Hans Minderman

Summary

Affiliation: Roswell Park Cancer Institute
Country: USA

Publications

  1. doi request reprint Image cytometry-based detection of aneuploidy by fluorescence in situ hybridization in suspension
    Hans Minderman
    Flow and Image Cytometry Laboratory, Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cytometry A 81:776-84. 2012
  2. ncbi request reprint Flow cytometric analysis of breast cancer resistance protein expression and function
    Hans Minderman
    Leukemia Section, Department of Medicine, Roswell Park Cancer Institute, Science Building 616, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cytometry 48:59-65. 2002
  3. ncbi request reprint In vitro and in vivo irinotecan-induced changes in expression profiles of cell cycle and apoptosis-associated genes in acute myeloid leukemia cells
    Hans Minderman
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Mol Cancer Ther 4:885-900. 2005
  4. ncbi request reprint Sequential administration of irinotecan and cytarabine in the treatment of relapsed and refractory acute myeloid leukemia
    Hans Minderman
    Leukemia Section, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Cancer Chemother Pharmacol 57:73-83. 2006
  5. ncbi request reprint Bortezomib activity and in vitro interactions with anthracyclines and cytarabine in acute myeloid leukemia cells are independent of multidrug resistance mechanisms and p53 status
    Hans Minderman
    Department of Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Chemother Pharmacol 60:245-55. 2007
  6. ncbi request reprint The 4'-O-benzylated doxorubicin analog WP744 overcomes resistance mediated by P-glycoprotein, multidrug resistance protein and breast cancer resistance protein in cell lines and acute myeloid leukemia cells
    Tracy A Brooks
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA
    Invest New Drugs 25:115-22. 2007
  7. ncbi request reprint Broad-spectrum modulation of ATP-binding cassette transport proteins by the taxane derivatives ortataxel (IDN-5109, BAY 59-8862) and tRA96023
    Hans Minderman
    Leukemia Section, Department of Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, USA
    Cancer Chemother Pharmacol 53:363-9. 2004
  8. ncbi request reprint VX-710 (biricodar) increases drug retention and enhances chemosensitivity in resistant cells overexpressing P-glycoprotein, multidrug resistance protein, and breast cancer resistance protein
    Hans Minderman
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Clin Cancer Res 10:1826-34. 2004
  9. ncbi request reprint Breast cancer resistance protein (BCRP/MXR/ABCG2) in adult acute lymphoblastic leukaemia: frequent expression and possible correlation with shorter disease-free survival
    Attaya Suvannasankha
    Leukemia Section, Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Br J Haematol 127:392-8. 2004
  10. ncbi request reprint Cyclosporin A is a broad-spectrum multidrug resistance modulator
    Misbah Qadir
    Leukemia Section, Department of Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Clin Cancer Res 11:2320-6. 2005

