Shawn P Murphy

Summary

Affiliation: Roswell Park Cancer Institute
Country: USA

Publications

  1. doi request reprint Alterations in CIITA constitute a common mechanism accounting for downregulation of MHC class II expression in diffuse large B-cell lymphoma (DLBCL)
    Kelly A Cycon
    Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY, USA
    Exp Hematol 37:184-194. 2009
  2. ncbi request reprint DNA alkylating agents alleviate silencing of class II transactivator gene expression in L1210 lymphoma cells
    Shawn P Murphy
    Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Immunol 169:3085-93. 2002
  3. pmc Regulation of major histocompatibility complex class II gene expression in trophoblast cells
    Shawn P Murphy
    Department of Immunology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Reprod Biol Endocrinol 2:52. 2004
  4. ncbi request reprint Class II transactivator (CIITA) promoter methylation does not correlate with silencing of CIITA transcription in trophoblasts
    Renae Holtz
    Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Biol Reprod 69:915-24. 2003
  5. pmc Histone deacetylase inhibitors activate CIITA and MHC class II antigen expression in diffuse large B-cell lymphoma
    Kelly A Cycon
    Zeptometrix Corp, Buffalo, NY, USA
    Immunology 140:259-72. 2013
  6. pmc The immunogenicity of L1210 lymphoma clones correlates with their ability to function as antigen-presenting cells
    Kelly A Cycon
    Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY, USA
    Immunology 128:e641-51. 2009
  7. ncbi request reprint Dampening of IFN-gamma-inducible gene expression in human choriocarcinoma cells is due to phosphatase-mediated inhibition of the JAK/STAT-1 pathway
    Jason C Choi
    Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Immunol 178:1598-607. 2007
  8. ncbi request reprint Differential in vivo and in vitro HLA-G expression in melanoma cells: potential mechanisms
    Chien Chung Chang
    Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Hum Immunol 64:1057-63. 2003
  9. doi request reprint Maternal-fetal immunology
    B Anne Croy
    Immunol Invest 37:389-94. 2008

Collaborators

Detail Information

Publications9

  1. doi request reprint Alterations in CIITA constitute a common mechanism accounting for downregulation of MHC class II expression in diffuse large B-cell lymphoma (DLBCL)
    Kelly A Cycon
    Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY, USA
    Exp Hematol 37:184-194. 2009
    ..However, the molecular mechanisms responsible for decreased MHC-II expression in DLBCL are poorly defined. We therefore examined these mechanisms in established DLBCL cell lines...
  2. ncbi request reprint DNA alkylating agents alleviate silencing of class II transactivator gene expression in L1210 lymphoma cells
    Shawn P Murphy
    Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Immunol 169:3085-93. 2002
    ....
  3. pmc Regulation of major histocompatibility complex class II gene expression in trophoblast cells
    Shawn P Murphy
    Department of Immunology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Reprod Biol Endocrinol 2:52. 2004
    ..The elucidation of the silencing of CIITA in trophoblast cells may shed light on how the semi-allogeneic fetus evades immune rejection by the maternal immune system during pregnancy...
  4. ncbi request reprint Class II transactivator (CIITA) promoter methylation does not correlate with silencing of CIITA transcription in trophoblasts
    Renae Holtz
    Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Biol Reprod 69:915-24. 2003
    ..The fact that CIITA is expressed in the stable hybrids implies that trophoblasts may be missing a factor that regulates chromatin structure at the CIITA promoter...
  5. pmc Histone deacetylase inhibitors activate CIITA and MHC class II antigen expression in diffuse large B-cell lymphoma
    Kelly A Cycon
    Zeptometrix Corp, Buffalo, NY, USA
    Immunology 140:259-72. 2013
    ..These observations may have important implications for patient therapy. ..
  6. pmc The immunogenicity of L1210 lymphoma clones correlates with their ability to function as antigen-presenting cells
    Kelly A Cycon
    Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY, USA
    Immunology 128:e641-51. 2009
    ..Therefore, the immunogenicity of L1210 cells directly correlates (i) with their ability to stimulate naïve T cells, and (ii) with the concomitant expression of MHCII, B7-1, B7-2, and CD40...
  7. ncbi request reprint Dampening of IFN-gamma-inducible gene expression in human choriocarcinoma cells is due to phosphatase-mediated inhibition of the JAK/STAT-1 pathway
    Jason C Choi
    Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Immunol 178:1598-607. 2007
    ..We propose that phosphatase-mediated suppression of IFN-gamma signaling in TBCs contributes to fetal maintenance by inhibiting expression of genes that could be detrimental to successful pregnancy...
  8. ncbi request reprint Differential in vivo and in vitro HLA-G expression in melanoma cells: potential mechanisms
    Chien Chung Chang
    Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Hum Immunol 64:1057-63. 2003
    ..If proven correct, this model represents a useful background to investigate the mechanisms regulating HLA-G expression in melanoma cells and to devise strategies to counteract HLA-G expression in patients with melanoma...
  9. doi request reprint Maternal-fetal immunology
    B Anne Croy
    Immunol Invest 37:389-94. 2008