor survival in normal karyotype adult acute myeloid leukemia
    George Deeb
    Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA
    Leuk Res 35:579-84. 2011
    ..HIF-1α expression correlated with VEGF-C but not VEGF-A, marrow angiogenesis, FLT3 ITD or NPM1 mutations. These results support HIF-1α as an outcome marker for NK-AML...
  8. ncbi request reprint Acute myeloid leukemia developing during imatinib mesylate therapy for chronic myeloid leukemia in the absence of new cytogenetic abnormalities
    Attaphol Pawarode
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Leuk Res 31:1589-92. 2007
    ..Thus, development of AML as a rare event in CML patients with cytogenetic responses to imatinib therapy does not depend on the development of secondary cytogenetic abnormalities...
  9. pmc Recurrent deletion of 9q34 in adult normal karyotype precursor B-cell acute lymphoblastic leukemia
    Norma J Nowak
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Cancer Genet Cytogenet 199:15-20. 2010
    ..This aberration has not been described before in adult NK B-ALL. Larger number of samples is warranted to determine the prognostic significance of this cryptic deletion...
  10. pmc Metachronous and synchronous presentation of acute myeloid leukemia and lung cancer
    Ramya Varadarajan
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Leuk Res 33:1208-11. 2009
    ..In summary, this study supports the need for effective smoking cessation programs...
  11. doi request reprint CD19 expression in acute leukemia is not restricted to the cytogenetically aberrant populations
    Jawad Francis
    Leukemia Section, Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Leuk Lymphoma 54:1517-20. 2013
    ..There were no significant differences in karyotypic pattern between the CD19-positive and CD19-negative leukemic cells, raising the concern that therapeutically targeting CD19 for acute leukemia may not eradicate all malignant clones...
  12. doi request reprint Image cytometry-based detection of aneuploidy by fluorescence in situ hybridization in suspension
    Hans Minderman
    Flow and Image Cytometry Laboratory, Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cytometry A 81:776-84. 2012
    ..Additionally, FISH-IS analysis of samples procured at the time of clinical remission demonstrated the presence of residual +8 cells indicating that this approach may be used to detect MRD and associated chromosomal defects...
  13. doi request reprint Acute myeloid leukemia and diabetes insipidus with monosomy 7
    Antoine Harb
    Leukemia Section, Department of Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Genet Cytogenet 190:97-100. 2009
    ..In conclusion, it appears that AML with monosomy 7 and DI is a disease entity with specifically poor outcome...
  14. doi request reprint Acute myeloid leukemia and myelodysplastic syndrome following breast cancer: increased frequency of other cancers and of cancers in multiple family members
    Aruna Padmanabhan
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA
    Leuk Res 32:1820-3. 2008
    ..9%; p<0.0001) and >or=4 first-degree relatives with any type of cancer (OR: 5.37, CI: 1.44-19.9). Thus risk factors for AML/MDS following breast cancer include older age, other cancers and multiple first-degree relatives with cancer...
  15. ncbi request reprint Massive hyperdiploidy and tetraploidy in acute myelocytic leukemia and myelodysplastic syndrome
    Renuka V Iyer
    Leukemia Section, Department of Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Genet Cytogenet 148:29-34. 2004
    ..Massive hyperdiploidy and tetraploidy define a prognostically unfavorable cytogenetic group in de novo AML...
  16. ncbi request reprint Double minute chromosomes in acute myeloid leukemia and myelodysplastic syndrome: identification of new amplification regions by fluorescence in situ hybridization and spectral karyotyping
    Sheila N J Sait
    Clinical Cytogenetics Laboratory, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Genes Chromosomes Cancer 34:42-7. 2002
    ..dmin originating from chromosome 19 have not been reported previously in hematologic malignancies...
  17. pmc Treating octogenarian and nonagenarian acute myeloid leukemia patients--predictive prognostic models
    Antoine J Harb
    Leukemia Section, Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer 115:2472-81. 2009
    ..However, it is unclear whether the Charlson comorbidity index (CCI) or the hematopoietic cell transplant comorbidity index (HCTCI) is more sensitive...
