Fengzhi Li

Summary

Affiliation: Roswell Park Cancer Institute
Country: USA

Publications

  1. pmc The mechanism of methylselenocysteine and docetaxel synergistic activity in prostate cancer cells
    Rami G Azrak
    Department of Cancer Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Mol Cancer Ther 5:2540-8. 2006
  2. doi request reprint Discovery of survivin inhibitors and beyond: FL118 as a proof of concept
    Fengzhi Li
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York, USA
    Int Rev Cell Mol Biol 305:217-52. 2013
  3. pmc Every single cell clones from cancer cell lines growing tumors in vivo may not invalidate the cancer stem cell concept
    Fengzhi Li
    Departments of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Mol Cells 27:491-2. 2009
  4. pmc Role of the Survivin gene in pathophysiology
    Fengzhi Li
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Am J Pathol 169:1-11. 2006
  5. pmc Role of survivin and its splice variants in tumorigenesis
    F Li
    Department of Pharmacology and Therapeutics, Grace Cancer Drug Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Br J Cancer 92:212-6. 2005
  6. pmc Differential regulation of survivin expression and apoptosis by vitamin D3 compounds in two isogenic MCF-7 breast cancer cell sublines
    Fengzhi Li
    Department of Pharmacology and Therapeutics, Grace Cancer Drug Center, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Oncogene 24:1385-95. 2005
  7. pmc Nuclear or cytoplasmic expression of survivin: what is the significance?
    Fengzhi Li
    Department of Pharmacology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Int J Cancer 114:509-12. 2005
  8. pmc Generation of a novel transgenic mouse model for bioluminescent monitoring of survivin gene activity in vivo at various pathophysiological processes: survivin expression overlaps with stem cell markers
    Fengzhi Li
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Am J Pathol 176:1629-38. 2010
  9. pmc Survivin study: an update of "what is the next wave"?
    Fengzhi Li
    Department of Pharmacology and Therapeutics, Grace Cancer Drug Center, Roswell Park Cancer Institute, Buffalo, New York, USA
    J Cell Physiol 208:476-86. 2006
  10. ncbi request reprint Survivin study: what is the next wave?
    Fengzhi Li
    Department of Pharmacology and Therapeutics, Grace Cancer Drug Center, Roswell Park Cancer Institute, Elm and Carlton Street, Buffalo, New York, USA
    J Cell Physiol 197:8-29. 2003