Research Grants

Collaborators

Detail Information

Publications21

  1. doi request reprint Image cytometry-based detection of aneuploidy by fluorescence in situ hybridization in suspension
    Hans Minderman
    Flow and Image Cytometry Laboratory, Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cytometry A 81:776-84. 2012
    ..Additionally, FISH-IS analysis of samples procured at the time of clinical remission demonstrated the presence of residual +8 cells indicating that this approach may be used to detect MRD and associated chromosomal defects...
  2. ncbi request reprint Flow cytometric analysis of breast cancer resistance protein expression and function
    Hans Minderman
    Leukemia Section, Department of Medicine, Roswell Park Cancer Institute, Science Building 616, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cytometry 48:59-65. 2002
    ..Assessing the clinical relevance of the BCRP will require sensitive and specific methods for detecting its expression and function that allow high-volume specimen throughput and employ widely available instrumentation...
  3. ncbi request reprint In vitro and in vivo irinotecan-induced changes in expression profiles of cell cycle and apoptosis-associated genes in acute myeloid leukemia cells
    Hans Minderman
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Mol Cancer Ther 4:885-900. 2005
    ..To study irinotecan (CPT-11)-induced changes in expression profiles of genes associated with cell cycle control and apoptosis in myeloid leukemia cells in vitro and in vivo...
  4. ncbi request reprint Sequential administration of irinotecan and cytarabine in the treatment of relapsed and refractory acute myeloid leukemia
    Hans Minderman
    Leukemia Section, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Cancer Chemother Pharmacol 57:73-83. 2006
    ..Pharmacokinetic and pharmacodynamic studies were performed with the first irinotecan dose...
  5. ncbi request reprint Bortezomib activity and in vitro interactions with anthracyclines and cytarabine in acute myeloid leukemia cells are independent of multidrug resistance mechanisms and p53 status
    Hans Minderman
    Department of Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Chemother Pharmacol 60:245-55. 2007
    ..We also tested whether bortezomib interactions with cytarabine and anthracyclines are affected by p53, because proteasome inhibition stabilizes p53 and may thus cause cell cycle arrest...
  6. ncbi request reprint The 4'-O-benzylated doxorubicin analog WP744 overcomes resistance mediated by P-glycoprotein, multidrug resistance protein and breast cancer resistance protein in cell lines and acute myeloid leukemia cells
    Tracy A Brooks
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA
    Invest New Drugs 25:115-22. 2007
    ..We compared its uptake and cytotoxicity with those of doxorubicin and daunorubicin in cell lines overexpressing Pgp, MRP-1 or breast cancer resistance protein (BCRP) and in acute myeloid leukemia (AML) cells...
  7. ncbi request reprint Broad-spectrum modulation of ATP-binding cassette transport proteins by the taxane derivatives ortataxel (IDN-5109, BAY 59-8862) and tRA96023
    Hans Minderman
    Leukemia Section, Department of Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, USA
    Cancer Chemother Pharmacol 53:363-9. 2004
    ..We studied the effects of ortataxel and tRA96023 on the other MDR-associated ABC transport proteins, multidrug resistance protein (MRP-1) and breast cancer resistance protein (BCRP, MXR, ABCG2)...
  8. ncbi request reprint VX-710 (biricodar) increases drug retention and enhances chemosensitivity in resistant cells overexpressing P-glycoprotein, multidrug resistance protein, and breast cancer resistance protein
    Hans Minderman
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Clin Cancer Res 10:1826-34. 2004
    ....
  9. ncbi request reprint Breast cancer resistance protein (BCRP/MXR/ABCG2) in adult acute lymphoblastic leukaemia: frequent expression and possible correlation with shorter disease-free survival
    Attaya Suvannasankha
    Leukemia Section, Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Br J Haematol 127:392-8. 2004
    ..0374) in this small patient population. Poor correlations between mRNA, protein and function indicate the complex biology of BCRP in adult ALL, and the possible correlation of BCRP expression with DFS should be studied in larger series...
  10. ncbi request reprint Cyclosporin A is a broad-spectrum multidrug resistance modulator
    Misbah Qadir
    Leukemia Section, Department of Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Clin Cancer Res 11:2320-6. 2005
    ..Cyclosporin A is known to also modulate MRP-1, and we hypothesized that broad-spectrum multidrug resistance modulation might contribute to its clinical efficacy...
  11. ncbi request reprint Differential effects of the immunosuppressive agents cyclosporin A, tacrolimus and sirolimus on drug transport by multidrug resistance proteins
    Attaphol Pawarode
    Department of Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Chemother Pharmacol 60:179-88. 2007