  18. ncbi request reprint Isochromosome 1q in a myelodysplastic syndrome after treatment for acute promyelocytic leukemia
    Attaphol Pawarode
    Leukemia Section, Department of Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Genet Cytogenet 167:155-60. 2006
    ..The literature on t-MDS/t-AML after APL therapy and on isochromosome 1q is reviewed...
  19. ncbi request reprint Expression of the neural cell adhesion molecule CD56 is not associated with P-glycoprotein overexpression in core-binding factor acute myeloid leukemia
    Attaya Suvannasankha
    Department of Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Leuk Res 28:449-55. 2004
    ..CD56 expression did not correlate with Pgp expression or function, nor with expression of the other MDR proteins. Treatment failure associated with CD56 expression in CBFalpha-AML is not likely attributable to Pgp...
  20. ncbi request reprint Extra copies of chromosome 2 are a recurring aberration in ALK-negative lymphomas with anaplastic morphology
    Rina Kansal
    Department of Pathology, Buffalo General Hospital, The State University of New York, Buffalo, NY, USA
    Mod Pathol 18:235-43. 2005
    ..Further investigation of this finding is necessary to further our understanding of the heterogeneous group of ALK- lymphomas...
  21. ncbi request reprint Evaluation of urinary plasminogen activator, its receptor, matrix metalloproteinase-9, and von Willebrand factor in pancreatic cancer
    Shashi R Harvey
    Department of Laboratory Medicine, Roswell Park Cancer Institute, State University of New York at Buffalo, Buffalo, New York 14263, USA
    Clin Cancer Res 9:4935-43. 2003
    ....
  22. ncbi request reprint Routine immunophenotyping in acute leukemia: Role in lineage assignment and reassignment
    Misbah Qadir
    Leukemia Section, Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cytometry B Clin Cytom 70:329-34. 2006
    ..The data support routine inclusion of at least limited immunophenotyping in the diagnostic evaluation of acute leukemia...
  23. ncbi request reprint Unsuspected Klinefelter syndrome diagnosed during oncologic evaluation: a case series
    Margaret M Eberl
    Division of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Am Board Fam Pract 18:132-9. 2005
    ..This case series highlights the importance of maintaining a comprehensive and holistic approach to medical care. The medical, genetic, and psychosocial implications of the Klinefelter diagnosis are discussed...
  24. ncbi request reprint Chronic myeloid leukemia after treatment of lymphoid malignancies: response to imatinib mesylate and favorable outcomes in three patients
    Jeyanthi Ramanarayanan
    Department of Medicine, Roswell Park Cancer Institute, State University of New York, Buffalo, NY 14263, USA
    Leuk Res 30:701-5. 2006
    ..All three patients received imatinib therapy, with one patient subsequently undergoing allogeneic hematopoietic stem cell transplantation. All three patients have ongoing favorable responses to CML therapy...
  25. doi request reprint Co-expression of urokinase with haptoglobin in human carcinomas
    Shashikumar Harvey
    Department of Pathology, Roswell Park Cancer Institute and State University of New York at Buffalo, Buffalo, New York 14263, USA
    J Surg Res 152:189-97. 2009
    ..The question arose whether it would be possible to show the presence of Hp in the same cells where uPA was found...
  26. doi request reprint Acute promyelocytic leukemia after mitoxantrone therapy for multiple sclerosis
    Bhuvaneswari Ramkumar
    Department of Internal Medicine, Rochester General Hospital, Rochester, NY 14621, USA
    Cancer Genet Cytogenet 182:126-9. 2008
    ....
  27. ncbi request reprint Remission of Philadelphia chromosome-positive central nervous system leukemia after dasatinib therapy
    Ahmed Abdelhalim
    Leuk Lymphoma 48:1053-6. 2007