Collaborators

Detail Information

Publications36

  1. pmc The mechanism of methylselenocysteine and docetaxel synergistic activity in prostate cancer cells
    Rami G Azrak
    Department of Cancer Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Mol Cancer Ther 5:2540-8. 2006
    ..The synergy between MSeC and docetaxel in C2G prostate cancer cells is associated with increased level of caspase-dependent apoptosis and decreased level of survivin...
  2. doi request reprint Discovery of survivin inhibitors and beyond: FL118 as a proof of concept
    Fengzhi Li
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York, USA
    Int Rev Cell Mol Biol 305:217-52. 2013
    ..This review provides an overview of current information in the area relevant to survivin inhibitors that may facilitate future studies. ..
  3. pmc Every single cell clones from cancer cell lines growing tumors in vivo may not invalidate the cancer stem cell concept
    Fengzhi Li
    Departments of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Mol Cells 27:491-2. 2009
    ..We argue that in vivo tumor formation from single cell clones, isolated in vivo from cancer cell lines, may not provide conclusive evidence to disprove the cancer stem cell (CSC) theory without additional data...
  4. pmc Role of the Survivin gene in pathophysiology
    Fengzhi Li
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Am J Pathol 169:1-11. 2006
    ..Our view of potential future research directions for survivin pertinent to potential therapeutic applications will also be discussed...
  5. pmc Role of survivin and its splice variants in tumorigenesis
    F Li
    Department of Pharmacology and Therapeutics, Grace Cancer Drug Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Br J Cancer 92:212-6. 2005
    ..In this minireview, the author intends to summarise and discuss the current data relevant to the role of survivin and its splicing variants in tumorigenesis, which may facilitate further investigation in this interesting area...
  6. pmc Differential regulation of survivin expression and apoptosis by vitamin D3 compounds in two isogenic MCF-7 breast cancer cell sublines
    Fengzhi Li
    Department of Pharmacology and Therapeutics, Grace Cancer Drug Center, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Oncogene 24:1385-95. 2005
    ..Targeting survivin through these pathways may lead to novel applications for cancer therapeutics...
  7. pmc Nuclear or cytoplasmic expression of survivin: what is the significance?
    Fengzhi Li
    Department of Pharmacology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Int J Cancer 114:509-12. 2005
    ..This would alert researchers to pay attention to potential pitfalls in the determination of nuclear or cytoplasmic expression of survivin for the future...
  8. pmc Generation of a novel transgenic mouse model for bioluminescent monitoring of survivin gene activity in vivo at various pathophysiological processes: survivin expression overlaps with stem cell markers
    Fengzhi Li
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Am J Pathol 176:1629-38. 2010
    ..Thus, we have generated a unique animal model for analysis of diverse pathophysiological processes and possible stem cell distribution/activity in vivo...
  9. pmc Survivin study: an update of "what is the next wave"?
    Fengzhi Li
    Department of Pharmacology and Therapeutics, Grace Cancer Drug Center, Roswell Park Cancer Institute, Buffalo, New York, USA
    J Cell Physiol 208:476-86. 2006
    ..This review article will update the role of survivin, and its splice variants in the mitosis/cell cycle, apoptosis, tumorigenesis, chemoprevention, drug/radiation resistance, and cancer therapeutics...
  10. ncbi request reprint Survivin study: what is the next wave?
    Fengzhi Li
    Department of Pharmacology and Therapeutics, Grace Cancer Drug Center, Roswell Park Cancer Institute, Elm and Carlton Street, Buffalo, New York, USA
    J Cell Physiol 197:8-29. 2003
    ....
  11. ncbi request reprint Induction of survivin expression by taxol (paclitaxel) is an early event, which is independent of taxol-mediated G2/M arrest
    Xiang Ling
    Department of Pharmacology and Therapeutics, Grace Cancer Drug Center, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    J Biol Chem 279:15196-203. 2004
    ..This appears to be a new mechanism for cancer cells to evade taxol-induced apoptosis. Targeting this survival pathway may result in novel approaches for cancer therapeutics...
  12. pmc Differential expression of survivin-2B and survivin-DeltaEx3 is inversely associated with disease relapse and patient survival in non-small-cell lung cancer (NSCLC)
    Xiang Ling
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Lung Cancer 49:353-61. 2005
    ..Thus, controlling the differential expression of survivin-2B and survivin-DeltaEx3 may represent novel approaches for cancer therapeutics in NSCLC...
  13. pmc Molecular mechanism of upregulation of survivin transcription by the AT-rich DNA-binding ligand, Hoechst33342: evidence for survivin involvement in drug resistance
    Jianguo Wu