    ....
  12. ncbi request reprint Expression of the neural cell adhesion molecule CD56 is not associated with P-glycoprotein overexpression in core-binding factor acute myeloid leukemia
    Attaya Suvannasankha
    Department of Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Leuk Res 28:449-55. 2004
    ..CD56 expression did not correlate with Pgp expression or function, nor with expression of the other MDR proteins. Treatment failure associated with CD56 expression in CBFalpha-AML is not likely attributable to Pgp...
  13. pmc Down-regulation of signal transducer and activator of transcription 3 improves human acute myeloid leukemia-derived dendritic cell function
    Michael T Brady
    Leukemia Section, Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, United States
    Leuk Res 37:822-8. 2013
    ..We conclude that AML-DCs have improved immunogenicity after reducing STAT3...
  14. ncbi request reprint Taxane-based reversal agents modulate drug resistance mediated by P-glycoprotein, multidrug resistance protein, and breast cancer resistance protein
    Tracy A Brooks
    Department of Pharmacology and Therapeutics and Leukemia Section, Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Mol Cancer Ther 2:1195-205. 2003
    ..These tRAs, especially tRA 98006, have promise for development as clinical broad-spectrum MDR modulators and warrant more preclinical analysis to determine pharmacokinetic interactions and efficacy...
  15. pmc Quantifying nuclear p65 as a parameter for NF-κB activation: Correlation between ImageStream cytometry, microscopy, and Western blot
    Orla Maguire
    Department of Flow and Image Cytometry, Roswell Park Cancer Institute, Buffalo, New York, USA
    Cytometry A 79:461-9. 2011
    ..We conclude that the ImageStream has the potential to be a powerful tool to evaluate NF-κB /p65 activity as a determinant of response to therapies designed to target aberrant NF-κB signaling activities...
  16. ncbi request reprint Phase 3 study of the multidrug resistance modulator PSC-833 in previously untreated patients 60 years of age and older with acute myeloid leukemia: Cancer and Leukemia Group B Study 9720
    Maria R Baer
    Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Blood 100:1224-32. 2002
    ..Moreover, for patients with PSC-833-modulated efflux, median disease-free survival was 5 months with ADE and 14 months with ADEP (P =.07). Further modulation trials in older patients must await the design of less-toxic regimens...
  17. ncbi request reprint Small ubiquitin-related modifier pathway is a major determinant of doxorubicin cytotoxicity in Saccharomyces cerevisiae
    Ruea Yea Huang
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, and Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Cancer Res 67:765-72. 2007
    ..Cumulatively, these results reveal that SUMO modification of proteins mediates the doxorubicin cytotoxicity in yeast, at least partially, by modification of septins and of proteins that control the intracellular drug concentration...
  18. pmc NADPH oxidase limits innate immune responses in the lungs in mice
    Brahm H Segal
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York, United States of America
    PLoS ONE 5:e9631. 2010
    ..g., inflammatory bowel disease). The mechanisms by which NADPH oxidase regulates inflammation are not well understood...
  19. pmc Human ovarian tumor ascites fluids rapidly and reversibly inhibit T cell receptor-induced NF-κB and NFAT signaling in tumor-associated T cells
    Michelle R Simpson-Abelson
    The State University of New York at Buffalo, Department of Microbiology and Immunology and The Witebsky Center for Microbial Pathogenesis and Immunology, University at Buffalo, Buffalo, NY, USA
    Cancer Immun 13:14. 2013
    ..The soluble immunosuppressive factors represent potential therapeutic targets for ovarian cancer. ..
  20. pmc The prolyl isomerase Pin1 targets stem-loop binding protein (SLBP) to dissociate the SLBP-histone mRNA complex linking histone mRNA decay with SLBP ubiquitination
    Nithya Krishnan
    Hauptman Woodward Medical Research Institute, SUNY at Buffalo, Buffalo, New York, USA
    Mol Cell Biol 32:4306-22. 2012
    ..Our data suggest that Pin1 and PP2A act to coordinate the degradation of SLBP by the ubiquitin proteasome system and the exosome-mediated degradation of the histone mRNA by regulating complex dissociation...
  21. pmc Neem oil limonoids induces p53-independent apoptosis and autophagy
    Pragya Srivastava
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Carcinogenesis 33:2199-207. 2012
    ..Together, for the first time, we demonstrate that neem induces caspase-dependent and AIF-mediated apoptosis, and autophagy in cancer cells...

Research Grants2

  1. Clinical application of multispectral imaging flow cytometry
    Hans Minderman; Fiscal Year: 2007
    ..The aim of the proposed studies is to determine necessary adjustments to this instrument's hardware and analysis software to accurately and efficiently use it in a clinical research setting. ..