    Department of Pharmacology, Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Nucleic Acids Res 35:2390-402. 2007
    ..We propose that hindrance of H369W-Gfi-1 interactions in the survivin promoter, initiated by Hoechst33342, contributes to upregulation of survivin transcription, and as a consequence, hampers Hoechst33342's cytotoxicity...
  14. pmc Selenium inhibition of survivin expression by preventing Sp1 binding to its promoter
    Jae Yeon Chun
    Department of Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Mol Cancer Ther 6:2572-80. 2007
    ..In addition, down-regulation of survivin expression may account for one of the molecular mechanisms of the anticancer effects of selenium...
  15. pmc Prostate-derived Ets transcription factor as a favorable prognostic marker in ovarian cancer patients
    Ali Ghadersohi
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Int J Cancer 123:1376-84. 2008
    ....
  16. doi request reprint Transcriptional inhibition of p21WAF1/CIP1 gene (CDKN1) expression by survivin is at least partially p53-dependent: evidence for survivin acting as a transcription factor or co-factor
    Lei Tang
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Biochem Biophys Res Commun 421:249-54. 2012
    ....
  17. pmc Cancer cell sensitivity to bortezomib is associated with survivin expression and p53 status but not cancer cell types
    Xiang Ling
    Departments of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    J Exp Clin Cancer Res 29:8. 2010
    ....
  18. pmc Molecular mechanism of inhibition of survivin transcription by the GC-rich sequence-selective DNA binding antitumor agent, hedamycin: evidence of survivin down-regulation associated with drug sensitivity
    Jianguo Wu
    Department of Pharmacology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    J Biol Chem 280:9745-51. 2005
    ..Drug-induced modulation of survivin gene expression may provide novel approaches for cancer therapeutics...
  19. pmc Forced expression of survivin-2B abrogates mitotic cells and induces mitochondria-dependent apoptosis by blockade of tubulin polymerization and modulation of Bcl-2, Bax, and survivin
    Xiang Ling
    Department of Pharmacology and Therapeutics, Grace Cancer Drug Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    J Biol Chem 282:27204-14. 2007
    ..These findings advance our current knowledge about survivin-2B and may help to develop novel approaches for cancer treatment...
  20. ncbi request reprint Estrogen receptor alpha inhibits p53-mediated transcriptional repression: implications for the regulation of apoptosis
    Aejaz Sayeed
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 67:7746-55. 2007
    ..The findings could have translational implications in developing new therapeutic and prevention strategies against breast cancer...
  21. pmc A novel small molecule FL118 that selectively inhibits survivin, Mcl-1, XIAP and cIAP2 in a p53-independent manner, shows superior antitumor activity
    Xiang Ling
    Departments of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY, USA
    PLoS ONE 7:e45571. 2012
    ..Together, the molecular targeting features of FL118 plus its superior antitumor activity warrant its further development toward clinical trials...
  22. pmc Prostate-derived Ets transcription factor (PDEF) is a potential prognostic marker in patients with prostate cancer
    Ali Ghadersohi
    Roswell Park Cancer Institute, Department of Pharmacology and Therapeutics, Buffalo, New York, USA
    Prostate 71:1178-88. 2011
    ..However, the clinical relevance of PDEF expression and its relationship to anti-apoptotic protein survivin is yet to be determined...
  23. pmc Prostate-derived Ets transcription factor (PDEF) downregulates survivin expression and inhibits breast cancer cell growth in vitro and xenograft tumor formation in vivo
    Ali Ghadersohi
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Elm and Carlton Street, Buffalo, NY 14263, USA
    Breast Cancer Res Treat 102:19-30. 2007
    ..Furthermore, loss of PDEF expression in breast cancer tissues tends to be associated with unfavorable prognosis. These studies provide new information for the role of PDEF and survivin in breast cancer cell growth and tumor formation...
  24. ncbi request reprint Nuclear survivin expression predicts poor outcome in cholangiocarcinoma
    Milind M Javle
    Department of Medicine, Roswell Park Cancer Institute and State University of New York at Buffalo, 14263, USA
    Hepatogastroenterology 51:1653-7. 2004
    ..Survivin is an anti-apoptotic protein expressed in cancer and may have prognostic value. Our study examined the prognostic role of survivin in biliary cancer...
  25. ncbi request reprint Silencing of antiapoptotic survivin gene by multiple approaches of RNA interference technology
    Xiang Ling
    Roswell Park Cancer Institute, Buffalo, NY, USA
    Biotechniques 36:450-4, 456-60. 2004
    ....
  26. pmc Exploring long-term protection of normal human fibroblasts and epithelial cells from chemotherapy in cell culture
    Pasha Apontes
    Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Oncotarget 2:222-33. 2011
    ....
  27. pmc An intravenous (i.v.) route-compatible formulation of FL118, a survivin, Mcl-1, XIAP, and cIAP2 selective inhibitor, improves FL118 antitumor efficacy and therapeutic index (TI)
    Xiang Ling
    Departments of Pharmacology and Therapeutics, Roswell Park Cancer Institute RPCI Buffalo, New York 14263, USA
    Am J Transl Res 5:139-54. 2013
    ..The striking improvement of the TI makes FL118 a much safer drug for further development toward clinical trials...
  28. ncbi request reprint Loss of inhibitor of apoptosis proteins as a determinant of polyamine analog-induced apoptosis in human melanoma cells
    Ying Chen
    Grace Cancer Drug Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Oncogene 22:4964-72. 2003
    ..The findings implicate survivin and ML-IAP as important determinants of polyamine analog drug action in melanoma cells...
  29. ncbi request reprint Transcriptional targeting of tumors with a novel tumor-specific survivin promoter
    Zeng B Zhu
    Division of Human Gene Therapy, Department of Medicine, Pathology, and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham AL 35291, USA
    Cancer Gene Ther 11:256-62. 2004
    ....
  30. ncbi request reprint An alternatively spliced survivin variant is positively regulated by p53 and sensitizes leukemia cells to chemotherapy
    Ningxi Zhu
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Oncogene 23:7545-51. 2004
    ..These results suggest that survivin-2B variant is a proapoptotic factor and its expression is upregulated by p53...
  31. ncbi request reprint Effects of human papillomavirus type 16 oncoproteins on survivin gene expression
    Agnes A Borbély
    Department of Medical Microbiology, Medical and Health Science Centre, University of Debrecen, PO Box 17, H 4012 Debrecen, Hungary
    J Gen Virol 87:287-94. 2006
    ..Importantly, cell cycle synchronization experiments showed that the effect of HPV-16 E6 on survivin transcription is independent of the cell cycle...
  32. doi request reprint Inhibition of the Akt/survivin pathway synergizes the antileukemia effect of nutlin-3 in acute lymphoblastic leukemia cells
    Ningxi Zhu
    Department of Pediatrics, Emory University School of Medicine, 2015 Uppergate Drive, Atlanta, GA 30322, USA
    Mol Cancer Ther 7:1101-9. 2008
    ....
  33. ncbi request reprint VRK1 signaling pathway in the context of the proliferation phenotype in head and neck squamous cell carcinoma
    Claudio R Santos
    Instituto de Biologia Molecular y Celular del Cancer, Centro de Investigacion del Cancer, Consejo Superior de Investigaciones Cientificas, Universidad de Salamanca, Campus Miguel de Unamuno, E 37007 Salamanca, Spain
    Mol Cancer Res 4:177-85. 2006
    ..These data suggest that VRK1 might play a role in cell cycle regulation and is likely to represent the beginning of a new control mechanism of cell cycle, particularly late in the G1-S phase...
  34. ncbi request reprint DNA damage induces a novel p53-survivin signaling pathway regulating cell cycle and apoptosis in acute lymphoblastic leukemia cells
    Muxiang Zhou
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Pharmacol Exp Ther 303:124-31. 2002
    ..Furthermore, our data indicate that loss of wt-p53 function in tumor cells may contribute to up-regulation of survivin and resistance to DNA-damaging agents...
  35. pmc Induction of cell cycle arrest by human T-cell lymphotropic virus type 1 Tax in hematopoietic progenitor (CD34+) cells: modulation of p21cip1/waf1 and p27kip1 expression
    Adam Tripp
    Department of Microbiology and Immunology, SUNY Upstate Medical University, 750 East Adams St, Syracuse, NY 13210, USA
    J Virol 79:14069-78. 2005
    ..These remarkable differences in the activities of Tax1 and Tax2 in CD34(+) hematopoietic progenitor cells may underlie the sharp differences observed in the pathogenesis resulting from infection with HTLV-1 and HTLV-2...
  36. pmc Survivin repression by p53, Rb and E2F2 in normal human melanocytes
    Deepak Raj
    Department of Dermatology, University of Utah, 30 North 1900 East, Salt Lake City, UT 84132, USA
    Carcinogenesis 29:194-201. 2008
    ..These studies suggest that compromise of either p53 or Rb pathways during melanocyte transformation leads to up-regulation of survivin expression in melanoma...

Research Grants7

  1. Survivin expression and cancer cell drug resistance
    Fengzhi Li; Fiscal Year: 2007
    ..These studies may extend the current understanding of the mechanisms of drug resistance and survivin action, and may reveal alternative therapeutic sites and/or targets to develop novel approaches for cancer treatment. ..
  2. PDEF and survivin: cancer prognosis, initiation, progression and metastasis
    Fengzhi Li; Fiscal Year: 2009
    ..These studies may provide novel approaches for cancer prognosis and personalized medicine, by considering survivin and PDEF as interconnected biomarkers and targets. ..
  3. PDEF and survivin: cancer prognosis, initiation, progression and metastasis
    Fengzhi Li; Fiscal Year: 2010
    ..These studies may provide novel approaches for cancer prognosis and personalized medicine, by considering survivin and PDEF as interconnected biomarkers and targets. ..